• Asian-Australasian Journal of Animal Sciences
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• 제31권11호
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• pp.1818-1827
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• 2018

Objective: The objective of this work was to determine the prevalence of the pathologies that caused the condemnation of pig carcasses in an area of intensive pig farming and Mediterranean climatology and to evaluate their influence in a risk-based inspection procedure for slaughterhouses. Methods: A retrospective observational investigation was carried out from 2002 to 2016 into the pathological processes that caused the condemnation of pig carcasses in a slaughterhouse from South-eastern Spain. The seasonal effect on the causes of condemnation carcass was reported. Negative binomial model was used to evaluate the effect of season on the rate of antemortem rejections and post-mortem condemnations. Histopathological examinations were performed to confirm the diagnosis. Results: The risk of antemortem rejections (0.0564%) was significantly greater in summer (risk ratio [RR] = 1.57). Autumn was associated with higher rate (RR = 1.69) of the total postmortem condemnations (0.1046%). Significantly higher rates of pronounced anaemia (0.0111%) were observed in summer (RR = 3.20). The main causes of anaemia were observed gastroesophageal ulcers and haemorrhagic enteropathies. Significantly highest risk of erysipelas (0.0074%) were observed in autumn (RR = 5.485). About other zoonosis, only eight cases (0.0013%) of carcasses were declared unfit due to tuberculosis lesions. Porcine muscular cysticercosis was not detected. Nevertheless, nonspecific causes such as generalized infections and emaciation represented the half of the condemned carcasses (50.90%). Conclusion: The pathologies leading to the condemnation of carcasses in this study can be considered representative of the pathologies that affect the pig population from a region with a high intensive production and Mediterranean climatology because this slaughterhouse receives a lot of animals from many farms of different size in a high intensive pig production zone (Mediterranean region). Increased knowledge of environmental factors that may foment the appearance of the diseases is essential for implementing inspection programs based on risk assessment in pig's slaughterhouses.

• 한국지능시스템학회논문지
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• 제23권6호
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• pp.519-526
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• 2013

심전도 신호는 P, Q, R, S, T파를 한 주기로 하여 반복되는 특징을 가지고 있으며 일반적으로 높은 표본화 주파수로 샘플링 된다. 이러한 심전도 신호의 주기적인 특징을 이용하여 진단에 중요한 정보의 손실을 최소화하면서 압축 효율을 극대화시키는 방법이 필요하다. 그러나 이러한 주기적인 특징은 심검자와 측정 시기에 따라 진폭과 주기가 일정하지가 않다. 또한 환자의 경우, 같은 시기에 측정하더라도 주기적 특징이 다르게 나타나는 구간이 존재한다. 본 논문에서는 적응적 멀티 레벨 코드를 이용하여 주도적인 신호 구간과 비주도적인 신호 구간의 심전도 신호를 적응적으로 코드화하는 방법을 제안한다. 제안하는 방식은 주도적인 신호 구간과 비주도적인 신호 구간에 따른 손실 대비 압축률을 차등 적용함으로써 반복적인 신호를 멀티 레벨 코드를 이용하여 압축의 효율성을 극대화하는 것이다. 이는 심전도 신호의 주기성을 이용하지 않은 기존의 압축 방식에 비해 장시간 측정 데이터의 압축률을 극대화시키고 비주도적인 신호를 코드화하여 무손실 압축을 함으로써 진단에 중요한 정보를 손실 없이 보존할 수 있는 장점이 있다. MIT-BIH 부정맥 데이터베이스에 있는 심전도 신호에 대한 실험을 통하여 압축의 효용성을 검증하였다.

• 대한의용생체공학회:의공학회지
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• 제23권3호
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• pp.197-205
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• 2002

본 연구에서는 잡음이 존재하는 공간에서 획득한 음성신호로부터 후두질환을 감별진단 할 수 있는 분류기를 구현하였다. 이를 위해 후두질환 환자로부터 수집한 /아/ 모음에 잡음을 혼입하여 음성 신호를 획득하였고, 여러 가지 후두질환을 감별진단 할 수 있는 파라미터를 추출하였으며. 이를 입력으로 하는 계층적 신경회로망을 구성하여 후두질환을 감별진단 하도록 하였다. 감별진단용 분류기는 다섯 단계의 계층적 신경회로망으로 구성하였다 첫 번째 신경회로망은 정상 양성 후두질환과 악성 후두질환을. 두 번째 신경회로망은 정상과 양성 후두질환을 감별진단 하도록 하였다 그리고 세 번째 신경회로망은 양성 후두질환 중 후두용. 성대결절 후두마비를 감별진단 하도록 하였으며. 네 번째와 다섯 번째 신경회로망은 성문암 1-4기를 감별진단 하도록 구성하였다. 분류기에 적용된 신경회로망은 다층퍼셉트론 구조로써 역전파 알고리듬으로 학습시켰으며, 선형변환 표준점수변환 등 전처리과정을 적용하여 분류기의 성능을 개선하였다. 후두질환의 감별진단 결과 후두용 88.23%. 정상. 성대결절. 후두마비 100%. 성문암 1기 90%, 성문암 2-4기 100%의 감별진단율을 관찰할 수 있었다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.357-360
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• 1997

For medical students and doctors, knowledge of the 3-dimensional (3D) structure of the heart is very important in diagnosis and treatment of the heart diseases. 2-dimensional (2D) tools (e.g. anatomy book) or classical 3D tools (e.g. plastic model) are not sufficient or understanding the complex structures of the heart. Moreover, it is not always guaranteed to dissect the heart of cadaver when it is necessary. To overcome this problem, virtual dissection systems of the heart have been developed. But these systems are not satisfactory since they are made of radiographs; they are not true 3D images; they can not be used to dissect freely; or they can only be operated on the workstation. It is also necessary to make the dissection systems incorporating the various races and tribes because of the organ's difference according to race and tribe. This study was intended to make the 3D image of the heart from a Korean cadaver, and to establish a virtual dissection system of the heart with a personal computer. The procedures or manufacturing this system were as follows. 1. The heart from a Korean adult cadaver was embedded with gelatin solution, and serially cross-sectioned at 1mm-thickness on a meat slicer. Pictures or 153 cross-sectioned specimens were inputted into the computer using a digital camera ($756{\times}504$ resolution, true color). 2. The alignment system was established by means of the language of IDL, and applied to align 2D images of the heart. In each of 2D images, closed curves lining clean and dirty blood pathways were drawn manually on the CorelDRAW program. 3. Using the language of IDL, the 3D image and the virtual dissection system of the heart were constructed. The virtual dissection system of the heart allowed or ree rotation, any-directional sectioning, and selected visualization of the heart's structure. This system is expected to become more advanced, and to be used widely through Internet or CD-title as an educational tool for medical students and doctors.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.57-59
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• 1998

For medical students and doctors, knowledge of the three-dimensional (3D) structure of brain is very important in diagnosis and treatment of brain diseases. Two-dimensional (2D) tools (ex: anatomy book) or traditional 3D tools (ex: plastic model) are not sufficient to understand the complex structures of the brain. However, it is not always guaranteed to dissect the brain of cadaver when it is necessary. To overcome this problem, the virtual dissection programs of the brain have been developed. However, most programs include only 2D images that do not permit free dissection and free rotation. Many programs are made of radiographs that are not as realistic as sectioned cadaver because radiographs do not reveal true color and have limited resolution. It is also necessary to make the virtual dissection programs of each race and ethnic group. We attempted to make a virtual dissection program using a 3D image of the brain from a Korean cadaver. The purpose of this study is to present an educational tool for those interested in the anatomy of the brain. The procedures to make this program were as follows. A brain extracted from a 58-years old male Korean cadaver was embedded with gelatin solution, and serially sectioned into 1.4 mm-thickness using a meat slicer. 130 sectioned specimens were inputted to the computer using a scanner ($420\times456$ resolution, true color), and the 2D images were aligned on the alignment program composed using IDL language. Outlines of the brain components (cerebrum, cerebellum, brain stem, lentiform nucleus, caudate nucleus, thalamus, optic nerve, fornix, cerebral artery, and ventricle) were manually drawn from the 2D images on the CorelDRAW program. Multimedia data, including text and voice comments, were inputted to help the user to learn about the brain components. 3D images of the brain were reconstructed through the volume-based rendering of the 2D images. Using the 3D image of the brain as the main feature, virtual dissection program was composed using IDL language. Various dissection functions, such as dissecting 3D image of the brain at free angle to show its plane, presenting multimedia data of brain components, and rotating 3D image of the whole brain or selected brain components at free angle were established. This virtual dissection program is expected to become more advanced, and to be used widely through Internet or CD-title as an educational tool for medical students and doctors.

• Parasites, Hosts and Diseases
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• 제50권3호
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• pp.199-205
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• 2012

Toxoplasmic encephalitis is caused by reactivation of bradyzoites to rapidly dividing tachyzoites of the apicomplexan parasite Toxoplasma gondii in immunocompromised hosts. Diagnosis of this life-threatening disease is problematic, because it is difficult to discriminate between these 2 stages. Toxoplasma PCR assays using gDNA as a template have been unable to discriminate between an increase or decrease in SAG1 and BAG1 expression between the active tachyzoite stage and the latent bradyzoite stage. In the present study, real-time RT-PCR assay was used to detect the expression of bradyzoite (BAG1)- and tachyzoite-specific genes (SAG1) during bradyzoite/tachyzoite stage conversion in mice infected with T. gondii Tehran strain after dexamethasone sodium phosphate (DXM) administration. The conversion reaction was observed in the lungs and brain tissues of experimental mice, indicated by SAG1 expression at day 6 after DXM administration, and continued until day 14. Bradyzoites were also detected in both organs throughout the study; however, it decreased at day 14 significantly. It is suggested that during the reactivation period, bradyzoites not only escape from the cysts and reinvade neighboring cells as tachyzoites, but also converted to new bradyzoites. In summary, the real-time RT-PCR assay provided a reliable, fast, and quantitative way of detecting T. gondii reactivation in an animal model. Thus, this method may be useful for diagnosing stage conversion in clinical specimens of immunocompromised patients (HIV or transplant patients) for early identification of tachyzoite-bradyzoite stage conversion.

• 한국의사학회지
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• 제25권1호
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• pp.53-60
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• 2012

In recent times, a medical book called "WooJam JabJeo" has been published in complete Korean version. Not a few cases where the vivid appearance of the place for medical treatment are included intact in this medical book. This study is attempting to analyze one symptom of a disease by choosing it among the diseases our ancient sages treated in the light of the fact that there are only a few models which are applied to today's clinical treatment by our ancient sages appearance of medical service. This study believes that such an analysis of ancient medicine could be a part of the efforts to increase the applicable models to today's clinical treatment one by one. This paper is aimed at introducing and analyzing the three cases of Ganwul which are found in "WooJam JabJeo". It's because this study thinks that Ganwul is a symptom over which oriental medicine can not only establish dominance over western medicine it its diagnosis and prescription but Ganwul will also have high applicability to today's clinical treatment. Through this research, this study was able to perceive that the author. Jang, Tae-kyeong of "WooJam JabJeo" had vast knowledge of medical theories, especially in author's understanding diseases and composing prescription based on "Donguibogam". Up to the present time, domestic medical circles have understood the emergence of "Jejungshinpyeon(濟衆新編)"(1799) or "Bangyakhappyeon(方藥合編)"(1885) as an outlining work at most for overcoming such a limit of "DonguiBogam" superficially. However, by looking into Jang Tae-kyeong's understanding of "Dongui Bogam". this study was able to know the fact that the emergence of such medical books was possible because the medical knowledge included in "Dongui Bogam" was fully understood and digested in society of the Josen Dynasty. Conclusively, such a fact reminds us that it serves as a momentum to confirm once more that "Dongui Bogam" could be a good model for even today's clinical treatment.

• 대한지역사회영양학회지
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• 제20권2호
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• pp.129-140
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• 2015

Objectives: We examined the association between the adherence to dietary guidelines for breast cancer survivors and health-related quality of life in a cross-sectional study of Korean breast cancer survivors. Methods: A total of 157 women aged 21 to 79 years who had been diagnosed with stage I to III breast cancers according to the American Joint Committee on Cancer (AJCC) and had breast cancer surgery at least 6 months before the baseline were included. We used a Korean version of the Core 30 (C30) and Breast cancer 23 (BR23) module of the European Organization for Research and Treatment Cancer Quality of Life Questionnaire (EORTC-QLQ), both of which have been validated for Koreans. Participants were asked about their adherence to dietary guidelines for breast cancer survivors, suggested by the Korean breast cancer society, using a 5-point Likert scale. We summed dietary guideline adherence scores for each participant and calculated the least squares means of health-related quality of life according to dietary guideline adherence scores using the generalized linear model. Results: Breast cancer survivors who had higher adherence to dietary guidelines for breast cancer survivors had lower constipation scores than those with lower adherence (p for trend=0.01). When we stratified by the stage at diagnosis, this association was limited to those who had been diagnosed with stage II or III breast cancers. Also, sexual functioning scores increased significantly with increasing adherence scores of dietary guidelines among those with stage II or III breast cancers (p for trend < 0.001). However, among those who had been diagnosed with stage I, higher scores of dietary guidelines were associated with higher scores of pain (p for trend=0.03) and breast symptoms (p for trend=0.05). Conclusions: Our study suggested that the health-related quality of life levels of breast cancer survivors are associated with the adherence to dietary guidelines and may differ by the stage of the breast cancer.

• 한국농림기상학회지
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• 제21권4호
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• pp.261-268
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• 2019

한발 발생이 갈수록 증가하고 있는 가운데, 작물의 생리생화학적 기작과 광합성능을 효율적으로 진단 및 평가 할 수 있는 방법을 찾는 것은 매우 중요한 과제이다. 본 연구를 통해 광화학 반사 지수인 PRI가 콩의 한발 스트레스에 대하여 고온과 고CO₂ 등 미래 기후 변화 환경에서도 유의미한 생육 지표로 활용될 수 있음을 확인하였다. PRI와 대표적 한발 생육지표들(군락 광이용효율, 건물중 변동율, 엽록소 형광, 기공전도도)과의 밀접한 관계를 통해 한발 스트레스 하에서 콩의 광합성 활성과 생장량을 원격으로 모니터링할수 있는 진단 모델 개발의 가능성을 볼 수 있었다. 다만 향후 고온, 고CO₂ 등 기후변화 조건에서 PRI의 성능에 대한 지속적인 평가와 함께 민감도 향상을 위한 광학지표 개발 및 모델 개선 연구가 선행되어야 할 것으로 보인다.

• 대한두경부종양학회지
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• 제35권2호
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• pp.19-25
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• 2019

Background/Objectives: Although anaplastic thyroid carcinoma (ATC) is rare, it is one of the deadliest forms of thyroid cancer. The fatality rate for ATC is high, and the survival rate at one year after diagnosis is <20%. The present study aimed to investigate the anti-tumor activities of paclitaxel, radiation, and tyrosine kinase inhibitor (TKI) combined therapy in anaplastic thyroid cancer cells both in vitro and in vivo and explore its effects on apoptotic cell death pathways. Materials & Methods: ATC cell line was exposed to TKI, lenvatinib in the presence or absence of paclitaxel with radiation, and cell viability was determined by MTT assay. Effects of the combined treatment on cell cycle and intracellular signaling pathways were assessed by flow cytometry and western blot analysis. The ATC cell line xenograft model was used to examine the anti-tumor activity in vivo. Results: Our data revealed that the combined administration of paclitaxel, TKI, and radiation decreased cell viability in ATC cells, and also significantly increased apoptotic cell death in these cells, as demonstrated by the cleavage of caspase-3 and DNA fragmentation. This combination therapy reduced anti-apoptotic factor levels in ATC cells, while significantly decreasing tumor volume and increasing survival in ATC xenografts. Conclusion: These results indicate that administering the combination of paclitaxel, TKI, and radiation therapy may exert significant anticancer effects in preclinical models, potentially suggesting a new clinical approach for treating patients with ATC.