• Title/Summary/Keyword: dextran

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Adverse Drug Reactions of Dextran 40 Treated to the Cerebral Infarction Patients (뇌경색 환자에게 사용된 덱스트란 40의 부작용 분석)

  • Kim, Jae-Hyeon
    • The Journal of the Korea Contents Association
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    • v.16 no.9
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    • pp.473-481
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    • 2016
  • Adverse drug reactions(ADRs) were caused by dexran 40 in patient with ischemic stroke and related 22 patients reported to formal ADRs at Jesus Hospital in Jeonju. This study was aimed to search ADRs related factors, type and the degree associated with dextran 40. Adverse Effects of Dextran 40 is including marked hypotension, nausea, dyspnea, generalized urticaria, fever and pulmonary edema. The average hospitalization period was 20 days and it was extended 26.8%. ADRs of Dextran 40 to incidence is 12.4%, and 9 persons(28.1%), itching, rash was 7 people (21.9%). Dextran induced ADRs reaction may be reported on early injection period and first time shot, but adverse drug reactions occurred after 4 days in 4 patients(18.2%). US FDA has recommanded that Dextran 1 significantly reduces the incidence of severe ADRs in USA. Because low molecular weighted dextran 1 prevented dextran molecules from combined Ig G completely. In Korea. Generally not yet introduced dextran 1, active use dextran 1 is able to be a good way in order to reduce ADRs of dextran 40.

Synthesis and Properties of Dextran-5-amonosalicyclic Acid Ester as a Potential Colon-specific Prodrug of 5-Aminosalicyclic Acid

  • Jung, Yun-Jin;Lee, Jeoung-Soo;Kim, Hak-Hyun;Kim, Yun-Taek;Kim, Young-Mi
    • Archives of Pharmacal Research
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    • v.21 no.2
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    • pp.179-186
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    • 1998
  • Dextran-5-aminosalicylic acid ester (dextran-5-ASA) was synthesized as a colon-specific prodrug of 5-aminosalicylic acid (5-ASA) which is active against inflammatory bowel diseases. Chemical stability of dextran-5-ASA in the bath of pH 1.2 or 6.8 was investigated at $37^{\circ}C$ for 6 hrs, and 5-ASA was not released on such conditions. Depolymerization (%) of dextran-5-ASA by dextranase with the degree of substitution (DS) of 18, 23, or 30 was 92, 62 or 45 in 8 hrs respectively, but was not affected by the MW of dextran (9,000, 40,600, 80,200 or 580,000). Distribution of 5-ASA in dextran, determined by gel filtration chromatography, appeared to be relatively uniform. Incubation of dextran-5-ASA (DS 18) in cecal contents of rats released 20% (28 g) and 35% (49 g) of 5-ASA in 8 hrs and 24 hrs, respectively, but no 5-ASA was liberated from small intestinal contents.

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Studies on the Effect of Panax ginseng on the Interactions of Human Plasma Lipoproteins and Lecithin Dispersions with Dextran Sulfate (인삼(人蔘) Saponin이 혈장(血漿) Lipoproteins 및 Lecithin Dispersion과 Dextran Sulfate의 상호작용(相互作用)에 미치는 영향(影響))

  • Kim, Young-Choong;Jeon, Mee-Hee
    • Korean Journal of Pharmacognosy
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    • v.15 no.4
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    • pp.206-212
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    • 1984
  • The effect of saponin fractions of Panax ginseng root on the interactions of human plasma lipoproteins and lecithin dispersions with dextran sulfate were studied in order to examine the effect of Panax ginseng on the lipid accumulation in the aorta. The total saponin fraction and protopanaxadiol glycosides of Panax ginseng root seemed to slightly enhance the interaction of low density lipoproteins with dextran sulfate in the absence of divalent metal ions. Protopanaxatriol glycosides remarkably inhibited the interaction of low density lipoproteins with dextran sulfate. However, all of these three saponin fractions of Panax ginseng root showed the tendency of inhibition to the interaction of high density lipoproteins with dextran sulfate in the presence of divalent metal ions by the order of protopanxatriol glycosides, protopanaxadiol glycosides and total saponin. Three saponin fractions of Panax ginseng exerted almost same tendency to the interaction of lecithin dispersions with dextran sulfate in the presence of divalent metal ions as the interaction of low density lipoproteins with dextran sulfate absence of divalent metal ions.

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Effects of Sodium Carboxymethylcellulose and Dextran 70 on Prevention of Adhesion in Rats (쥐에서 Sodium Carboxymethylcellulose 및 Dextran 70의 유착방지 효과)

  • Choi Min-Cheol;Kang Tae-Young;Lee Hyo-Jong
    • Journal of Veterinary Clinics
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    • v.9 no.2
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    • pp.451-456
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    • 1992
  • The 2% Sodium carboxymethylcellulose(CMC) and 10% Dextran 70 solutions were evaluated for the prevention of postoperative adhesion formation in rats. The artificial injuries(2cm longitudinal incision and suture) were performed on the colon and uterine horns in the rats. 2% CMC and 10% dextran solutions were applied to the injured surfaces and peritoneal cavity in the rats. Ten days later, there were significant difference(p<0.01) in the prevention of adhesion formation between control and treated groups(2% CMC and 10% dextran 70), but the,$\boxUl$ was no significant difference between 2% CMC and 10% dextran 70 treated groups. The increment rate of body weight in the 10% dextran 70 treated group was lower than 2% CMC and control groups(p<0.05.). A positive correlation was found between the severity of adhesion formation and the plasma fibrinogen concentration in blood.

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Effect of Administration of Sodium Carboxymethylcellulose and Dextran on Prevention of Adhesion Formation on Uterus and Embryo Collection in Rabbits (Sodium Carboxymethylcellulose 및 Dextran의 투여가 토끼 자궁의 유착방지와 수정란에 미치는 영향)

  • 이효종;강태영;윤희준;최민철
    • Journal of Veterinary Clinics
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    • v.13 no.2
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    • pp.144-148
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    • 1996
  • The effectiveness of sodium carboxymethylcellulose (SCMC) and deztran in the prevention of adhesion formation on the uterus and embryo collection in rabbits was elucidated. Following induction of adhesion on uterus and uterine horns by abrasion and retrograde flushing of embryos in gonadotropins primed rabbits, the solutions of saline (for control), 1% SCMC, 10% dextran and a synthetic solution of 1% SCNC and 10% dextran in saline were infused in the abdominal cavity at the dose of 5 ml/kg of body weight. The average percentage of adhesion was 11.1, 28.6, 41.7 and 73.3% in the rabbits infused with the synthetic, 1% SCMC, 10% dextran and saline solutions, respectively. The synthetic solution was more effective than other solutions in the rabbits. The average number and recovery rate of embryos were significantly (P<0.01) higher in the synthetic solution group than 1% SCMC, 10% dextran or saline solution groups. Among the collected embryos in the groups, the distribution of the normal embryos was higher in the synthetic solution group (99%) and the 10% dextran solution group (95.7%) than the 1% SCMC solution group (78.4%) and saline (66.2%). Theretore, a synthetic solution which is combined with 1% SCMC and 10% deztran in saline can be effectively used for the prevention of adhesion formation after uterine surgery and embryo collection.

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Study on the Dextran and the Inside Structure of Jeung-Pyun of Adding Soybean (콩 첨가 증편의 Dextran과 내부구조에 관한 연구)

  • 신광숙;우경자
    • Journal of the East Asian Society of Dietary Life
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    • v.11 no.2
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    • pp.121-130
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    • 2001
  • Jeung-Pyun Is a traditional fermented Korean food made with rice flour, water, sugar salt and unrefined rice wine(Tak-ju). In order to investigate how the addition of soybean and dextran have an influence on Jeung-Pyun fermentation and forming structure of Jeun-Pyun, adding soybean 20% and dextran 1%based on rice weight, we measured physicochemical properties. Also we measured dextran content of Jeung-Pyun batter according to the fermentation time and observed the inside of Jeung-Pyun by SEM in order to find out air pore condition. The dextran content of rice Jeung-Pyun and Jeung-Pyun adding soybean 20% was gradually increased as fermentation time was longer and Jeung-Pyun adding soybean 20% was higher than rice Jeung-Pyun. The specific volume of rice Jeung-Pyun and Jeung-Pyun adding soybean 20% was increased up to a fermentation time of 7~ 10 hours but it was decreased as fermentation time was longer. In the inside structure of Jeung-Pyun observed by SEM, the fermentation condition of Jeung-Pyun fermented for 3 and 7 hour was better and air pore size became larger, the number of it was decreased as fermentation time was longer. The air pore size of soybean 20% Jeung-Pyun is smaller more uniform than that of rice Jeung-Pyun. In conclusion. it can be suggested that the audition of soybean improves the quality of Jeung-Pyun and dextran has an influence on fermentation and forming structure of Jeung-Pyun.

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Acceptor and transglycosylation reaction by mixed dextransucrase prepared from Leuconostoc mesenteroides B-512MCM, 742CB3, 1299C

  • Park, Hyeon-Jeong;Lee, So-Yeong;Ryu, Hwa-Ja;Lee, Jin-Ha;Kim, Do-Man;Kim, Do-Won
    • 한국생물공학회:학술대회논문집
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    • 2002.04a
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    • pp.235-238
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    • 2002
  • Leuconostoc mesenteroides B-512FMCM, 742CB3, 1299C의 dextransucrase들의 glycosyl기 전이 특성을 수용체 반응과 transglycosylation반응을 통해 확인하였다. 수용체 반응의 경우 10% sucrose에 수용체로 4% maltose를 첨가하여 반응시켰고 transglycosylation반응은 다른 크기, 다른 농도 그리고 다른 종류의 가지 결합의 dextran 을 합성하는 효소들을 이용하여 수행하였다. 각각의 효소들은 maltose를 이용한 수용체 반응에서 유사한 종류의 수용체 산물들을 합성한 것에 비해 세 dextransucrase들 (512FMCM, 742CB3, 1299C) 을 일정 비율로 혼합하여 maltose를 이용한 수용체 반응 결과 512FMCM 효소의 활성 비율을 줄이고 742CB3, 1299C 효소의 활성 비율을 증가시켰을 경우에는 ${\alpha}-1{\rightarrow}$3 의 가지결합이 많은 dextran 을 합성하였다. 또한, 세 가지 다른 구조의 dextran(T40, 742CB, B1299)에 100mM maltose을 수용체로 첨가해 각각의 dextransucrase(512FMCM, 742CB3, 1299C)와 transgly cosylation을 수행한 결과 1299C 효소가 세 종류의 dextran(T40, 742CB, B1299) 에 모두 가지 결합이 많은 dextran을 합성함을 확인하였다. 또한 ${\alpha}-1{\rightarrow}$6 결합으로 주로 이루어진 2%, 5% dextran(T10, T40, T7O, T500, T2000)에 dextransucrase(512FMCM, 742CB3, 1299C)를 반응시켜 기존의 dextran 보다 가지 결합이 더 많이 형성된 transglycosylation 산물을 합성하였다. 이때 maltose를 첨가했을 경우 이 수용 체에 의해 많은 ${\alpha}-1{\rightarrow}$6 가지 결합의 dextran 을 합성함을 확인하였다.

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A Study on the Dextran Formation and Inner Structure of Jeung-Pyun during the Fermentation by the Added Chitosan-Oligosaccharide (키토산 올리고당 첨가 증편 발효 중 Dextran 형성과 증편의 내부구조에 관한 연구)

  • 남태희;우경자
    • Journal of the East Asian Society of Dietary Life
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    • v.13 no.2
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    • pp.122-129
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    • 2003
  • This study was carried out in order to investigate the dextran formation and the internal structure of the chitosan-oligisaccharide(COS) Jeung-Pyun during the fermentation. To develop a functional Jeung-Pyun, COS was added to the rice at the level of 0, 2, 4, and 6% to the 2-hour-soaked rice. The pH, dextran and reducing sugar contents of COS batter, specific volume and the internal structure of COS were analyzed as a function of fermentation time. The specific volume of COS peaked at the 3 hour fermentation. The pH values of COS batters reduced with the fermentation time. The dextran content of the control batters peaked at the 7 hour fermentation. In contrast, the dextran contents of COS batters reduced up to 7th hour of fermentation, and then increased slowly until 20th hour of the fermentation process. From the air pore size and distribution of COS observed by SEM, the COS fermented fur 3 hour was judged as the best. It was concluded that COS prevented the fermation of dextran at the early stage of fermentation process.

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Study on Prevention of Adhesion Formation by Use of Sodium Carboxymethylcellulose and Dextran 70 II. Effect of Administration of Sodium Carboxymethylcellulose and Dextran 70 Solutions on Peripheral Blood Pictures in Adhesion-induced Rabbits (Sodium Carboxymethylcellulose 및 Dextran 70을 이용한 유착형성 방지에 관한 연구 II. 유착자극후 Sodium Carboxymethylcellulose 및 Dextran 70의 투여가 토끼의 혈액상에 미치는 영향)

  • Lee Hyo-Jong;Choi Min-Cheol;Kang Tae-Young;Park Choong-Saeng
    • Journal of Veterinary Clinics
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    • v.10 no.2
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    • pp.227-235
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    • 1993
  • The effectiveness of sodium carboxymethylcellulose(SCMC) and dextran 70 in the prevention of adhesion formation in abdominal cavity of rabbits following artificial injuries was elucidated and the effects -of these medicines on blood pictures were also examined. After abrasion treatment on jejunum in gonadotropins primed rabbits, 1, 2 and 3% of SCMC solutions, 6 and 10% dextran 70 solutions and a synthetic solution of 1% SCMC and loft dextran 70 in 0.9% saline solution were infused into the abdominal cavity. Four weeks later the abdominal cavities were reopened under general anesthesia. The synthetic solution showed the highest adhesion reduction rate(100%), while 1% SCMC, 6 and loft dextran solutions showed no significantly evident effect of adhesion prevention. The SCMC solutions showed better adhesion reduction effect than dextran 70 solutions. After infusion of these adhesion preventive medicines, the changes of total leucocytes, erythrocytes, lymphocytes, PCV, plasma fibrinogen and protein contents were examined. No remarkable difference in blood pictures was shown between the synthetic solution and the other medicines. Therefore, it can be suggested that the synthetic solution of 1% SCMC and 10% dextran 70 in 0.9% saline solution at dose of 5$m\ell$/kg of body weight is prominently effective in the prevention of postoperative adhesion formation and wolf be safe in animals and human.

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Measurement of Phase Behavior for Dextran/DMSO/scCO2 System (Dextran/DMSO/초임계 CO2계의 상거동 측정)

  • Rho, Seon-Gyun;Kang, Dong-Yuk;Kang, Choon-Hyoung
    • Korean Chemical Engineering Research
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    • v.55 no.2
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    • pp.225-229
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    • 2017
  • Micron-sized dextran particles, which now attract wide attention as a promising drug delivery systems, can be prepared via the supercritical anti-solvent (SAS) process. In SAS process, dextran particles are obtained as a result of recrystallization of dissolved dextran in dimethyl sulfoxide (DMSO) on addition of supercritical $CO_2$ as an anti-solvent. In this work, with an intention to provide information on the feasible operating conditions of the process, the phase behavior of Dexran/DMSO/$CO_2$ is observed by measuring the cloud point in favor of a variable volume cell. From the experimental study, it is concluded that a feasible operating condition of the SAS process for preparation of dextran particles would be 300.15 K~330.15 K and 90 bar~130 bar, respectively, and solute concentration ranges from 5mg/ml to 20 mg/ml.