• Child Health Nursing Research
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• 제22권3호
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• pp.199-206
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• 2016

Purpose: This study was conducted to monitor the development of Korean premature infant at six-month age and to explore factors related to developmental status of the premature infants. Methods: Participants were 58 premature infants whose corrected age was six-months old and their mothers. The developmental states of infants were followed-up with the Korean Prescreening Developmental Questionnaire (KPDQ-II). Clinical characteristics of the infants were identified from the medical records. Other characteristics including Edinburgh Postnatal Depression Scale, husband's support, social support, and mother-infant attachment were assessed using self-report questionnaires from the mothers. Results: Forty three percent of the infants were in the group of questionable status of development on the KPDQ-II. There were significant differences between the premature infants with normal developmental status and those with questionable developmental status depending on gender ($x^2$=5.03, p=.034), gestational age (t=2.59, p=.012), hospital stay (p=.013), revised Neurobiologic Risk Score (p=.005) and mother-infant attachment score (t=2.12, p=.040). Conclusion: Mother-infant attachment, as well as physiological state of premature infants, is an important variable in early development. Therefore, early monitoring for the development has to be done for physiologically vulnerable premature groups. Also, providing proper nursing support to improve maternal attachment needs to be considered.

• Journal of Korean Neurosurgical Society
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• 제61권3호
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• pp.292-301
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• 2018

Medulloblastoma is the most common malignant brain tumor of childhood and remains a major cause of cancer related mortality in children. Significant scientific advancements have transformed the understanding of medulloblastoma, leading to the recognition of four distinct clinical and molecular subgroups, namely wingless (WNT), sonic hedgehog, group 3, and group 4. Subgroup classification combined with the recognition of subgroup specific molecular alterations has also led to major changes in risk stratification of medulloblastoma patients and these changes have begun to alter clinical trial design, in which the newly recognized subgroups are being incorporated as individualized treatment arms. Despite these recent advancements, identification of effective targeted therapies remains a challenge for several reasons. First, significant molecular heterogeneity exists within the four subgroups, meaning this classification system alone may not be sufficient to predict response to a particular therapy. Second, the majority of novel agents are currently tested at the time of recurrence, after which significant selective pressures have been exerted by radiation and chemotherapy. Recent studies demonstrate selection of tumor sub-clones that exhibit genetic divergence from the primary tumor, exist within metastatic and recurrent tumor populations. Therefore, tumor resampling at the time of recurrence may become necessary to accurately select patients for personalized therapy.

• Clinical and Experimental Pediatrics
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• 제58권4호
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• pp.117-122
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• 2015

Global developmental delay (GDD) is a relatively common early-onset chronic neurological condition, which may have prenatal, perinatal, postnatal, or undetermined causes. Family history, physical and neurological examinations, and detailed history of environmental risk factors might suggest a specific disease. However, diagnostic laboratory tests, brain imaging, and other evidence-based evaluations are necessary in most cases to elucidate the causes. Diagnosis of GDD has recently improved because of remarkable advances in genetic technology, but this is an exhaustive and expensive evaluation that may not lead to therapeutic benefits in the majority of GDD patients. Inborn metabolic errors are one of the main targets for the treatment of GDD, although only a small proportion of GDD patients have this type of error. Nevertheless, diagnosis is often challenging because the phenotypes of many genetic or metabolic diseases often overlap, and their clinical spectra are much broader than currently known. Appropriate and cost-effective strategies including up-to-date information for the early identification of the "treatable" causes of GDD are needed for the development of well-timed therapeutic applications with the potential to improve neurodevelopmental outcomes.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• 제25권3호
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• pp.316-321
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• 2023

Developmental venous anomalies (DVAs) are composed of mature venous vessels that lack malformed or neoplastic elements. Although the hemorrhage risk is considered negligible, some patients may have neurological symptoms attributable to acute infarction or intracranial hemorrhage secondary to thrombosis, in the absence of a coexisting cavernous malformation. We report the case of a 42-year-old patient who presented with acute left-hand paresis secondary to a subcortical hemorrhage. This bleeding originated from a DVA in the corticospinal tract area and was surgically drained through an awake craniotomy. To accomplish this, we used a trans-precentral sulcus approach. After the complete removal of the coagulum, small venous channels appeared, which were coagulated. No associated cavernoma was found. Although the main DVA trunk was left patent, no signs of ischemia or venous infarction were observed after coagulating the small venous channels found inside the hematoma cavity. Two weeks after the procedure, the patient's hand function improved, and he was able to resume desktop work. DVA-associated hemorrhage within the cortico-spinal tract could be safely removed with modern awake mapping techniques. This technique allowed the patient to rapidly improve his hand function.

• 한국가스학회지
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• 제18권2호
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• pp.55-61
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• 2014

본 연구는 고무 화학제품의 제조에 연화제로 많이 사용되며 국제암연구소(IARC)에 발암추정물질(2A)로 등록되어 있는 Biphenyl에 대해 국내 취급사업장에 대한 작업환경 측정과 근로자 노출량 산출, 그리고 유해성에 따른 위험성을 결정하였다. 노출시나리오를 바탕으로 노출량 산출 결과는 각각 $1.0{\times}10^{-2}$, $4.2{\times}10^{-4}$, $7.0{\times}10^{-6}mg/m^3$이었으며, 위해성 분류에 따라 산출한 $RfC_{work}$는 발암성 0.21, 표적독성(경구) 2.13, 표적독성(흡입) 0.53, 발달독성 $0.31mg/m^3$으로 산출되었다. 유해성 및 노출평가의 결과를 바탕으로 한 위험성은 발암성 0.57, 비발암성(발달독성) 0.39로 도출되어, 1이하의 비교적 낮은 위험도로 나타났으나, Biphenyl은 일부 유해성이 확인되었으며 사용량이 많고 취급 부주의시 근로자에 직접 노출될 수 있어 취급근로자의 건강장해 예방을 위해 노출 감시가 필요한 물질로 판단되었다.

• 한국산학기술학회논문지
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• 제14권8호
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• pp.3804-3814
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• 2013

본 연구는 여자 청소년의 생물학적 위험성향, 사회문화적 위험요인, 자기통제, 사회적지지 및 자살생각의 관계에 대한 구조모형의 부합도를 검증하고자 시도되었다. 자료수집은 2012년 12월 3일부터 2013년 3월 28일까지 D광역시의 여자 중고등학생 343명을 대상으로 하였다. 자료는 SPSS 및 AMOS 프로그램을 이용하여 분석하였다. 연구결과, 여자 청소년의 자살생각에 대해 생물학적 위험성향, 사회문화적 위험요인, 자기통제 및 사회적지지는 직접효과, 생물학적 위험성향과 사회문화적 위험요인은 간접효과가 있었다. 여자 청소년의 생물학적 위험성향과 사회문화적 위험요인은 자기통제와 사회적지지에 직접효과가 있었다. 이러한 결과에서 여자 청소년의 자살생각을 예방하기 위해 생물학적 위험성향과 사회적 위험요인을 감소시키고 자기통제와 사회적지지를 증진시키는 중재 프로그램 개발이 필요하다.

• 아동학회지
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• 제29권5호
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• pp.13-30
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• 2008

This study aimed to examine the reliability and validity of a diagnostic instrument to be used to measure the developmental level of very young children (aged birth through 36 months) and to screen young children at risk. The subjects of this study were 861 young children. Data were analyzed by item response distribution, item discrimination, reliability, and validity of the scale. Items reflected the developmental level of each age group. Overall internal consistency was relatively high (Cronbach's ${\alpha}=.90{\sim}.95$), and test-retest (after 2 weeks) reliability was high. Content validity was examined by a panel of experts in the related field. The construct validity as well as the concurrent validity of this instrument was also established.

• 아동학회지
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• 제29권4호
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• pp.79-95
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• 2008

This study investigated developmental pathways mediating effects of child abuse on peer rejection. Participants were 904 poor children aged 10-15 from 16 nationwide cities/provinces who receive financial sponsorship from Childfund in cooperation with the Ministry for Health, Welfare and Family Affairs. Structural equation modeling was employed for statistical analyses. Results showed that child abuse was directly associated with heightened risk of rejection by peers; the relationship was indirectly mediated by aggression and cognitive ability. The hypothesized partially mediated model had a better model fit than the fully mediated model. Aggression and low cognitive ability, significant effects of abuse, were associated with peer rejection. Social withdrawal, also associated with child abuse, did not account for the association between abuse and peer rejection.

• 아동학회지
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• 제30권3호
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• pp.113-125
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• 2009

This study advances knowledge of developmental patterns in poverty and delinquency; data was obtained from waves 1-5 (2003-2007) of the Korea Youth Panel Survey. Semi-parametric group-based modeling (SGM) identified 4 trajectories of poverty from age 13 to 17 : non-poor, poverty increasing, low-level continuous poverty and chronic poverty groups and five developmental trajectories of delinquency : non-offending, late onset, low-level continuous, desisting, and chronic groups. A joint trajectory method predicted patterns of delinquency conditional on poverty trajectories. Chronic and low-level continuous poverty groups were more likely than others to follow chronic trajectories of delinquency; the non-poor group was more likely to be non-offending. Implications of this study for youth welfare were discussed to reduce risk for delinquency.

• 한국보육지원학회지
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• 제17권5호
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• pp.83-103
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• 2021

Objective: This study aimed to develop a longitudinal predictive model that identifies first-grade children who are at risk for ADHD and to investigate the factors that predict the probability of belonging to the at-risk group for ADHD by using machine learning. Methods: The data of 1,445 first-grade children from the 1st, 3rd, 6th, 7th, and 8th waves of the Korean Children's Panel were analyzed. The output factors were the at-risk and non-risk group for ADHD divided by the CBCL DSM-ADHD scale. Prenatal as well as developmental factors during infancy and early childhood were used as input factors. Results: The model that best classifies the at-risk and the non-risk group for ADHD was the LASSO model. The input factors which increased the probability of being in the at-risk group for ADHD were temperament of negative emotionality, communication abilities, gross motor skills, social competences, and academic readiness. Conclusion/Implications: The outcomes indicate that children who showed specific risk indicators during infancy and early childhood are likely to be classified as being at risk for ADHD when entering elementary schools. The results may enable parents and clinicians to identify children with ADHD early by observing early signs and thus provide interventions as early as possible.