• Journal of Genetic Medicine
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• v.7 no.1
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• pp.1-8
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• 2010

Hemophilia A is a sex-linked recessive coagulation disorder associated with diverse mutations of the factor VIII gene and a variety of phenotypes. The type of mutation involved dictates the activity of factor VIII, and in turn the severity of bleeding episodes and development of alloantibodies against factor VIII (inhibitors). Missense mutations are the most common genetic risk factors for hemophilia A, especially mild to moderate cases, but carry the lowest risk for inhibitor development. On the other hand, intron 22 inversion is the most common mutation associated with severe hemophilia A and is associated with high risk of inhibitor formation. Large deletions and nonsense mutations are also associated with high risk of inhibitor development. Additional mutations associated with hemophilia A include frameshift and splice site mutations. It is therefore valuable to assess the mutational backgrounds of hemophilia A patients in order to to interpret their symptoms and manage their health problems.

• Proceedings of the KIEE Conference
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• 2000.07e
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• pp.85-88
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• 2000

This paper was development a discharge lamp ballast in order to wave improvement of high power factor and high efficiency. The discharge lamp ballast consists of a power factor correction circuit and a correction circuit on switching frequency of inverter. Instead of passive power factor circuit, active power factor circuit is adopted. Because it has the advantage of size, weight, total harmonic distortion, out DC voltage regulation, and power factor. The power factor circuit with MG34262 is controlled by variable frequency discontinuous mode. Results experiments, discharge lamp ballast is showed to have excellent for the proposed electronic ballast's operation and characteristics.

• Journal of the Korean Institute of Educational Facilities
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• v.21 no.1
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• pp.13-22
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• 2014

The purpose of this study is to figure out the differences in children's 'sense of place' followed by their development stages and to suggest a positive space design of school suited by their development. Haeng-Hyeon Elementary school was selected as the target area. The research methods of this study were based on drawing the cognitive map and a questionnaire survey. Through the cognitive map, children's development stages were determined. Also, through an awareness assessment, the places where the children had deep recognition were extracted. The questionnaires were based on knowing the places where children create their 'sense of place' and its reasons. The sense of place development factors are comprehended as physical factor, behavioral factor and psychological factor based on Relph(1976). The results were organized into a guide which has to be considered when designing an elementary school, sorted by adequate space responding to children's development stages.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.437-442
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• 2021

This article highlights the importance of design in the formation of worldview paradigms in global culture. The research aims to investigate the design development as a part of the culture and its significance in the social development of society and worldview standards. The article uses general scientific methods of cognition, showing the transformation of design in the social and cultural sphere based on scientific and business literature. The research results show the chronology of design development as a factor determining the development of society and its worldview. In particular, the epoch of modernism, classical functionalism, postmodernism, post-industrialism, and digital design show their own particularities of design development. Furthermore, the article reveals the peculiarities of design development and its requirements depending on the development of society, progress, and civilization in general. The question of current and future trends in the development of design as a factor of worldview paradigms in the culture is based on digitalization, globalization, and the formation of design as an independent entity that determines man's place in the world and society.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.4
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• pp.495-499
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• 2006

In our previous studies, we demonstrated that Vascular Endothelial Growth Factor (VEGF) enhances bovine oocyte maturation and early embryonic development in serum supplemented media. In this experiment, to determine the synergistic effect of VEGF with serum components on early embryonic development in vitro in cattle, 1 mg/ml polyvinyl-alcohol (PVA) was replaced with foetal bovine serum (FBS) in maturation and culture media. Bovine oocytes were matured in Synthetic Oviduct Fluid (SOF) supplemented with PVA, PVA+5 ng/ml of VEGF, FBS, or FBS+VEGF. Fertilized oocytes were cultured in the same conditions for 8 days. The development of embryos was examined at 48 h post- insemination and on days 6, 7 and 8. The results were analyzed using repeated measures two- factor ANOVA, in which the effects of VEGF and serum were assigned as two factors. The development rate to 4- to 8-cell embryos at 48 h was significantly higher in the PVA+VEGF group than in the PVA group (44.7% and 31.5%, respectively). However, the highest development rate to 4- to 8-cell embryos was obtained from the FBS+VEGF group (58.8%). On day 8, the blastocyst rates were higher in the PVA+VEGF (22.8%), FBS (32.1%, p<0.05) and FBS+VEGF (42.1%, p<0.05) groups than in the PVA group (17.1%). Two- factor ANOVA of the development rates indicates that VEGF had a significant effect, but had no synergistic effect with serum components on early embryonic development. The results of the present study demonstrate that VEGF improves the in vitro developmental competence of bovine oocytes and/or embryos independent of the effect of serum components.

• The KIPS Transactions:PartD
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• v.11D no.1
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• pp.163-172
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• 2004

In the software development project applying object-oriented development methodology, the research on the UCP(Use Case Point) as a method to estimate development effort is being carried on. The existing research proposes the linear model calculating the development effort that multiplies an invariant on AUCP(Adjusted Use Case Point) which applied technical and environmental factors. However, the statistical model that estimates the development effort using AUCP and UUCP(Unadjusted Use Case Point) is not being studied. The irrelevant relationship of the linear regression model, whose development period is increasing tremendously as the software size increases, is confirmed. Moreover, during the UCP calculating process, there can be errors in FP by applying the TCF(Technical Complexity Factor) and EF(Environmental Factor). This paper presents a non-linear regression model, that does not consider the TCF and EF, and that estimate the development effort from UUCP directly by utilizing the exponential function. An exponential function is selected among the linear, logarithm, polynomial, power, and exponential model via statistical evaluations of the models mentioned above.

• Proceedings of KOSOMES biannual meeting
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• 2006.11a
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• pp.181-186
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• 2006

Geostationary Orbit satellite, unlike other sun-synchronous polar-orbit satellites, will be able to take a picture of a large region several times a day (almost with everyone hour interval). For geostationary satellite, the target region is fixed though the location of sun is changed always. However, Sun-synchronous polar-orbit satellites able to take a picture of target region same time a everyday. Thus Ocean signal is almost same. Accordingly, the ocean signal of a given target point is largely dependent on time. In other words, the ocean signal detected by geostationary satellite sensor must translate to the signal of target when both sun and satellite are located in nadir, using another correction model. This correction is performed with a standardization of signal throughout relative geometric relationship among satellite-sun-target points. This relative ratio called bidirectional factor. To find relationship between time and $[L_w]_N$/Bidirectional Factor differences, we are calculate solar position, geometry parameters. And reflectance, total radiance at the top of atmosphere(). And water leaving radiance, normalized water leaving radiance. And calculate bidirectional factor, that is the ratio of $[L_w]_N$ between target region and aiming the point. Then, we can make the bidirectional factor lookup table for one year imaging. So, we suggested for necessary to simulation experiment bidirectional factor in more various condition(wavelength and ocean/air condition).

• The KIPS Transactions:PartD
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• v.15D no.1
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• pp.61-72
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• 2008

One of the most significant tasks of software development project is to know how much it will be the software development cost in the early stage of software development cycle. The software development environment and technology are changing very rapidly. For accuracy, we should apply those to the software cost estimation. And it is important that we select the suitable adjustment factor and the value of a suitable adjustment factor. For that, this paper have applied the method of AHP. And we have also analyzed the sensitivity of the adjustment factor which is influenced by decision metrics. In conclusion, the value of the application type adjustment factor is responded more sensitively to the data complexity and the control complexity than processing complexity. And the value of the language adjustment factor is responded more sensitively to the supplying manpower and the time of the coding than the time of the debugging. In the future, we will research the selection of an additional adjustment factor and a suitable value of the adjustment factor which are influenced by the environment and the technology of the domestic software development. And then, in the language adjustment factor, we will try to calculate the value about the individual programming language.

• Journal of Korean Academy of Nursing
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• v.27 no.3
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• pp.588-600
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• 1997

Postpartum depression is one of the most serious problems in maternal health because it affects not only the mother but also her family. Postpartum depression disturbs the maternal-infant interaction and attachment. However, most postpartum depression patients ignore this problem and do not seek treatment. Many clinicians and researchers realiza there is a need to develop a postpartum depression scale. Thus, this study has been designed to development of a postpartum depression scale. Data were collected through a survey over a period of three months. Subjects who participated in the study were 167 Korean mothers in their postpartum period. The author used a convenience sampling method. The analysis of the data was done with SPSS PC/sup ＋/ for descriptive statistics, item analysis and factor analysis. Initially 62 items were generated from the interview data of eight postpartum depression patients and from a literature review. This preliminary scale was analyzed for reliability and validity. The results of this analysis are as follows. 1. Initially 62 items were analyzed through the Index of Content Validity(CVI) and 48 items were selected. 2. Seven factors were extracted through the principal component analysis, and these contributed 61% of the variance in the total score. Finally 46 items in the scale loaded .41∼ .84 on one of seven factors. 3. Each factor was labeled. Factor 1 was labeled 'emotional phenomena-emotional upset' and included 13 items, factor 2 was labeled' cognitive phenomena-self concept disturbance' and included seven items, factor 3 was labeled 'relationship to baby-negative feeling' and included six items, factor 4 was labeled 'relationship to baby- overload' and included eight items, factor 5 was labeled 'negative maternal identity' and included five items, factor 6 was labeled 'biophysiological phenomena-disturbance of physical functioning' and included four items, and factor 7 was labeled' interpersonal relationship phenomena-blamed others' and included three items. 4. Cronbach Coefficient Alpha for internal consistency was .95 for the total 46 items. Finally, the author suggests that this scale could be adequately applied in assessing the postpartum depression of mothers during the postpartum period. The results of this study can contribute to designing an appropriate postpartum depression prevention strategy.

• Korean Journal of Social Welfare
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• v.66 no.1
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• pp.277-306
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• 2014

The purpose of this study was to develop the first social work values scale in Korea. Its development would be expected to increase empirical studies on social work values. Based upon the literature review of social work values, the examination of codes of ethics as well as existing scales, and the comments from professionals in this field, 62 preliminary items were developed. Preliminary items were evaluated with a total of 521 social workers who were working in various fields of social work in Seoul and surrounding areas. A series of exploratory factor analyses were conducted to find out the optimal structure of the scale. After deleting 29 items with low factor loadings or being cross-loaded, the scale is composed of three factors with each factor having 11 items. Confirmatory factor analysis confirmed the factor structure of the scale obtained by exploratory factor analysis. The first factor was named autonomy, the second factor was named equality, and third factor was named paternalistic intervention. Each component of the social work values scale is found to be reliable and valid.