• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.33 no.4
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• pp.1-15
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• 2020

Objectives : To investigate aggravating and mitigating factors of atopic dermatitis and to utilize the outcome in treatment planning. Methods : The research has a cross-sectional study design. Patients' SCORing Atopic Dermatitis (SCORAD) Index, demographic, physical characteristics, social history, serologic index and skin related instrumental measurements were analyzed with correlation and regression analysis method. Results : 48 patients in total were enrolled in the study. Skin Surface Hydration (SSH) and sex were found to be statistically significant aggravating and mitigating factors. As SSH increased, Total SCORAD (tSCORAD) and Objective SCORAD (oSCORAD) increased as well. As SSH decreased, tSCORAD and oSCORAD decreased as well. Female patient had a higher probability of suffering from severer subjective symptoms than that of male. Age, body mass index (BMI), alcohol consumption and smoking, transepidermal water loss (TEWL), IgE, IL-4, IL-5, IL-6, IFN-γ were found not to be statistically significant. There was no correlation between Subjective SCORAD (sSCORAD) and oSCORAD neither with Eczema Area and Severity Index (EASI). Conclusions : Increasing cutaneous moisture should be included in the treatment plan of atopic dermatitis. More emphasis should be put on alleviating subjective discomforts of female patients than that of male. Establishing separate strategies of managing objective eczema status and subjective discomforts respectively should be considered.

• Clinical and Experimental Pediatrics
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• v.54 no.1
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• pp.6-10
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• 2011

Many patients assume that allergic reactions against foods are responsible for triggering or worsening their allergic symptoms. Therefore, it is important to identify patients who would benefit from an elimination diet, while avoiding unnecessary dietary restrictions. The diagnosis of food allergy depends on the thorough review of the patients's medical history, results of supplemented trials of dietary elimination, and in vivo and in vitro tests for measuring specific IgE levels. However, in some cases the reliability of such procedures is suboptimal. Oral food challenges are procedures employed for making an accurate diagnosis of immediate and occasionally delayed adverse reactions to foods. The timing and type of the challenge, preparation of patients, foods to be tested, and dosing schedule should be determined on the basis of the patient's history, age, and experience. Although double-blind, placebo-controlled food challenges(DBPCFC) are used to establish definitively if a food is the cause of adverse reactions, they are time-consuming, expensive and troublesome for physician and patients. In practice, An open challenge controlled by trained personnel is sufficient especially in infants and young children. The interpretation of the results and follow-up after a challenge are also important. Since theses challenges are relatively safe and informative, controlled oral food challenges could become the measure of choice in children.

• Korean Parent-Child Health Journal
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• v.19 no.1
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• pp.9-16
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• 2016

Purpose: The disease specific self-efficacy of mothers caring children with atopic dermatitis is a crucial factor for adherence to recommended treatments. This study investigated factors associated with disease specific self-efficacy of mothers of atopic dermatitis children. Methods: A cross-sectional study was used. One hundred twenty five mothers recruited from the out-patient clinic of three hospitals completed self-administrative questionnaires, including the disease specific self-efficacy, general parenting efficacy, and severity of atopic dermatitis. Descriptive statistics, ANOVA, and multiple regression analysis were performed. Results: The degree of disease specific self-efficacy of mothers was significantly different according to the disease severity, and parenting efficacy. 26.0% of the variance of disease specific self-efficacy was explained by the severity of disease and parenting efficacy. Conclusions: Future studies need to focus on the development of educational programs that will help to improve mothers' disease specific self-efficacy as well as parenting efficacy.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.4
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• pp.167-175
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• 2019

Objetives : The purpose of this study is to report the effect of Oryeong-san on adult whole-body atopic dermatitis. Methods : We treated a 21-year-old male patient who have adult whole-body atopic dermatitis by Korean medicine. This treatment was enforced from 2019.5.25 to 2019.6.29. And we have confirmed the improvement of itching, rashes and oozing. We recorded photos that includes change of symptoms. Results : After the treatments was done, the grade of VAS and SCORAD was decreased. The VAS grade was decreased from grade 8 to grade 2. The SCORAD score was decreased from 72.1 to 52.1. And itching, rashes, oozing were clearly decreased. Conclusions : Oryeong-san has effect on decreasing itching, rashes and oozing. Also, sleeping time reduced due to itchness was normalized. Thus, It is able that Oryeong-san works on skin desease like atopic dermatitis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.4
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• pp.200-208
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• 2014

Objective : The purpose of this report is to know the effect of Sopung-san and Cheonggisamseup-tang(消風散 合 淸肌滲濕湯) on seborrheic dermatitis. Methods : We experienced one case of seborrheic dermatitis patient with Sopung-san and Cheonggisamseup-tang. To evaluate the effectiveness of this treatment, we used the Visual Analogue Scale(VAS) about symptoms of flare, itching, and observe scales. Results : After the treatment, the grade of flare and itching VAS was decreased, and clinical symptoms were improved including scales. Conclusion : The result indicate that Sopung-san and Cheonggisamseup-tang is helpful in the treatment of seborrheic dermatitis. And an author consider that additional clinical studies are needed to verify the effectiveness of herbal medicine with objective assessment tools.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.27 no.4
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• pp.209-220
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• 2014

Objectives : The purpose of this study is to report the effect of Korean medicine treatment on occupational allergic contact dermatitis caused by mortar. Methods : The patient treated by herbal medicine, acupuncture, pharmacopuncture and external therapy. The progress is evaluated by Numerical Rating Scale(NRS) and Dermatology Life Quality Index(DLQI). Results : NRS and DLQI score were significantly decreased as a result of Korean medicine treatment. Conclusions : Korean medicine treatment should be effective for the occupational allergic contact dermatitis caused by mortar. More studies are needed to confirm stability of these treatment.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.9 no.1
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• pp.114-128
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• 1996

"Chimumchang" seems to be a kind eczema. The cause and symptom of eczema is similar to that of chimumchang. so, I investigated the literatures of oriental medicin and recent medicine. The results are summarized as follows. 1. Chimumchang seems to be a kind of eczema. Allergic contact dermatitis, atopic dermatitis, seborrheic dermatits, neurodermatitis, nummular dermatitis, xerotic eczema and so on are similar to chimumchang on cause & symptom. 2. The cause of chimumchang are summer vital energy excess(夏脈太過), sehwa excess(歲火太過), herat meridian wind-heat(心經風熱), heart fire(心火), wind taken spleen dampnees(脾濕受風), and so on. The cause of eczema are contact of external agent, immunological problem, heridity, infection, abnormalities of sebaceous glands, neurologic dysfuction, and so on. 3. The symptoms of chimumchang have been described to the three pattern on literature of oriental medicine until now. 1) scratching slightly, It has exudation, and combination. 2) Vital energy on skin is irritable by psychological problem. At the acute stage the patient is complain of itching & pain, and gradually the exudation expands in whole body. 3) early peorid it's size is very small, and at first the patient is complain of itching, later complain of pain. The exudation change to ulcer and expands in the whole body. 4. In the investigation of prescription(Total: 34, Oral medicine: 4, Ointment: 30), the most frequently used oral medicine is sungmatang(4 times), and the most frequently used ointment are kohosan, korvunsan and kegwanhyuldobang.

• The Journal of Korean Medicine
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• v.37 no.4
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• pp.22-29
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• 2016

Objectives: We developed a Korean translation of this questionnaire by sequential forward-and-backward translation. The purpose of this study is to validate the Korean version of the POEM, the "POEM-K" by Korean patients with atopic dermatitis (AD). Methods: A single-center prospective study was conducted with 50 participants diagnosed with AD. The POEM was translated to Korean version by an expert panel. Scoring Atopic Dermatitis (SCORAD) and Short Form 36 Health Survey (SF-36) were used as external comparators. Results: Twenty men and thirty women between the ages of 18 and 63 participated in the study. The test-retest reliability of the total POEM-K was estimated using the intra-class correlation coefficient (ICC) that showed a strong agreement (ICC = 0.72). By using Pearson correlation coefficients, we compared the POEM-K to SCORAD and yielded a concurrent validity that showed a significant result. The responsiveness of the POEM-K was represented by the effect size (ES) of 1.41 and statistically significant (p = 0.004). Conclusions: The Korean version of the POEM is a reliable, valid, and responsive disease-specific questionnaire for assessing the symptoms and quality of life of Korean patients with AD.

• Biomedical Science Letters
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• v.25 no.1
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• pp.15-22
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• 2019

The diagnosis of atopic dermatitis (AD) includes a test that checks allergen-mediated skin reactions and a method of measuring the total IgE and allergen-specific IgE in blood. However, these test methods are performed directly on the patient, which cause some pain or discomfort. In addition, the skin response test or IgE may result in false negative in about 20% of patients. In the present study, to identify specific biomarkers, HaCaT cells were used as a human keratinocyte that make up the skin, were treated IL-4 and IL-13 for 24 hours to induce a situation similar to keratinocytes in AD patients. In the HaCaT cells, pro-inflammatory cytokine such as IL-5, IL-6, and MCP-1 were increased by IL-4 and IL-13 and skin barrier proteins was reduced by IL-4 and L-13. This results showed that a situation similar to the stratum corneum of an actual patient is induced in HaCaT cells. And then the secretions of Kallikrein (KLK) 5 and KLK7 protease were checked by enzyme-linked immunosorbent assay (ELISA). It was specifically increased by IL-4 and IL-13. This showed that AD-related protease can be detected at the protein level using keratinocytes that can be taken in a non-invasive manner and suggested the possibility of applying it to AD diagnosis.

• The Journal of Pediatrics of Korean Medicine
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• v.25 no.2
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• pp.8-14
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• 2011

Objectives: This study is performed to investigate the use of oriental medicine on pediatric outpatients with atopic dermatitis(AD). Methods: The study was carried out with 267 AD outpatients who visited the Department of Pediatrics, Oriental Medical Hospital from January 2010 to May 2011 and was completed by reviewing patients' chart. Results: The relative frequency of AD on the oriental pediatrics hospital was 6.8%. In a sexual distribution, the male children were more frequent than the females. In an age distribution, atopic dermatitis children visited the hospital were the most frequent in the age from 3 to 10. The highest frequency that started the oriental therapy after the outbreak of AD was from 1 month to 1 year. Approximately, 49.4% of the children who visited hospital relied on western medicine in treating their atopic dermatitis. The therapeutic effect of the oriental medicine was found to be excellent in 47.9%, no change was seen in 16.9%, and aggravation was seen in 3.4% of the patients. Less than a month of oriental treatment was the most common. The improvement depending on the length of the treatment was found to be 91.8% in more than 3 months, and 21.8% in less than 1 month. The use of the herbal medicine and herbal external treatment was seen in 67.4% and the therapeutic effect was improved in 63.3% of the patients. Conclusions: Considering the results, we can improve accommodation of oriental therapies for the pediatric outpatients with atopic dermatitis, and enhance the doctor-patient relationship to help the children with atopic dermatitis.