• Journal of Nutrition and Health
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• 제37권4호
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• pp.291-301
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• 2004

We studied the effects of soy isoflavones supplementation with exercise on bone mineral density and the urinary excretion of deoxypyridinoline as an index of bone resorption rates in postmenopausal women. A total of 67 postmen-opausal women were assigned to Isoflavone (90 mg/day) or placebo groups. These group were further divided into groups that undergone a regular exercise or a rather sedentary state performing daily activity only. Four groups were Placebo-control group (n = 16), Placebo-exercise group (n = 16), Isoflavone-sedentary group (n = 19) and Isofla-vone-exercise group (n = 16). After the intervention, we compared anthropometric mesurement, dietary recall, bone mineral density (femoral neck, lumbar spine), urinary deoxypyridinoline between the groups and between the pre and post studies. There were no significant differences between the four groups in terms of average age, height, weight, period after menopause at the baseline. The average age of the subjects were 55.2 yrs, average height, weight, period after menopause were 154.7 cm, 59.3 kg, 5.58 yrs, respectively. After eight week intervention period, there were no significant differences between the four groups in bone mineral density, but urinary deoxypyridinoline excretion was significantly decreased both in Isoflavone-sedentary and Isoflavone-Exercise groups. These results suggest that Isofla-vone supplementation alone or with exercise may be preventive measures through the decrease of bone reabsorption rate in post-menopausal subjects. Whereas exercise alone did not appear to be an effective measure in bone loss with these subjects.

• 동아시아식생활학회지
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• 제16권4호
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• pp.421-428
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• 2006

This study assessed the effects of daily isoflavone intake on urinary excretion of deoxypyridinoline(DPD), Ca and Zn excretion as an index of bone resorption rates in 162 postmenopausal osteoporotic women. There were 87 participants in the osteoporosis group and 75 in the control group. The average age in the osteoporosis group was 62.97 years and that of the control group was 63.67 years. There were no significant differences between the two groups in height, weight and body mass index. The osteoporosis group consumed significantly lower amounts of soy foods compared to the control group(p<0.00l). Daily isoflavone intake was significantly different between the osteoporosis group(29.19 mg) and the control group(48.56 mg). The average urinary excretion of deoxypyridinoline in the osteoporosis and control groups were 5.71 nmol/mmol Cr and 5.15 nmol/mmol Cr, respectively and these values were significantly different(p<0.05). In addition, the subjects in the osteoporosis group and control group exhibited significant difference in urinary excretion of Ca(200.16 mg/day, 177.05 mg/day respectively) and Zn(333.32 $\mu$g/day, 303.68 $\mu$g/day respectively) at the levels of p<0.0l and p<0.05, respectively. There were no significant differences between the two groups in mineral intake. Thus, daily isoflavone intakes may contribute to decreases in the rates of urinary excretion of deoxypyridinoline, Ca and Zn in postmenopausal subjects.

• Journal of Korean Biological Nursing Science
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• 제4권2호
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• pp.93-112
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• 2002

Recently, the number of the elderly has increased according to the improvement of socioeconomic status and the efficient medical care system. In spite of the development of medicine, the elderly suffers from the various health problems caused by weakness of musculoskeletal system, cardiopulmonary function and immunologic dysfunction. Regular rhythmic exercise program is known to be one of the effective tools to enhance the health condition in the elderly. However, there has been few studies to evaluate the comprehensive effects of rhythmic movement program on the elderly. This study was focused to evaluate the indices of cardiopulmonary function, life satisfaction, calcium, phosphorous, osteocalcin and deoxypyridinoline which are the essential factors of health problems in the elderly women. Twenty six subjects, aged between 68 and 72, who can do the ordinary activities and do not have cardiovascular dysfunction and mental disorder, participated in this study. They were divided into two groups: 13 in the experimental group and 13 in the control group. The experimental group participated in the rhythmic movement program at the welfare center located in G-city. The program were consisted of three sessions a week during 10 weeks. Each session had three parts: warming up(10 minutes), main exercise(40 minutes), finishing(10 minutes). Heart rate, blood pressure and peripheral arterial oxygen saturation were measured for the evaluation of cardiopulmonary function. Serum calcium, phosphorous, osteocalcin and urine deoxypyridinoline were measured as the indices of bony metabolism. Data were analyzed with mean, standard deviation, $x^2$-test, t-test, paired t-test using SPSS PC+ program. The results of this study were as follows. 1) Heart rate of the experimental group showed significant decrease following the rhythmic movement program. Peripheral arterial oxygen saturation of the experimental group showed significant increase following the program. 2) The degree of life satisfaction of the experimental group showed significant increase following the program. 3) Calcium showed significant decrease following the program but remained within normal range. There was no significant difference of phosphorous between two groups. 4) Osteocalcin, the index of bone formation, showed no significant change following the program, but significant increase in the experimental group comparing with the control group. 5) Deoxypyridinoline, the index of bone resorption, in urine of the experimental group showed significant decrease following the program. In conclusion, the rhythmic exercise program in the elderly showed the improvement of physiologic function and favorable effects on life satisfaction and bony metabolism. According to the above results, the regular rhythmic movement program can be strongly recommended for the improvement of health in the elderly women.

• KSBB Journal
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• 제16권6호
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• pp.614-619
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• 2001

두충의 골다공증 억제 효과를 연구하였다. 난소절제된 흰쥐에 기본사료, 칼슘, 비타민 D$_3$, 비타민 $K_1$를 함유하는 조성물과 두충추출물을 추가한 조성물을 7개월간 투여한 후 기본사료만 투여한 대조군과 비교하였다. 골 흡수 지표로 deoxypyridinoline을 분석한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.0%, 두충 추가 조성물 투여군의 경우 26.9% 감소하였다. 경골의 trabecular 골면적을 측정한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.9%, 두충 추가 조성물 투여군의 경우 42.0% 증가하여 골다공증 억제 효과를 확인할 수 있었다.

• Journal of Nutrition and Health
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• 제36권5호
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• pp.476-482
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• 2003

We studied the effects of soy isoflavone supplements on bone metabolism marker (serum osteocalcin, urinary deoxypyridinoline) and urinary mineral excretion (urinary Ca, Mg, Zn) in 47 postmenopausal women. There were 24 participants in the treatment group and 23 in the control group. The treatment group consumed isoflavone extract capsules daily (which contained 90 mg of soy isoflavones) for 12 weeks. The study compared before and after isoflavone intake in the following areas: Physical examination, diet survey, bone metabolism marker and urinary mineral excretion. The average age of the treatment group was 64.6 years and that of the control group was 66.5 years. There were no significant differences between the two groups in terms of height, weight and body mass index. Both groups maintained a regular diet pattern in terms of their average daily nutrient intake. There were no significant differences between the treatment group (23.9 mg) and the control group (25.4 mg) in terms of daily isoflavone intake based on diet. The analysis of bone metabolism marker changes in the treatment group after 12 weeks of taking the isoflavone supplements demonstrated significant differences in the following: Serum osteocalcin (13.7 ng/mL in befor versus 6.8 ng/mL in after) and urinary deoxypyridinoline (5.9 nmol/mmol Cr in befor versus 4.5 nmol/mmol Cr in after). The subjects in the treatment group showed no significant difference in urinary Ca excretion. But the subjects showed a significant difference in urinary Mg (131.9 mg/day in befor versus 115.6 mg/day in after) and Zn (400.5 $\mu\textrm{g}$/day in befor versus 310.2 $\mu\textrm{g}$/day in after) excretion in the isoflavone treatment group at the levels of p<0.001, p<0.01, respectively. No changes were made in the intake of minerals. The composition of serum osteocalcin and urinary deoxypyridinoline, and indicators of bone metabolism, including the excretion Mg and Zn, significantly decreased. As a result, bone mineral loss was lessened. (Korean J Nutrition 36(5): 476~482, 2003)

• 생명과학회지
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• 제17권12호
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• pp.1739-1743
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• 2007

본 연구에서는 40대 중년여성 16명을 벨리댄스군 8명, 대조군 8명으로 구성하여 후 벨리댄스 그룹은 12주에 걸쳐 주3회 1회 60분 동안 운동을 지속적으로 실시하여 혈액성분과 골다공증, Osteocalcin을 분석한 결론은 다음과 같다. 1. WBC는 벨리댄스 그룹이 집단간, 집단내에서 유의한 감소를 나타내었다. 하지만 RBC, Hb, PLT은 모든 그룹이 집단내, 집단간 유의한 차이를 나타내지 못했다. 2. 골밀도는 벨리댄스 그룹이 집단간 유의하게 증가하였고, 집단내에서는 유의하게 증가한 것으로 나타났다. 3. Osteocalcin은 벨리댄스 그룹내 증가양상은 보였지만 유의성은 나타나지 않았다. 이상의 결과를 통해서, 벨리댄스가 WBC와 골밀도에 유익한 변화를 가져왔으며 이로 인하여 중년여성의 건강증진과 골다공증 및 골 관련 질환의 예방을 위해 큰 도움을 줄 것이며, 아직 국내에 벨리댄스에 대한 연구가 미흡한 실정이라 향후 장기간 연구가 필요할 것으로 사료된다.

• KSBB Journal
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• 제16권4호
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• pp.420-425
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• 2001

동물실험을 통하여 이소플라본의 골다공증 억제 효과를 연구하였다. 난소절제된 흰쥐에 기본사료, 칼슘, 비타민D$_3$, 비타민K$_1$를 함유하는 조성물과 이소플라본을 추가한 조성물을 7개월간 투여한 후 기본사료만 투여한 대조군과 비교하였다. 골 흡수 지표로 deoxypyridinoline을 분석한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.0%, 이소플라본 추가 조성물 투여군의 경우 29.5% 감소하였다. 경골의 trabecular 골면적을 측정한 결과 칼슘 비타민 조성물 투여군의 경우 대조군과 비교하여 9.0%, 이소플라본 추가 조성물 투여군의 경우 15.8% 증가하여 이소플라본의 골다공증 억제 효과를 확인할 수 있었다.

• Nutrition Research and Practice
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• 제4권5호
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• pp.421-427
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• 2010

The purpose of this study was to evaluate the daily vegetable and fruit intake status of Korean adults and to examine the relationship of vegetable and fruit intake with bone metabolism. The vegetable and fruit intake of 542 healthy male and female adults was analyzed. Then, by selecting 51 targets from the subjects, the relation of vegetable and fruit intake with serum calcium, osteocalcin and deoxypyridinoline (DPD) excretion in urine was examined. The total vegetable intake per day was 397.7 g and 333.5 g by men and women respectively for the age group of 20-29, 366.9 g and 309.2 g respectively for the age group of 30-49, 378.4 g and 325.9 g respectively for the age group of 50-64. Of vegetable varieties, leafy and stem vegetables displayed the highest intake. The order of major intake items of vegetables and fruits was found to be Chinese cabbage kimchi, onion, radish, cucumber, and welsh onion for the age group of 20-29, watermelon, Chinese cabbage kimchi, peach, potato, and onion for the age group of 30-49 and watermelon, Chinese cabbage kimchi, tomato, potato, and peach for the age group of 50-64. Of 51 targets, ${\beta}$-carotene intake displayed a significantly negative correlation with serum osteocalcin. While caloric intake as well as protein, carbohydrate, calcium, phosphorous, zinc and total food intake displayed a significantly negative correlation with DPD excretion in urine, tuber vegetable intake displayed a significantly positive correlation with DPD excretion in urine. In the future, a study will be necessary to accurately explain the relevance of vegetable and fruit intake with bone mineral density and bone metabolism. Also, efforts will be required to increase vegetable and fruit intake.

• 한국식품영양과학회지
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• 제33권6호
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• pp.995-999
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• 2004

액상칼슘을 첨가한 한방 칼슘제를 중년여성에게 칼슘제 섭취 수준에 따라 3개의 그룹(대조군, Ca500, Ca750)으로 구분하여 일정 기간 섭취시키고, 이들의 골밀도 및 골형성 지표의 변화에 대해 조사하였다. 6개월 후 대조군의 골밀도가 감소한 반면, Ca750군의 요추 골밀도는 초기값 0.850에서 0.865로 증가하였다. 또한 혈청 칼슘과 혈청 osteocalcin의 증가 및 요중 deoxypyridinoline의 감소는 액상칼슘 첨가 수준이 높을수록 섭취 전후 차이가 뚜렷하였다. 특히 Ca750군에서는 혈청 osteocalcin함량이 초기 5.50 ng/mL에서 칼슘제 섭취 후 7.93 ng/mL로 유의적인 증가를 나타내었다. 전반적인 연구 결과에서 액상칼슘 섭취에 의한 유의적인 골밀도 증가는 확인되지 않았으나, 칼슘제 섭취에 따른 위장장애나 변비등의 부작용이 없고 골형성 표지성분의 증가 및 골흡수 표지성분의 감소를 나타내어, 장기적인 연구가 요망된다.

• 식품기술
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• 제15권1호
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• pp.16-26
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• 2002

이 논문은 대두 이소플라본 섭취가 난소를 절제한 쥐의 골격 손실에 미치는 영향을 투여량에 따라 조사한 것이다. 실험 초기에 암컷의 Wistar rats(7개월령; n=55)을 절제 후 봉합시킨 군(SH; n=14)과 난소절제군(OVX; n=41)으로 각각 구분하여 사육하고 80일 후에 각 5마리씩을 해부하여 난소절제로 인한 골손실 진행여부를 확인하였다. 그 후 난소절제 쥐(OVX)를 9마리씩 4그룹으로 나누고 대두 이소플라본(IF, 대두단백질이 없는 실험식이에 혼합하여 공급)을 각각 0, 20, 40, 80mg/ (kg body.d)씩 84일간 공급하였다. 동시에 SH rats에게도 이소플라본이 없는 실험식이를 섭취시켰으며 164일 후에 해부하였다. 예상했던 대로 골 무기질 밀도(대퇴골, 골간부위와 골간단부위) 및 골 표면적에 대한 다공성 골 면적의 비(대퇴골 원위부 골간단에서)가 OVX군이 SH군보다 낮았다(P<0.05). OVX군은 SH군보다 혈장 osteocalcine 농도가 높았으며 소변으로의 deoxypyridinoline 배설량이 많았다(P<0.05). 164일째 osteocalcine 과 deoxypyridinoline 농도는 OVX군에서보다 IF40 및 IF80군에서 더 낮았다(P<0.05). 그럼에도 불구하고 골 무기질 밀도와 다공성 골 면적이 OVX군에서보다 IF군들에서 더 낮아지지는 않았다. 그러므로 난소를 절제한 성숙한 쥐에게 대두 이소플라본을 매일 섭취시키는 것은 골격조직의 재흡수를 감소시킬 수 있으나 이미 진행된 골감소증(osteophenia)을 회복시킬 수는 없는 것으로 나타났다.