• 한국임상약학회지
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• 제22권3호
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• pp.251-259
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• 2012

Ulcerative colitis (UC) is characterized by a life-long chronic course with remissions and exacerbations. Use of biological therapies may reduce or delay the surgical procedures in patients with UC. The aim of this study was to determine the impact of infliximab (IFX) use on the rate of remission, surgical interventions, and the effect on quality of life in patients with moderate to severe UC. Literature was searched for studies that investigated the efficacy of IFX on the rate of remission, colectomy and quality of life (QoL) between January 1990 and June 2012 at MEDLINE, January 1988 and June 2012 at EMbase and others. Eleven trials were included in the meta-analysis; divided into placebo controlled 8 trials and intravenous corticosteroid controlled group 3 trials. In comparison to placebo control groups, patients who received IFX had an odds ratio (OR) of 3.712 (95% CI: 2.714, 5.079) for the short-term clinical remission, and 3.053 (95% CI: 2.044, 4.559) for the rate of long-term remission. In colectomy rate and quality of life (QoL), odds ratio were 0.566(95% CI: 0.387, 0.827) and 0.658 (0.505, 0.811) respectively. Any adverse reactions including infections, infusion reaction, rash and arthralgia were equivalent in both groups. Compared with intravenous corticosteroid controlled group, patients who received IFX had lower remission rate with short-term odds ratio 0.227 (95% CI: 0.033, 1.556) and long-term odds ratio 1.054 (95% CI: 0.317, 3.502) respectively. However, statistical significance was not showed with both two analyses. The higher adverse drug reaction (ADR) rates were occurred in the corticosteroid controlled groups. 73.3% of patients treated corticosteroid reported Cushing-like syndrome with moon face. In conclusion, IFX does increase remission rate and decrease the rate of colectomy in patients with UC without elevating any adverse reactions significantly. IFX also improves QoL in moderate to severe UC patients. It would not exceed the efficacy of intravenous corticosteroid, whereas intravenous corticosteroid also reported high rate of adverse reactions.

• Clinical and Experimental Pediatrics
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• 제50권11호
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• pp.1061-1066
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• 2007

목 적 : 소아의 발달 장애는 조기에 발견하면 조기 치료가 가능하게 되어 치료 효과가 높아지고 후유 장애를 최소화할 수 있다. 발달 장애의 조기 발견을 위하여 기존에 사용해 오던 정식 발달 선별검사는 대부분 시간이 오래 걸리고, 복잡하며, 의료인력이 추가로 필요하기 때문에 바쁜 소아과 외래에서 모든 소아에게 적용하기는 어렵다. 기존의 발달검사 대신에 부모가 작성한 내용을 토대로 평가하는 발달 설문 양식들 중 Ages and Stages Questionnaire (ASQ)는 60개월 이전의 소아의 발달 선별을 목적으로 개발된 검사이다. 본 연구의 목적은 소아과 외래에서 시행하는 발달 지연의 선별 도구로서 ASQ의 타당성을 알아보기 위한 것이다. 방 법 : 가톨릭대학교 의과대학 부속 성모병원 소아과 외래를 방문한 소아의 부모에게 진료 전 대기 시간 동안 한국형 ASQ (K-ASQ)를 완성하도록 하였다. 설문지를 완성한 총 150명 중 만삭 출생아이며 이전에 발달지연의 진단을 받은 적이 없고, 기타 선천성 기형, 경련성 질환을 포함한 신경학적 이상, 유전성 질환의 경력이 없는 소아 67명을 대상으로 하였다. K-ASQ는 각 영역별로 평균에서 2 표준편차(SD) 아래 점수보다 낮으면 "실패"로 판정하며, 한 발달 분야 이상에서 "실패"가 있는 경우를 "선별검사 양성"으로 하였다. 최종 발달평가는 Bayley Scales of Infant Development-II (BSID-II)를 사용하여 판단하였으며, 지능 혹은 운동발달 지수가 평균보다 -1 SD 미만인 경우는 발달지연으로 판정하였다. K-ASQ의 결과를 BSID-II와 비교하여 분석하였다. 결 과 : 1) 대상아의 평균 연령은 $16.4{\pm}7.4$개월($6{\pm}30$개월 범위, 중앙치 14개월)이었다. 10명(14.9%)은 출생 시 부당경량아였으며, 평균 출생체중 $3.1{\pm}0.6kg$, 재태기간 $38.8{\pm}1.4$주이었다. 9명(13.4%)이 쌍생아였고, 33명(49.0%)이 남아였다. 대상 소아들의 모친의 평균 교육 기간은 $13.6{\pm}2.4$년, 53명(79.1%)이 고등학교 졸업 이상의 학력을 가졌고, 21명(31.3%)이 정규직 근무자였다. ASQ 설문지를 완성하는데 평균 $10.2{\pm}3.0$분이 소요되었다. (2) 17명(25.4%)이 ASQ 선별검사 양성이었는데, 그 중 4명은 발달이 지연되었고, 나머지 13명의 발달은 정상이었다. BSID-II로 판정한 발달 지연아 8명 중 4명은 ASQ 선별검사에서 양성이었고, 다른 4명은 선별검사 음성이었다. ASQ 선별검사 음성인 50명 중 4명이 발달지연으로 판단되었다. (3) BSID-II와 비교한 K-ASQ의 민감도(sensitivity)는 50.0%, 특이도(specificity) 78.0%, 양성 예측치 (positive predictive value) 23.5%, 음성 예측치(negative predictive value)는 92.0%로 나타났다. 결 론 : K-ASQ는 높은 음성 예측치를 보여 소아과 외래에서 소아 발달 지연의 선별 도구로서 사용하는 것이 타당한 것으로 판단되었다.

• Asian-Australasian Journal of Animal Sciences
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• 제24권6호
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• pp.825-833
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• 2011

Forty-five Hisex commercial layers and forty-five local Saudi breed layers were used to determine the acceptable limit of short-term water restriction in the late phase of production, when the problem of high feed and water consumption is expected. The experiment was performed under hot and arid environmental conditions when the layers were at fifty weeks of age. Layers from each breed were randomly assigned in groups of five into nine floor pens. The average environmental temperature was 37.2-$38.6^{\circ}C$, and the relative humidity was between 20 to 37%. The trial was divided into 3 periods; control (1 week), water restriction (2 weeks) and rehydration (1 week). During the restriction period, layers from each breed were divided into three groups that received 20, 40, and 0% restriction of drinking water relative to their consumed water during the control period. During the study, feed and water consumption, body weight, changes in body weight, egg production, primary antibody response to SRBC, and rectal temperature were evaluated. Water restriction did not result in any clear effect on feed intake in either breed, however, commercial layers tended to consume less feed compared to the local breed. Body weight declined with water restriction during the first week of restriction in the commercial breed regardless of rate of restriction, but it was delayed until the second week in the local breed. Water restriction of 40% decreased egg production in both breeds but with a delay of 1 week in the local breed. Antibody level to SRBC was not affected by water restriction in the commercial line while it was highly affected in the local breed. A water restriction of 20% is considered to be an acceptable limit under the current experimental conditions without a negative effect on egg production in both breeds and considering the immune status of the local breed. Whereas, 40% restriction had a negative effect on egg production, and varied effects in the other traits in both breeds.

• Clinical and Experimental Pediatrics
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• 제61권8호
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• pp.245-252
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• 2018

Purpose: This study investigated patterns of ischemic injury observed in brain images from patients with neonatal group B Streptococcal (GBS) meningitis. Methods: Clinical findings and brain images from eight term or near-term newborn infants with GBS meningitis were reviewed. Results: GBS meningitis was confirmed in all 8 infants via cerebrospinal fluid (CSF) analysis, and patients tested positive for GBS in both blood and CSF cultures. Six infants (75.0%) showed early onset manifestation of the disease (<7 days); the remaining 2 (25.0%) showed late onset manifestation. In 6 infants (75%), cranial ultrasonography showed focal or diffuse echogenicity, suggesting hypoxic-ischemic injury in the basal ganglia, cerebral hemispheres, and periventricular or subcortical white matter; these findings are compatible with meningitis. Findings from magnetic resonance imaging (MRI) were compatible with bacterial meningitis, showing prominent leptomeningeal enhancement, a widening echogenic interhemisphere, and ventricular wall thickening in all infants. Restrictive ischemic lesions observed through diffusion-weighted imaging were evident in all eight infants. Patterns of ischemic injury as detected through MRI were subdivided into 3 groups: 3 infants (37.5%) predominantly showed multiple punctuate lesions in the basal ganglia, 2 infants (25.0%) showed focal or diffuse cerebral infarcts, and 3 infants (37.5%) predominantly showed focal subcortical or periventricular white matter lesions. Four infants (50%) showed significant developmental delay or cerebral palsy. Conclusion: Certain patterns of ischemic injury are commonly recognized in brain images from patients with neonatal GBS meningitis, and this ischemic complication may modify disease processes and contribute to poor neurologic outcomes.

• 한국건축시공학회지
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• 제2권1호
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• pp.155-162
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• 2002

In this research, I finally came to a conclusion analyzing the connection among managing of each items in management expenses, the size of each complex and stories, and the term of using. (1) In the managing cost regarding to the management manner, although the managing cost of self-governing management is less imposed than the one of commission management, there is slight difference between those Costs. And it is more important to consider the effectiveness of management than to emphasize reduction of management cost. (2) The higher the stories, the higher the managing cost of elevator per the unit area. It Is caused by the fact that the father the distance of the elevator operating, the higher the electric charges. (3) The third of one of total management cost goes to pay the personnel expenses. So I found that the effective management of the expenses is available to reduce management cost. (4) The higher the stones, the lower the cost of personnel expenses including the cleaner cost. (5) The sum of costs assigned in repairment and management increases in proportion to the term of using. The costs assigned in special repairment and management are interacting to each other. (6) To reduce the management cost, we have to cut down the personnel in security guard that occupies one third of total management cost with application to the joint security system and operation of the self-governing guard. Through this process, it will be easy to accomplish the rationalization of contract with an outside order. Because the improvement of management service is not only the responsibility of owner but also the one of dwellers. And it Is imperative to realize the importance of cooperation and trust between the owner and dwellers. And the establishment of effective managing system which has convenience and rationality must be settled without delay.

• 건축역사연구
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• 제19권6호
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• pp.99-120
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• 2010

According to it, a final goal of this study sets up 'Renovation of the Red brick architecture' and development of theoretical foundation and substantial conservation about Red brick architecture through historical records must be settled without delay. Firstly, it analyzes related terminology and adjusts brick architecture's history and features for architectural authenticity about Red brick architecture. It would study production and construction process of brick in korea. From analysis of records, brick of traditional meaning is 'Jeondol' and western brick of modern meaning is 'Red brick'. 'Brick' defines a common designation. This study shows definition of words based on documents published until 19th century and a korean language and architecture terms dictionary. In view of this results, the meaning of brick which combines different types extensively uses 'Chu', 'Jeon', 'Byeok' according to the purpose of use and the current of the times. In case of 'Jeon', it uses jointly different types such as '塼', '磚', '甎'. but '塼' is frequently used. Even though these words like 'byeok' used individual or combination types until the late 19th century, there is no use because of japanese terms in japanese colonial. After liberation, it was the term of the traditional brick. Brick is generally used through modern times. In an unabridged Korean language dictionary, it defines this term as orthodox korean '壁乭' and '?乭'. At that time of japanese colonial, 'Yeonwa(煉瓦)' used in combination with brick. Due to influence it, it partly uses until now but it is not in common use. Also, a Korean language dictionary contains transcription of 'Yeonwa' with same definition as 'Byeokdol'. In the other side, it results from translating japanese into Korean. It would make exact definition of 'Yeonwa'.

• 한국컴퓨터정보학회논문지
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• 제4권3호
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• pp.35-46
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• 1999

본 논문에서는 시간적 조건에서 실행시간을 개선한 새로운 CPLD 기술매핑 알고리즘을 제안한다. 본 기술매핑 알고리즘은 주어진 논리식을 DAG로 구성하여 각 노드를 검색한 후. 출력 에지의 수가 2이상인 노드를 분할하지 않고 최상위 노드만을 복제(replication)하여 DAG를 팬 아웃 프리 트리로 재구성함으로써 지연시간과 CLB의 개수가 최소화되며 실행 시간도 개선하였다. 시간제약 조건과 소자의 지연시간을 이용하여 그래프 분할이 가능한 다단의 수를 정하고, 각 노드의 초기비용과 전체비용을 계산하여 CLB의 k-OR텀수보다 비용이 초과되는 노드를 분할하여 서브그래프를 구성한다. 분할된 서브그래프들은 collapsing을 통해 노드들를 병합하고. 주어진 소자의 CLB안에 있는 k-OR텀 개수에 맞게 Bin packing를 실행하였다. 본 논문에서 제안한 기술매핑 알고리즘을 MCNC 논리합성 벤치마크 회로들에 적용하여 실험한 결과 기존의 CPLD 기술 매핑 툴인 TMCPLD에 비해 실행 시간이 20.3% 감소되었다.

• 한국통신학회논문지
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• 제32권6A호
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• pp.558-564
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• 2007

무선 성능 향상을 통해 다양한 이동 멀티미디어 서비스 제공을 목표로 하는 3G Long Term Evolution (3G LTE)은 Packet Switching (PS) 도메인에서 VoIP 기반 음성 서비스를 제안하고 있다 패킷 지연과 손실에 민감한 VoIP 트래픽을 PS 도메인을 통해 처리할 경우 기존 3G 시스템의 CS 도메인 기반 음성 서비스와 달리 여러 가지 기술적 어려움이 예상된다. 더욱이 OFDM을 물리계층으로 채택한 3G LTE는 Physical Resource Block (PRB) 단위로 전송 자원을 관리함에 따라 새로운 자원관리 방식 개발도 필요하게 된다. 본 논문에서는 3G LTE 의 VoIP 기반 음성 서비스를 위한 MAC 계층의 PRB 할당 스케줄링 알고리즘을 제안하고 시뮬레이션을 통한 검증 결과를 보인다. 알고리즘의 핵심은 VoIP 우선 모드를 동적으로 활성화하여 VoIP 서비스의 QoS를 보장하고, 이러한 우선 모드 적용으로 인한 시스템 자원효율성 저하를 최소화하기 위해 우선 모드 지속시간을 적응적 조절하는 것이다.

• 한국위성정보통신학회논문지
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• 제5권1호
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• pp.43-47
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• 2010

미래의 이동통신에서 하이브리드/통합 위성-지상 시스템의 중요성이 증가할 것으로 예상된다. 대부분의 이동통신 시스템은 지상 시스템 규격에 맞게 구성되어 있는데 이 경우 위성 시스템에 적합하게 호환성을 가지도록 하는 것이 시스템의 효율성 측면에서 매우 중요하다. 모든 4G 이동통신의 지상 시스템 규격에서는 자원을 효과적으로 사용하기 위해 수 msec 단위로 갱신이 가능한 적응형 변조 및 부호화 방식을 채택하였으나 위성 시스템의 긴 왕복지연 때문에 이러한 적응형 방식을 그대로 적용하기는 불가능하고, 단기 페이딩에 효과적으로 대응할 수 없다. 본 논문에서는 지상 시스템 규격과 최대의 호환성을 가지면서도 이동위성통신 시스템의 채널 환경에 적합한 적응형 변조 및 부호화 방식을 제시한다. 또, 단기 페이딩에 효과적으로 대응하기 위해 인터리버를 결합한 성능 시뮬레이션 결과를 비교 분석한다.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권2호
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• pp.129-143
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• 2022

Background: Patient-controlled analgesia (PCA) has been widely used as an effective medical treatment for pain and for postoperative analgesia. However, improper dose errors in intravenous (IV) administration of narcotic analgesics from a PCA infusion pump can cause patient harm. Furthermore, opioid overdose is considered one of the highest risk factors for patients receiving pain medications. Therefore, accurate delivery of opioid analgesics is a critical function of PCA infusion pumps. Methods: We designed a microbalance method that consisted of a closed acrylic chamber containing a layer and an oil layer with an electronic balance. A commercially available infusion analyzer (IDA-5, Fluke Co., Everett, WA, USA) was used to measure the accuracy of the infusion flow rate from a commercially available smart PCA infusion pump (PS-1000, UNIMEDICS, Co., Ltd., Seoul, Korea) and compared with the results of the microbalance method. We evaluated the uncertainty of the flow rate measurement using the ISO guide (GUM:1995 part3). The battery life, delay time of the occlusion alarm, and bolus function of the PCA pump were also tested. Results: The microbalance method was good in the short-term 2 h measurement, and IDA-5 was good in the long-term 24 h measurement. The two measurement systems can complement each other in the case of the measurement time. Regarding battery performance, PS-1000 lasted approximately 5 days in a 1 ml/hr flow rate condition without recharging the battery. The occlusion pressure alarm delays of PS-1000 satisfied the conventional alarm threshold of occlusion pressure (300-800 mmHg). Average accuracy bolus volume was measured as 63%, 95%, and 98.5% with 0.1 ml, 1 ml, and 2 ml bolus volume presets, respectively. A 1 ml/hr flow rate measurement was evaluated as 2.08% of expanded uncertainty, with a 95% confidence level. Conclusion: PS-1000 showed a flow accuracy to be within the infusion pump standard, which is ± 5% of flow accuracy. Occlusion alarm of PS-1000 was quickly transmitted, resulting in better safety for patients receiving IV infusion of opioids. PS-1000 is sufficient for a portable smart PCA infusion pump.