• 대한치과교정학회지
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• 제3권1호
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• pp.7-13
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• 1972

정상 치열궁에 관한 연구는 많은 학자들에 의해 시행되어온 바 학자들 간에는 아무런 일관성이 없다는 의견과 치열궁을 대표할 만한 기하학적 곡선이 존재한다는 의견이 상충되어 왔다. 그중 후자의 이론이 지배적인 것으로 보이나 그 중에서도 곡선의 형태에 관하여서는 다시 많은 논란이 있었다. Bonwill과 Hawley등에 의한 Circle론, Black의 반타원론, Angle의 포물선론, 이외에도 많은 의견이 있는 가운데 저자는 정상교합을 유지하는 한국인 성인을 대상으로 Bonwill과 Hawley의 이론을 기초로 한 연구를 시행한 바 다음과 같은 결과를 얻었다. 1. 정상교합을 유지하는 한국인 성인의 치열은 전치에 있어서 원호에 근사한 배열을 갖는다. 2. 원의 지름은 6전치의 폭경의 합에 대하여 다양하므로, 전치 배열이 치아의 크기에 엄격히 연관됐다고 단정 할 수는 없다. 3. 그러나 6전치 폭경의 합에 대한 원의 지름의 비율은 그 평균치가 상하악 모두 1 : 1에 매우 근접하고 이 사실은 Bonwill의 결론에 부합한다. 4. 견치간 폭경과 구치간 폭경은 육전치의 합에 대한 비율이 상하악에 있어서 그 형태가 다름에 따라 상이하나 비교적 일정하게 나타난다.

• 대한소아치과학회지
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• 제34권3호
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• pp.481-489
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• 2007

상악 견치의 매복은 임상에서 종종 관찰되며 인접치의 치근을 흡수하거나 낭종을 형성하는 등 여러 문제점을 유발한다. 매복 치아의 치료는 치근단의 완성 정도, 치아 매복의 방향과 위치, 맹출 공간의 존재 여부, 매복치 주변의 과잉치, 치아종, 낭종 등의 존재 여부 등에 따라 발치, 교정적 견인, 외과적 자가이식 등의 술식이 결정된다. 자가이식은 치아의 위치가 교정력을 가할 수 없는 위치에 존재하거나 치아 이동이 제한을 받게 되어 통상적인 치료가 불가능할 경우에 발거에 앞서 고려할 수 있으며, 자가이식의 예후는 치주인대의 보존, 치근의 완성도, 외과적 술식, 환자 연령, 근관치료 시기, 치아고정 기간 및 형태와 구강외 저장 용액 등에 의해 결정된다. 본 증례들은 영구 치열기 말기에 상악 견치 매복으로 내원하였고 그 매복 위치가 자발적인 맹출 유도나 교정적 견인 및 배열이 어렵다고 판단되었다. 따라서 자가이식과 근관치료를 시행하고 주기적인 관찰 중이다.

• 대한조선학회논문집
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• 제55권1호
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• pp.66-74
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• 2018

In order to evaluate the precision degree of the blocks on the dock, the shipyards recently started to use the point cloud approaches using the 3D scanners. However, they hesitate to use it due to the limited time, cost, and elaborative effects for the post-works. Although it is somewhat traditional instead, they have still used the electro-optical wave devices which have a characteristic of having less dense point set (usually 1 point per meter) around the contact section of two blocks. This paper tried to expand the usage of point sets. Our approach can estimate the rework time to weld between the Pre-Erected(PE) Block and Erected(ER) block as well as the precision of block construction. In detail, two algorithms were applied to increase the efficiency of estimation process. The first one is K-mean clustering algorithm which is used to separate only the related contact point set from others not related with welding sections. The second one is the Concave hull algorithm which also separates the inner point of the contact section used for the delayed outfitting and stiffeners section, and constructs the concave outline of contact section as the primary objects to estimate the rework time of welding. The main purpose of this paper is that the rework cost for welding is able to be obtained easily and precisely with the defective point set. The point set on the blocks' outline are challenging to get the approximated mathematical curves, owing to the lots of orthogonal parts and lack of number of point. To solve this problems we compared the Radial based function-Multi-Layer(RBF-ML) and Akima interpolation method. Collecting the proposed methods, the paper suggested the noble point matching method for minimizing the rework time of block-welding on the dock, differently the previous approach which had paid the attention of only the degree of accuracy.

• 한국철도학회논문집
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• 제14권5호
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• pp.433-441
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• 2011

한글초록은 기존선 고속화의 여러 대안 중 선로의 직 복선화 및 신선 건설에 의한 기존철도의 고속화는 시간단축 효과나 선로용량 증대의 폭은 크지만 막대한 투자 재원이 소요된다. 이에 비해 기존선을 그대로 사용하면서 속도를 향상하기 위해 선형개량 및 준고속 틸팅열차의 투입은 기존 인프라를 이용함으로서 보다 경제적이며 실용적이라는 장점이 있다. 하지만, 틸팅열차의 경우 기존열차와는 주행 메카니즘이 다르기 때문에 주행 안전성을 확보하기 위해서는 기존에 부설되어 있는 궤도노반의 성능평가가 선행되어야 한다. 또한 열차주행에 따라 발생하는 노반의 침하는 궤도틀림이나 열차의 탈선 등을 유발할 수 있으므로 틸팅열차 주행에 의해 발생하는 궤도 부담력에 따른 노반의 거동 특성을 분석할 필요가 있다. 본 연구에서는 현장계측을 통해 틸팅열차의 기존선 주행속도별(120~180km/h) 주행안전성과 노반성능을 평가하였다. 모든 주행속도에서 탈선계수와 윤중감소율 허용한계치를 만족하였으며, 또한 노반성능 면에서는 기존 운행 고속열차(KTX)에 비하여 작은 노반응답(노반압력, 노반침하, 노반진동가속도)을 보였다. 이러한 계측 결과를 기반으로, 기존열차와 혼용 투입될 틸팅열차는 본 연구의 계측대상 노선과 동일한 성능수준의 궤도노반에서는 최고운영속도(180km/h)에서 안전한 주행이 가능할 것으로 판단된다.

• Journal of Microbiology
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• 제45권2호
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• pp.158-167
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• 2007

In this study, we have cloned a novel cDNA encoding for a papain-family cysteine protease from the Uni-ZAP XR cDNA library of the polychaete, Periserrula leucophryna. This gene was expressed in Escherichia coli using the T7 promoter system, and the protease was characterized after partial purification. First, the partial DNA fragment (498 bp) was amplified from the total RNA via RT-PCR using degenerated primers derived from the conserved region of cysteine protease. The full-length cDNA of cysteine protease (PLCP) was prepared via the screening of the Uni-ZAP XR cDNA library using the $^{32}P-labeled$ partial DNA fragment. As a result, the PLCP gene was determined to consist of a 2591 bp nucleotide sequence (CDS: 173-1024 bp) which encodes for a 283-amino acid polypeptide, which is itself composed of an 59-residue signal sequence, a 6-residue propeptide, a 218-residue mature protein, and a long 3'-noncoding region encompassing 1564 bp. The predicted molecular weights of the preproprotein and the mature protein were calculated as 31.8 kDa and 25 kDa, respectively. The results of sequence analysis and alignment revealed a significant degree of sequence similarity with other eukaryotic cysteine proteases, including the conserved catalytic triad of the $Cys^{90},\;His^{226},\;and\;Asn^{250}$ residues which characterize the C1 family of papain-like cysteine protease. The nucleotide and amino acid sequences of the novel gene were deposited into the GenBank database under the accession numbers, AY390282 and AAR27011, respectively. The results of Northern blot analysis revealed the 2.5 kb size of the transcript and ubiquitous expression throughout the entirety of the body, head, gut, and skin, which suggested that the PLCP may be grouped within the cathepsin F-like proteases. The region encoding for the mature form of the protease was then subcloned into the pT7-7 expression vector following PCR amplification using the designed primers, including the initiation and termination codons. The recombinant cysteine proteases were generated in a range of 6.3 % to 12.5 % of the total cell proteins in the E. coli BL21(DE3) strain for 8 transformants. The results of SDS-PAGE and Western blot analysis indicated that a cysteine protease of approximately 25 kDa (mature form) was generated. The optimal pH and temperature of the enzyme were determined to be approximately 9.5 and $35^{\circ}C$, respectively, thereby indicating that the cysteine protease is a member of the alkaline protease group. The evaluation of substrate specificity indicated that the purified protease was more active towards Arg-X or Lys-X and did not efficiently cleave the substrates with non-polar amino acids at the P1 site. The PLCP evidenced fibrinolytic activity on the plasminogen-free fibrin plate test.

• 한방재활의학과학회지
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• 제29권4호
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• pp.81-88
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• 2019

Objectives This study is a preliminary study for safe and accurate cervical Hyeopcheok acupuncture by comparing the depth of cervical Hyeopcheok acupoint with cervical spine rotation. Methods Researchers took ultrasonographic images of cervical Hyeopcheok acupoint during full rotation of cervical spine, 45 degree rotation and neutral condition in a prone position. 4 healthy volunteers were recruited. Results No significant difference in needling depth of cervical Hyeopcheok acupoint was observed. However, there were a differences in anatomical structures' shape such as muscles. Conclusions There are no significant difference in needling depth, but anatomical structures' shape were changed. This result mean that if patient rotate cervical spine during acupuncture treatment, it can occur complications. Thus, when acupuncture treatment on cervical Hyeopcheok acupoint, practioner should make subject's cervical spine alignment corrected and be careful not to change posture during the procedure.

• 한방재활의학과학회지
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• 제23권2호
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• pp.139-149
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• 2013

Objectives : The aim of this study was to investigate the characteristic of low back pain(LBP) and lumbosacral-pelvic alignments, and the relationship between them, depending on the presence and the duration of LBP. Methods : Ninety six patients were classified into the no LBP group(n=31), the acute LBP group(n=33) and the chronic LBP group(n=32), based on the presence and duration of LBP. In each group, lumbosacral-pelvic indicators were measured. The data were analysed by one way analysis of variance(ANOVA) and pearson correlation. Results : 1. The chronic LBP group showed the lower mean value in Ferguson angle, Lumbar lordosis angle, Pelvic Incidence and difference between left and right iliac height, being compared to acute LBP group. 2. There was not significant correlation between lumbosacral-pelvic alignments and LBP in every group. 3. A positive correlation was found among period of LBP and visual analogue scale(VAS), Oswestry disability index(ODI). Conclusions : For presence and duration of LBP, there were different characteristic values in descriptive statistics. And period of LBP is the most important factor for the degree of LBP. These results show that the lumbosacral-pelvic alignments and LBP have distinctive relationships depending on the duration of LBP.

• Korean Journal of Radiology
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• 제23권6호
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• pp.638-648
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• 2022

Objective: The study aimed to investigate the diurnal variation in cervical disc hydration and its relationship with cervical degeneration. Materials and Methods: C3-C7 discs of 86 prospectively enrolled participants (37 males, 49 females; mean age ± standard deviation, 23.5 ± 2.5 years) were assessed using T2 mapping in the morning and evening. All discs were stratified by Miyazaki grade or C2-C7 Cobb angle and T2 values (T2). The degree of diurnal T2 variation (T2-DDV), defined as (morning T2 - evening T2)/morning T2 x 100%, was measured for the entire disc, annulus fibrosus (AF), nucleus pulposus (NP), and endplate zones. Results: T2 of the entire disc decreased significantly after the daytime load (p < 0.001), with a T2-DDV of 13.3% for all discs and 16.0%, 12.2%, and 13.0% for healthy (grade I), mild degenerative (grade II), and advanced degenerative (grade III/IV) discs, respectively. T2 of regional NPs and AFs decreased significantly from morning to evening (p ≤ 0.049) except in the healthy anterior inner AF (p = 0.092). Compared with healthy discs, mild degenerative discs displayed lower T2 and T2-DDV in regional NPs (p < 0.001). Advanced degenerative discs showed higher T2-DDV in the anterior inner AF compared with healthy discs (p = 0.050). Significant diurnal T2 changes in the endplate zones were observed only in healthy discs (p = 0.013). Cervical discs in the low Cobb angle group showed higher T2-DDV in the anterior AFs and anterior NP and lower T2-DDV in the posterior AF than those in the high Cobb angle group (p ≤ 0.041). Conclusion: This study characterized the diurnal variation in hydration of the cervical discs as assessed using T2 mapping and revealed early chemo-mechanical coupling dysfunction in degenerating discs. Cervical sagittal alignment on MRI can affect the diurnal stress patterns of the cervical discs. T2 mapping is sensitive to disc biomechanical dysfunction and offers translational potential from biomechanical research to clinical application.

• 대한방사선기술학회지:방사선기술과학
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• 제42권3호
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• pp.167-173
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• 2019

The Cobey method and the modified Cobey method are most commonly used in clinical practice. Therefore, the purpose of this study was to investigate the radiological differences between Cobey and modified Cobey and provide radiographic information about changes of hindfoot image with X-ray entrance center and tube angle change in modified Cobey. This study was performed on foot and ankle phantom. First, for image comparison of Cobey and modified Cobey, the images obtained by applying the same X-ray entrance center to the ankle joint were compared and analyzed. Second, in the modified Cobey, the X-ray entrance center is set as ankle joint and lateral malleolus. The X-ray tube angle was varied from $10^{\circ}$ to $40^{\circ}$ at $5^{\circ}$ intervals for each X-ray entrance center. The images obtained by varying the X-ray tube angle from $10^{\circ}$ to $40^{\circ}$ at intervals of $5^{\circ}$ for each X-ray entrance center were compared and analyzed. The irradiation conditions were the same with 110 kVp, 200 mA, 10 ms, and 110 cm of source - image receptor distance (SID). Image evaluation was performed by two radiologists. Measurements were made on the lateral point, middle point, and calcaneus width based on a hypothetical line parallel to the calcaneal tuberosity. Data were analyzed by using descriptive statistics as the mean of the distance to each measurement location. The modified Cobey was longer than the Cobey by an average of 3 to 4 mm lateral and medial points, and the calcaneus width was similar (ICC = 0.939). In modified Cobey method, when the X-ray entrance center is ankle joint, the lateral point is about 3 mm and the medial point is about 4.3 mm longer than lateral malleolus. Also, when the X-ray tube angle is more than $20^{\circ}$, the degree of distortion is large. The ICCs for the lateral, medial point, and calcaneus width were 0.998, 0.961, and 0.997, respectively, as the X-ray entrance center and tube angle were changed. There was no significant difference between Modified Cobey and Cobey. Modified Cobey showed no need to compensate the $20^{\circ}$ detector angle of the Cobey. In addition, we suggest that tube angle should be limited within $20^{\circ}$ when modified Cobey is performed.

• 생명과학회지
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• 제12권5호
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• pp.610-621
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• 2002

미생물 유전체(genome)들 사이의 보존된 유전자 (con-served gene)를 밝히는 것은 생명의 본질을 이해하는데 있어 다양한 의미를 갖는다고 할 수 있을 것이다. 본 연구에서는 보존적 유전자를 찾아내고, distance value를 이용하여 구한 보존성의 정도 C(conservation score)를 이용하여 종간의 유전자 변이의 정도를 단백질 관점에서 분석하였다. 분석에 사용된 자료는 COGs 데이티베이스의 총 43종의 미생물 유전체들이며, 이들은 총 n,009개의 유전자들을 포함하는 3,852 개의 ortholog들로 구성되어있었다. 분석 결과 43종의 미생물 유전체에 대하여 총 $\ulcorner$2개의 유전자들이 보존적인 것으로 나타났으며, 이들 중 72.2%인 52종의 유전자가 단백질 합성에 관련되는 것으로 나타났다. 이들 보존적 유전자들에 대하여 보존성의 정도 C를 계산하여 보존성의 순위를 얻었으며, 가장 잘 보존된 유전자는 CTPase-trans-lation elogation factor (COG0050)로 나타났다. 그리고 72개의 보존적 유전자가 나타내는 CU 모두를 이용한 분석결과 고세균(archaea)과 진정세균(bacteria)이 각각 독자적인 그룹을 형성하는 것을 관찰하였다. 본 연구의 결과에서 도출한 72개의 보존적 유전자는 생명체의 본질적 기능에 중요한 역할을 담당하는 것으로 사료되었고, 생명체의 진화 과정에서 이 유전자들이 보존된 이유와 기능적 연계에 대한 생물학적 연구에 기초 자료를 제공할 것으로 판단되어 진다.