• Molecules and Cells
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• 제39권10호
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• pp.762-767
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• 2016

Fasciclin II (FasII), the Drosophila ortholog of neural cell adhesion molecule (NCAM), plays a critical role in synaptic stabilization and plasticity. Although this molecule undergoes constitutive cycling at the synaptic membrane, how its membrane trafficking is regulated to ensure proper synaptic development remains poorly understood. In a genetic screen, we recovered a mutation in Drosophila mical-like that displays an increase in bouton numbers and a decrease in FasII levels at the neuromuscular junction (NMJ). Similar phenotypes were induced by presynaptic, but not postsynaptic, knockdown of mical-like expression. FasII trafficking assays revealed that the recycling of internalized FasII molecules to the cell surface was significantly impaired in mical-like-knockdown cells. Importantly, this defect correlated with an enhancement of endosomal sorting of FasII to the lysosomal degradation pathway. Similarly, synaptic vesicle exocytosis was also impaired in mical-like mutants. Together, our results identify Mical-like as a novel regulator of synaptic growth and FasII endocytic recycling.

• Food Science and Biotechnology
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• 제14권5호
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• pp.604-607
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• 2005

In this study, the effect of ${\beta}$-sitosterol (SS) in the liposome bilayer on the stability of incorporated retinol was evaluated. Retinol was incorporated into liposomes consisting of various ratios of soybean phoaphatidylcholine (PC) to SS, while liposomes were prepared as multilamellar vesicles by the dehydration/rehydration method. Retinol was readily incorporated into liposomes with various SS contents, with incorporation efficiencies higher than 98% for all conditions. The incorporation efficiency of retinol increased slightly as the SS content in liposomes increased. Its average particle size also increased as the SS content increased. Mean particle size at PC to SS ratios of 100:0, 90:10, 80:20, 70:30, 60:40, and 50:50 were 12.16, 17.57, 35.00, 40.62, 83.45, and $88.94\;{\mu}m$, respectively. Liposomal retinol degradation in aqueous solution was measured with respect to SS content at various periods of time at four different temperatures of 4, 25, 37, and $50^{\circ}C$, and the stability of the incorporated retinol enhanced as the SS content increased. At $4^{\circ}C$, for example, retinol in the liposomes of 50:50 (PC:SS) remained at 84.42% after storage for 10 days, while in 100:0 (PC/SS) it remained at 42.62%. These results indicate that SS content in liposomes played an important role in the incorporation efficiency of retinol and its stability.

• Journal of Pharmaceutical Investigation
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• 제22권3호
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• pp.211-217
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• 1992

Stabilization of liposomes against degradation by bile salts has been investigated in order to develop a liposomal model system for oral drug delivery. Two polysaccharides, amylopectin (AP) and chitin (CT), were employed to coat both empty liposomes and bromthymol blue (BTB)-encapsulated liposomes by adsorption-coating techniques. Turbidity changes and BTB-release characteristics in pH 5.6 buffer solutions with or without bile salts, sodium cholate and sodium glycocholate, were observed to compare the differences between uncoated liposomes and polysaccharide-coated liposomes. Initial turbidities of both uncoated and polysaccharide-coated liposomes in buffer solution were kept constant within 3% range during 4 hours of experiments. But they were decreased in a different manner in bile salts-containing buffer solutions, showing 10% or less decrease for polysaccharide-coated liposomes and 25% or more decrease for uncoated liposomes. BTB release from uncoated liposomes has been greatly increased upto 90% after 4 hours in bile salts-containing buffer solution, which is a clue for breakdown of liposomal vesicles. However, polysaccharide-coated liposomes showed the controlled-release pattern which is proportional to square-root of time, followed by around 50% release for the same time period. Consequently, it is possible to conclude that these polysaccharide-coated liposomes might be an available system for oral delivery of a drug which is unstable in gut environment.

• Journal of Institute of Control, Robotics and Systems
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• 제20권10호
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• pp.1014-1022
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• 2014

In mechatronic systems using electric signals to drive control systems, driving signals including the frequency band of the unwanted signals, such as resonant frequencies and noise frequencies, can affect the accuracy of the controlled system and can cause serious damage to the system due to the resonance phenomenon of the mechatronic system. An LOS (Line of Sight) control unit is used to automatically rotate the gimbal system with a video imaging system generally mounted on modern aerial vehicles. However, it still suffers from natural frequency variation problems due to variations of operational temperature. To prevent degradation in performance, this paper proposes an adaptive filtering technique based on real-time noise analysis and adaptive notch-filtering for LOS control systems, and verifies how our proposed method maintains the LOS stabilization performance. Additionally, this filtering technique can be applied to the image noise filtering of the video imaging system. It is designed to reduce image noises generated by switching circuits or power sources. The details of design procedures of the proposed filtering technique and the experiments for the performance verification are described in this paper.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• 제5권3호
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• pp.226-233
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• 1993

Thermosyphons are simple devices that can passively transport thermal energy over relatively large distance with little temperature degradation. Especially, the thermosyphon system requires no costly energy input and is completely maintenance free. These attributes permit the use of low grade thermal energy for thermal control of structures including the stabilization of highway foundations. This paper presents the experimental results of the snow melting system in which thermosyphon was utilized to ransfer the earth energy to the pavement to remove snow and ice. The test facility, three earth heated and one unheated test panels, is designed to investigate the variables associated with removing snow and ice from pavement surfaces. The results of these test show that the earth heated panel surface temperature is higher $2{\sim}6^{\circ}C$ than unheated panel when the ambient air temperature is $-7^{\circ}C$. The thermal performance of this earth source thermosyphon system for road heating showed that there was no snow on the heated test panels when the snowfall was 5cm average for the region.

• Environmental Engineering Research
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• 제19권3호
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• pp.185-195
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• 2014

Despite the enormous technical and economic efforts to improve environmental conditions, currently about 40% of the global population (or 2 billion people) are still lack access to safe water supply and adequate sanitation facilities. Pollution problems and transmission of water- related diseases will continue to proliferate. The rapid population growth and industrialization will lead to a reduction of arable land, thus exacerbating the food shortage problems and threatening environmental sustainability. Natural systems in this context are a transdisciplinary approach which employs the activities of microbes, soil and/or plants in waste stabilisation and resource recovery without the aid of mechanical or energy-intensive equipments. Examples of these natural systems are: waste stabilisation ponds, aquatic weed ponds, constructed wetlands and land treatment processes. Although they require relatively large land areas, the natural systems could achieve a high degree of waste stabilisation and at the same time, yield potentials for waste recycling through the production of algal protein, fish, crops, and plant biomass. Because of the complex interactions occurring in the natural systems, the existing design procedures are based mainly on empirical or field experience approaches. An integrated kinetic model encompassing the activities of both suspended and biofilm bacteria and some important engineering parameters has been developed which could predict the organic matter degradation in the natural systems satisfactorily.

• Journal of Satellite, Information and Communications
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• 제7권1호
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• pp.1-6
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• 2012

This research is performed to upgrade the performance and stabilize ther operation of GSS L1 receiver. One of the this research result is that the pre-development GSS receiver is amended to remove performance degradation factor so GSS L1 receiver performance enhancement is achieved. Other is that as a result of long run test, real environment test is performed and GSS L1 receiver operate under the GPS live signal receiving environment. Key result of this research is localization of GSS receiver.

• Journal of Power System Engineering
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• 제10권1호
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• pp.96-101
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• 2006

In ship operation the consequence of roll and pitchingmotion can seriously degrade the performance of mechanical and personnel effectiveness. So many studies for the roll stabilization and trimming control system design have been performed and good results have been achieved where the stabilizing fins, tanks, rudders and flaps are used. However the ultimate objective of such approach should be focused on improving the boarding sensitivity. But there may exist many unsolved problems, for examples, ship control performance degradation and increasing of system complexity. So, the achieved control performance could not give us enough comfortable boarding sensitivity where the residual rolling and pitching motion are main drawbacks. To get rid of these disadvantages, the main hull control systems design approach has been considered using semiactive absorber. In this system, dampers, spring, dynamic dampers and control system with sensors are incorporated. In our system considered in this study, just two motors and control system with sensors are used for the bed. And the control system can be installed on each bed. So, we can control every bed on the specified control objective respectively. Above all, the good advantages of this system are the facts followed from simple idea and usefulness. Of course the structural modifications are needed. Considering disturbances, we design control system and verify the usefulness of developed system from the experimental study.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 한국윤활학회 2001년도 제33회 춘계학술대회 개최
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• pp.346-353
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• 2001

Zirconia powder containing 3 mol% yttria(3Y-PSZ) with and with out Fe$_2$O$_3$ addition was coated on tile cast iron substrate by plasma spraying method. The erosion experiments were performed at temperatures from $25^{\circ}C$ to $600^{\circ}C$. A gas blast type erosion tester was used to examine erosion behavior of the specimens. The results of 3Y-PSZ coatings showed that tile erosion rate had maximum value at 40$0^{\circ}C$. It coincided with tile results of phase transformation tetragonal phase to monoclinic phase caused by low temperature thermal degradation. The tensile stress relaxation and the micro-hardness improvement significantly influenced on the erosion rate at $600^{\circ}C$. In the case of Fe$_2$O$_3$ added 3Y-PSZ coatings, the erosion rate of tested at $25^{\circ}C$ showed maximum value at 5.0 mol% Fe$_2$O$_3$ added coating. This tendency is caused by the improvement of mechanical properties and the tensile residual stress. The erosion rate at 200'c and 400'L showed significantly decrease by Fe203 addition. This decrease is believed to be the stabilization of the tetragonal phase and the increase of micro-hardness.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2006년도 춘계학술대회
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• pp.145-148
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• 2006

The protocrystalline silicon (pc-Si:H) multilayer solar cell is very promising owing to its fast stabilization with low degradation against light irradiation. However, the pc-Si:H multi layers have not extensively been investigated in detail on its material characteristics yet. We present the material characteristics of pc-Si:H multilayer using a transmission electron microscopy(TEM), and Raman spectroscopy. In addition, we present the superior light-soaking behavior of the pc-Si:H mutt i layer solar cell. A TEM micrograph shows that a pc-Si:H multilayer has a repeatedly layered structure and crystalline-like objects in a-Si:H matrix. A Raman spectra introduces improved short-range-order and medium-range-order in pc-Si:H multilayer. As a result the excellent metastability of the pc-Si:H multilayer solar cell is primarily due to the repeatedly layered structure that improves a structural order in absorber layer.