• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 1998년도 제13회 하계학술발표회 논문집
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• pp.226-249
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• 1998

Technology diffusion policy can be defined as the role of government in linking knowledge production with usage. It has an importance due to the fact that linking knowledge between the producing agent and using agent does not automatically occur. If knowledge produced by an R&D agent is not used by somebody else, the knowledge may deteriorate to a social loss since knowledge production consumes a considerable degree of social resources. Explicit technology diffusion policies are not found in Korea. There we, however, a number of implicit policies to promote technology diffusion, mainly by promoting cooperation among universities, industries and research institutes. Government R&D programs have provided incentives for cooperative research projects, and many government sponsored institutes have been assigned the role of technology assistance for small and medium sized firms. Nevertheless, diffusion policies remain weak in comparison to other innovation and technology policies. This is reflected in the relatively small scale of government support for technology diffusion programs. In addition, there is no systematic approach between the different ministries for enhancing diffusion across technologies, institutions, sectors and regions. A comprehensive evaluation of government diffusion programs, which is necessary for improving policy and program design, is lacking. Enhancing the diffusion of technology in Korea will require the strengthening of policies at different levels, including; 1) increasing the orientation of science and technology policies towards diffusion; 2) increasing the scale of existing diffusion programs; 3) developing new diffusion programs, in particular sector-specific or manpower training programs; 4) developing policies to encourage a culture of cooperation that can facilitate technology diffusion; and 5) carrying out substantial policy research to develop diffusion policies.

• 대한수의학회지
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• 제35권2호
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• pp.375-381
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• 1995

Two intraocular tumors were identified in low and medium dosed groups of a carcinogenicity study using 200 males and 200 females Sprague-Dawley rats in Screening & Toxicology Research Center, Korea Research Institute of Chemical Technology. The tumors were grossly observed as white or yellow, unilateral nodules. They were approximately $1-2{\times}3-5mm$ in size. The tumors located in the region of iris and/or ciliary body invaded peripheral cornea. The microscopic features were usually composed of spindle cells arranged in parallel, forming gently curving bundles or whorls. The spindle cells had poorly defined cell boundaries, scant to moderate cytoplasm, fusiform nuclei and indistinct nucleoli. Mitotic figures were rare and areas of necrosis were present. The spindle cells had positive immunoreactivity for S-100 protein and vimentin but negative for desmin, collagen and HMB-45 antibody. In special histochemical studies, the spindle cells react with Gomori's stain for argyrophih fibers, Prussian blue stain for iron but negative with Masson-Fontana's stain for melanin granules. Ultrastructurally, cytoplasmic premelanosomes were not observed in the tumor cells due to the poor preservation of tumor masses. Based on the results, the tumors were diagnosed as amelanotic melanoma.

• 한국식품영양학회지
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• 제13권6호
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• pp.611-618
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• 2000

폐수처리 중 생물학적 처리에 활용할 수 있는 질소분해 능력을 가진 미생물을 분리하여 동정하고자 경기도내 하천 6지점에서 채취한 시료로부터 60개 균주를 선별하였다. 형태학적, 생화학적 및 배양학적 실험결과 Bergey\`s mannual of systematic bacteriology의 색인을 통하여 Aeromonas hydrophila로 동정하였다. Aeromonas hydrophila(AH-1), (AH-3), (AH-4), (AH-6) 균이 질산화 능력이 우수하였다. 4개 균주모두 amoxillin, ampicillin. cephalothin 과 ticarcillin에 내성을 나타내었다. 본 실험에서 분리한 Aeromonas hydrophila의 질산화의 최적조건은 균 농도 1.0$\times$$10^{6}$cells/ml, 배양온도 37$^{\circ}C$로 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2345-2348
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• 2012

Epidemiological studies of cancer incidence in Kazakhstan have revealed an uneven distribution for cervical cancer. Incidence and mortality rates were calculated for different regions of the republic, including the two major cities of Almaty and Astana, in 1999-2008. Defined levels for cartograms for incidence were low (up to 12.8/100,000), medium (12.8 to 15.9) and high (above 15.9) and for mortality were up to 7.1, 7.1 to 10.8 and more than 10.8, respectively. Basically high incidence rates were identified in the eastern, central and northern parts of the country and in Almaty. Such differences in cervical cancer data, and also variation in mortality/ incidence ratios, from a low of 0.4 in Almaty to a high of 0.71 in Zhambyl, point to variation in demographic and medical features which impact on risk and prognistic factors for cervical cancer in the country. Further research is necessary to highlight areas for emphasis in cancer control programs for this important cancer.

• 대한한의학원전학회지
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• 제31권3호
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• pp.99-107
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• 2018

Objectives: This article aims to clarify the understanding and publication status of both The Treasured Mirror of Eastern Medicine (Donguibogam) and some of its recent research progress made in North Korea, as well as their influences upon the academic of Koryo medicine in North Korea. Methods: Analysis was carried out based on various reference books, dictionaries and Korean translation of Donguibogam (1964 Ver.) published by North Korea, as well as the North Korean quarterly medical journal, Koryo Medicine. Results: The academic of Koryo medicine in North Korea regards Donguibogam, a Korean medical classic as it was written by native Korean physicians and it became an important ground material for basic research and clinical study. Various terminologies used in the original version of Donguibogam were defined as unscientific and superstitious by North Korean academics, which were then subsequently removed from the Korean translation of Donguibogam (1964 Ver.) published by North Korea. Therefore, this version cannot be seen as a complete edition of Donguibogam. Conclusions: The Donguibogam is known as one of the 'three major books of Koryo medicine' in North Korea. As a treasure of East-Asian traditional medical classic, Donguibogam is expected to become the medium for a closer research collaboration between the North and South Koreas including China in the future.

• Journal of Microbiology and Biotechnology
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• 제19권11호
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• pp.1408-1414
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• 2009

The obtention of high yields of purified plasmid DNA is viewed as an essential issue to be considered towards efficient production of DNA vaccines and therapeutic plasmids. In this work, Escherichia coli $DH5\alpha$. bearing the pVAXI-LacZ plasmid was grown in a developed semi-defined medium at different temperatures and tryptone concentrations. Analysis of pDNA yields and E. coli morphology revealed that at higher temperatures (37 and $40^{\circ}C$), higher specific yields and E. coli filamentation were obtained. However, the best results were achieved when a lower tryptone concentration was used. This approach was shown to be a powerful tool to promote plasmid amplification, keeping the desirable plasmid structure, and favoring the attainment of quality. Our results suggest that by using tryptone alone as an amino acid source, pDNA amplification was improved and a specific yield of 20.43 mg pDNA/g dcw was achieved, proving that this strategy can improve pDNA yield even at a small scale.

• Journal of Microbiology and Biotechnology
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• 제20권11호
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• pp.1597-1602
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• 2010

Chitinase is one of the most important mycolytic enzymes with industrial significance. This enzyme is produced by a number of organisms including bacteria. In this study, we describe the optimization of media components with increased production of chitinase for the selected bacteria, Stenotrophomonas maltophilia, isolated from soil. Different components of the defined media responsible for influencing chitinase secretion by the bacterial isolate were screened using Plackett-Burman experimental design and were further optimized by Box-Behnken factorial design of response surface methodology in liquid culture. Maximum chitinase production was predicted in medium containing 4.94 g/l chitin, 5.56 g/l maltose, 0.62 g/l yeast extract, 1.33 g/l $KH_2PO_4$, and 0.65 g/l $MgSO_4{\cdot}7H_2O$ using response surface plots and the point prediction tool of the DESIGN EXPERT 7.1.6 (Stat-Ease, USA) software.

• Advances in aircraft and spacecraft science
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• 제7권1호
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• pp.79-90
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• 2020

The dynamic coupling between shaker and test-article has been investigated by recent research through the so called Virtual Shaker Testing (VST) approach. Basically a VST model includes the mathematical models of the test-item, of the shaker body, of the seismic mass and the facility vibration control algorithm. The subsequent coupled dynamic simulation even if more complex than the classical hard-mounted sine test-prediction, is a closer representation of the reality and is expected to be more accurate. One of the most remarkable benefits of VST is the accurate quantification of the frequency down-shift (with respect to the hard-mounted value), typically affecting the first lateral resonance of heavy test-items, like medium or large size Spacecraft (S/Cs), once mounted on the shaker. In this work, starting from previous successful VST experiences, the parameters having impact on the frequency shift are identified and discussed one by one. A simplified analytical system is thus defined to propose an efficient and effective way of calculating the lower bound frequency shift through a simple equation. Such equation can be useful to correct the S/C lateral natural frequency measured during the test, in order to remove the contribution attributable to the shaker in use. The so-corrected frequency value becomes relevant when verifying the compliance of the S/C w.r.t. the frequency requirement from the Launcher Authority. Moreover, it allows to perform a consistent post-test correlation of the first lateral natural frequency of S/C FE model.

• 한국지하수토양환경학회지:지하수토양환경
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• 제20권3호
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• pp.15-24
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• 2015

The soil ecosystem is a complex system performing particularly complicated and varied functions, such as providing a habitat for organisms, acting as a medium for plant cultivation and growth, and functioning as a buffer against external materials in the environment. To assess whether these important functions of the soil ecosystem are executed appropriately, the concept of soil ecosystem health has been introduced, which is defined as the ability to perform the specific functions of the soil ecosystem. Understanding soil properties and soil indicators related to soil functions is essential to assess the soil health. In this study, systems, the indicators, and evaluation factors for assessing soil ecosystem health employed in a number of countries were investigated and discussed. In particular, it is necessary to introduce a technique for the evaluation of soil ecosystem health in Korea and to develop techniques and indicators appropriate to the soil ecosystem and status in Korea.

• 한국가축번식학회지
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• 제21권3호
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• pp.281-285
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• 1997

The study was conducted to investigate on in vitro developmental rates of bisected bovine embryos co-culture in 10% FCS＋TCM-199 media containing hormones, oviductal epithelial cells and cumulus cells 0 to 7 days after bisection. In vitro developmental rates was defined as development rates on in vitro culture or FDA-test. The results are summarized as follows : 1. In vitro developmental rates of bisected bovine embryos co-cultured in 10% FCS＋TCM-199 media containing PMSG＋hCG, PMSG＋$\beta$-estradiol, hCG＋$\beta$-estradiol, PMSG, hCG 0 to 3 days and 4 to 7 days were 16.7~30.0% and 11.1~25.0%, respectively. In vitro developmental rates of bisected embryos co-cultured in 10% FCS＋TCM-199 media containing hormones significantly higher than that of non co-culture. 2. In vitro developmental rates of bisected bovine embryos co-cultured 10% FCS＋TCM-199 media containing oviductal epithelial cells 0 to 3 days and 4 to 7 days were 25.0% and 22.2%, respectively.