• BMB Reports
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• v.43 no.9
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• pp.593-598
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• 2010

Tetrahydrobiopterin ($BH_4$) is a pivotal cofactor for enzymes responsible for the synthesis and release of monoamine neurotransmitters including dopamine and serotonin as well as the release of glutamate. Deficiencies in $BH_4$ levels and reduced activities of $BH_4$-associated enzymes have been recently reported in patients with schizophrenia. Accordingly, it is possible that abnormalities in the biochemical cascades regulated by $BH_4$ may alter DA, 5-HT and Glu neurotransmission, and consequently contribute to the pathophysiology of different neuropsychiatric diseases including schizophrenia. The development of a novel strain of mutant mice that is deficient in $BH_4$ by knocking out the expression of a functional sepiapterin reductase gene (spr -/-) has added new insights into the potential role of $BH_4$ in the pathophysiology and improved treatment of schizophrenia.

• Korean Journal of Pharmacognosy
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• v.20 no.1
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• pp.32-36
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• 1989

Effects of Lycium chinensis, Epimedium koreanum and tuguaconitine which is isolated from Aconitum sibiricum on primary culture chicken embryonic brain cells were studied by microscopic observation and determined of the activity of pyruvate dehydrogenase complex(PDHC). Brain cells were prepared from the brain of 10-day-old chicken embryo and cultured with a medicine consisted of 90% Dulbecco's Modified Eagle Medium(DMEM) and 10% horse serum. It was observed that all substances studied seemed to show the tendency to stimulate the neurite outgrowth of brain cells which were cultured with a deficient medium under microscopic observation. The activity of PDHC in brain cells cultured with a deficient medium was increased by Lysium chinensis and Epimedium koreanum. However, tuguaconitine had not influence on the activity of PDHC.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.33 no.3
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• pp.218-225
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• 1997

The formerly proposed spectral model of turbulent burning velocity is refined for nonstoichiometric hydrocarbon mixtures. Refinements are made in regard to the following two points : (1) an effect of the diffusivity of deficient reactant on the turbulent burning velocity and (2) consideration of increasing laminar name thickness with a decrease in the laminar burning velocity A comparison between the predicted turbulent velocities and the measured ones is made. The predictions by the refined spectral model agree quantatively well with the experimental results in the regime of practical equivalence ratio, but not in the high and low equivalence ratio regime.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.128-129
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• 2001

Tilianin, purified from acrial part of Agastache rugosa Kuntze, reduces progression and may induce some regression of aortic foam cell formation in low density lipoprotein receptor deficient mice (LDLR -/- mice). We investigated whether tilianin can prevent high fat diet-induced atherosclerosis. Twenty-six male mice were divided into three groups.(omitted)

• The Academic Congress of Korean Shoulder and Elbow Society
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• 2002.10a
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• pp.7-7
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• 2002

Historically, the decision to perform a hemiarthroplasty (HHR) versus a total shoulder arthroplasty (TSA) is based on the status of the glenoid and the status of the soft tissues (rotator cuff). In disease processes where the glenoid articular cartilage is relatively well preserved such as avascular necrosis and complex proximal humerus fractures, most orthopaedists recommend performing a HHR while preserving the native glenoid articular surface. At the other end of the spectrum, if the glenoid has excessive bone loss or is unreconstructible, a HHR is the preferred procedure. In patients who have deficient so(t-tissues (rotator cuff) such as rotator cuff tear arthropathy and, occasionally, rheumatoid arthritis, a HHR is the procedure of choice. The indications for HHR in osteoarthritis remain somewhat controversial. There is mounting evidence that performing a HHR for osteoarthritis is inferior to TSA. Recent developments, or 'third generation techniques and materials', in shoulder arthroplasty are expected to improve the longevity of TSA, particularly the glenoid component. In addition, newer designs of reverse-ball prostheses are entering the market with promising early results in patients with deficient rotator cuff mechanisms.

• Structural Engineering and Mechanics
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• v.21 no.3
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• pp.333-350
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• 2005

This paper presents results of an experimental study to evaluate a new retrofit technique for strengthening shear deficient short concrete beams and columns. In this technique a mortar jacket reinforced with expanded steel meshes is used for retrofitting. Twelve short reinforced concrete specimens, including eight retrofitted ones, were tested. Six specimens were tested under a constant compressive axial force of 15% of column axial load capacity based on original concrete gross section, $A_g$, and the concrete compressive strength, ${f_c}^{\prime}$. Main variables were the spacing of ties in original specimens and the volume fraction of expanded metal in jackets. Original specimens failed before reaching their nominal calculated flexural strength, $M_n$, and had very poor ductility. Strengthened specimens reached their nominal flexural strength and had a ductility capacity factor of up to 8 for the beams and up to 5.5 for the columns. Based on the test results, it can be concluded that expanded steel meshes can be used effectively to strengthen shear deficient concrete members.

• Earthquakes and Structures
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• v.10 no.6
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• pp.1291-1314
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• 2016

The paper presents the development of experimental fragility functions for exterior RC beam-column connections based on results obtained from extensive testing carried out in the present study. Three typical types of seismically deficient beam-column connections, which are commonly prevalent in Indian sub-continent, were considered. These specimens were tested under cyclic displacement histories with different characteristics to induce different damage states. Rehabilitation specific fragility functions for damaged specimens were developed considering drift angle as a demand parameter. Four probability distributions were fit to the data and suitability of each distribution was evaluated using standard statistical method. Specimens with different damage states were rehabilitated appropriately and rehabilitated specimens were tested under similar displacement histories. Fragility functions for rehabilitated specimens have also been developed following similar procedure. Comparison of fragility functions for both original and rehabilitated specimens for each rehabilitation method showed close agreement, which establishes the effectiveness of the adopted rehabilitation strategies and hence would provide confidence in field application.

• Molecules and Cells
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• v.24 no.2
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• pp.294-300
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• 2007

The mammalian glycosylphosphatidylinositol (GPI) anchor consists of three mannoses attached to acylated GlcN-(acyl)PI to form $Man_3$-GlcN-(acyl)PI. The first of the three mannose groups is attached to an intermediate to generate Man-GlcN-(acyl)PI by the first mannosyltransferase (GPI-MT-I). Mammalian and protozoan GPI-MT-I have different substrate specificities. PIG-M encodes the mammalial GPI-MT-I which has 423 amino acids and multiple transmembrane domains. In this work we cloned PIG-M homologues from humans, Plasmodium falciparum (PfPIG-M), and Saccharomyces cerevisiae (GPI14), to test whether they could complement GPI-MT-I-deficient mammalian cells, since this biosynthetic step is likely to be a good target for selective screening of inhibitors against many pathogenic organisms. PfPIG-M partially restored cell surface expression of the GPI-anchored protein CD59 in PIG-M deficient mammalian cells, and first mannose transfer activity in vitro; however, this was not the case for GPI14.

• Microbiology and Biotechnology Letters
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• v.14 no.4
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• pp.299-304
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• 1986

The cell volume, cell surface, cell concentration, dry cell weight, frequence of respiratory deficient mutation, resistance against ultraviolet irradiation, fermentation power, DNA contents of haploid diploid, triploid and tetraploid of Saccharomyces cerevisiae strain were investigated. Respiratory deficient mutants by spontaneous mutation were absolved more frequently in the haploid than in the diploid, triploid and tetraploid. And cell volume, cell surface, cell concentration, dry cell weight, resistance against ultraviolet irradiation, fermentation power, and DNA contents were significantly increased as the ploidy increased.

• Archives of Pharmacal Research
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• v.8 no.1
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• pp.45-48
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• 1985

The amount of norepinephrine and dopamine in the brain of the mouse fed with normal diet or protein deficient diet with supplement of the saponin fraction of ginseng were determined by the sluorometric method. THe amount of norepinephrine in mouse brain was vivider in the case of protein deficiency. The increase amount of dopamine was observed only in the case of mouse fed with normal diet with supplement of the saponin fraction normal diet with supplement of the saponin fraction of ginseng for 8 weeks.