• 수산해양기술연구
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• 제47권3호
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• pp.248-256
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• 2011

The inherent efficiency of a ship would be prior to any other quality factors in ship's safety, because lack of it may give rise to a serious sea casuality even if it were a light mistake in operation. And the representative casualty comes from a deficiency of stability and an operating error combined would be capsizing. The Korean offshore large purseiner looks to have a structural weak point with small range of stability in spite of her big initial metacentric height, and have various type of roll reduction devices in order to cover up the defect. The aim of this study is to grasp for the roll reduction characteristics of the purseiner with bilge keel only and a stern keel additionally attached. The results are summarized as follows; The rolling angle of the model ship was increased in accordance with increase of the wave period and height, especially at close to the natural wave period of her, and the trends were more distinguished in the situation of bilge keel only installation than in the stern keel additionally installed. And stern keel has not noticeable effect on the reduction of the roll in the light ship condition, but has a little effect in full load condition.

• 대한한의학원전학회지
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• 제24권1호
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• pp.73-84
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• 2011

In the pathological theory of Oriental medicine, the concept of Ul(鬱) largely comprises the two meanings as follows. One is the concept used as the meaning of pathological state originated from stasis in Qi-Xie(氣血) or the function of internal organs. The other is the concept used as the meaning of Ul-disease(鬱病), which is a group of symptom that is mostly characterized by stasis in function of Qi system. The concept of Ul in the medical classics was originated from "Neijing(內經)", and in this book it was depicted as five-Ul(五鬱). Since the concept of Ul was depicted in "Neijing", many relevant theory about it had been developed on the basis of the theory in "Neijing", and in the theoretical development like this, the concept of Ul had become a little bit complicated. With regard to the historical change like this, this study is going to focus on some argument in Ming(明) dynasty, which asserted the existence of deficiency[虛證] in Ul that had opposed the general thought of that time usually recognizing the concept of Ul as [實證]. In this point of view, this study regards Zhang-zihe(張子和) as a doctor who had made an important role in the theoretical development of Ul after "Neijing", and will newly analyze the theoretical development of Ul on the basis of the Zhang-zihe's Ul theory, which is seemed to have played the main role in the formation of concept of Ul as excessive state[實證].

• 인지과학
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• 제10권1호
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• pp.1-11
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• 1999

최근 에이전트 기반 시스템 기술은 소프트웨어 시스템의 개념화, 설계, 구현을 위한 새로운 패러다임을 제공하며 많은 기대를 받아왔다. 특히 멀티 에이전트 시스템은 분산적이고 개방적인 인터넷 환경에 잘 부합되는 특징을 가지고 있어서 많은 연구가 진행되고 있다. 멀티 에이전트 시스템에서는 각 에이전트들이 자신의 목적을 위해 행동하기 때문에 에이전트간 충돌이 발생하는 경우에 조정을 통해 협력할 수 있어야 한다. 그러나 기존의 멀티 에이전트 시스템에서의 에이전트 간 협력 방법에 관한 연구 방법들은 동적 환경에서 서로 다른 목적을 갖는 에이전트간의 협동 문제를 올바로 해결할 수 없다는 문제가 있었다. 본 논문에서는 강화학습을 이용한 자동 역할 조정 방법을 통하여 에이전트가 처한 동적 환경에서 서로 다른 목적을 갖는 에이전트간의 협력 문제를 해결한다. 이를 위하여 멀티 에이전트 시스템 분야의 전통적인 문제인 추적 문제에 동적 환경과 서로 다른 목표를 갖는 에이전트들을 모델 링 하여, 두 가지 수정된 추적 문제를 제안하고 이 문제의 해결을 통하여 제안한 방법이 타당함을 보였다.

• Journal of Microbiology and Biotechnology
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• 제30권10호
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• pp.1583-1591
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• 2020

CRISPR/Cpf1 has emerged as a new CRISPR-based genome editing tool because, in comparison with CRIPSR/Cas9, it has a different T-rich PAM sequence to expand the target DNA sequence. Single-base editing in the microbial genome can be facilitated by oligonucleotide-directed mutagenesis (ODM) followed by negative selection with the CRISPR/Cpf1 system. However, single point mutations aided by Cpf1 negative selection have been rarely reported in Corynebacterium glutamicum. This study aimed to introduce an amber stop codon in crtEb encoding lycopene hydratase, through ODM and Cpf1-mediated negative selection; deficiency of this enzyme causes pink coloration due to lycopene accumulation in C. glutamicum. Consequently, on using double-, triple-, and quadruple-base-mutagenic oligonucleotides, 91.5-95.3% pink cells were obtained among the total live C. glutamicum cells. However, among the negatively selected live cells, 0.6% pink cells were obtained using single-base-mutagenic oligonucleotides, indicating that very few single-base mutations were introduced, possibly owing to mismatch tolerance. This led to the consideration of various target-mismatched crRNAs to prevent the death of single-base-edited cells. Consequently, we obtained 99.7% pink colonies after CRISPR/Cpf1-mediated negative selection using an appropriate single-mismatched crRNA. Furthermore, Sanger sequencing revealed that single-base mutations were successfully edited in the 99.7% of pink cells, while only two of nine among 0.6% of pink cells were correctly edited. The results indicate that the target-mismatched Cpf1 negative selection can assist in efficient and accurate single-base genome editing methods in C. glutamicum.

• Journal of Acupuncture Research
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• 제20권4호
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• pp.237-244
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• 2003

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.

• 혜화의학회지
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• 제22권1호
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• pp.1-10
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• 2013

Through a consideration of the contralateral collateral needling(繆刺) from "Neijing", the conclusions are as follows. The contralateral collateral needing is defined as a disordered state, and also as the pricking bloodletting method. Unlike the seasonal deficiency pathogen(虛邪), which are affected by the four seasons, the subject of the contralateral collateral needling is the extra pathogen(奇邪), which is the cause of the extra disease(奇病), therefore the treatment should be different from the general. The contralateral collateral needling is generally used when a pain is generated from the veins(絡) by an external pathogen(邪). However, it can be used as the treatment for an emotional disorder, such as flight or sorrow, or a body constituent(身形) disorder caused by internal parts of the five viscera. Although the contralateral collateral needling(繆刺) and the contralateral meridian needling(巨刺) share the left and right cross treatment(右取左, 左取右) in common, but they are different in every aspect, as the causes, transmutation, location, and feature of disease, relation of qi and blood, and location and method of needling(刺鍼). The medical procedure of the contralateral collateral needling is collateral needling(刺絡) the parts of blood collaterals(血絡) or bruising(痏) well points(井穴) of the end of the both sides of limbs, and using the left and right cross treatment when the former methods are not making any progress. The symptoms of contralateral collateral needling are head, chest, and abdomen pains, and they are treated at the end of the limbs. The bloodletting method(刺絡法), extracting a little amount of blood at well points or blood collaterals, or the collateral vessel pricking therapy(瀉血法), extracting a lot of blood by using cupping(附缸), for example, are contemporary successions of the collateral needling(絡刺), the leopard-spot needling(豹文刺), and the contralateral collateral needling.

• Journal of Periodontal and Implant Science
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• 제46권4호
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• pp.277-287
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• 2016

Purpose: The purpose of this study was to evaluate the clinical efficacy of enhancing deficient interdental papilla with hyaluronic acid gel injection by assessing the radiographic anatomical factors affecting the reconstruction of the interdental papilla. Methods: Fifty-seven treated sites from 13 patients (6 males and 7 females) were included. Patients had papillary deficiency in the upper anterior area. Prior to treatment, photographic and periapical radiographic standardization devices were designed for each patient. A 30-gauge needle was used with an injection-assistance device to inject a hyaluronic acid gel to the involved papilla. This treatment was repeated up to 5 times every 3 weeks. Patients were followed up for 6 months after the initial gel application. Clinical photographic measurements of the black triangle area (BTA), height (BTH), and width (BTW) and periapical radiographic measurements of the contact point and the bone crest (CP-BC) and the interproximal distance between roots (IDR) were undertaken using computer software. The interdental papilla reconstruction rate (IPRR) was calculated to determine the percentage change of BTA between the initial and final examination and the association between radiographic factors and the reconstruction of the interdental papilla by means of injectable hyaluronic acid gel were evaluated. Results: All sites showed improvement between treatment examinations. Thirty-six sites had complete interdental papilla reconstruction and 21 sites showed improvement ranging from 19% to 96%. The CP-BC correlated with the IPRR. More specifically, when the CP-BC reached 6 mm, virtually complete interdental papilla reconstruction via injectable hyaluronic acid gel was achieved. Conclusions: These results suggest that the CP-BC is closely related to the efficacy of hyaluronic acid gel injection for interdental papilla reconstruction.

• 한방안이비인후피부과학회지
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• 제17권1호
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• pp.1-15
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• 2004

The different growth steps of human show the different energetic phenomenon such as the strength of triple energizer, the sale of extra meridian, and the stability of 12 meridians. So we have to understand the physiological and pathological phenomena on this point of view. Especially atopic dermatitis means the loss of adaptability under the lack of genuine energy. If you approach to this disease not with any perception of excess or deficiency of the human genuine energy but with simple symptom enumeration or partial diagnosis, it will be dangerous. So we must approach to this disease with more concrete and objective body-centered standard. Thus when we cure and diagnose infants with this disease, we should focus on stablizing the "Energy of Earth(土)" digestive ability, under the consideration of inducement to the enough "Byun-Jeung-Hu(變蒸候)" and the function of Triple Energizer. Through this process we can lead infants to the beginning equipment state(始全). Until 7 years old, we should stabilize the Link Vessel(維脈) by clarifying interior and exterior classification of Nutritive Element and Defensive Energy to control the child's energy of metal(金), water(水), wood(木) and fire(火) in the basis of the energy of earth(土). And also we should stabilize the Heel Vessel(？脈) through the Water and Fire complement each other to control the movements and to control sleep and awakening. Through this process, we can lead children to the basal equipment state(本全). After then, until adolescent phase, we should control 12 meridian and 8 extra meridian by leading vital function to be harmonized and prosperous on the basis of the meridian to reach the mature equipment state(旣全). Adult atopic dermatitis should be controlled through conciliation between meridian and internal organs by differentiating male from female.

• Archives of Plastic Surgery
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• 제39권5호
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• pp.470-476
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• 2012

Background The whistle deformity is one of the common sequelae of secondary cleft lip deformities. Santos reported using a crossed-denuded flap for primary cleft lip repair to prevent a vermilion notching. The authors modified this technique to correct the whistle deformity, calling their version the cross-muscle flap. Methods From May 2005 to January 2011, 14 secondary unilateral cleft lip patients were treated. All suffered from a whistle deformity, which is characterized by the deficiency of the central tubercle, notching in the upper lip, and bulging on the lateral segment. The mean age of the patients was 13.8 years and the mean follow-up period was 21.8 weeks. After elevation from the lateral vermilion and medial tubercle, two muscle flaps were crossed and turned over. The authors measured the three vertical heights and compared the two height ratios before and after surgery for evaluation of the postoperative results. Results None of the patients had any notable complications and the whistle deformity was corrected in all cases. The vertical height ratios at the midline on the upper lip and the affected Cupid's bow point were increased (P<0.05). The motion of the upper lip was acceptable. Conclusions A cross muscle flap is simple and it leaves a minimal scar on the lip. We were able to reconstruct the whistle deformity in secondary unilateral cleft lip patients with a single state procedure using a cross-muscle flap.

• 대한한방소아과학회지
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• 제30권2호
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• pp.10-22
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• 2016

Objectives This study is to analyze current guidelines for health check-ups in infants and children, and to develop better guidelines based on oriental medicine. Methods We analyzed The Manual of 2015's Health Examination for Infants and Children which is a Korean Developmental Screening Test for Infants and Children (K-DST). The statistics from the test was collected from 2010 to 2014 to figure out the problems of Health Examinations for Infants and Children. 20 articles from 2000 to 2014 from RISS, NDSL were also analyzed. Results The current guidelines for health examinations in infants and children didn't include major pediatric diseases such as allergy and asthma. Also, the pediatrics health education materials were mainly focused on hypernutrition but not so much on nutrition deficiency. The number of the centers for Health Examinations for Infants and Children was 52.2% of the number of NIP-Participating medical institutions for infants and children. Conclusions Oriental medicine can be useful to prevent major pediatric diseases and to promote general health in pediatrics. By legislating 'Geon-a-beop', which is a law for infants and children, we can increase the number of medical centers for infants and children to get health check-ups. Currently, there are 9,769 Korean medical institutions, and the rate of traditional medical doctors of public health doctors was 25.5%. Weak Children Questionnaire is developed, considered to be more useful when it is developed with 5-point scale rather than 2.