• Korean Journal of Acupuncture
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• 제39권1호
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• pp.8-15
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• 2022

Objectives : Saam acupuncture is one of the indigenous therapeutic modalities in traditional Korean medicine. In this study, the neuroprotective effect of Saam acupuncture of kidney tonification was investigated using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Methods : Twelve-week-old male C57BL/6 mice were intraperitoneally administered with 30 mg/kg of MPTP at 24-h intervals for 5 days and acupuncture stimulation at LU8, KI7, SP3 and KI3 was performed once a day for 12 days from the first MPTP injection. The pole test and the rotarod test were performed to evaluate motor function, and dopaminergic neuronal survival in the substantia nigra (SN) and striatum was evaluated using tyrosine-hydroxylase immunohistochemistry. Results : MPTP administration caused behavioral impairment and dopaminergic neuronal death in the nigrostriatal pathway. Whereas the Saam acupuncture treatment alleviated the MPTP-induced motor dysfunction and dopaminergic neuronal death in the SN and striatum. Conclusions : Saam acupuncture of kidney tonification can alleviate the MPTP-induced motor dysfunction and dopaminergic neuronal death in the nigrostriatal pathway, suggesting a possible role for acupuncture in the treatment of Parkinson's disease.

• 한방안이비인후피부과학회지
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• 제18권2호
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• pp.99-103
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• 2005

The tinnitus is a very common otorhinolaryngologic disease. But, we do not know the exact cause and the healing method of that. We have a case report of the patient who has both tinnitus during two years. He has also chest distress, chest pain, shoulder.neck pain, obesity. In Oriental Medicine, the cuases of tinnitus have diagnosed as the hepatic fire, phlegm-fire, heart fire, deficiency of the kidney, deficiency of vital energy and blood, and so on. In this study the patient classified by Sasang constitutional medicine, and the cuase of tinnitus diagnosed as cold turbid phlegm in Middle Cho, had a medical effects. And in the result, the other symptoms are reduced. So we report the healing process and result of this patient in this study.

• 동의생리병리학회지
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• 제20권6호
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• pp.1375-1387
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• 2006

Through abdominal diagnoses, deficiency and excess, and cold and heat of the eight principles for differentiating syndromes can be determined, pathogens such as fluid retention, dry stool, retention of undigested food, abdominal mass, blood stagnation, stagnation of Gi, deficiency of Kidney Yang, and, spermatorrhea can be identified, nature and stages of the symptoms can be understood and then pathogenesis analyzed. Abdominal diagnosis can be one of primary factors in deciding treatment, expecting prognosis and treatment effect, and choosing herbal prescriptions. Representative herbs for epigastric stuffiness/fullness are Radix Ginseng, Pericarpium Citri, etc; for fullness of epigastrium, Rhizoma Pinelliae, Pericarpium Citri, Rhizoma Rhei, etc.; for severely rigid epigastrium, Radix Glycyrrhizae, Radix Ginseng, etc.; for epigastric pain, Rhizoma Pinelliae, Pericarpium Citri, etc.; for epigastric fullness and rigidity, Rhizoma Coptidis, Radix Ginseng, etc.; for feeling of obstruction in the epigastirum, Radix Bupleuri, Radix Ginseng, etc.; for palpitation in the epigastrium, Radix Glycyrrhizae, Ramulus Cinnamomi, etc. It is essential to rightly diagnose through comprehensive analysis of the data gained by the four methods of diagnosis, and in doing this, further studies on how to utilize abdomen diagnosis for clinical practice.

• 동의신경정신과학회지
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• 제18권2호
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• pp.35-44
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• 2007

Objective : The purpose of this study is to take around the oriental medical treatment about Attention Deficit Hyperactivity Disorder in China. Method : We reviewed the 22 studies about ADHD which were published from 2005 to 2006. We selected those studies from CNKI (中國知識基礎設施工程 http://www.cnki.net). Result : We could find 22 studies about ADHD in CNKI from 2005 to 2006. DSM (III-R of IV) was used frequently in the diagnosis of ADHD. Herbal medicines, acupuncture, auricular therapy, moxibustion, chuna treatment, cupping therapy were used in the tre atments of ADHD. Differentiation of syndromes-Eum deficiency, heart and spleen deficiency, Damwha- was important in the diagnosis and treatments of ADHD in TCM. Jang and Bu(the internal organs; 臟腑) concerned in differentiation of syndromes about ADHD were Liver 肝, Kidney 賢, Heart 心, Spleen 脾. Most of studies reported very good results compared with western medicine treatment- Ritalin medication. Conclusion :There have been reported many ADHD clinical studies in China and these studies can be applied to the clinical practices in Korea.

• Clinical and Experimental Pediatrics
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• 제54권2호
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• pp.51-54
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• 2011

Vitamin D is present in two forms, ergocalciferol (vitamin $D_2$) produced by plants and cholecalciferol (vitamin $D_3$) produced by animal tissues or by the action of ultraviolet light on 7-dehydrocholesterol in human skin. Both forms of vitamin D are biologically inactive pro-hormones that must undergo sequential hydroxylations in the liver and the kidney before they can bind to and activate the vitamin D receptor. The hormonally active form of vitamin D, 1,25-dihydroxyvitamin D3 $[1,25(OH)_2D]$, plays an essential role in calcium and phosphate metabolism, bone growth, and cellular differentiation. Renal synthesis of $1,25(OH)_2D$ from its endogenous precursor, 25-hydroxyvitamin D (25OHD), is the rate-limiting and is catalyzed by the $1{\alpha}$-hydroxylase. Vitamin D dependent rickets type I (VDDR-I), also referred to as vitamin D $1{\alpha}$-hydroxylase deficiency or pseudovitamin D deficiency rickets, is an autosomal recessive disorder characterized clinically by hypotonia, muscle weakness, growth failure, hypocalcemic seizures in early infancy, and radiographic findings of rickets. Characteristic laboratory features are hypocalcemia, increased serum concentrations of parathyroid hormone (PTH), and low or undetectable serum concentrations of $1,25(OH)_2D$ despite normal or increased concentrations of 25OHD. Recent advances have showed in the cloning of the human $1{\alpha}$-hydroxylase and revealed mutations in its gene that cause VDDR-I. This review presents the biology of vitamin D, and $1{\alpha}$-hydroxylase mutations with clinical findings.

• 동국한의학연구소논문집
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• 제5권
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• pp.97-129
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• 1996

According to the literatural study om ryuk-jeol disease(歷節病), we obtained the result as follows : First, ryuk-jelo disease(歷節病) was stated a kind of arthralgia syndrome(痺病), Because ryuk-jeol disease(歷節病) is only joint disease while arthrlgia syndrome(痺病) affects skin, muscle, joint, bone, organs, etc. Second, ryuk-jeol disease(歷節病) can bne thought to be a category of rheumatoid arthritis in western medical science. Third, etiology factors of ryuk-jeol disease(歷節病) was classified endogenous and exogenous pathogenic factors. The formers was the deficiency in both Qi and Blood(氣血不足), the deficiency in both the liver and kidney(肝腎虧損), dam(痰), blood stasis(瘀血). The latter was Windg風), Cool(寒), Dampness(濕), Heat(熱). Forth, the therapy of ryuk-jeol disease(歷節病) was based on 'diagnosis and trentment based on over all analysis of symptoms and sings(辨證施治)'

• 한국동물학회지
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• 제34권2호
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• pp.203-208
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• 1991

Nicotinic acid 결핍시 메추리는 심각한 체중의 감소를 보였으며, 심장 및 간의 무게도 약간 감소하였다. 포도당의 농도는 현저하게 증가하였으나 콜레스테롤, 알부민 그리고 총 단백질 양의 변화는 없었다. Glutamic oxaloacetate iransaminase 와 glutamic pyruvate transaminase의 활성은 증가하였으나 alkaline phosphatase와 LDH의 활성은 변화가 없었다. 혈청속의 아미노산중 tryptophan, tyrosine, aspartic acid, glutamic acid 등의 농도는 감소하였으나, arginine, histidine, lysine 등은 변화가 없었다.

• 동의신경정신과학회지
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• 제12궈1호
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• pp.81-95
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• 2001

Though, these days there are increasing many patient of insomnia, there was not considered literatual study on insomnia. So, the result of consideration about cause and process of insomnia from thirty kinds of literatures, are as follows. 1. Early literature like Huangjaenankyung(黃帝內經), Sanghanron(傷寒論) reffered to insomnia as accompanying symptom. on the other hand, Myung(明), Chung(淸)'s literatures reffered to that as chief symptom or distinguished chief symptom from accompanying symptom. 2. There were tendency of deductive expanding of various masters and tendency of induction of simple theory that was based on Huangjaenankyung(黃帝內經). 3. Huangjaenankyung(黃帝內經) showed basic process of the sleep disorder that 'exhausting of Yin and excess of Yang (陰盡陽盛)', protecting energy does not invade Yin portion(陽氣不入於陰). And Huangjaenankyung(黃帝內經) showed cause of insomnia that deficiency of vital energy and blood, imbalanced of spleen and stomach, a fever as a invasion in the outside, lung system's disease. This became a basic cause and process of the sleep disorder in ancient period. 4. Sanghanron(傷寒論) occurred to insomnia as accompanying symptom in progress, remedy of a fever invaded outside, Kumkyeyoriak showed as origination in weakness, fatique, various diseases. Out of that, there is a significance in description of insomnia from some disease like histery or neurosis. 5. Jaebyungwonhuron(諸病源候論), Chunkumbang(千金方), Kukbangseo(局方書.) occured to a fire of heart(心慤) and a deficiency of heart and gall bladder(心膽虛) in defails. Insomnia is caused by agony of seven emotion, delivering of a child, are similar to insomnia is caused by psychologic disorders. Injaesanghanyusu(仁劑傷寒類書) occured to exhausting of Yin and excess of Yang (陰盡陽盛), imbalanced of stomach(胃不和) invasion of coldness(傷寒) are brought a conclusion of assumption of sap(津液耗損) brought about unreturn of yin energy. 6. Manbyunghuechum(萬病回春) in Myung period (明代) made much of portion of phlegm's influence about spiritual function. Kyungakjunsu(景岳全書) valued much of treatment divided according to excess and deficiency. Junginmaekchi(證因脈治) occurred to concept of pyorihesil(表裏虛實), Dongyibokam(東醫寶鑑) synthesised various theories. 7. Hyuljungron(血證論), Byunjungkimun(辨證奇聞), Suksilbirok(石室秘錄) made much of surprisemeni(驚恐) Consideration(思慮), liver's dryness(肝燥) is caused by liver's weakness(肝虛), imbalance of haert -kidney(心腎不交), seven emotion(七情). Especially, ftyujungchijae(類證治載) said that heart, liver, gall-bladder, kidney, surprisment, consideration baought to a conclusion of inbalance of Yang and Yin (陽不交陰). There is a tendency in literature mostly that literature showed separation of insomnia as a chief symptom. 8. These days there are increasing many patient of insomnia. So, it is needed to study about insomnia as a psychologic disease. Saying in conclusion, it is needed that we have to recognize in modern style based on ancient style of cause and process of insomnia. It is regarded to study about insomnia definitely and experimently.

• 대한한방소아과학회지
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• 제19권2호
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• pp.229-241
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• 2005

Objective : This study was designed to investigate causes, symptoms and treatments for the diabetes insipidus with oriental medical literatures. Methods : We surveyed the oriental and western medical books from to recent published bocks that have articles on diabetes insipidus Results and Conclusions : The symptoms of diabetes insipidus are polyuria and polydipsia, these are similar symptoms of Pae-so(肺消), Gouk-so, So-gal(消渴), Sang-so(上消), Sin-so(腎消), So-sin(消腎), Ha-so(下消) and Sin-jung(腎中) of kinds of So-gal(消渴) in the oriental medicine. The major causes of diabetes insipidus are the deficiency of the yin of the kidney, the heat of the heart and the dryness of the pulmonary. The methods of treatment are tonifying the yin of the kidney(滋補腎陰), tonifying qi and arrest discharges(益氣固澁), removing heat to moisten dryness (淸熱潤燥) and promoting fluid production to quench thirst(生津止葛). The herbal-medications for treatment are So-galbang and Yidongtang(消渴方合二冬湯), Ryoumijihawangtang gamibang(六味地黃湯加味方).

• 대한한의학방제학회지
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• 제14권1호
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• pp.42-51
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• 2006

This study was investigated to make sure the range of Radix Asparagi treatment. the nature of disease. the pathology and the dosage of it in Dongeuybogam. The consequences were as follows: 1. The Radix Asparagi is used in 11 fields of treatment such as exhaustion, tussis and phlegm. blood diseases. etc 2. The Radix Asparagi is primarily used in the treatment of heart and lung disease, weak and infirm. and controlling hydrate and fever as well as tussis and phlegm. 3. The Radix Asparagi is used for nature of disease which of transmitting between sap and fever. cardiac disease caused by stress. floating fever. debility of blood, malfunction of heart and kidney. and deficiency of vitality. 4. The Radix Asparagi is used in a range of $2g{\sim}16g$ per dose with 4g being the typical dose for most treatments. 5. The Radix Asparagi is used as a fundamental prescription with several herb remedies for the pathology. The Radix Asparagi has been used to moisten the dryness and to keep the balance among fever of heart, lung, and kidney. According to the results. I suggest to use Radix Asparagi in a various pathogenic fields. The Radix Asparagi is able to use to improve not only fatigue. but also diabetes, cataract, and debility of blood.