• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 1996.10a
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• pp.187-193
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• 1996

This paper presents a new approach to modify the traditional method for sampling inspectionby variables to suit undesired measurement conditions. On the basis of a systematic analysis of the effects of measurement errors on different types of acceptance schemes this paper gives two modified equations for revising the sampling size η and the acceptability constant $textsc{k}$ to form a new acceptance scheme (η'$textsc{k}$) under undesired measurement conditions. It has proved that the new method is suitable to different types of sampling inspection by variables including that for mean value and that for percent defective. The new acceptance scheme based on the proposed technique provides an engineering feasibility to replace the traditional scheme to suit undesired measurement conditions.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.92-92
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• 1993

Point mutations in a highly conserved central region of the HIV-1 integrase protein were analyzed for their effects on viral replication and virion morphogenesis. Conservative amino acid replacements of two amino acid residues invariant un retroviral integrases, D116 and E152 of HIV-1, as well as the highly conserved amino acid S147, completely blocked viral replication in two CD4$\^$＋/ human T cell lines. Mutation of four other highly conserved amino acids in the region had no detectable effect on viral replication, while Mutations at two positions, N117 and Y143, resulted in viruses with a delayed replication phenotype. Characteristic and reproducible defects id virion core structure were observed by electron microscopic analysis of sore of the replication defective integrase point mutants, indicating that mutant integrase proteins can interfere with the process of virion core maturation.

• Communications for Statistical Applications and Methods
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• v.6 no.3
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• pp.801-812
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• 1999

Change-point hazard rate models arise for example in applying "burn-in" techniques to screen defective items and in studing times until undesirable side effects occur in clinical trials. Sometimes in screening defectives it might be sensible to model two stages of burn-in. In a clinical trial there might be an initial hazard rate for a side effect which after a period of time changes to an intermediate hazard rate before settling into a long term hazard rate. In this paper we consider the multiple change points hazard rate model. The classical approach's asymptotics can be poor for the small to all moderate sample sizes often encountered in practice. We propose a Bayesian approach avoiding asymptotics to provide more reliable inference conditional only upon the data actually observed. The Bayesian models can be fitted using simulation methods. Model comparison is made using recently developed Bayesian model selection criteria. The above methodology is applied to a generated data and to a generated data and the Lawless(1982) failure times of electrical insulation.

• Biomedical Science Letters
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• v.24 no.4
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• pp.305-310
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• 2018

Microglia are emerging as critical regulators of innate immune responses in AD and other neurodegenerative disorders, highlighting the importance of understanding their molecular and cellular mechanisms. We attempted to determine the role of crosstalk signaling between $IFN-{\gamma}$ and $TGF-{\beta}$ in $A{\beta}$ clearance by microglia cells. We used in vitro and in vivo mouse models that recapitulated acute and chronic aspects of microglial responses to $A{\beta}$ peptides. We showed that crosstalk signaling between $TGF-{\beta}$ and Smad2 was an important mediator of neuro-inflammation. These findings suggest that microglial $TGF-{\beta}$ activity enhances the pathological progression to AD. As $TGF-{\beta}$ displays broad regulatory effects on beneficial microglial functions, the activation of inflammatory crosstalk signaling between $TGF-{\beta}$ and Smad2 may be a promising strategy to restore microglial functions, halt the progression of $A{\beta}$-driven pathology, and prevent AD development.

• Journal of the Semiconductor & Display Technology
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• v.20 no.2
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• pp.14-18
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• 2021

Electric Vehicle industry requires high technologies to stabilize apparatuses for the Coolant heater manufacturing. Vibrations of Leak Machine are one of the most critical factors for causing delivered of the defective product or poor inspection, which are the main reasons of the defects. In this study, the structure of the Leak Machine was analyzed through the experiment and the computer simulation to investigate the main reasons of the vibrations, and further to alter the design for the improved stability. And that design alterations were applied to the machine to identify the effects of those alterations. The result of the study shows that design alterations of the Leak Machine can effectively suppress about 97.8% of the vibrations, and further can improving the Inspection precision of the Coolant heater.

• ETRI Journal
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• v.44 no.2
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• pp.260-273
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• 2022

This study presents a novel multilayer structure of parallel coupled-line bandpass filtercentered at 2.42 GHz with a fractional bandwidth value of approximately 19.4%. The designed filter can suppress harmonics with an appropriate frequency response by incorporating different techniques based on the multilayer technique. A combination of different techniques such as radial microstrip stubs and defected ground structure (DGS) and defected microstrip structure techniques are employed to suppress harmonics up to 5f₀. These techniques are used in two layers to suppress up to 5f₀. In addition, in this study, the effects of different parameters, such as the width of slot-line DGS, the angle of diagonal line slots in the upper layer, and the air gap between the two layers on the filter performance, are investigated. To verify the correct circuit operation, the designed filter is implemented and tested. The measurement results of the proposed filter are compared with the simulation results.

• The Korean Society of Law and Medicine
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• v.10 no.1
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• pp.213-260
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• 2009

While the medical supplies have positive functions such as extending lifespan, recovering health, and preventing diseases, they also cause unexpected tragic consequences due to their side effects, and the magnitude of such damage inevitably increases due to the mechanism of mass production, mass distribution, and mass consumption of those medical supplies. Therefore, needless to say, the optimal way to prevent or reduce such damage is rather through medical supply manufacturers' producing non-defective products, or through the government's controlling production and sales of medical supplies with more aggressive exercise of regulatory authority on medical supply manufacturers, than through a remedy by a legal relief after using medical supplies. In this case, although the victim died due to the defect of the cold medicine, 'CONTAC 600', the drug company's responsibility to cover damages was not recognized because a defect could not be found in the then-manufacturing process. Thus, while pharmaceutical companies are gaining economic profits by producing and selling a medical supplies, if they do not take any remedy measures for the victims of their products' side effects, the victims have to use medical supplies under their own responsibility of taking a risk, and they have to accept the full damage of the potential consequence. Therefore, to remove such absurdity and contradiction, and to practically remedy the victim of medical supplies' side effects, the pharmaceutical side effects remedy project pending in the the Drugs, Cosmetics and Medical Instruments Lawneeds to be actively implemented.

• Steel and Composite Structures
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• v.30 no.6
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• pp.517-534
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• 2019

In this paper, the effects of inevitable out-of-plane defects on the postbuckling behavior of single-layered graphene sheets (SLGSs) under in-plane loadings are investigated based on nonlocal first order shear deformation theory (FSDT) and von-Karman nonlinear model. A generic imperfection function, which takes the form of the products of hyperbolic and trigonometric functions, is employed to model out-of-plane defects as initial geometrical imperfections of SLGSs. Nonlinear equilibrium equations are derived from the principle of virtual work and variational formulation. The postbuckling equilibrium paths of imperfect graphene sheets (GSs) are presented by solving the governing equations via isogeometric analysis (IGA) and Newton-Raphson iterative method. Finally, the sensitivity of the postbuckling behavior of GS to shape, amplitude, extension on the surface, and location of initial imperfection is studied. Results showed that the small scale and initial imperfection effects on the postbuckling behavior of defective SLGS are important and cannot be ignored.

• Nuclear Engineering and Technology
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• v.42 no.6
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• pp.680-689
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• 2010

The crack-tip stress fields and fracture mechanics assessment parameters for a surface crack, such as the elastic stress intensity factor or the elastic-plastic J-integral, can be affected significantly by the adjacent cracks. Such a crack interaction effect due to multiple cracks can alter the fracture mechanics assessment parameters significantly. There are many factors to be considered, for instance the relative distance between adjacent cracks, the crack shape, and the loading condition, to quantify the crack interaction effect on the fracture mechanics assessment parameters. Thus, the current assessment codes on crack interaction effects (crack combination rules), including ASME Sec. XI, BS7910, British Energy R6 and API 579-1/ASME FFS-1, provide different rules for combining multiple surface cracks into a single surface crack. The present paper investigates crack interaction effects by evaluating the elastic stress intensity factor and the elastic-plastic J-integral of adjacent in-plane surface cracks in a plate through detailed 3-dimensional elastic and elastic-plastic finite element analyses. The effects on the fracture mechanics assessment parameters of the geometric parameters, the relative distance between two cracks, and the crack shape are investigated systematically. As for the loading condition, an axial tension is considered. Based on the finite element results, the acceptability of the crack combination rules provided in the existing guidance was investigated, and the relevant recommendations on a crack interaction for in-plane surface cracks are discussed. The present results can be used to develop more concrete guidance on crack interaction effects for crack shape characterization to evaluate the integrity of defective components.

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2002.04a
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• pp.69-75
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• 2002

Sterols play two major roles in plants: a bulk component in biological membranes and precursors of plant steroid hormones. Physiological effects of plant steroids, brassinosteroids (BRs), include cell elongation, cell division, stress tolerance, and senescence acceleration. Arabidopsis mutants that carry genetic defects in BR biosynthesis or its signaling display characteristic phenotypes, such as short robust inflorescences, dark-green round leaves, and sterility. Currently there are more than 100 dwarf mutants representing 7 genetic loci in Arabidopsis. Mutants of 6 loci, dwf1/dim1/cbb1, cpd/dwf3, dwf4, dwf5, det2/dwf6, dwf7 are rescued by exogenous application of BRs, whereas bri1/dwf2 shares phenotypes with the above 6 loci but are resistant to BRs. These suggest that the 6 loci are defective in BR biosynthesis, and the one locus is in BR signaling. Biochemical analyses, such as intermediate feeding tests, examining the levels of endogenous BR, and molecular cloning of the genes revealed that dwf7, dwf5, and dwf1 are defective in the three consecutive steps of sterol biosynthesis, from episterol to campesterol via 5-dehydroepisterol. Similarly, det2/dwf6, dwf4, and cpd/dwf3 were shown to be blocked in $D^4$ reduction, 22a-hydroxylation, and 23 a-hydroxylation, respectively. A signaling mutant bri1/dwf2 carries mutations in a Leucine-rich repeat receptor kinase. Interestingly, the bri1 mutant was shown to accumulate significant amount of BRs, suggesting that signaling and biosynthesis are dynamically coupled in Arabidopsis. Thus It is likely that transgenic plants over-expressing the rate-limiting step enzyme DWF4 as well as blocking its use by BRI1 could dramatically increase the biosynthetic yield of BRs. When applied industrially, BRs will boost new sector of plant biotechnology because of its potential use as a precursor of human steroid hormones, a novel lead compound for cholesterol-lowering effects, and a various application in plant protection.