• Fisheries and Aquatic Sciences
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• v.21 no.8
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• pp.22.1-22.7
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• 2018

Background: Apoptosis is a process of programmed cell death, and apoptosis defect results in serious diseases such as cancer. Apoptosis induction is one of the key mechanisms of anti-cancer agents. This study was aimed to find anti-prostate cancer compounds from marine-derived fungus Microsporum sp. Results: We found that physcion isolated from the fermentation broth extract of the marine fungus Microsporum sp. strain MFS-YL decreases the cell proliferation of PC3 human prostate cancer cells. Physcion induced cell apoptosis as determined by Annexin V/propidium iodide double staining. Physcion downregulated the anti-apopotoic proteins such as Ras, Bcl-xL, and Bcl-2, whereas upregulated the pro-apoptotic Bax. Physcion also activated caspase-3, caspase-8, and caspase-9. Conclusion: These results suggest that physcion from Microsporum sp. inhibits the proliferation of PC3 human prostate cancer cells via the pathway leading to apoptotic cell death. Physcion may be a potential candidate in the field of anticancer drug discovery against human prostate cancer.

• Proceedings of the KWS Conference
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• 2009.11a
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• pp.115-115
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• 2009

아연코팅강판의 레이저 용접시 발생하는 용접결함은 이미 널리 알려진 이슈이다. 그러나 대부분의 연구가 박판을 중심으로 이루어지고 있어서, 후판을 중심으로 한 조선산업에서의 아연코팅 강판의 연구는 매우 미진한 실정이다. 이중 후판 아연코팅강판의 결함검출연구는 그 연구가 거의 전무한 실정으로, 본 연구에서는 후판 아연코팅강판의 레이저 겹치기용접시의 결함검출을 중심으로 실험을 실시하였다. 실험은 Fig. 1에서와 같이 광신호와 음향신호의 RMS를 통하여 raw signal에서 잘 나타나지 않았던 신호의 패턴을 확인함으로써 실제 신호와 비드와를 대응을 가능하게 하였다. 또한 결함 발생시의 RMS값을 건전한 상태와 비교분석하여 실제 결함검출의 가능성도 확인할 수 있었다.

• Journal of Korean Society of Water and Wastewater
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• v.29 no.1
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• pp.97-106
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• 2015

A CCTV inspection method has been widely used to assess sewer condition and performance, but Korea lacks a proper decision support system for prioritizing sewer repair and rehabilitation (R&R). The objective of this paper is to introduce the results that we have developed in the Sewer Condition Assessment and Rehabilitation Decision-making (SCARD) Program using MS-EXCEL. The SCARD-Program is based on a standardized defect score for sewer structural and hydraulic assessment. Priorities are ranked based on risk scores, which are calculated by multiplying the sewer severity scores by the environmental impacts. This program is composed of three parts, which are decision-making for sewer condition and performance assessment, decision-making for sewer R&R priority assessment, and decision-making for optimal budget allocation. The SCARD-Program is useful for decision-makers, as it enables them to assess the sewer condition and to prioritize sewer R&R within the limited annual budget. In the future, this program logic will applied to the GIS-based sewer asset management system in local governments.

• Transactions of Materials Processing
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• v.24 no.2
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• pp.115-120
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• 2015

Deep drawing of cylindrical cups is one of the most fundamental and important processes in sheet metal forming. Circular cups are widely used in industrial fields such as automobile and electronic appliances. Some of these cups are formed by a one-stage process, others such as battery cases and beverage cans are made by a multi-stage process. In the current study the multi-stage deep drawing of aluminum sheet metal is examined. The process consists of two deep drawing operations followed by two ironing operations. The press die, which can be used for the four-stage forming process, was manufactured allowing punch and die components to be easily changed for various experiments. The rolling direction of both the sheet and the drawn cups was always positioned toward the horizontal x-direction on the die face to minimize experimental errors during the progressive forming. The dimensional accuracy of the cylindrical cups formed at each stage and the earing defect due to the anisotropy of sheet were investigated. The influence of anisotropy on the thickness distribution was also examined. Both the thickness and the outer diameter of the cups were measured and compared for each set of experimental conditions. It was found that the dimensional accuracy of cups rapidly improves by employing the ironing process and also by increasing the amount of ironing.

• Journal of Welding and Joining
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• v.33 no.1
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• pp.87-93
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• 2015

This study was performed to develop repair technology for J-Groove dissimilar metal weld of pressurizer heater sleeve in nuclear power plants. Pad, J-Groove automatic welding and mechanical machining equipments to develop repair technology using 'Half Nozzle Repair' were designed and manufactured. To obtain the optimum welding process parameters during Pad temperbead overlay welding, several welding experiments using Taguchi method were conducted. Weldability of Pad overlay weld specimens was estimated by PT/RT test, FE-SEM, EDS and Vickers hardness test. Also, J-Groove welding to adjust weld shape conditions requiring in ASME Code was carried out and its integrity of weld specimens was evaluated through PT/RT test and optical microscope. Consequently, it was revealed that Pad and J-Groove overlay welding for dissimilar metal weld of pressurizer heater sleeve could be possible to meet Code standard without weld defect.

• Journal of Welding and Joining
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• v.26 no.6
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• pp.59-66
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• 2008

Recently, automobile parts progress with modularization, which a great many allied products are modularized. Therefore, the purpose of this study is to develope modular housing for modularization of steering gear. Generally, steering gear housing is composed of valve housing and rack housing, it is important to combine two housings. However, housing having the pipe shape is very sensitive to welding distortion, and welding trajectory is very complicated. In order to solve this subject, cooperative control by using robots was constructed. Further, we developed the dedicated system to suit modular housing based on it, and applied laser welding to there. Moreover, welding speed was controlled in the rapid curve section so that the defect in trajectory of housing was reduced to obtain sound weldment. Accordingly, produced housing by this way is presented enough withstanding pressure to $100kg/cm^2$, and roundness and straightness are measured about 10/100 and 0.9/100 respectively.

• Korean Journal of Materials Research
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• v.14 no.6
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• pp.413-419
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• 2004

Recently, Silicon On Insulator (SOI) devices emerged to achieve better device characteristics such as higher operation speed, lower power consumption and latch-up immunity. Nevertheless, there are many detrimental defects in SOI wafers such as hydrofluoric-acid (HF)-defects, pinhole, islands, threading dislocations (TD), pyramid stacking faults (PSF), and surface roughness originating from quality of buried oxide film layer. Although the number of defects in SOI wafers has been greatly reduced over the past decade, the turn over of high-speed microprocessors using SOI wafers has been delayed because of unknown defects in SOI wafers. A new characterization method is proposed to investigate the crystalline quality, the buried oxide integrity and some electrical parameters of bonded SOI wafers. In this study, major surface defects in bonded SOI are reviewed using HF dipping, Secco etching, Cu-decoration followed by focused ion beam (FIB) and transmission electron microscope (TEM).

• Analytical Science and Technology
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• v.5 no.2
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• pp.213-216
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• 1992

Semiinsulating GaAs crystals employing LPLEC technique should be grown from the Ga-rich melt due to a very low incorporation of unintentional impurities such as carbon (<$10^{15}cm^{-3}$). High resisitivity of this material can be derived from the balanced compensation among not only EL2 deep donors and carbon acceptors but also H1 double charge native acceptors(Ev + 77meV, Ev + 200 meV) and H2 native acceptors(Ev + 68 meV). Considering of the complicated compensation mechanism using statistical calculation of the electron occupancy of each level, SI GaAs crystal with low impurity contents(<$10^{15}cm^{-3}$) can be successfully obtained by maintaining the melt composition around 0.45 As mole fraction.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.28 no.2
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• pp.85-91
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• 2015

A gasoline engine automobile uses high voltage generation of the ignition coil, igniting and burning mixed fuel in the combustion chamber, which drives the engine. When the electronic control unit intermits a current supplied to the power transistor, counter electromotive force with a low voltage is generated by self induction action in the ignition primary coil and a high voltage is induced by mutual induction action with the primary ignition coil in the second ignition coil. The high voltage is supplied to the ignition plug in the combustion chamber, causing a spark, igniting the compressed mixed fuel. If a very small defect occurs inside the insulating material when a voltage is applied in said ignition coil, the performance of the insulation material will get worse and breakdown by a partial discharge of corona discharge. Thus, in this experiment, we are to contribute to improve the performance and ensure the reliability of the ignition coil by investigating partial discharge characteristics according to the change of voltage and temperature when a voltage is applied to the specimen of the epoxy molding ignition coil.

• Journal of the Optical Society of Korea
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• v.19 no.5
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• pp.449-455
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• 2015

In this study we propose a new photonic crystal fiber (PCF) design that simultaneously offers broadband single-mode operation, high birefringence, and large normal dispersion in the optical-communication wavelength regime. The waveguide is based on a hybrid square-lattice PCF (HS-PCF) that has circular air holes of two different diameters alternating in the cladding, plus a pure silica defect at the center. The optical properties of the guided modes are analyzed numerically by the finite-element method (FEM) with a perfectly matched layer as the boundary condition. The optimized HS-PCF has a dispersion coefficient of $-601.67\;ps\;nm^{-1}\;km^{-1}$ and a high birefringence of $1.025{\times}10^{-2}$ at $1.55{\mu}m$. In addition, over the S+C+L+U wavelength bands the proposed HS-PCF with ultraflat birefringence with a slope on the order of $10^{-5}$.