• 한국임상수의학회지
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• 제31권6호
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• pp.527-530
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• 2014

7살 중성화된 수컷 한국집 고양이가 6개월동안 지속된 변비를 주증으로 본원에 내원하였다. 직장검사에서 골반강의 우측 외측부분의 좁아짐을 보였고, 방사선검사에서는 골반골절의 부정유합으로 인한 골반강의 협착을 확인할 수 있었다. 골반강 직경 비율은 0.68이었다. 직장검사와 방사선검사를 기반으로 골반강 협착으로 인한 변비로 진단하였다. 그래서 골반결합을 절골하여 골반강 확장술을 시행하였고 이를 용이하게 하기 위하여 장골 절골술도 함께 시행하였다. 확장된 골반강을 유지하기 위하여 골반결합 사이에 폴리메칠메타크릴레이트를 성형하여 구조물로 삽입하였다. 절골 한 장골은 뼈판과 나사를 이용하여 다시 고정시켜주었다. 방사선 검사에서 술 후 골반강 직경 비율은 0.91로 증가했음을 알 수 있었다. 술 후 처치로는 항생제, 진통소염제, 락툴로오스경구제 투여와 함께 수액요법을 시행하였다. 환자는 골반강 확장술 후 일주일부터 정상적인 배변을 보였고, 그 이후 6개월동안 재발은 없었다. 이 증례를 바탕으로 골반강 확장술은 골반골절의 부정유합으로 인한 골반강 협착에 따라 발생한 변비에서 유용한 치료법으로 사료된다.

• 한국임상수의학회지
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• 제30권2호
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• pp.119-122
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• 2013

암컷, 9개월, 2.2 kg의 단모종 고양이가 2주간의 심한 변비 증상을 주증으로 내원하였다. 보호자 보고에서 증상 발생 4개월 전 골반 골절이 있었음을 확인 하였다. 신체 검사에서 이급후중 및 오른쪽 고관절의 운동 제한을 확인 하였고, 직장 검사에서 양측 관골구의 내측 돌출과 치골의 배측 변위를 동반한 골반 강 협착을 확인할 수 있었다. 방사선 검사에서 확장 된 대장과 골반 강의 비정상적 구조를 동반한 골반 강 협착을 확인 하였다. 배변 유연제와 관장을 이용한 보존적 치료를 실시하였으나 심한 변비 증상이 개선 되지 않았다. 장골, 좌골, 치골, 관골구의 부분 절골술을 실시 하였다. 수술 후 방사선 검사와 직장검사에서 확장 된 골반 강을 확인 할 수 있었다. 수술 후 배변 유연제(5 ml, PO, q12h; Duphalac$^{(R)}$)를 2주간 투약 하였고 그 후 2주간은 2.5 ml 용량으로 투여 하였다. 수술 후 따뜻한 물을 이용한 관장을 2회 실시 하였다. 수술 후 14일 째 검사에서 배변과 보행에 문제가 없음을 확인 하였고 5개월 째 검사에서 심한 배변과 오른쪽 뒷다리 파행 증상이 관찰 되지 않았다.

• 대한한방부인과학회지
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• 제28권3호
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• pp.21-29
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• 2015

Objectives This study aimed to investigate therapeutic effect of Korean Medicine Steam Therapy (KMST) for leukorrhea patients. Methods From December 1st 2013 to Nov 31st 2014, 16 leukorrhea outpatients treated with KMST filled out questionnaire before and after treatments. The questionnaire was composed of 8 question items such as sleep, appetite & digestion, urination, defecation, emotion, cold hypersensitivity, menstrual pain, leukorrhea and patients were told to evaluate their symptoms as NRS score. We analyzed mean NRS score of each question item before and after KMST by using Wilcoxon's signed rank test of SPSS ver. 19. Results Mean age of participants was 40.8±13.0 years and mean value of treatment numbers per person was 3.8±1.8 times. 43.75% (n=7) of the patients had history of vaginitis caused by gardnella vaginalis, ureaplasma urealyticum or candida albicans. All patients were treated with acupuncture, moxibustion and Korean medicine. In addition, there was no side effect reported by participants. NRS score of quantity, odor of leukorrhea, perineal unpleasant sensation such as itching, dryness, burning sensation remarkably decreased (p<0.01, p<0.05, p<0.01 each). NRS score of symptoms including sleep, urination, cold hypersensitivity, menstrual pain also remarkably decreased (p<0.05). Conclusions Symptoms of leukorrhea patients including sleep, urination, cold hypersensitivity, menstrual pain, leukorrhea showed significant decrease after treated with concurrent KMST.

• Journal of Neurogastroenterology and Motility
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• 제24권4호
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• pp.656-668
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• 2018

Background/Aims MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats in our previous study. However, whether and how miRNAs regulate visceral hypersensitivity in IBS-D remains largely unknown. Methods We established the IBS-D rat model and evaluated it using the nociceptive visceral hypersensitivity test, myeloperoxidase activity assay, restraint stress-induced defecation, and electromyographic (EMG) activity. The distal colon was subjected to miRNA microarray analysis followed by isolation and culture of colonic epithelial cells (CECs). Bioinformatic analysis and further experiments, including dual luciferase assays, quantitative real-time polymerase chain reaction, western blot, and enzyme-linked immunosorbent assay, were used to detect the expression of miRNAs and how it regulates visceral hypersensitivity in IBS-D rats. Results The IBS-D rat model was successfully established. A total of 24 miRNAs were differentially expressed in the distal colon of IBS-D rats; 9 were upregulated and 15 were downregulated. Among them, the most significant upregulation was miR-200a, accompanied by downregulation of cannabinoid receptor 1 (CNR1) and serotonin transporter (SERT). MiR-200a mimic markedly inhibited the expression of CNR1/SERT. Bioinformatic analysis and luciferase assay confirmed that CNR1/SERT are direct targets of miR-200a. Rescue experiments that overexpressed CNR1/SERT significantly abolished the inhibitory effect of miR-200a on the IBS-D rats CECs. Conclusions This study suggests that miR-200a could induce visceral hyperalgesia by targeting the downregulation of CNR1 and SERT, aggravating or leading to the development and progression of IBS-D. MiR-200a may be a regulator of visceral hypersensitivity, which provides potential targets for the treatment of IBS-D.

• 동의생리병리학회지
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• 제32권6호
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• pp.403-410
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• 2018

Lifestyle of adolescents cause a lot of health effects in the future. Therefore, in Korea, school health law was enacted and relevant business such as school education program is being carried out. This study was conducted to recognize symptom according to grade. A survey of youth health status was conducted at 19 middle and high schools in Seongnam city from May 2015 to December 2015. The survey made up of 14 questions which was about the health status satisfaction on the adolescent was conducted to investigate frequency by year and the respective health status of 6 grades. A total of 9,584 students responded to the survey, 58.22% answered that they were not free of constipation. 25.69% of respondents had no symptoms of headache, consequently over 70% of respondents had headache. 57.06% of respondents had no symptoms of low back pain and 34.7% had no symptoms of neck & shoulder pain, therefore over 50% of respondents had muscular skeletal symptoms. In menstrual history, only 17.95% of respondents said their period was regular and painless. In respiratory history, except cold, no nasal drop & obstruction has appeared in the group of 54.02%. And 62.97% of respondents had persistent cough usually with cold and 23.41% had cough with cold breeze even if not catch cold. In the third grade of high school students, there were many complaints of pain in various parts such as headache, back pain and shoulder pain, neck pain and menstrual pain, and there was a high rate of complaints of digestive system symptom and defecation symptom. More than half of respondent had constipation discomfort, headache and musculo-skeletal symptoms, menstrual problems and cough. In the third grade of high school students, the rate of complaints of pain complaints, digestive system symptoms, and bowel symptoms was high. Therefore, there is a need for measures and management for continuous health care and health promotion in accordance with students' symptoms and age at each grade level.

• 한국동물생명공학회지
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• 제36권2호
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• pp.99-105
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• 2021

In horse management, the alarm system with sensors in the foaling period enables the breeder can appropriately prepare the time of the parturition. It is important to prevent losses by unpredictable parturition because there are several high risks such as dystocia and the death of foals and mares during foaling. However, unlike analysis in the alarm system that detects specific motions has been widely performed, analysis of classification following specific behavior patterns or number needs to be more organized. Thus, the objective of this study is to classify signs of the specific behaviors of the mares for the prediction of pre-foaling behaviors. Five Thoroughbred mares (9-20 yrs) were randomly selected for observation of the pre-foaling behaviors. The behaviors were monitored for 90 min that was divided into three different periods as 1) from -90 to -60 min, 2) from -60 to -30 min, 3) from -30 min to the time for the discharge of the amniotic fluid, respectively. The behaviors were divided into two different categories as state and frequent behaviors and each specific behavioral pattern for classification was individually described. In the state behaviors, the number of mares in the standing of the foaling group (3.17 ± 0.18^b) at period 3 was significantly higher than the control group (1.67 ± 0.46^a). In contrast, the number of the mares in the eating of the foaling group (1.17 ± 0.34^b) at period 3 was significantly lower than the control group (3.33 ± 0.46^a). In the frequent behaviors, the weaving of the foaling group was significantly higher than the control group, and looking at the belly of the foaling group was significantly lower than the control group. In period 2, defecation, weaving, and lowering the head of the foaling group were significantly higher than the control group, respectively. In period 3, sitting down and standing up, pawing, weaving, and lowering the head in the foaling group were also significantly higher than the control group. In conclusion, the behavior is significantly different in foaling periods, and the prediction of foaling may be feasible by the detection of the pre-foaling behaviors in the mares.

• 대한한방부인과학회지
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• 제35권3호
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• pp.105-121
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• 2022

Objectives: It is a statistical analysis study to examine the results of CaPSPI (Diagnostic System for Climacteric and Postmenopausal Syndrome Pattern Identification), developed for objective defecation of climacteric and postmenopausal syndrome. Methods: Total 341 people's questionnaire responses were statistically analyzed. 275 people involved in developing CaPSPI 2018 (E) and 146 people involved in 2019-2020 study of research1,3). Results: The frequency of diagnosis for examination was the highest at liver depression, 93.8% for 320 times, the lowest at heartheat, 62.8% for 214 times. The frequency of treatment for examination was the highest at liver depression, 54.3% for 185 times, and the lowest at dual deficiency of heart-spleen, 16.7% for 57 times. The diagnosis ratio was the lowest at dual deficiency of heart-spleen, 19.72%, and the highest at liver depression, 57.81%. As a result of comparing these diagnoses with the Kupperman's index, all showed significant differences. As a result of comparing these disease elements, all showed significant differences. The correlation between diagnosis and dialectic elements was found to have similar results with the korean medical pathology, and in 7 dialectics except for heartheat, the treatment version was more severe or progressing to perjury than for examination. Conclusions: The CaPSPI shows the characteristics of korean medicine well, and it is needed to utilize the high correlative disease elements to upgrade the system.

• 대한한방내과학회지
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• 제43권4호
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• pp.625-642
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• 2022

목적: 본 연구는 위암 수술 후 장마비의 한의학적 치료 효과를 평가하기 위해 수행하였다. 방법: 2007년 1월 1일부터 2022년 5월 11일까지 출판된 연구들을 6개의 데이터베이스를 통해 수집하였다. 수술 후 한의학적 치료를 받은 위암 환자를 장마비 관련 지표들을 통해 관찰한 연구들을 선정하였다. 결과: 한약, 침, 뜸, 전기혈위자극, 이혈요법, 족삼리혈의 약물 주입을 수술 후 장마비 치료법으로 사용한 27편의 연구를 선정하였다. 한약, 한약과 침 병용요법, 침, 뜸, 전기혈위자극, 이혈요법, 족삼리혈의 네오스티그민 주입 치료군에서 수술 후 첫 가스 배출까지의 시간이 감소하였고 (p<0.00001), 수술 후 첫 배변까지의 시간이 한약. 한약과 침 병용요법, 침, 뜸, 전기혈위자극, 이혈요법, 족삼리혈의 네오스티그민 주입 치료군에서 유의미하게 감소하였다 (p<0.00001). 심각한 이상반응은 나타나지 않았다. 결론: 한의학적 치료는 위절제술 후 위암 환자에게 수술 후 장마비의 예방과 치료법으로 활용될 수 있으며 수술 후 장마비 치료의 임상적 효과를 명확히 하기 위해 후속 연구가 필요하다.

• 한국식생활문화학회지
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• 제25권4호
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• pp.389-399
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• 2010

This study was conducted in order to investigate and compare anthropometric measurements, bone density, nutrient intake, blood composition and food habits between non-smoking, non-alcohol drinking and smoking, alcohol drinking male university students in Seoul, South Korea. The data for food habits and health-related behaviors were obtained by selfadministered questionnaires. The BQIs of the subjects were measured by Quantitative Ultrasound (QUS). The subjects were divided into two groups: NSND (non-smoking and non-alcohol drinking, n=62) group and General (smoking and alcohol drinking, n=160) group. The results were analyzed using the SPSS program and were as follows: The average heights, weights, and BMIs of the two groups were 173.3 cm, 66.5 kg and 22.1 and 173.4 cm, 68.7 kg and 22.9, respectively. There were no differences between the groups regarding height, weight or BMI. SBP and DBP, however, were significantly higher in the general group than in the NSND group (p<0.01). The BQIs, Z-scores and T-scores of the two groups were 99.83, -0.23, and -0.31 and 98.24, -0.27 and -0.39, respectively, producing no significant differences between the two groups. The percentages for normal bone status, osteopenia and osteoporosis were 83.88%, 16.12% and 0.0% and 74.37%, 25.62% and 0.01%, respectively. Mean intakes of animal protein (p<0.05), animal fat (p<0.05), fiber (p<0.05), animal Ca(p<0.05), animal Fe (p<0.001), Zn(p<0.05), vitamin B1 (p<0.05) and niacin (p<0.05) were significantly different between the two groups, and mean serum levels of SGOT (p<0.01), SGPT (p<0.001), ${\gamma}$-GTP (p<0.001), triglycerides (p<0.01), total cholesterol (p<0.05) and hematocrit (p<0.05) were also significantly different between the two groups. Overall, there were no differences in meal regularity, frequency of snacking, reasons for overeating, exercise and defecation between the groups. However, favorite foods (p<0.05) and night-time meals (p<0.05) were significantly different. In conclusion, the health status of the NSND group was superior compared to the general group. Thus, students who smoke and alcohol drink should receive a practical and systematically-organized education regarding the increased health benefits of quitting smoking and alcohol drinking.

• 한국임상수의학회지
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• 제41권2호
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• pp.71-78
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• 2024

Changes in elimination behavior, including urination and defecation, are common clinical signs of numerous disorders in cats. Therefore, this study attempted to automatically measure the elimination behavior of cats using the litter box and develop an early warning system for the guardian in case of abnormalities. To construct an early warning system for abnormal changes through cat elimination behavior, it consisted of a litter box, an automatic sensor for data collection and data wifi transmission, a server for data analysis, and a mobile phone app for result transmission and early warning. To establish the reference interval (RI), the elimination behavior was monitored for more than 2 weeks using a motion sensor within a litter box in 37 healthy cats and 19 diseased cats. The data were expressed as daily total visits, daily total stay duration, average stay duration per elimination, weekly total visits, and weekly total stay duration. Healthy cats showed median daily total visits of 3 times/day (RI 1.0-7.0) and daily total stay duration of 192 s/day (RI 8.0-452.0). For weekly data, the median total visits were 20 times/week (RI 3.0-35.25) and the median total stay duration was 1,147 s/week (RI 80.0-2,249.5). The average stay duration per elimination was 59 s/elimination (RI 4.67-132.0). Diseased cats showed more frequent elimination behavior than healthy cats (p < 0.001). Otherwise, for each elimination, diseased cats had shorter stay durations than healthy cats (p < 0.001). This study established the RIs of elimination behavior parameters (frequency and duration) in healthy cats. The present study might help guardians and veterinarians detect changes in elimination behaviors in diseased cats at an early stage.