• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.289.1-289.1
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• 2002

Quercetin, one of the most abundant flavonoids in human diet has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of quercetin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant decrease in body and liver weight. Oral administration of quercetin (10 mg/kg daily for 4 weeks) remarkably prevented this DMN-induced loss in body and liver weight and inhibited the elevation of serum alanine transaminase. aspartate transaminase, and bilirubin levels. (omitted)

• Nutrition Research and Practice
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• 제6권2호
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• pp.106-112
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• 2012

This study was conducted to investigate the effects of $Sasa$ $quelpaertensis$ bamboo and green tea on plasma and liver lipids, platelet aggregation, and erythrocyte membrane Na channels in ovariectomized (OVX) rats. Thirty female rats were OVX, and ten female rats were sham-operated at the age of 6 weeks. The rats were divided into four groups at the age of 10 weeks and fed the experiment diets: sham-control, OVX-control, OVX-bamboo leaves (10%), or OVX-green tea leaves (10%) for four weeks. Final body weight increased significantly in the OVX groups compared with that in the sham-control, whereas body weight in the OVX-green tea group decreased significantly compared with that in the OVX-control ($P$ < 0.01). High density lipoprotein (HDL)-cholesterol level decreased in all OVX groups compared with that in the sham-control rats ($P$ < 0.05) but without a difference in plasma total cholesterol. Plasma triglycerides in the OVX-green tea group were significantly lower than those in the sham-control or OVX-control group ($P$ < 0.05). Liver triglycerides increased significantly in the OVX-control compared with those in the sham-control ($P$ < 0.01) but decreased significantly in the OVX-green tea group compared with those in the OVX-control or OVX-bamboo group ($P$ < 0.01). Platelet aggregation in both maximum and initial slope tended to be lower in all OVX rats compared with that in the sham-control rats but was not significantly different. Na-K ATPase tended to increase and Na-K cotransport tended to decrease following ovariectomy. Na-K ATPase decreased significantly in the OVX-green tea group compared with that in the OVX-control group ($P$ < 0.01), and Na-K cotransport increased significantly in the OVX-bamboo and OVX-green tea groups compared with that in the OVX-control ($P$ < 0.05). Femoral bone mineral density tended to be lower in OVX rats than that in the sham-control, whereas the green tea and bamboo leaves groups recovered bone density to some extent. The results show that ovariectomy caused an increase in body weight and liver triglycerides, and that green tea was effective for lowering body weight and triglycerides in OVX rats. Ovariectomy induced an increase in Na efflux via Na-K ATPase and a decrease in Na efflux via Na-K cotransport. Furthermore, consumption of green tea and bamboo leaves affected Na efflux channels, controlling electrolyte and body water balance.

• International journal of advanced smart convergence
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• 제10권3호
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• pp.214-224
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• 2021

We was confirmed that the antler extract increases the expression of marker genes expressed in the process of bone formation, and that the effect on the increase in the expression of the gene is further increased by fermentation of the antler extract. In addition, the mouse model in which menopausal was induced by ovary extraction significantly reduced the movement distance and exercise time of mice compared to the control group. But the decrease was somewhat alleviated by the administration of the antler extract, and completely restored when the fermented antler extract was administered. In the menopause-induced mice, the body weight ratio of heart, liver, and spleen weights increased compared to the control group, but the antler extract and the antler ferment extract restored the body weight ratio of various organ weights to the level of the control group in the menopause-induced mice. Consequently, this has led to mitigating changes in the metabolism affected by menopause.

• 동의생리병리학회지
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• 제17권2호
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• pp.380-393
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• 2003

In order to evaluate the effect of Chekambohyulansin-tang (CST) which was a traditional poly-herbal formula has been used for treatment of obesity in Korea, on the obesity in ovariectomized rats, the changes of body weight, peri-kidney, abdominal and perineal subcutaneous fat weight and their histological changes were measured with the detection of number and/or size of adipocytes after an oral administration of CBT extracts (125, 250 and 500 mg/kg, respectively). CBT significantly attenuated elevations in the body weight, the absolute and relative weight of peri-kidney, abdominal and perineal fat tissues and decrease the severe hypertrophy, the number of adipocytes, and the diameter of adipocytes of peri-kidney, abdominal and perineal fat tissues in ovariectomized rats in a dose dependent manner. These results provide a story evidence that CBT can playa role in the treatment of obesity induced by ovariectomy. Determination of the specific mechanisms involred toxicological dosage of CBT on obesity will require addition study.

• Journal of Ginseng Research
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• 제19권2호
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• pp.108-113
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• 1995

Effect of ginseng polysaccharide fraction was examined for $CCl_4$-induced hepatotoxicity in vitro and in vivo. In $CCl_4$-injured primary cultured rat hepatocytes, treatment of the polysaccharide fraction (0.1, 0.3, 1.0 mg/ml) significantly Inhibited the release of LDH and GOT into the culture medium in a dose-dependent manner. Oral administration of the polysaccharide fraction (100, 200 mg/kg) inhibited the decrease of body weight and the increase of the ratio of liver to body weight in $CCl_4$-intoxicated rats. Elevation of GOT, GPT and ALP activity in the serum by $CCl_4$-induced hepatotoxicity was suppressed by administration of ginseng polysaccharide fraction. MDA levels increased in the serum as well as in the liver tissue by treatment with $CCl_4$ showed a tendency to be 연w in the rats given to the polysaccharide fraction. These results suggest that the polysaccharide fraction may be active substance responsible for antihepatotoxic effect of Panax ginseng.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.227-237
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• 2002

One prominent characteristic of2,3,7,8-tetrachlorodibenzop-dioxin (TCDD) toxicity in rats is a reduction of body weight accompanied by an altered serum lipid profile such as hyperlipidemia. A single administration of TCDD (50 ug/kg) resulted in a decrease of body weight and increase of serum cholesterol in rats. TCDD-induced weight loss and serum cholesterol elevation was reduced in rats administered with water extract (100 mg/kg) or saponin fraction (40 mg/kg) of Panax ginseng C.A.Meyer. In contrast, the administration of Panax quinquefolium did not inhibit the TCDD-induced weight loss and serum cholesterol elevation. Histological examinations of liver and testis revealed the administration of saponin fraction of Panax ginseng attenuated the TCDD-induced hispathologicallesions whereas the administration of saponin fraction of Panax quinquefolium did not. High performance liquid chromatographic analysis demonstrated high percentiles of ginsenoside Rg and ginsenoside $Rh_1$ were evident in saponin fraction of Panax ginseng. Results indicate that the protective effects of Panax ginseng, not Panax quinquefolium, on the TCDD-induced toxicity might be resulted from different compositions of saponins in Panax ginseng.

• Asian-Australasian Journal of Animal Sciences
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• 제16권3호
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• pp.359-367
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• 2003

Supplementary feeding strategies were evaluated from pre-calving throughout lactation on 24 dual-purpose Mpwapwa breed cows in their second or greater lactation, weighing 246-455 kg. The Mpwapwa breed is an established breed of 4 Bos indicus breeds and 8% of Bos taurus. The cows were penned and stall-fed individually. Eight weeks before calving to eight weeks after calving, the cows were divided into two groups and offered hay ad libitum with either 2 kg DM (L) or 4 kg DM/day (H) concentrates. Nine weeks after calving half of the cows on L-level continued with 2 kg DM/day (L-L) while the remainder received 4 kg DM concentrate daily (L-H). Half of the cows on H-group continued with 4 kg DM/day (H-H) while the remainder received 2 kg DM/day (H-L). The concentrate mixture comprised of sunflower seed cake (33%) and maize bran (67%). The cows consumed all the concentrate offered. Hay DM intake was similar (6.8 kg/day) and tended to decrease the last two weeks before calving increased again after calving. Live weight change and body condition score were similar across treatments before calving but differed after calving (p<0.05). Heavier cows with higher condition score pre-calving had a higher body weight loss and regained weight later. After treatment reallocation, live weight change and condition differed between treatments (p<0.05). Calves were allowed to suckle milk from one quarter. The amount of milk suckled and calf weight gains were not significantly different between treatments. The cows were removed from the experiment when the milk yield was below 4 kg per day. Cows on treatment H produced 6.2 kg and on treatment L 5.0 kg saleable milk/day (p<0.05) during the first 8 weeks post partum. During the period 9-18 weeks post partum the saleable daily milk on H-H, L-H, H-L and L-L were 5.2, 4.8, 4.7 and 4.3 kg, respectively (p>0.05).

• 대한한방부인과학회지
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• 제28권2호
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• pp.91-108
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• 2015

Objectives : The aim of this study was to investigate the effect of Omibaekchul-san on postpartum edema in women hospitalized at korean medical postpartum care center in comparison with Saenghwa-tang. Methods : The body composition data was collected from 102 women, who took postpartum care in postpartum care center attached to Won-kwang University Jeonju Korean Medical Hospital, from March 2012 to July 2013. The data was analyzed by Body Composition Analyzer (Inbody 720). Specifically the data was composed of the Extra Cellular Fluid/Total Body Fluid (ECF/TBF), Total Body Water (TBW), Intra Cellular Water (ICW), Extra Cellular Water (ECW), Body Weight, Body Mass Index (BMI), Waist Hip Ratio (WHR), and the ECF/TBF of each body parts such as the upperlimb, lowerlimb and trunk. The body composition was measured twice during 2~8.5 days from childbirth and once again after 7~13.5 days from childbirth by Body Composition Analyzer. Results : The Omibaekchul-san -treated group showed a significant decrease of ECF/TBF, ECW, TBF, Body weight, BMI, ECF/TBF of each body parts and increase of WHR in comparison with the data of the Saenghwa-tang-treated group. In two groups, only the change of ICW was unsignificant. Conclusions : Statistically this study suggests that the Omibaekchul-san will help the quality of life of women who are in postpartum edema.

• 한국환경보건학회지
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• 제29권4호
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• pp.27-34
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• 2003

Bisphenol A is used in the manufacture of epoxy, polycarbonate, and corrosion-resistant unsaturated polyester-styrene resins required for food packaging materials in industrial processing. Some reports indicated the possibility of harmful effects on rats. In this study was used a method for the determination of bisphenol A in blood according to the OSHA High Performance Liquid Chromatography (HPLC) guideline. The method involved blood extraction using methylene chloride. And it was evaluated developmental and teratogenic effects in pregnant rats and second generation. The results obtained were as follows. There was a significant increase in the body weights and treated groups F1 female in liver, spleen, kidney, but according to dose-response. F1 female rat's relative body weight and absolute body weight are not different. There was a significant increase liver, spleen, kidney organ weight and reproductive organ weight epididymis, prostate gland in F1 male rats. There was a proestrous in pregnant rat, group 200 $\mu\textrm{g}$/kg, 2000 $\mu\textrm{g}$/kg, 20,000 $\mu\textrm{g}$/kg. The effect on rat treated with bisphenol A decrease organ weight and reproductive organ weight. Identification and quantitation were performed with using HPLC C18 column and using at retention time 5.5 min. The results of the detection of bisphenol A were at 20,000 $\mu\textrm{g}$/kg in average 1 $\mu\textrm{g}$/ml, 200 $\mu\textrm{g}$/kg average in 0.9 $\mu\textrm{g}$/ml blood samples. From those results, it could be concluded that the effects of pregnant rat and second generation(F1) by bisphenol A treatment during lactational period were estrogenic and bisphenol A was remained in serum at low level.

• Advances in Traditional Medicine
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• 제8권2호
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• pp.187-191
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• 2008

Trema orientalis Linn. is commonly grown in many parts of Bangladesh. Its leaves have been used for analgesic and anti-diarrhoeal activity in traditional medicine. This study evaluates the potential analgesic and anti-diarrhoeal activity of methanol and aqueous extracts of leaves in experimental acetic acid induced writhing and castor oil induced diarrhoea in mice. The aqueous extract of leaves showed significant (P < 0.001) analgesic effect in acetic acid induced writhing in mice at a dose of 500 mg/kg body weight In castor oil induced antidiarrhoeal screening both extract increased latent period (P < 0.025) and decrease the number of stool (P < 0.025) at the dose of 500 mg/kg body weight comparable with that of the standard drug loperamide. The results provide a support for the use of this plant in traditional medicine and suggest its further investigation.