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COVID-19 progression towards ARDS: a genome wide study reveals host factors underlying critical COVID-19

  • Shama Mujawar;Gayatri Patil;Srushti Suthar;Tanuja Shendkar;Vaishnavi Gangadhar
    • Genomics & Informatics
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    • v.21 no.2
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    • pp.16.1-16.14
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    • 2023
  • Coronavirus disease 2019 (COVID-19) is a viral infection produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus epidemic, which was declared a global pandemic in March 2020. The World Health Organization has recorded around 43.3 billion cases and 59.4 million casualties to date, posing a severe threat to global health. Severe COVID-19 indicates viral pneumonia caused by the SARS-CoV-2 infections, which can induce fatal consequences, including acute respiratory distress syndrome (ARDS). The purpose of this research is to better understand the COVID-19 and ARDS pathways, as well as to find targeted single nucleotide polymorphism. To accomplish this, we retrieved over 100 patients' samples from the Sequence Read Archive, National Center for Biotechnology Information. These sequences were processed through the Galaxy server next generation sequencing pipeline for variant analysis and then visualized in the Integrative Genomics Viewer, and performed statistical analysis using t-tests and Bonferroni correction, where six major genes were identified as DNAH7, CLUAP1, PPA2, PAPSS1, TLR4, and IFITM3. Furthermore, a complete understanding of the genomes of COVID-19-related ARDS will aid in the early identification and treatment of target proteins. Finally, the discovery of novel therapeutics based on discovered proteins can assist to slow the progression of ARDS and lower fatality rates.

Mothering in "Tell Me a Riddle": Living for vs. Living with (틸리 올슨의 「수수께끼 내 주세요」에 나타난 엄마 노릇 -위하여 살 것인가 vs. 더불어 살 것인가)

  • Na, Younsook
    • Journal of English Language & Literature
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    • v.56 no.2
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    • pp.357-382
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    • 2010
  • Motherhood as an ideological construction has been regarded as an oppressing apparatus enforced by patriarchism. On the one hand, demystifying motherhood helps expose dehumanization of women, and accordingly liberate women from being an ideal mother. On the other hand, however, feminists' attempts to unearth the distorted images of mothers result in devaluation of such values as love and sacrifice attached to motherhood. "Tell Me a Riddle" by Tillie Olsen, who is a declared socialist as well as a feminist, occupies a significant position in a sense that it neither condemns motherhood as evil nor idealizes it. Through the main character, Eva, it examines the meaning of motherhood in a way that a real mother experiences it in a real life, and thus Olsen challenges the readers to ponder upon the mothers' dilemma: a conflict between a desire for self-fulfillment and sacrifice for others. Eva, a mother of seven grown-up children, and now dying, shows an ambivalent attitude toward motherhood. She realizes that she is a victim of idealized motherhood in that, toward the end of her life, she feels uncomfortable accepting her personal desires as they are. Yet at the same time, she appreciates her experiences as a mother in that she could consume her passion for the ideals as she has spent her youth working toward, trying to construct an idealistic socialist country. Eva's real ideal, as a human being, is to live "with" others, not just "for" others. In other words, she does not want to allow herself to live only for others in the name of the mother because she does not have any alternatives to do otherwise. Rather, she desires to live a life of voluntary sacrifice and love. In this way, through Eva, Olsen tries to help us to construct a community where we--not just mothers-can live "with" others.

Won Buddhism in America: Exploring Ways to Balance Tradition and Innovation

  • Grace J. SONG
    • Journal of Daesoon Thought and the Religions of East Asia
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    • v.3 no.2
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    • pp.93-119
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    • 2024
  • The introductionof Won Buddhism to the United States has reached its fifty-year mark. Brought to the West by Korean kyomus (Won Buddhist clergy), these initial Won Buddhist clergy set a foundation for future ordained devotees to reside in America and further the religion's mission. Innovation has always played an important role in the formation and growth of Won Buddhism. The founder, Sotaesan, declared the necessity to reform traditional Buddhism to make it accessible to the laity and espoused values such as inclusiveness, equality, public work, and practicality. Over the past few decades, these innovations have helped Won Buddhism in America to shift from a strictly ethnic-related context to an emphasis on its universal nature. However, as the religion continues achieving a foothold in Western soil, critical questions arise such as how can Won Buddhism honor its Korean origins while becoming increasingly international? What are the detriments to decontextualizing and de-emphasizing elements thought to be "too Korean" or "too traditional," or thought to be irrelevant in the West? When Buddhism spreads to a new country, it not only influences the culture it enters but is also shaped by the adopting culture. In American history, this has often meant the erasure of Asian cultures that were home to Buddhism for millennia and from which the dharma is inextricable. I argue in this article that if Won Buddhism is to thrive in the United States conscious consideration will have to be given to the indispensable aspects of its Korean roots and tradition while connecting with the current circumstance in fresh, relevant, and effective ways that include the multi-cultural and ethnic makeup of the US. This entails understanding American history and Asian Buddhism's history in America, as well as cultivating a competency or fluency in the cultures that allowed Won Buddhism to survive for decades.

An inquiry concerning early philosophy of G. Deleuze (초기 들뢰즈 철학에 관한 연구)

  • Jin, Gi-haeng
    • Journal of Korean Philosophical Society
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    • v.123
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    • pp.409-440
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    • 2012
  • It is well known that Deleuze began his philosophical work from researching the biographies of many predecessors' such as D. Hume, Lucretius, I. Kant, B. Spinoza, F. W. Nietzsche, H. Bergson, and etc. Among them, especially Spinoza, Nietzsche, and Bergson constitute a foundation supporting the whole idea of Deleuze. He declared that the goal of his early biographical work is a theme converging the identity of two philosophers, Spinoza and Nietzsche, and it shows that these two philosophers had such a huge significance to Deleuze, at least by then. However, we may point out two issues here. The first is why Deleuze, who is recognized as a philosopher of 'difference', deals the identity. The other issue is, what kind of identity exists between the two philosophers, Spinoza and Nietzche. In a common sense, their ideas contradict to each other. Spinoza puts God at the center of his philosophical system, whereas Nietzsche declared 'God is dead'. Though Nietzsche expressed a concurrent opinion with Spinoza at first, it is well known that he turned his side against him soon after and criticized him sharply. There is a conflict at the core of this criticism concerning the existence or non-existence of God. Many think that Spinoza, however, cannot be free from the argument that his philosophy allows a possibility of atheism. Deleuze, who also called Spinoza an atheist, suggested a new viewpoint of the philosophy of Spinoza based on his attribution to the concept of 'power'. On the other hand, Deleuze reinterpreted Nietzsche, where he analyzed 'the will to power' in a totally inventive way. Likewise, the reciprocal communication of ideas connected by the concept of 'power' gives a foundation of identifying the two philosophers to Deleuze. In this paper, considering this reciprocal communication, I intent to reveal the foundation of identity of the two philosophers, Spinoza and Nietzsche, and as a result, investigate what the concept of identity means to Deleuze, the philosopher of difference. Furthermore, we will also take a look at how Deleuze presents a new perspective on the conflict on the existence of God of the two philosophers in the process of validating the identity.

Analysis of the Fog Detection Algorithm of DCD Method with SST and CALIPSO Data (SST와 CALIPSO 자료를 이용한 DCD 방법으로 정의된 안개화소 분석)

  • Shin, Daegeun;Park, Hyungmin;Kim, Jae Hwan
    • Atmosphere
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    • v.23 no.4
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    • pp.471-483
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    • 2013
  • Nighttime sea fog detection from satellite is very hard due to limitation in using visible channels. Currently, most widely used method for the detection is the Dual Channel Difference (DCD) method based on Brightness Temperature Difference between 3.7 and 11 ${\mu}m$ channel (BTD). However, this method have difficulty in distinguishing between fog and low cloud, and sometimes misjudges middle/high cloud as well as clear scene as fog. Using CALIPSO Lidar Profile measurements, we have analyzed the intrinsic problems in detecting nighttime sea fog from various satellite remote sensing algorithms and suggested the direction for the improvement of the algorithm. From the comparison with CALIPSO measurements for May-July in 2011, the DCD method excessively overestimates foggy pixels (2542 pixels). Among them, only 524 pixel are real foggy pixels, but 331 pixels and 1687 pixels are clear and other type of clouds, respectively. The 514 of real foggy pixels accounts for 70% of 749 foggy pixels identified by CALIPSO. Our proposed new algorithm detects foggy pixels by comparing the difference between cloud top temperature and underneath sea surface temperature from assimilated data along with the DCD method. We have used two types of cloud top temperature, which obtained from 11 ${\mu}m$ brightness temperature (B_S1) and operational COMS algorithm (B_S2). The detected foggy 1794 pixels from B_S1 and 1490 pixel from B_S2 are significantly reduced the overestimation detected by the DCD method. However, 477 and 446 pixels have been found to be real foggy pixels, 329 and 264 pixels be clear, and 989 and 780 pixels be other type of clouds, detected by B_S1 and B_S2 respectively. The analysis of the operational COMS fog detection algorithm reveals that the cloud screening process was strictly enforced, which resulted in underestimation of foggy pixel. The 538 of total detected foggy pixels obtain only 187 of real foggy pixels, but 61 of clear pixels and 290 of other type clouds. Our analysis suggests that there is no winner for nighttime sea fog detection algorithms, but loser because real foggy pixels are less than 30% among the foggy pixels declared by all algorithms. This overwhelming evidence reveals that current nighttime sea fog algorithms have provided a lot of misjudged information, which are mostly originated from difficulty in distinguishing between clear and cloudy scene as well as fog and other type clouds. Therefore, in-depth researches are urgently required to reduce the enormous error in nighttime sea fog detection from satellite.

A Latent Profile Analysis of Stress Coping Strategies among Korean Adults at the Early Stage of the Coronavirus Pandemic(COVID-19) and Verification of Influencing Factors (코로나 팬데믹 초기 한국인의 스트레스 대처 양상에 따른 잠재계층 분류와 영향요인 검증)

  • Nam, Seulki;Lee, Dong Hun
    • Korean Journal of Culture and Social Issue
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    • v.28 no.3
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    • pp.483-512
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    • 2022
  • This study examined the patterns of coping strategies among Koreans during the early stage of the COVID-19 pandemic, explored the influence of demographic information (gender, age, economic level, household type), along with the unusual experiences due to COVID-19 (fear, stress of COVID, constraints of routine, income risk) on the classification of subclasses, and analyzed the latent profile differences in psychological wellbeing (life satisfaction, depression, and anxiety). An online survey was conducted among Korean Adults(n=600) between April 13, 2020 and 21, when WHO declared COVID-19 a global pandemic and Daegu as well as Gyeongsangbuk-do was nominated as a special disaster zone. First, Latent Profile Analysis (LPA) was used to identify subclasses of coping strategies and results suggested that the 4-class model had the best fit. Second, Class memberships were predicted by gender, age, economic level, as well as fear, stress, constraints of routine, and income risk, among the unusual experiences due to COVID-19. Finally, there are differences in psychological wellbeing among latent profiles. 'High level of adaptive coping group 3' showed the highest level of life satisfaction, 'Adaptive-maladaptive coping group 4' showed the highest level of depression, anxiety. Implications and suggestions are discussed based on the study results.

Cooling Time Determination of Spent Nuclear Fuel by Detection of Activity Ratio $^{l44}Ce /^{l37}Cs$ (방사능비 $^{l44}Ce /^{l37}Cs$ 검출에 의한 사용후핵연료 냉각기간 결정)

  • Lee, Young-Gil;Eom, Sung-Ho;Ro, Seung-Gy
    • Nuclear Engineering and Technology
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    • v.25 no.2
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    • pp.237-247
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    • 1993
  • Activity ratio of two radioactive primary fission products which had sufficiently different half-lives was expressed as functions of cooling time and irradiation histories in which average burnup, irradiation time, cycle interval time and the dominant fissile material of the spent fuel were included. The gamma-ray spectra of 36 samples from 6 spent PWR fuel assemblies irradiated in Kori unit-1 reactor were obtained by a spectrometric system equipped with a high purity germanium gamma-ray detector. Activity ratio $^{l44}$Ce $^{l37}$Cs, analyzed from each spectrum, was used for the calculation of cooling time. The results show that the radioactive fission products $^{l44}$Ce and $^{l37}$Cs are considered as useful monitors for cooling time determination because the estimated cooling time by detection of activity ratio $^{l44}$Ce $^{l37}$Cs agreed well with the operator declared cooling time within relative difference of $\pm$5 % despite the low counting rate of the gamma-ray of $^{l44}$Ce (about 10$^{-3}$ count per second). For the samples with several different irradiation histories, the determined cooling time by modeled irradiation history showed good agreement with that by known irradiation history within time difference of $\pm$0.5 year. From this result, it would be expected to be possible to estimate reliably the cooling time of spent nuclear fuel without the exact information about irradiation history. The feasibility study on identification of and/or sorting out spent nuclear fuel by applying the technique for cooling time determination was also performed and the result shows that the detection of activity ratio $^{l44}$Ce $^{l37}$Cs by gamma-ray spectrometry would be usefully applicable to certify spent nuclear fuel for the purpose of safeguards and management in a facility in which the samples dismantled or cut from spent fuel assemblies are treated, such as the post irradiation examination facility.mination facility.

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Recognition and Enforcement of Foreign Arbitral Awards in Korea (한국에서의 외국중재판정의 승인과 집행)

  • Kim, Sang-Ho
    • Journal of Arbitration Studies
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    • v.17 no.3
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    • pp.3-30
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    • 2007
  • The New York Convention(formally called "United Nations Convention on the Recognition and Enforcement of Foreign Arbitral Awards") done in New York on June 10, 1958 has been adhered to by more than 140 States at the time of this writing, including almost all important trading nations from the Capitalist and Socialist World as well as many developing countries. The Convention can be considered as the most important Convention in the field of arbitration and as the cornerstone of current international commercial arbitration. Korea has acceded to the New York Convention since 1973. When acceding to the Convention, Korea declared that it will apply the Convention to the recognition and enforcement of awards made only in the territory of another Contracting State on the basis of reciprocity. Also, Korea declared that it will apply the Convention only to differences arising out of legal relationships, whether contractual or not, which are considered as commercial under the national law of Korea. The provisions relating to the enforcement of arbitral awards falling under the New York Convention begin at Article III. The Article III contains the general obligation for the Contracting States to recognize Convention awards as binding and to enforce them in accordance with their rules of procedure. The Convention requires a minimum of conditions to be fulfilled by the party seeking enforcement. According to Article IV(1), that party has only to supply (1) the duly authenticated original award or a duly certified copy thereof, and (2) the original arbitration agreement or a duly certified copy thereof. In fulfilling these conditions, the party seeking enforcement produces prima facie evidence entitling it to obtain enforcement of the award. It is then up to the other party to prove that enforcement should not be granted on the basis of the grounds for refusal of enforcement enumerated in the subsequent Article V(1). Grounds for refusal of enforcement are stipulated in Article V is divided into two parts. Firstly, listed in the first Para. of Article V are the grounds for refusal of enforcement which are to be asserted and proven by the respondent. Secondly, listed in Para. 2 of Article V, are the grounds on which a court may refuse enforcement on its own motion. These grounds are non-arbitrability of the subject matter and violation of the public policy of the enforcement country. The three main features of the grounds for refusal of enforcement of an award under Article V, which are almost unanimously affirmed by the courts, are the following. Firstly, The grounds for refusal of enforcement mentioned in Article V are exhaustive. No other grounds can be invoked. Secondly, and this feature follows from the first one, the court before which enforcement of the award is sought may not review the merits of the award because a mistake in fact or law by the arbitrators is not included in the list of grounds for refusal of enforcement set forth in Article V. Thirdly, the party against whom enforcement is sought has the burden of proving the existence of one or more of the grounds for refusal of enforcement. The grounds for refusal of enforcement by a court on its own motion, listed in the second Para. of Article V, are non-arbitrability of the subject matter and public policy of the enforcement country. From the court decisions reported so far at home and abroad, it appears that courts accept a violation of public policy in extreme cases only, and frequently justify their decision by distinguishing between domestic and international public policy. The Dec. 31, 1999 amendment to the Arbitration Act of Korea admits the basis for enforcement of foreign arbitral awards rendered under the New York Convention. In Korea, a holder of a foreign arbitral award is obliged to request from the court a judgment ordering enforcement of the award.

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Environmental Auditing-Analysis of Enterprises (환경감사 - 기업분석)

  • Wotte, Joris
    • Journal of Environmental Impact Assessment
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    • v.4 no.3
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    • pp.9-13
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    • 1995
  • In July 1993 a new prescription of the EC was finished, concerning the voluntary participation of enterprises in a common auditing system. By this in the EC-member countries there must be founded centers of environmental auditing where experienced experts of environmental auditing should be accredited. These accredited experts are controllers for evaluating and certification of carried out environmental-auditings. An environmental-auditing practically represents an environmental assessment for an already existing enterprise with establishing corresponding programmes and strategies for the internal management to improve the environmental relations. Much experiences, which could be collected in the field of EIA during the last years may be transfered to this new task immediately. Only an essential difference there should not be overseen because of national legislation EIA in the defined cases must be carried out. By the EC-prescription carrying out an environmental-auditing for an enterprise is optional, it is recommended only. It was not introduced as a must. In spite of this fact because of the hard competition on the market there will be developed a pressure for the enterprises, to carry out such environmental-auditings. At present already a number of first projects in this direction can be seen, in the first line above all enterprises with the necessary economic power want to use this possibility, to gain better positions on the market. We have already gathered the first experiences in this field. We arranged corresponding contacts to several enterprises within the surroundings of Dresden. Within an opening discussion, where the project is explained and discussed with the management of the enterprise very detailed, the understanding, the readiness and the cooperation for the project are generated necessary prerequesits for the success of the whole work. By means of careful detail-work in collaboration with all departments and on all levels of the enterprise the total mass and energy-balances of the factory established and analysed. There are included also such ranges like material delivery, personal policy, public relations and sale as well as waste management. It is important that all people working in the factory have the feeling to be our partners, and not to have the impression to be checked or controled by an outside organization. This one of the most important factors of environmental auditing, in order to wake up and to develop a common interest on all sides. At the end of the environmental auditing there will be according to the prescription of the EC a catalogue of measures to do immediately, short time, mean time and long time for improvement of the environmental situation of the enterprise. All proposals are made in connection with a corresponding economic evaluation. These measures and programmes are declared as the environmental manual and are the basis for the work of the environmental management of the enterprise for the next three years. According to the EC-prescription, the enterprise with this environmental manual can get a corresponding certificate, which may be used for public relation purposes.

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Biodiversity Conservation & World Natural Heritage in Bangladesh (방글라데시의 생물다양성 보전 및 세계자연유산)

  • Nayna, Omme Kulsum;Lee, Sang Don
    • Journal of Environmental Impact Assessment
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    • v.26 no.5
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    • pp.376-384
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    • 2017
  • Bangladesh is a South Asian country with subtropical monsoonal climate between the intersection of the Indo-Himalayan and Indo-Chinese sub-regions, is known as biodiversity hotspot of the Asian region. The country has different types of forest like deciduous forest, evergreen forest, mixed forest, haor (wetlands) and mangrove forest. The natural beauty of the country is increased with the presence of so many rivers, longest sea beach of the world, green plants, critical hilly regions and green agricultural forest widely spread here and there. Sundarbans is the world largest mangrove forest and world natural heritage site declared by UNESCO in 1999 situated in Bangladesh and India. About 62 percent of this mangrove forest is situated in Bangladesh and there are so many plants and animals are found in this forest. To meet the increasing demand of the large population most of the natural ecosystem is now altered, deforestation rate is increased, natural habitat of the species is disturbed. Due to the imbalance of the climate and natural system many of the rare species of the world found this region is now endangered and some of the species are extinct. Directly or indirectly they are benefited from natural resources. At present time community, based ecotourism is also an important source of income for rural poor peoples. To protect the natural resources the government is now developed so many conservation acts and policy as well NGOs are also doing work for the conservation of ecosystem and biodiversity. At present transboundary pollutants and so many natural disasters also destruct the natural resources of Bangladesh.