• Preventive Nutrition and Food Science
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• 제19권3호
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• pp.145-155
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• 2014

Vascular dementia is characterized by white matter lesions involving the demyelination and activation of astrocytes and microglia. In a previous study, we showed that the supernatant of a laboratory-scale, hot water extract of ground whole wheat (TALE) attenuated white matter injury and astrocytic activation in a rat model of bilateral common carotid artery occlusion (BCCAO). In the present study, we made several modifications to the hot water extraction process to remove starch and enable large-scale production. We used wheat bran (WB), which contains less starch, instead of ground whole wheat. In addition, we removed starch granules with a decanter before hot water extraction. The final product, wheat bran extract (WBE), contained 2.42% arabinose, a surrogate marker of arabinoxylan, which is an active constituent of WBE. Supplementation of the rat model of BCCAO with WBE (400 mg/kg/day) for 33 days attenuated white matter injury, which was assessed by Luxol Fast Blue staining, in the corpus callosum (cc) and optic tract (opt) regions. Attenuation of white matter injury in the opt region was accompanied by improvement of the pupillary light reflex. Immunochemical staining revealed that supplementation with WBE reduced astrocytic activation in the cc and opt regions and reduced microglial activation in the opt region. These findings indicate that supplementation with WBE is effective at attenuating white matter injury accompanied by the inhibition of astrocytic and microglial activation. Therefore, extracts from WB, a cheap by-product of wheat milling, can be developed as a nutraceutical to prevent vascular dementia, a disease for which there is no approved pharmaceutical treatment.

• 대한기계학회논문집A
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• 제36권5호
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• pp.571-577
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• 2012

본 논문에서는 우수관로부터 발생되는 퇴적토의 준설처리를 위한 소형의 이동식 준설일괄처리 시스템을 제안하고, 특히 진공사이로와 1차 선별분리기 그리고 컨베이어를 일체화하는 진공사이로 선별분리장치를 설계하였다. 진공사이로 선별분리장치는 저장조, 이송 스크류, 진공 게이트, 스크린 바, 스크린 바 클리너, 진공배출장치로 구성된다. 특히 저장조 내에서 흡입공기의 흐름은 선별분리 성능의 주요 요소임을 고려하여 CFD 유동해석을 통해 최적형상을 도출하였다. 또한 CAE 구조해석을 통해 판재로 이루어지는 저장조의 안전성을 검토하였다. 그리고 3D-CAD 모델링을 통한 구동 메커니즘의 기구적, 역학적 시뮬레이션을 수행하여 사양을 결정하였다. 본 연구에 이어서, 드럼 스크린형 2차선별기, 데칸터형 탈수장치 그리고 보조장치인 오수탱크와 펌프 등을 설계할 것이다. 그리고 본 설계를 바탕으로 시제품을 제작하고 필드테스트를 수행할 것이다.