• Clinical and Experimental Pediatrics
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• v.64 no.4
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• pp.180-187
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• 2021

Background: Severe perinatal asphyxia results in multiple organ involvement, neonate hospitalization, and eventual death. Purpose: This study aimed to investigate the predictive factors of death in newborns with hypoxic-ischemic encephalopathy (HIE) receiving selective head cooling. Methods: This cross-sectional descriptive-retrospective study was conducted from 2013 to 2018 in Fatemieh Hospital of Hamadan and included 51 newborns who were admitted to the neonatal intensive care unit with a diagnosis of HIE. Selective head cooling for patients with moderate to severe HIE began within 6 hours of birth and continued for 72 hours. The required data for the predictive factors of death were extracted from the patients' medical files, recorded on a premade form, and analyzed using SPSS ver. 16. Results: Of the 51 neonates with moderate to severe HIE who were treated with selective head cooling, 16 (31%) died. There were significant relationships between death and the need for advanced neonatal resuscitation (P=0.002), need for mechanical ventilation (P=0.016), 1-minute Apgar score (P=0.040), and severely abnormal amplitude-integrated electroencephalography (a-EEG) (P=0.047). Multiple regression of variables or data showed that the need for advanced neonatal resuscitation was an independent predictive factor of death (P=0.0075) and severely abnormal a-EEG was an independent predictive factor of asphyxia severity (P=0.0001). Conclusion: All cases of neonatal death in our study were severe HIE (stage 3). Advanced neonatal resuscitation was an independent predictor of death, while a severely abnormal a-EEG was an independent predictor of asphyxia severity in infants with HIE.

• Journal of Digital Convergence
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• v.17 no.11
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• pp.427-434
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• 2019

The purpose of this study is to investigate the factors influencing the willingness of nursing college students to have respect for life and to use them as basic principle to help develop an effective bioethics education program for nursing students. A descriptive study was used with 442 nursing students. Data were collected with a structured questionnaire and analyzed using descriptive analysis, t-test, ANOVA, Pearson correlation coefficients, and Multiple regression. The result showed that factors affecting respect for life and will were meanings of death, death anxiety, death concern and these three variables explained about 43.6% of respect for life and will. It is necessary for nursing students to understand the meaning of death and to reduce death anxiety by improving understanding of meanings of death. It also suggests the need to develop an educational program that can improve the respect for life and will by establishing their own views on death and improving the involvement of death in nursing a dying patient and family.

• 한국노년학
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• v.28 no.4
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• pp.1227-1248
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• 2008

In this study, death preparation was used as an independent variable, with ego integrity as successful aging used as a dependent variable while depression and death anxiety were used as mediate variables. The purpose of this study is to investigate the differences of the study variables according to the demographic characteristics of the research subjects, and to create a database for developing and improving current educational programs and welfare services to help the elderly achieve successful aging. Two hundred and eighty three elderly people above the age of sixty in Cheongju city were given standardized questionnaires, and the collected data were analyzed. The results of this study are the following. First, the differences of the study variables according to the level of education, health, economy, and social involvement of the elderly are statistically significant. Second, there exists a positive relationship between mental preparation for death and ego integrity (successful aging) while there is no such relation in case of formal preparation for death and ego integrity. Third, depression and death anxiety of the elderly partially mediate ego integrity, which leads to successful aging.

• The Journal of the Convergence on Culture Technology
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• v.8 no.2
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• pp.7-13
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• 2022

The purpose is a qualitative study that explores the essential meaning of death for fourth-year students of nursing college who have completed the practical training in the Department of Nursing. The participants of this study were 15 students who were 4th graders at a university in M city, Jeollabuk-do and had a strong awareness of death. As for data collection, students who read a thesis related to death and completed 1004 hours of hospital practice were asked to write a self-report within 72 hours for questions. The collected data were analyzed using Krippendorff's phenomenological method. As a result of analyzing the experience related to death, it was derived into 30 meaningful statements in 3 categories, 9 topics. The three categories were derived from 'the end and together', 'death, fighting alone,' and 'fear and fear'. It is expected that the results of this study will be used as useful basic data for developing a professional understanding of death in nursing students and coping with the stress of death faced by new nurses.

• Health Policy and Management
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• v.33 no.1
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• pp.19-28
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• 2023

Background: With the enactment of the Hospice, Palliative, Care, and Life-sustaining Treatment Decision-Making Act in February 2018, legal guidelines for physician orders for life-sustaining treatment (POLST) were presented. This study was conducted to analyze the association of writing POLST on the use of health care before death. Methods: The study analyzed the electronic medical records and POLSTs of 1,003 adult patients who died at a tertiary hospital located in Seoul from February 4, 2018 to February 4, 2019. Results: Of the deaths, 80% (n=804) completed POLST. Among patients who completed POLST before death, 51% (n=412) were written 1-7 days before death, and only 31% (n=246) were completed by patients themselves. 99% (n=799) decided to withdraw or withhold cardiopulmonary resuscitation. As a result of analyzing the effect of POLST on medical use before death, it was found that POLST and inpatient cost had a significant negative correlation, and POLST completion significantly reduced death in the intensive care unit (ICU). However, both inpatient costs and death at ICU increased when the POLST was completed by surrogate decision-makers rather than patients themselves. Conclusion: The enactment of the Hospice, Palliative, Care, and Life-sustaining Treatment Decision-Making Act provided a legal basis for withdrawing and withholding meaningless life-sustaining treatment. By specifying the treatment to be received at the end of one's life through the POLST, inpatient treatment costs and death at the ICU were decreased. However, the frequent decision-making by the surrogates and completion of POLST close to death may hinder the original purpose of the law.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.1
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• pp.199-205
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• 2009

It is unclear whether Fructus ligustri Lucidi (FLL) extract anti-proliferative effect in human glioma cells. The present study was therefore undertaken to examine the effect of FLL on cell viability and to determine the underlying mechanism in A172 human glioma cells. Cell viability and cell death were estimated by MTT assay and trypan blue exclusion assay, respectively. Apoptosis was measured by Annexin-V binding assay and cell cycle analysis. Activation of kinases and caspase-3 was estimated by Western blot analysis. FLL resulted in apoptotic cell death in a dose- and time-dependent manner. FLL-induced cell death was not associated with reactive oxygen species generation. Western blot analysis showed that FLL treatment caused down-regulation of PI3K/Akt pathway, but not ERK. The PI3K/Akt inhibitor LY984002 sensitized the FLL-induced cell death and overexpression of Akt prevented the cell death. FLL induced caspase-3 activation and the FLL-induced cell death was prevented by caspase inhibitors. These findings indicate that FLL results in a caspase-dependent cell death through a P13K/Akt pathway in human glioma cells. These data suggest that FLL may serve as a potential therapeutic agent for malignant human gliomas.

• The Korean Journal of Health Service Management
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• v.8 no.3
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• pp.219-228
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• 2014

The purpose of this study was to provide a basic data for the establishment of attitude on death, perception on hospice and attitude of DNR by nursing students. The survey was performed with 214 nursing students in Busan. The data was collected by questionnaires and were analyzed using SPSS/win 21.0 program. The period of data collection was from June 1, 2013 to June 15, 2013. The mean scores of attitude on death, perception on hospice and attitude of DNR were 2.63, 3.30 and 3.83 point. The attitude of DNR of the nursing students was significantly different according to the grade and satisfaction of major. The attitude of DNR showed the significant positive relationship with attitude on death and perception on hospice. Attitude on death and perception on hospice accounted for 16.8% of variance in attitude of DNR. Finding of this study is necessary to develop nursing understanding for the attitude of DNR by considering attitude on death and perception on hospice.

• Journal of Families and Better Life
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• v.25 no.5
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• pp.15-29
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• 2007

The purposes of this study were to examine if there is a relationship between elderly people's anxiety towards death and their reactions to the Star-Wave drawing, and to verify if the Star-Wave drawing was a good enough tool to measure elderly people's degree of death anxiety. The subject for this study were 307 elderly people (male 127, female 180) over 60 years of age with no physical and cognitive damage, who were residing in Geongsan city and attending colleges or welfare centers for the aged. The collected data were analyzed with SPSS WIN(ver. 12.0) program, and factor analysis, correlation analysis, Chi-square test, t-test, one-way ANOVA, and $Scheff\acute{e}$ test were utilized. The results showed that factors showing different levels of anxiety towards death in the Star-Wave drawing were the total harmony of the drawing, drawing style, repetition of wave, size of the star, and location of the star. In particular, the group that drew the Star-Wave drawing with total harmony felt less anxiety towards death than the other group. Therefore, the results of this study suggested a possibility of the Star-Wave drawing to be used as a good tool that could diagnose the elderly's degree of anxiety towards death.

• The Korean Journal of Rehabilitation Nursing
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• v.18 no.1
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• pp.11-19
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• 2015

Purpose: The purpose of this study was to identify the perception on hospice, attitudes toward death and needs of hospice care between the patients with cancer and family. Methods: This study used descriptive research design. The participants were 118 patients with cancer hospitalized and 118 family caregivers of patients with cancer. The data collected by questionnaires from October to December, 2013. Results: There was significant difference in perception on hospice (recognition of hospice term and definition of hospice) and needs of hospice care between patients and family. Among the categories of the needs, 'medical needs' was the highest in patients and 'emotional care' was the highest in family. But there was no significant difference in attitudes toward death. There correlation between attitudes toward death and needs of hospice care was significant only in patients. Conclusion: Hospice care must be provided considering the death attitudes and needs of patients with cancer and family based on the understanding of perception on hospice, attitudes toward death of the patients with cancer and family.

• BMB Reports
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• v.45 no.8
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• pp.482-487
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• 2012

To identify the novel inhibitors of endoplasmic reticulum stress-induced cell death, we performed a high throughput assay with a chemical library containing a total of 3,280 bioactive small molecules. Cyclosporine A and bromocriptine were identified as potent inhibitors of thapsigargiin-induced cell death (cut-off at $4{\sigma}$ standard score). However, U74389G, the potent inhibitor of lipid peroxidation had lower activity in inhibiting cell death. The inhibition effect of cyclosporine A and bromocriptine was specific for only thapsigargin-induced cell death. The mechanism of inhibition by these compounds was identified as modification of the expression of glucose regulated protein-78 (GRP-78/Bip) and inhibition of phosphorylation of p38 mitogen activated protein kinase (MAPK). However, these compounds did not inhibit the same events triggered by tunicamycin, which was in agreement with the cell survival data. We suggest that the induction of protective unfolded protein response by these compounds confers resistance to cell death. In summary, we identified compounds that may provide insights on cell death mechanisms stimulated by ER stress.