• 한국수정란이식학회지
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• 제24권1호
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• pp.65-69
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• 2009

The aim of the present study was to investigate the cleavage pattern, its developmental ability and apoptosis of porcine embryo in vitro. Morphology data on a total of 919 embryos were analyzed retrospectively. Forty-eight hours after insemination, embryos were classified into five groups based on the cleavage state as follows; 1 cell, 2 cell, 4 cell, 5 to 8 cell and fragmentation. These groups were cultured another 120 hours and then evaluated for blastocyst formation. Blastocyst formation rates were significantly higher in 4 cell (42.5%) and 5 to 8 cell (48.6%) cleaving groups than in other groups (p<0.05). On the other hand, 2 cell and fragmentation groups produced 4.9% and 3,9% blastocysts, respectively. And we could verify that in the event of 2 cell block and fragmentation of embryo. To analyze the apoptotic frequency in preimplantation development of porcine IVF embryos, all cells of each blastocyst were performed by TUNEL assay. There were no significantly differences in the total cell numbers of embryos and apoptotic cell rate in blastocysts among the each classified groups. Data suggest that 4 cell and 5 to 8 cell cleaving embryos at 48 hour after insemination have high developmental competence, and may be an useful parameter to predict the development of preimplantation embryos and to study using preimplanation embryonic research.

• Asia pacific journal of information systems
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• 제6권1호
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• pp.165-194
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• 1996

Data distribution is one of the most important steps in distributed database design. This paper proposes a methodology for distributing database by using a relational schema as an input. A design support system called DBDD (Database Distribution Design) is implemented within the framework of this methodology. The methodology consists of three phases such as (i) schema analysis, (ii) fragmentation, and (iii) allocation. In the schema analysis phase, all the table names are acquired from a global relational schema. In the fragmentation phase, fragments are generated according to transaction retrieval patterns. Furthermore, DBDD enhances the design quality by allocating fragments in a progressive manner. A real-life case is illustrated to demonstrate the practical usefulness of the DBDD.

• 한국컴퓨터정보학회논문지
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• 제4권4호
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• pp.170-176
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• 1999

본 논문에서는 분산 객체 지향 데이타베이스에서 객체를 여러 사이트에 분산시키는 기법에 관하여 연구하였다. 제안된 객체의 분산 기법은 클래스의 분할 과정과 할당 과정으로 구성된다. 클래스의 분할 과정에서는 메소드, 계승 및 복합 객체와 같은 객체 지향 데이터베이스의 특성을 반영한 애트리뷰트 분할 알고리즘의 정의하였고 할당 과정에서는 함께 참조되는 다른 클래스의 프래그먼트들은 같은 사이트에 할당함으로써 데이타 전송량을 줄일 수 있는 할당 수식을 정의하였다.

• BMB Reports
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• 제29권6호
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• pp.489-492
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• 1996

A number of anticancer-chemotherapeutic agents induce cell death through the process of apoptosis. Effects of echinomycin, an anticancer agent on cancer progression, were investigated in P388 murine leukemia cells. First, according to the results of cytotoxicity measurement. $IC_{50}$ of echinomycin was 1.12 nM, a relatively lower value than the other examined anticancer agents, mitomycin-C and etoposide Second, the DNA fragmentation assay for echinomycin-treated cells exhibited that echinomycin was able to induce apoptosis in a shorter period of time and with a lower dose than mitomycin-C or etoposide. The data of DNA fragmentation were quite comparable to those of cytotoxicity measurement. Finally we showed that mitogen-activated protein (MAP) kinase, a key protein in cell mitosis, was translocated into the nucleus from the cytosol after treatment with echinomycin. These findings suggest that a MAP kinase-related process may be involved in apoptosis induced by echinomycin.

• Archives of Pharmacal Research
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• 제19권2호
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• pp.91-94
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• 1996

In the course of a search for antitumor agents, we found that the extract of Curcuma longa was effective in inducing apoptosis or programmed cell death (PCD) in human myeloid leukemia cells (HL-60). Active compounds for PCD were isolated from the hexanic extraction of the rhizome of Curcuma longa. With the several chromatographies, and spectral data, they were identified as ar-turmerone and $\beta-atlantone$. The present results demonstrate that the exposure of human myeloid leukemia HL-60 cells to clinically achievable concentrations of arturmerone (TU) or .$\beta-atlantone$(AT) produced internucleosomal DNA fragmentation of approximately 200 base-pair multiples, and the morphological changes characteristic of cells undergoing apoptosis or PCD. This findings suggest that these agents may exert their antitumoral activity, in part, through induction of apoptosis(PCD).

• East Asian Economic Review
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• 제24권4호
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• pp.389-416
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• 2020

This paper provides empirical evidence on the reorganization of GVCs in East Asia, highlighting that structural trends explain a decrease in the fragmentation of production after 2011 but that it is not the result of rising trade costs along the value chain. Using harmonized inter-country input-output tables, the paper first analyzes the global import intensity of production to document changes in the structure of GVCs. It then calculates theory-consistent bilateral trade costs for intermediate and final products using an approach derived from the gravity literature and introduces a new index of cumulative trade costs along the value chain. These data are used to discuss whether the decrease in global imports is the consequence of shifts in demand, efficiency-enhancing strategies of firms or rising trade costs. Between 2011 and 2016, cumulative trade costs have decreased in East Asian GVCs. However, as COVID-19 is likely to intensify trade and investment uncertainties, trade costs could increase in the future. Policies aimed at reducing uncertainties and preserving the gains from trade and investment liberalization will be key in this new environment.

• 한국조경학회지
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• 제26권2호
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• pp.240-250
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• 1998

This study is to have attempted to analyze the characteristics of the change in forest landscape pattern of Seoul for 18 years by grasping it through satellite image data on the forest area in Seoul where a rapid change according urbanization and industrialization is going on. On the basis of Landsat MSS data- satellite image data, this writer analyzed the change in the number and size of patch and the mean edge length of each forest land, and the index of patch shape by each year from a landscape -ecological point of view. The results are as follows; First, in the pattern change of the forest patch of Seoul, the highest patch fragmentation area is the forest of the Yangchon-gu district where is decreasing it forest area by 654ha, 511ha, 495ha, 402ha each year from its total size of 742ha in 1979. Second, the change tendency shows that the average forest size decreased at 552.58ha in 1983, 435.03ha in 1988, 396.23ha in 1992, and 379.96ha in 1996. And analysis showed that even in the number of patches, the forest fragmentation phenomenon was presenting by the increase of development disturbance. Third, the mean edge by year was longest at 23,385m in 1979, but it is decreasing continuously. This shows the regular and artificial uniformity of forest landscape by disturbance-effect increase of the built-up development and shows low portion against edge effect by the time-series change like 1979>1983>198>1992>1996. Finally, in the analysis of a shape index indicated by ratio of size and edge, total averages were 2.56, 2.33, 2.17, 2.14, 2.14 each year, so that it is considered that the disturbance and ecological health status against forest landscape can be grasped according to being examined as 1979>1983>1988>1992, 1996 by the time-series change of the landscape.

• 정보과학회 논문지
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• 제45권2호
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• pp.165-174
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• 2018

온라인 커뮤니티란 SNS와 달리 사용자들이 닉네임을 통해 익명으로 관심사와 취미를 공유하는 가상 그룹 서비스이다. 그런데 이런 익명성을 악의적으로 활용하는 사용자들이 존재하고, 닉네임의 변경으로 인해 동일 사용자의 데이터가 서로 다른 닉네임에 존재하는 데이터 파편화 문제가 발생할 수 있다. 또한 온라인 커뮤니티에서는 닉네임을 변경하는 일이 빈번하므로 동일 사용자를 식별하는데 어려움을 겪는다. 따라서 본 논문에서는 이러한 문제를 해결하기 위해 온라인 커뮤니티 특성을 고려한 사용자의 행동 패턴 특징 벡터를 제시하며, 관계 패턴이라는 새로운 암시적 행동 패턴을 제안함과 동시에 랜덤 포레스트 분류기를 이용한 동일 사용자의 닉네임을 식별하는 기법을 제안한다. 또한 실제 온라인 커뮤니티 데이터를 수집해 제안한 행동패턴과 분류기를 이용해 동일 사용자를 유의미한 수준으로 식별할 수 있음을 실험적으로 보인다.

• Nuclear Engineering and Technology
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• 제53권8호
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• pp.2767-2773
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• 2021

We used the GEANT4 Monte Carlo MC Toolkit to simulate carbon ion beams incident on water, tissue, and bone, taking into account nuclear fragmentation reactions. Upon increasing the energy of the primary beam, the position of the Bragg-Peak transfers to a location deeper inside the phantom. For different materials, the peak is located at a shallower depth along the beam direction and becomes sharper with increasing electron density NZ. Subsequently, the generated depth dose of the Bragg curve is then benchmarked with experimental data from GSI in Germany. The results exhibit a reasonable correlation with GSI experimental data with an accuracy of between 0.02 and 0.08 cm, thus establishing the basis to adopt MC in heavy-ion treatment planning. The Kolmogorov-Smirnov K-S test further ascertained from a statistical point of view that the simulation data matched the experimentally measured data very well. The two-dimensional isodose contours at the entrance were compared to those around the peak position and in the tail region beyond the peak, showing that bone produces more dose, in comparison to both water and tissue, due to secondary doses. In the water, the results show that the maximum energy deposited per fragment is mainly attributed to secondary carbon ions, followed by secondary boron and beryllium. Furthermore, the number of protons produced is the highest, thus making the maximum contribution to the total dose deposition in the tail region. Finally, the associated spectra of neutrons and photons were analyzed. The mean neutron energy value was found to be 16.29 MeV, and 1.03 MeV for the secondary gamma. However, the neutron dose was found to be negligible as compared to the total dose due to their longer range.

• 한국멀티미디어학회논문지
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• 제23권7호
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• pp.819-829
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• 2020

Underwater communication is necessarily useful for various application domains such as saving of human lives from underwater disasters, marine resource exploration, underwater military fields, underwater environment or ecosystem monitoring, fish farm monitoring and management, etc. Even though the acoustic wave has been the main underwater communication media until now, several media such as optical waves, VLF/ELF waves, magnetic fields, and infrared rays also began to be treated as possible media for underwater communication. If these underwater communicate-possible media are used mixing together, the underwater communication can be much more reliable and efficient through complementing the disadvantages of each communication media with advantages of other communication media. In fact, mixing and using multi-media for underwater communication requires the data flow control in the connection process of different media due to their communication speed gaps and bandwidth differences, and, specially, in the flow control, the appropriate message fragmentation technique is required inevitably. For this reason, this paper presents a fragmentation framework and technique necessary to the flow control in the underwater multi-media communication. In addition, through its implementation and experiments, this paper shows the feasibility on the realization of the multi-media based underwater communication.