• Korean Journal of Head & Neck Oncology
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• v.24 no.2
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• pp.155-161
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• 2008

Head and neck squamous cell carcinoma(HNSCC) still has poor outcome, and laryngeal cancer is the most frequent subtype of HNSCC. Therefore, there is a need to develop novel treatments to improve the outcome of patients with HNSCC. It is critical to gain further understanding on the molecular and chromosomal alteration of HNSCC to identify novel therapeutic targets but genetic etiology of squamous cell carcinoma of the larynx is so complex that target genes have not yet been clearly identified. Array based CGH(array-CGH) allows investigation of general changes in target oncogenes and tumor suppressor genes, which should, in turn, lead to a better understanding of the cancer process. In this study, We used genomic wide array-CGH in tissue specimens to map genomic alterations found in laryngeal squamous cell carcinomas. As results, gains of MAP2, EPHA3, EVI1, LOC389174, NAALADL2, USP47, CTDP1, MASP1, AHRR, and KCNQ5, with losses of SRRM1L, ANKRD19, FLJ39303, ZNF141, DSCAM, GPR27, PROK2, ARPP-21, and B3GAT1 were observed frequently in laryngeal squamous cell carcinoma tissue specimens. These data about the patterns of genomic alterations could be a basic step for understanding more detailed genetic events in the carcinogenesis and also provide information for diagnosis and treatment in laryngeal squamous cell carcinoma. The high resolution of array-CGH combined with human genome database would give a chance to find out possible target genes which were gained or lost clones.

• Hip & pelvis
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• v.35 no.2
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• pp.73-87
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• 2023

The aim of this review is to conduct an analysis of existing literature on outcomes of application of various methods of joint decompression in management of septic arthritis of the hip in children. A search of literature in PubMed, Embase, and Google Scholar was conducted for identification of studies reporting on the outcomes of intervention for septic arthritis of the hip in children. Of the 17 articles selected, four were comparative studies; two of these were randomized controlled trials while the rest were single arm studies. Statistical difference was observed between the proportion of excellent clinical and radiological outcomes in arthrotomy (90%, 95% confidence interval [CI] 81-98%; 89%, 95% CI 80-98%), arthroscopy (95%, 95% CI 91-100%; 95%, 95% CI 90-99%), and arthrocentesis (98%, 95% CI 97-100%; 99%, 95% CI 97-100%), respectively. The highest overall rate of additional unplanned procedures was observed in the arthrocentesis group (24/207, 11.6%). Patients who underwent arthrocentesis had a statistically greater chance of excellent clinical and radiological outcomes, although the highest level of need for additional unplanned surgical intervention was observed in the arthrocentesis group, followed by the arthroscopy group and the arthrotomy group. Future conduct of a prospective multi-centric study focusing on the developed and developing world, along with acquisition of data. such as delay of treatment and severity of disease will enable assessment of the efficacy of one technique over the other by surgeons worldwide.

• Steel and Composite Structures
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• v.51 no.4
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• pp.441-456
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• 2024

This paper aims to develop Machine Learning (ML) algorithms to predict the buckling resistance of cold-formed steel (CFS) channels with restrained flanges, widely used in typical CFS sheathed wall panels, and provide practical design tools for engineers. The effects of cross-sectional restraints were first evaluated on the elastic buckling behaviour of CFS channels subjected to pure axial compressive load or bending moment. Feedforward multi-layer Artificial Neural Networks (ANNs) were then trained on different datasets comprising CFS channels with various dimensions and properties, plate thicknesses, and restraining conditions on one or two flanges, while the elastic distortional buckling resistance of the elements were determined according to the Finite Strip Method (FSM). To develop less biased networks and ensure that every observation from the original dataset has the chance of appearing in the training and test set, a K-fold cross-validation technique was implemented. In addition, the hyperparameters of the ANNs were tuned using a grid search technique to provide ANNs with optimum performances. The results demonstrated that the trained ANNs were able to predict the elastic distortional buckling resistance of CFS flange-restrained elements with an average accuracy of 99% in terms of coefficient of determination. The developed models were then used to propose a simple ANN-based design formula for the prediction of the elastic distortional buckling stress of CFS flange-restrained elements. Finally, the proposed formula was further evaluated on a separate set of unseen data to ensure its accuracy for practical applications.

• Journal of Korean Medical classics
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• v.35 no.2
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• pp.99-120
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• 2022

Objectives : To analyze symptoms of olfactory dysfunction caused by COVID-19 from a Korean Medical Perspective. Methods : Previous studies dealing with olfactory dysfunction accompanying COVID-19 were studied and analyzed for general characterization. Physiology and pathology of olfactory functions within the classical texts of Korean Medicine were collected and analyzed, through which symptoms of olfactory dysfunction in COVID-19 were examined. Results : Olfactory dysfunction manifested in high ratios in the early stages of confirmed COVID-19 cases, at times independent of other nasal symptoms such as blockage or discharge. There was a high chance of loss of taste being accompanied, while mental problems such as a tendency to have difficulty concentrating were present as well. In most cases, recovery took one to two weeks. From a Korean Medical perspective, physiology of olfactory function is closely linked to the Lungs, Ancetral Qi[宗氣], and the Heart, while its dysfunction could be explained by pathological factors such as Wind-Cold, Fire stagnation, Qi deficiency, Wind stroke, etc. Conclusions : In the context of external contraction disease[外感病], olfactory dysfunction could be caused by problems in the Lungs and Stomach that are responsible for breathing, or the Heart which is involved in recognizing and differentiating scent. General characteristics of COVID-19 imply it to be closely related to the Heart. In clinical application, overall symptoms need to be considered in diagnosis and treatment planning, after which further approaches could made to determine the problem to be of the Lung and Stomach, or of the Heart.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.10
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• pp.4703-4710
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• 2012

The purpose of this study was to examine the impact of the social maturity of sustained sport-for-all participants on their physical and mental health. The subjects in this study were 190 company employees who were selected by convenience sampling from among the residents in Gangwon Province. The selected office workers continued to participate in sport-for-all programs. After a survey was conduced from November 7 to 25, 2011, the statistical package SPSS WIN 18.0 was employed to analyze the collected data. To find out the general characteristics of the subjects, frequency analysis was made, and the reliability test of the instrument and factor analysis were carried out. Descriptive statistics analysis was made by factor, and multiple regression analysis was utilized to look for connections among their variables. As a result, it's found that the social maturity of the sustained sport-for-all participants made a significant difference to their physical health, and that their social maturity made a significant difference to mental health as well. As sustained sport-for-all participation was found to be correlated to their physical and mental health, office workers should be given a chance to participate in sport-for-all on a long-term basis.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8483-8488
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• 2014

Background: Breast cancer is the most common cancer and the second most common cause of cancer-induced mortalities in Iranian women, following gastric carcinoma. The survival of these patients depends on several factors, which are very important to identify in order to understand the natural history of the disease. Materials and Methods: In this retrospective study, 313 consecutive women with pathologically-proven diagnosis of breast cancer who had been treated during a seven-year period (January 2006 until March 2014) at Towhid hospital, Sanandaj city, Kurdistan province of Iran, were recruited. The Kaplan-Meier method was used for data analysis, and finally those factors that showed significant association on univariate analysis were entered in a Cox regression model. Results: the mean age of patients was $46.10{\pm}10.81$ years. Based on Kaplan-Meier method median of survival time was 81 months and 5 year survival rate was $75%{\pm}0.43$. Tumor metastasis (HR=9.06, p=0.0001), relapse (HR=3.20, p=0.001), clinical stage of cancer (HR=2.30, p=0.03) and place of metastasis (p=0.0001) had significant associations with the survival rate variation. Patients with tumor metastasis had the lowest five-year survival rate (37%)and among them patients who had brain metastasis were in the worst condition (5 year survival rate= $11%{\pm}0.10$). Conclusions: Our findings support the observation that those women with higher stages of breast malignancies (especially with metastatic cancer) have less chance of surviving the disease. Furthermore, screening programs and early detection of breast cancer may help to increase the survival of those women who are at risk of breast cancer.

• Journal of Korean Academy of Nursing
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• v.24 no.3
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• pp.364-376
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• 1994

This study was initiated to find the characteristic awareness of disease in Korean culture and then, with its applying to psychological nursing, to help cancer victims cope with their disease. Research period was from Dec. 1, 1989 to Aug.3, 1992. The research method, while the method of face-to-face interview with 33 cancer victims were mainly adopted, was to identify the causal perception through analyses of literature and traditional sayings deeply rooted in Korean culture. The causal perceptions were differentiated into 4 sections, which apply to 32 cancer victims with Q-sorting. Be-ing coded into grades from 1 to 9, the data were analyzed with the aid of Quanal program on PC ; in analyzing Q-factor principal component analysis method was used. The results were revealed as follows : 1. Subject victims owe their disease to 1) the omnipotent and animating powers in Shamanism rooted in Korean culture, 2) their intimate persons, i.e. their husband, wife, children, or other fellows ameng their groups. 3) victims themselves, and 4) nowhere, for they thought the disease is the struggle with their own self. 2. In Q-methodology analysis, cancer victims are categorized into 5 types. The first type, self-mastery type, consisting of 11 subjects, has the characteristic of overcoming their disease with their own strong will or by the help of the Omnipotent God, which is estimated to be the ideal type to cope with the disease. The second type, omnipotent & animating powers-dependent type, consisted of 7 subjects, who have the causal perception of traditional shamanism. The third type, intimate person-dependent type, consisted of 4, all of whom are women and whose causal perception has the characteristic of the their complains about each member of their family, espectially about their husband. The fourth type, fate-recipient type, was the com-plex form of the first and the second types. It consisted of 6 subjects, to whom cancer had meant bad fate coming on them but had to be overcome by their strong will. The fifth type, personal type, consisted of 4, whose causal perception is toward themselves personality It is hoped that the study provide the chance of developing nursing intervention to help cancer victims accept and overcome their disease as their own reality instead of attributing to anyone or any-thing else.

• Proceeding of Spring/Autumn Annual Conference of KHA
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• 2008.11a
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• pp.322-326
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• 2008

Due to the rapid increasing in the aged population, it calls for social countermeasures urgently. Especially, there are increasing needs of space environment to support physical and spiritual characteristics of elderly. When designing space environment including house, there are growing consideration for elderly and extending appreciation of aging. The purpose of this study is to investigate the perception on environment planning for the seniors among university students who majoring in Housing & Interior Design and who visited the Aging Simulation Center located in Seoul. The Aging Simulation Center gives a chance of space design to support the elderly based on the experiences of daily living for the designers who design environment for elderly. Questionnaire survey was conducted to obtain data from 93 university students in their 20s majoring in housing and interior design who visited the Aging Simulation Center. The research findings showed that the recognition for design elements of residential environment for the elderly of respondents was changed toward positive way after visiting the Aging Simulation Center. The Aging Simulation Center was an effective educational environment for the preliminary designers to understand aging and the importance of appropriate design for users' needs. That is, aging simulation space can improve recognition of necessity of universally designed environment to support the elderly. Handrails around bathtub and wash basin, stair slope, electric auto-level controlled kitchen counter and kitchen cabinet were especially perceived for the respondents as very essential design elements to support the aged.

• Journal of Korea Game Society
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• v.9 no.6
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• pp.127-137
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• 2009

Web Game provides computer games through a web browser, and have several benefits. First, we can access the game through web browser easily if we are connected to the internet environment. Second, usually we don't need much space of a game data for downloading it into a local disk. Nowadays, an industry area of Web Game has a chance to grow through advancements of mobile computing technologies and an age of Web 2.0. This study proposes a Web Game system that users can apply to manipulate the game with multimodal interfaces and mobile devices for intuitive interactions. In this study, multi modal interfaces are used to efficient control the game, and both ordinary computers and mobile devices are applied to the game scenarios. The proposed system is evaluated in both performance and user acceptability in comparison with previous approaches. The proposed system reduces total clear time and numbers of errors of the experiment in a mobile device. It can also provide good satisfactions of users.

• Journal of Korean society of Dental Hygiene
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• v.15 no.1
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• pp.31-38
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• 2015

Objectives: The purpose of this study is to investigate the factors of oral health beliefs on scaling performance by national health insurance coverage in consumers. Methods: The subjects were 353 people living in Seoul, Incheon, and Gyeonggi-do from September 25 to October 20, 2013. They filled out the self-reported questionnaire after receiving informed consents. The questionnaire included 6 questions of general characteristics, 6 questions of oral health behavior, 6 questions of health insurance coverage, and 1 question of subjective oral health recognition. The oral health belief consisted of 6 questions of seriousness, 6 questions of susceptibility, 8 questions of barriers, 5 questions of benefit, and 3 questions of self-efficacy measure by Likert 5 scale. Cronbach's alpha in the study was 0.759. Data were analyzed using SPSS version 20.0 for frequency analysis, t-test, ANOVA, post-hoc Scheffe test, Pearson's correlation coefficient, and binary logistic regression. Results: The influencing factors of oral health belief model were Seriousness(${\beta}=0.091$), Self efficacy(${\beta}=-0.471$) and age(${\beta}=0.855$)(p<0.05). Those who had highly perceived seriousness and younger age tended to have probability of scaling performance. Higher self-efficacy tended to take more chance to have scaling performance probability. Conclusions: In order to cover the scaling by national health insurance, it is very important to notice the benefit of health insurance coverage of scaling to the consumers. National health insurance coverage enables the scaling practice to be easily accessible to the people. Easy access to scaling by low cost strategy can improve the oral health behavior.