• 한국동물위생학회지
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• 제45권3호
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• pp.165-169
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• 2022

Immune-mediated hemolytic anemia (IMHA) is autoimmune disease which is anemia caused by own immune system destroying the red blood cells (RBC). It can be diagnosed with spherocytosis, positive auto-agglutination of RBCs and direct antiglobulin test (DAT, Coomb's test). The treatment for IMHA are blood transfusion, immunosuppressive agents including glucocorticoids and other supportive therapies. Danazol is synthetic androgen that has effect of interfering the autoimmune reaction to RBCs. It can be used as an adjunctive agent in addition to glucocorticoids. To investigate its effectiveness, the medical records of 10 IMHA-diagnosed dogs were evaluated. All subjects were treated with blood transfusion, prednisolone, mycophenolate mofetil, and intravenous human immunoglobulin G. Additionally, 6 subjects were administered with danazol and 4 subjects were not. The results of initial blood examination and responses to the treatment for IMHA were compared between the groups. There were significant differences in the number of blood transfusions; once in group with danazol, twice in group without danazol, duration of recovery to normal hematocrit; 7.67±3.08 days in group with danazol, 22.00±5.66 days in group without danazol, and hospitalization; 5.17±0.75 days in group with danazol, 12.75±2.22 days in group without danazol. Therefore, danazol has potential effective on treating IMHA for rapid improvement.

• 분석과학
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• 제11권5호
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• pp.353-359
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• 1998

국제 올림픽 위원회에서 금지하고 있는 합성 동화성 스테로이드로서 다양한 생물학적 효과를 나타내고 있는 danazol을 대상으로 androgenic 효과를 확인하기 위해 성인 남자 3명에게 100 mg씩 복용하게 한 후 그들의 소변을 채취하였다. 인체내 대사과정에서 생성되는 주요 대사체인 ethisterone의 배설에 따른 8가지의 내인성 스테로이드들의 배설정도를 GC/MS의 selected ion monitoring(SIM) 방법으로 동시분석 하였다. 그 결과 본실험방법에서 내인성 스테로이드들에 대한 회수율은 71.59%~93.56% 이었으며, within-a day 및 day-to-day 분석에서의 RSD 값은 각각 1.87%~10.48%와 1.32~11.25%이었다. 이때의 검출한계는 $0.01{\sim}0.05{\mu}g/mL$ 이었다. 각각의 내인성 스테로이드들과 ethisterone의 표준물질을 뇨시료에 0.1, 0.5, 1.0, 10, 20 그리고 $50{\mu}g/mL$를 첨가하여 작성한 검정곡선은 전체적으로 상관계수 0.963~0.991의 직선성을 보였다. 따라서 본 실험은 내인성 스테로이드들의 변화를 관찰함으로서 간접적으로 스테로이드 계열의 금지약물 복용여부를 판단할 수 있는 방법으로 매우 유용함을 알 수 있었다.

• Tuberculosis and Respiratory Diseases
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• 제38권4호
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• pp.384-388
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• 1991

Parenchymal pulmonary endometriosis is the likely cause in patients with hemoptysis, dyspnea, or chest pain during menstruation. Embolization of endometrial tissue from the uterus to the lungs via the pulmonary arteries has been proposed for the mechanism of the development of parenchymal pulmonary endometriosis. This is a report of a woman with catamenial hemoptysis which was responded successfully to danazol therapy; however, hemoptysis resumed after cessation of therapy. The patient was subsequently treated with danazol again because she refused surgical treatments.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2003년도 제45차 추계학술대회
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• pp.119.1-119.1
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• 2003

• 정신신체의학
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• 제15권1호
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• pp.14-21
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• 2007

월경전 불쾌기분 장애(premenstrual dysphoric disorder, PMDD)는 여성의 약 $4{\sim}5%$에서 발병하며 섹스 스테로이드 호르몬 양의 변화에 대한 증가된 반응성 및 세로토닌, 멜라토닌, GABA의 감소가 원인으로 생각된다. 우울증, 계절성 정동 장애, 공황장애, 신경성 폭식증은 질병 특성 상 공통점이 있어서 월경전 불쾌기분 장애와 상호 연관성을 암시한다. DSM-IV-TR의 진단 기준에 따라 월경전 불쾌기분 장애를 진단하려면 반드시 정신적 증상이었어야 한다. 흔한 정신적 증상은 이자극성, 분노, 우울, 기분 스윙, 정동 불안정, 긴장, 불안, 피로, 음식 갈망이다. 현재로서 최선의 치료 약물은 세로토닌 재흡수 차단제이며, leuprolide, danazol, estradiol, spironolactone, bromocriptine도 사용될 수 있다. 경증 및 중증도 환자에 대한 보조적 치료로는 식이요법, 운동, 광선요법, 정신치료, 일기 쓰기 등이 있다.

• 대한한방부인과학회지
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• 제33권4호
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• pp.23-35
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• 2020

Objectives: The purpose of this study is to confirm the effectiveness and safety of acupuncture for Endometriosis. So providing a clinical basis for abdominal acupuncture treatment helping to develop clinical practice guideline. Methods: Clinical studies applying acupuncture on Endometriosis were searched through Pubmed, China Academic journal (CAJ), Koreanstudies Information Service System (KISS), Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS). Interventions and results of the selected clinical studies were analyzed. Results: 8 Clinical studies were finally included according to inclusion and exclusion criteria. Those were randomized controlled studies. All of those studies were searched in China Academic journal (CAJ) in Chinese. Interventions of control group were made with simple acupuncture and oral administration of Danazol or herbal medicine. Outcome measurements included Treat effect, Relief in related symptoms, and CA-125. All studies reported statistically significant results on abdominal acupuncture and there were no serious adverse effects. Conclusions: This study suggested abdominal acupuncture has statistically significant treat effect. Thus this treat helps improve quality of life for patients. However the results should be taken cautiously as more clinical studies are needed.

• Mass Spectrometry Letters
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• 제11권4호
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• pp.113-117
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• 2020

Cytochrome P450 2J2 (CYP2J2) is a member of the cytochrome P450 superfamily, and is known to be arachidonic acid epoxygenase that mediates the formation of four bioactive regioisomers of epoxyeicosatrienoic acids (EETs). CYP2J2 is also involved in the metabolism of drugs such as albendazole, astemizole, danazol, ebastine, and terfenadine. CYP2J2 is highly expressed in the heart and cancer tissues. In this study, the inhibitory potential of ten natural products against CYP2J2 activity was evaluated using human liver microsomes and tandem mass spectrometry. Among them, bilobetin, which is a kind of biflavonoid, exhibits a strong inhibitory effect against the CYP2J2-mediated astemizole O-demethylation (IC50 = 0.73 μM) and terfenadine hydroxylation (IC50 = 0.89 μM). This result suggests that bilobetin can be used as strong CYP2J2 inhibitor in drug metabolism study.

• Tuberculosis and Respiratory Diseases
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• 제53권3호
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• pp.349-353
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• 2002

여러 국내외 논문에서 hormone 치료는 우수한 효과를 나타내었으나 치료 종료 후 객혈이 다시 발생하여 추가적인 수술을 받는 경우가 많았으며, GnRH analogue의 장점에도 불구하고 hormone 치료로 완치된 예는 대부분 danazol에 의한 경우가 많았다. 저자들이 경험한 환자는 월경과 동반된 객혈, 월경주기에 따라 변하는 방사선학전 변화와 GnRH analogue 치료에 대한 극적인 증상의 호전 등의 전형적인 소견으로 폐실질 자궁내막증에 의한 catamenial hemoptysis로 진단되었다. 6회의 hormone 치료 기간동안 임상양상의 호전을 보였고, 치료를 중단한 후에도 재발의 증거가 없는 상태로 외래를 다니고 있다.

• 대한한방부인과학회지
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• 제32권3호
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• pp.214-226
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• 2019

Objectives: The purpose of this study is to review clinical studies of Traditional Chinese medicine (TCM) on Genito-Pelvic Pain/Penetration Disorder (GPPPD) in women. Methods: Key words "Dyspareunia", "Vaginismus" were searched on Chinese National Knowledge Infrastructure Database (CNKI) on April 21th 2019. Results: 2 case reports and 7 clinical trials were collected in accordance with the selection and exclusion criteria. Among the 7 trials, 4 were controlled trials, and 3 were single-arm trials. The types of intervention were herb medication in 8 studies, and compound TCM treatment including acupuncture, moxibustion, and cupping therapy in 1 study. All 4 controlled trials were about dyspareunia and conducted by herbal medicine of TCM. The study results and methods of intervention were analyzed. Conclusions: 2 case reports described the effectiveness of compound TCM treatments (acupuncture, moxibustion, cupping therapy) and herb medicine in dyspareunia. In 4 controlled trials, 2 trials described the effectiveness of herb medicine (oral or vaginal agent) compared to western treatment in dyspareunia, and other 2 trials described no effectiveness of herbal enema compared to danazol. In 3 single-arm trials, 1 trial of dyspareunia and 2 trials of vaginismus described the effectiveness of herb medicine. All the 9 selected studies reported improved or disappeared symptoms of GPPPD, or high effective rate after TCM treatment. There was limitation that the selected studies were retrieved from only one site of CNKI, and generalized results could not be derived, further studies should be carried out. Additional well-designed clinical studies on GPPPD in women are needed in Korea.

• 대한한의학방제학회지
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• 제31권4호
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• pp.373-388
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• 2023

Objectives : This study aimed to provide basic data for research by investigating non-clinical experimental studies on herbal medicines and its compounds for precocious puberty. Methods : A search was conducted for all literature until October 2023 using combinations of keywords such as precocious puberty, puberty, and chinese medicine in three databases (Pubmed, OASIS, and ScienceON). Results : 1. In animal experiments, studies were mainly conducted using a model that induced precocious puberty by subcutaneously administering danazol to SD rats on the 5th day after birth, and in cell experiments, precocious puberty was induced by treating GT1-7 cells with kisspeptin 10 or estradiol. 2. Anemarrhenae Rhizoma, Phellodendri Cortex, and Prunellae Spica were mainly used as herbal medicine to evaluate their efficacy on precocious puberty in non-clinical experiments. 3. Macroscopic observation, hematological analysis, histological analysis, and genetic analysis were performed as methods to analyze the experimental results. Conclusions : In this study, the effects of herbal medicine on precocious puberty and non-clinical research methods were confirmed. Based on the results of this study, it is expected that non-clinical effectiveness and mechanism research on materials that are clinically effective in Traditional Korean Medicine will be revitalized.