• 한국화재소방학회논문지
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• 제30권3호
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• pp.73-78
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• 2016

'화재예방, 소방시설 설치유지 및 안전관리에 관한 법률'에 의하면 지하층 포함 30층 이상 고층 건축물에 대해 화재발생에 따른 위험성을 사전에 과학적으로 평가하여 재난발생 시 인명피해 및 재산피해를 최소화시킬 수 있도록 성능위주 설계를 실시해야 한다. 이에 따라 설계자는 컴퓨터 시뮬레이션 모델링 등 과학적인 분석 기법을 활용하여 거주자의 화재 및 피난 안전성을 평가하고 있다. 이 때, 인명안전성 평가를 위해 가용피난안전시간(ASET)과 소요피난안전시간(RSET) 을 산정하게 되는데 RSET 중에서도 가장 중요한 '반응시간(Response Time)'을 산정함에 있어 우리나라 사람들에 대한 실측 데이터에 기반한 명확한 법적 기준이 제시되지 못하고 있는 것이 현실이다. 이에 '소방시설 등의 성능위주설계 방 법 및 기준, 별표1'을 토대로 설계자별로 각각 상이한 값을 선택, 입력하거나 일본건축센터의 '건축방재계획지침'에 따라 계산하고 있는 경향을 보이고 있다. 따라서 본 연구에서는 최근 5년간 부산지역에서 성능위주 설계대상으로 지정된 고층 특정소방대상물을 대상으로 총 6명의 설계자가 실시한 성능위주 설계안 13건을 중심으로 RSET의 계산방법에 대해 비교 분석하였고, 특히 RSET 계산 시 결과값에 가장 큰 영향을 미치는 반응시간의 계산방법에 대한 결과를 비교하여 오차값을 산정하였다.

• 대한통합의학회지
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• 제8권3호
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• pp.33-41
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• 2020

Purpose : Conventional Balance Measurement can only measure the center of gravity and the shaking movement of the body. As a result, it has the disadvantages of not responding to visual changes and blocking functions of variables. This study was carried out to evaluate the performance of new equipment that measures the balance of the body using changes in body segment and pressure using the acceleration sensor to compensate for the disadvantages of the existing equipment. Methods : To this end, balance ability was measured in 43 healthy male/female adults without orthopedic injuries and nervous system damage in the last 6 months. in a situation where the visual information was restricted by Virtual Reality (VR) gear, all subjects measured and evaluated the balance ability utilizing the new equipment. Balance measurement (Prime Medilab, Korea) and Wii fit (Nintendo, Japan) were used to measure the balance ability of the subjects, and the balance ability test was performed in 4 postures using each device for data acquisition. The test duration for each posture was 30 seconds. For data acquisition, the average value of three experiments measured using each equipment was analyzed, and the statistical test was performed using the independent sample and the corresponding sample t-test, and the significance level was set to α=.05. Results : As a result of measuring the balance ability using individual equipment, blocking visual information using VR gear, the average speed, maximum speed, and moving area of the COP increased equally. It was found that the obtained absolute size of the result in Wii was somewhat larger than that of BM. Conclusion : It is considered that in the future research, it is necessary to measure changes in the body's center of gravity through image analysis, etc., to make clear comparison and evaluation of the usability.

• 대한후두음성언어의학회지
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• 제26권1호
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• pp.25-33
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• 2015

Background and Objectives:The objective of this study was to investigate the features of post-thyroidectomy subjective voice disorder by Voice Handicap Index (VHI) and Voice Symptom Scale (VOISS) through aerodynamic analysis and to investigate the appropriate voice therapy intervention. Materials and Methods:Twenty post-thyroidectomy patients who had no recurrent laryngeal nerve paralysis through laryngeal stroboscopy were enrolled for this study. Acoustic and aerodynamic evaluations were performed before operation, 2 weeks and 3 months after operation. Subjective voice evaluation was performed by VHI and VOISS. Aerodynamic evaluation was compared and analysed by maximum phonation time(MPT), phonation threshold pressure(PTP), mean air flow rate(MFR), etc. Subjective voice evaluation was surveyed through VHI and VOISS. To evaluate patients' symptoms related to functional voice disorder, scores on physical domain in VHI and VOISS were selected to be compared for each session. Results: The 10 out of 20 participants who complained of voice symptoms had no significant difference with pre-operation in acoustic evaluation, but all showed higher scores on 2 weeks and 3 months after operation compared to pre-operation, in VHI-physical domain and selected questionnaires in VOISS. They reduced MPT and increased PTP value simultaneously. Laryngeal massage and breathing training were simultaneously treated to them, 5 participants resulting in improvement in MPT and PTP compared to pre-treatment. Conclusion:Patients who complained voice change with no organic damage after thyroidectomy were all shown to have reduced MPT and increased PTP in some by aerodynamic evaluations. Reduced MPT may imply some problem in air flow beneath glottis. Increased PTP suggests much more effort in vocalization mechanism than pre-operation. Comparing aerodynamic evaluations in post-thyroidectomy may provide information on behavioral interventions. Additionally, study on laryngeal massage and breathing training simultaneously treated to patients with such voice disorder is needed to be conducted with larger number of participants.

• 한국콘텐츠학회논문지
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• 제12권7호
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• pp.261-272
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• 2012

본 연구는 작업기억 향상을 위한 직류두개자극(tDCS)이 뇌졸중 환자의 뇌파에 어떠한 변화를 가져오는지 알아보기 위해 시행되었다. MMSE와 숫자 외우기 검사(DST)를 통해 선별된 만성 뇌졸중 환자 20명을 전산화 인지 훈련(CCT)만 실시한 I군(10명)과 tDCS와 CCT를 병행한 II군(10명)으로 무작위 배치하여 주 3회, 1일 30분, 4주간 중재하였다. 뇌파 변화를 알아보기 위해 중재 전, 2주 후, 4주 후 시점에서 뇌전도로 단어, 사진, 암산과제 시 세가지 밴드(${\theta}$; 4~8 Hz, lower ${\alpha}$; 8~10.5 Hz, upper ${\alpha}$;10.5~13 Hz)로 절대 스펙트럼 파워를 산출하여, 기준뇌파에 대한 증감률(%)을 구하였다. 연구 결과, 첫째, 측정시점에 따라서, ${\theta}$ 파워는 단어기억과제와 사진기억과제에서 유의한 차이를 보였다. lower ${\alpha}$ 파워는 모든 기억과제에서 유의한 차이를 보였다. upper ${\alpha}$ 파워는 암산과제에서만 유의한 차이를 보였다. 둘째, 4주째에서 모든 과제의 lower ${\alpha}$ 파워에서만 두 군간에 유의한 차이를 보였다. 따라서 본 연구의 과제에 따른 세 가지 밴드의 차이를 통해 작업기억의 정도를 정량화 하여 비교가 가능하며, 뇌손상환자에게 tDCS의 병행이 인지재활에 보조적인 도움을 줄 수 있을 것으로 생각된다.

• 한국지반환경공학회 논문집
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• 제16권12호
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• pp.5-12
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• 2015

발파소음은 충격음이기 때문에 인체에 갑작스런 충격을 주며, 발파진동과 같은 경우에는 지반을 따라 진동이 이동하여 인근 주변의 노화된 건물, 가축과 인체에도 큰 피해를 끼칠 수 있다. 본 연구에서는 광산 굴착 시 발생하는 발파영향이 인근지역에 미치는 영향에 대하여 분석하였다. 연구대상 지역의 지반현황을 파악하기 위해 지질조사, 현장시험과 실내시험 등의 지반조사를 수행하였다. 발파진동소음에 대해서는 국내 외 적용사례와 각 기관별 허용기준을 비교하여 현장조건에 가장 적합한 기준을 설정하였다. 발파영향을 검토하기 위해 발파진동 추정 식은 현장에서 시험발파를 수행하여 측정된 발파진동 값을 활용하였다. 발파진동 추정 식을 활용한 영향원의 검토는 발파지점을 보안물건(농장, 민가 등)으로부터 최단거리로 정하여 보안물건에 미치는 영향을 검토하였다. 또한 3차원 수치해석을 수행하여 발파진동 영향검토를 수행하였다. 3차원 수치해석은 동적 발파하중에 대한 구조물의 거동을 해석하기 위해 시간이력해석을 수행하였으며, 3방향에 대한 발파진동 값을 구하였다. 시험발파에 따른 발파진동 추정 식을 이용한 발파진동 영향원 검토 결과와 발파영향에 대한 3차원 수치해석 값을 비교 분석한 결과, 유사한 결과 수치를 확인하였다.

• 한방재활의학과학회지
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• 제21권2호
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• pp.63-85
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• 2011

Objectives : This study was carried out to know the effects of Danggwisayeokgaohsuyusaenggang-tang(hereinafter referred to DST) on arthritis induced by collagen on DBA/1 OlaHsd mice. Methods : For this purpose, DST was orally administered to mouse with arthritis induced by collagen II. Cytotoxicity, high performance liquid chromatograph(HPLC) analysis, arthritis index, value of immunocyte in draining lymph node and paw joint, cytokine were measured in vivo. Results : 1. The cytotoxicity against human fibroblast cells(hFCs) was not measured in any concentration. 2. In HPLC analysis, There are high peak patterns at 8 minute(min), 12 min, 35 min, 45 min. 3. The arthritis index was decreased significantly. 4. The degree of arthritis induced damage of joint of DST group is slight compared with control group in histopathologic observation(Hematoxylin and eosin stain(H&E), Masson's trichrome(M-T) staining). 5. In total cell counts of draining lymph node(DLN) and paw joint, the cells in DLN decreased significantly on DST 200 mg/kg and the cells in paw joint decreased significantly on 200 mg/kg and 50 mg/kg. 6. In DLN, $CD4^+/CD25^+$, $CD3^+/CD69^+$, major histocompatibility complex(MHC), class-II/$CD11c^+$ cells decreased significantly on DST 200 mg/kg and 50 mg/kg $CD3^+/CD8^+$ cells decreased significantly on DST 200 200 mg/kg, $CD4^+$, $CD3^+/CD44^+$ cells decreased. 7. In paw joints, $CD4^+$, $CD11b^+/Gr-1^+$ cells decreased significantly on DST 200 mg/kg and 50 mg/kg. 8. In joints, levels of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, cyclo-oxygenase-2(COX-2), NOS-II were decreased on DST 200 mg/kg and DST 50 mg/kg. 9. In analysing of cytokine in CD3/CD28 activated spleen, IL-17 was decreased significantly, IL-4 was increased significantly $INF-{\gamma}$ was decreased on DST 200 mg/kg. 10. In analysing of cytokine in collagen activated spleen, IL-17 were decreased significantly, IL-4 was increased significantly. Conclusions : This results demonstrated that DST suppressed the inflammatory progression of collagen-induced arthritis(CIA) mice and supported further studies are required to survey continuously in looking for the effective substance and mechanism in the future.

• 한국컴퓨터정보학회논문지
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• 제18권3호
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• pp.107-118
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• 2013

본 논문에서는 반도체 식각 공정 모니터링 시스템을 개발한다. 반도체 산업은 첨단 산업 중, 전자제품의 필수 부품을 생산하는 대표적인 고부가가치 산업으로, 세계 각국에서 치열한 개발 경쟁을 벌이고 있다. 이에 따라 반도체 제품의 품질과 특성, 그리고 생산성을 향상하기 위한 많은 연구들이 진행되고 있는데, 공정 모니터링 기술이 이에 해당한다. 실제로 반도체 회로를 형성하는 식각 공정에서의 불량은 큰 피해를 야기 시키므로, 공정을 상세히 모니터링 할 수 있는 시스템의 개발이 필요하다. 본 논문에서 기술하는 반도체 식각 공정 모니터링 시스템은 플라즈마를 이용한 건식식각 공정을 상세하게 관찰 분석하여 관리자에게 피드백하고, 설정된 시나리오에 맞게 자동으로 공정을 제어하여 공정 자동화 효율을 극대화한다. 실시간으로 모니터링을 수행하고 그 결과를 즉각적으로 시스템에 반영한다. 관리자는 시스템에서 제공하는UI(User Interface)를 통해 공정의 현재 상태를 진단할 수 있다. 시스템은 관리자가 사전에 작성한 공정 시나리오를 따라 공정을 자동으로 제어하고, 공정중단 시점을 효율적으로 찾아내어 생산 효율을 높인다.

• 치위생과학회지
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• 제18권3호
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• pp.164-171
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• 2018

To improve the oral health status of Korean people, it is necessary to encourage proper oral hygiene management habits, such as toothbrushing, through appropriate health promotion techniques. Therefore, the purpose of this study was to evaluate the removal of plaque and tooth abrasion using ultra-soft (filament 0.11~0.12 mm) and soft toothbrushes for toothbrushing. The plaque removal was performed using a dentiform and Arti-spray, and the Patient Hygiene Performance (PHP) index was calculated as the sum total score divided by the total number of surfaces. In the abrasivity experiment, according to the number of brushings, a micro Vickers hardness tester was used, and a sample in the range of 280~380 Vickers hardness number was selected. The number of toothbrushing stroke were 1,800 (2 months), 5,400 (6 months), 10,800 (12 months), and 21,600 (24 months). The tooth abrasion was measured using a scanning electron microscope. Statistical analysis was performed using IBM SPSS Statistics 22.0 and a p-value <0.05 was considered significant. According to the results, there was no statistically significant difference in the degree of plaque removal between ultra-soft and soft toothbrushes. The difference in tooth abrasion between before and after toothbrushing was found to be greater with the soft toothbrushes than with the ultra-soft toothbrushes. Therefore, the ultra-soft toothbrush not only lowers tooth damage by reducing tooth abrasion, but also shows a similar ability to remove plaque as soft toothbrushes.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2018년도 춘계학술대회 및 임시총회
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• pp.13-13
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• 2018

Alternaria is a ubiquitous fungal genus, widely distributed in the environment and a range of different habitats. It includes both plant pathogenic and saprophytic species, which can affect crops in the field or cause post-harvest spoilage of plant fruits and kernels. Numerous Alternaria species cause damage to agricultural products including cereal grains, fruits and vegetables, and are responsible for severe economic losses worldwide. Most Alternaria species have the ability to produce a variety of secondary metabolites, which may play important roles in plant pathology as well as food quality and safety. Alternariol (AOH), alternariol monomethyl ether (AME), tenuazonic acid (TeA), tentoxin (TEN) and altenuene (ALT) are considered the main Alternaria compounds thought to pose a risk to human health. However, food-borne Alternaria species are able to produce many additional metabolites, whose toxicity has been tested incompletely or not tested at all. Both alternariols are mutagenic and their presence in cereal grain has been associated with high levels of human esophageal cancer in China. TeA exerts cytotoxic and phytotoxic properties, and is acutely toxic in different animal species, causing hemorrhages in several organs. The possible involvement of TA in the etiology of onyalai, a human hematological disorder occurring in Africa, has been suggested. Altertoxins (ALXs) have been found to be more potent mutagens and acutely toxic to mice than AOH and AME. Other metabolites, such as TEN, are reported to be phytotoxins, and their toxicity on animals has not been demonstrated up to now. Vegetable foods infected by Alternaria rot are obviously not suitable for consumption. Thus, whole fresh fruits are not believed to contribute significantly with Alternaria toxins to human exposure. However, processed vegetable products may introduce considerable amounts of these toxins to the human diet if decayed or moldy fruit is not removed before processing. The taxonomy of the genus is not well defined yet, which makes it difficult to establish an accurate relationship between the contaminant species and their associated mycotoxins. Great efforts have been made to organize taxa into subgeneric taxonomic levels, especially for the small-spored, food associated species, which are closely related and constitute the most relevant food pathogens from this genus. Several crops of agricultural value are susceptible to infection by different Alternaria species and can contribute to the entry of Alternaria mycotoxins in the food chain. The distribution of Alternaria species was studied in different commodities grown in Argentina. These food populations were characterized through a polyphasic approach, with special interest in their secondary metabolite profiles, to understand their full chemical potential. Alternaria species associated with tomato, bell pepper, blueberry, apples and wheat cultivated in Argentina showed a surprisingly high metabolomic and mycotoxigenic potential. The natural occurrence of Alternaria toxins in these foods was also investigated. The results here presented will provide background for discussion on regulations for Alternaria toxins in foods.

• Korean Journal of Acupuncture
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• 제23권1호
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• pp.45-57
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• 2006

Objective : This study was undertaker to determine if Juglandis Semen herbal acupuncture (JSA) exerts protective effect against alterations in membrane transport function in rabbits with mercury-induced acute renal failure. Methods : Nephrotoxicity was induced by subcutaneous administration of Hg(a single dose of 10mg/kg) and JSA was performed at both sides of Shenshu($(BL_{23})$, Sinsu) for 7 days. Results: The administration of Hg at a subcutaneous single dose of 10 mg/kg caused a reduction in GFR to 12% of the basal value and an increase in fractional $Na^+$ excretion to 8.9-fold, indicating generation of acute renal failure. When JSA were given for 7 days prior to Hg administration, such changes were significantly attenuated. The fractional excretion of glucose and phosphate was increased to approximately 102- and 35-fold, respectively, in rabbits treated with Hg alone. The increase in rabbits treated with Hg following ISA are significantly lower than that in animals treated with Hg alone. Uptakes of glucose and phosphate in purified isolated brush-border membrane and $Na^+-K^+-ATPase$ activity in microsomal fraction were inhibited in rabbits treated with Hg alone, suggesting that impairment in proximal reabsorption of glucose and phosphate is resulted from a direct damage of membrane transport carriers and disruption of the normal $Na^+$ gradient. Such changes were prevented by JSA. Conclusion These results indicate that the administration of Hg causes impairment in reabsorption of solutes in the proximal tubule via the generation of reactive oxygen species. JSA provides the protection against the Hg-induced impairment in proximal reabsorption, and its effect may be resulted from its antioxidant action.