• 국제물리치료학회지
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• 제3권2호
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• pp.429-434
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• 2012

Ischemia, the leading cause of strokes, is known to be deeply related to synaptic plasticity and apoptosis in tissue damage due to ischemic conditions or trauma. The purpose of this study was to research the effects of NEES(needle electrode electrical stimulation) in brain cells of ischemia-induced rat, more specifically the effects of Poly[ADP-ribose] polymerase(PARP) on the corpus striatum. Ischemia was induced in SD mice by occluding the common carotid artery for 5 minutes, after which blood was re-perfused. NEES was applied to acupuncture points, at 12, 24, and 48 hours post-ischemia on the joksamri, and at 24 hours post-ischemia on the hapgok. Protein expression was investigated through PARP antibody immuno-reactive cells in the cerebral nerve cells and western blotting. The number of PARP reactive cells in the corpus striatum 24 hours post-ischemia was significantly(p<.05) smaller in the NEES group compared to the global ischemia(GI) group. PARP expression 24 hours post-ischemia was very significantly smaller in the NEES group compared to the GI group. Results show that ischemia increases PARP expression and stimulates necrosis, making it a leading cause of death of nerve cells. NEES can decrease protein expression related to cell death, protecting neurons and preventing neuronal apoptosis.

• 국제물리치료학회지
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• 제7권2호
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• pp.1031-1036
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• 2016

c-Fos is known to related to synaptic plasticity and apoptosis in damage from ischemia or external injury. The purpose of this study was to investigate whether needle electrode electrical stimulation(NEES) is effective in increasing the number of c-Fos response cells and c-Fos expression in striatum after global ischemia in rats. There were no treatment and occlusion in the control group, global ischemia(GI) group were no treatment after carotid artery occlusion, and needle electrode electrical stimulation(NEES) group were treated with NEES after GI induced. The number of striatum c-Fos response cells and c-Fos protein expression significantly decreased in the NEES group compared to the GI group after 12, 24, 48 hours. The results of the present study suggest that NEES is ineffective in improving global ischemia in rats and may also be ineffective in the globally ischemic human brain.

• 소성∙가공
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• 제19권2호
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• pp.101-106
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• 2010

CB100 is one of the channel type products in the steel beam. In this study, rolling process of CB100 is analyzed by 3D FEM simulation and rolling process. FEM simulation result is compared with rolling process data. Also the intermediate & finishing roll stress analysis is carried out and the suitability of the roll through roll stress resultant analysis is evaluated. In order to decrease the roll stress, new pass schedule is developed for stable load balance between intermediate and finishing rolling stand. Therefore new rolling pass schedule is verified by the analysis results of rolling process and roll stress. By the analysis results, the credibility of rolling process analysis was obtained and it was determined that the possibility of roll damage between intermediate and finishing mill was high. So the new pass schedule was developed. Through the result of rolling process and roll stress analysis, it was obtained that the reduction of roll stress and stable load balance.

• Molecules and Cells
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• 제43권2호
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• pp.121-125
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• 2020

The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem cell markers have been successfully identified, there is no universal stem cell marker, which is exclusively expressed in all stem cells. Here, we discuss the roles of master developmental regulator RUNX1 in stem cells and the development of a 270 base pair fragment of the Runx1 enhancer (eR1) for use as stem cell marker. Using eR1 to identify stem cells offers a distinct advantage over gene promoters, which might not be expressed exclusively in stem cells. Moreover, RUNX1 has been strongly implicated in various cancer types, such as leukemia, breast, esophageal, prostate, oral, skin, and ovarian cancers-it has been suggested that RUNX1 dysfunction promotes stem cell dysfunction and proliferation. As tissue stem cells are potential candidates for cancer cells-of-origin and cancer stem cells, we will also discuss the use of eR1 to target oncogenic gene manipulations in stem cells and to track subsequent neoplastic changes.

• 소성∙가공
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• 제31권6호
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• pp.384-393
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• 2022

The flow forming process consists of a split process, a divide process, and a forming process. The split process is a forming process in which rollers radially permeate a simple disc-shaped forging material and split it in both directions to form a top-bottom bidirectional cup. It is advantageous for post-processing to deepen the forming depth in the split process but this characteristic causes the failure near the edge of the mandrel during the actual process. The split process was analyzed using Rigid Plastic FEM, and the stress analysis of the mandrel was conducted to find the cause of the failure. It was found that the failure occurred due to fatigue accumulation damage caused by repeated residual stress.

• Steel and Composite Structures
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• 제39권2호
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• pp.171-188
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• 2021

Plastic deformation of link beams in eccentrically braced frames is the primary dissipating source of seismic energy. Despite the excellent compatibility with the architectural designs, previous researches indicate the deficiency of flexural yielding links compared to the shear yielding ones because of their localized plastic deformation. Previous investigations have shown that implementing web openings in beams could be an efficient method to improve the seismic performance of moment-resisting connections. Accordingly, this research investigates the use of flexural links with stiffened and un-stiffened web openings to eliminate localized plasticity at the ends of the link. For this purpose, the numerical models are generated in finite element software "Abaqus" and verified against experimental data gathered from other studies. Models are subjected to cyclic displacement history to evaluate their behavior. Failure of the numerical models under cyclic loading is simulated using a micromechanical based damage model known as Cyclic Void Growth Model (CVGM). The elastic stiffness and the strength-based and CVGM-based inelastic rotation capacity of the links are compared to evaluate the studied models' seismic response. The results of this investigation indicate that some of the flexural links with edge stiffened web openings show increased inelastic rotation capacity compared to an un-perforated link.

• Structural Engineering and Mechanics
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• 제71권3호
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• pp.211-221
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• 2019

To study the eccentric compression behavior of ultra-high performance fiber reinforced concrete (UHPFRC) columns, six UHPFRC columns and one high-strength concrete (HSC) column were tested. Variation parameters include load eccentricity, volume of steel fibers and stirrup ratio. The crack pattern, failure mode, bearing capacity, and deformation of the specimens were studied. The results showed that the UHPFRC columns had different failure modes. The large eccentric compression failure mode was the longitudinal tensile reinforcements yielded and many horizontal cracks appeared in the tension zone. The small eccentric compression failure mode was the longitudinal compressive reinforcements yielded and vertical cracks appeared in the compressive zone. Because of the bridging effect of steel fibers, the number of cracks significantly increased, and the width of cracks decreased. The load-deflection curves of the UHPFRC columns showed gradually descending without sudden dropping, indicating that the specimens had better deformation. The finite element (FE) analysis was performed to stimulate the damage process of the specimens with monotonic loading. The concrete damaged plasticity (CDP) model was adopted to characterize the behaviour of UHPFRC. The contribution of the UHPFRC tensile strength was considered in the bearing capacity, and the theoretical calculation formulas were derived. The theoretical calculation results were consistent with the test results. This research can provide the experimental and theoretical basis for UHPFRC columns in engineering applications.

• Structural Engineering and Mechanics
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• 제71권4호
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• pp.363-375
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• 2019

A renewable energy storage pile foundation system is being developed through a multi-disciplinary research project. This system intends to use reinforced concrete pile foundations configured with hollowed sections to store renewable energy generated from solar panels attached to building structures in the form of compressed air. However previous research indicates that the compressed air will generate considerable high circumferential tensile stresses in the concrete pile, which requires unrealistic high hoop reinforcement ratio to avoid leakage of the compressed air. One possible solution is to utilize fiber reinforced concrete instead of placing the hoop reinforcement to resist the tensile stress. This paper investigates nonlinear structural responses and post-cracking behavior of the fiber reinforced concrete pile subjected to high air pressure through nonlinear finite element simulations. Concrete damage plasticity models were used in the simulation. Several parameters were considered in the study including concrete grade, fiber content, and thickness of the pile section. The air pressures which the pile can resist at different crack depths along the pile section were identified. Design recommendations were provided for the energy storage pile foundation using the fiber reinforced concrete.

• Geomechanics and Engineering
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• 제25권2호
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• pp.111-121
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• 2021

Large deformation and rapid pressure propagation take place inside the rock mass under the dynamic loads caused by the explosives, on quarry faces in order to extract aggregate material. The complexity of the science of rock blasting is due to a number of factors that affect the phenomenon. However, blasting engineering computations could be facilitated by innovative software algorithms in order to determine the results of the violent explosion, since field experiments are particularly difficult to be conducted. The present research focuses on the design of a Finite Element Analysis (FEA) code, for investigating in detail the behavior of limestone under the blasting effect of Ammonium Nitrate & Fuel Oil (ANFO). Specifically, the manuscript presents the FEA models and the relevant transient analysis results, simulating the blasting process for three types of limestone, ranging from poor to very good quality. The Finite Element code was developed by applying the Jones-Wilkins-Lee (JWL) equation of state to describe the thermodynamic state of ANFO and the pressure dependent Drucker-Prager failure criterion to define the limestone plasticity behavior, under blasting induced, high rate stress. A progressive damage model was also used in order to define the stiffness degradation and destruction of the material. This paper performs a comparative analysis and quantifies the phenomena regarding pressure, stress distribution and energy balance, for three types of limestone. The ultimate goal of this research is to provide an answer for a number of scientific questions, considering various phenomena taking place during the explosion event, using advanced computational tools.

• 소성∙가공
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• 제30권4호
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• pp.165-171
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• 2021

This study was conducted on the manufacturing method of high-strength aluminum bolts. We obtained the displacement-load information by tensile test of the Al 6056 raw material and the T6 heat-treated material and calculated the precise flow stress and fracture limit using repetitive finite element analysis for before and after heat treatment. We designed a multi-stage forging process for T6 heat-treated material, and calculated that the accumulated damage value does not exceed fracture limits by finite element method. We produced the prototype forgings without any harmful defects such as cracks and folding occurring. Bolts made of T6 heat treated material show 9.6%higher tensile strength than T6 heat treated material after wire drawing.