• 한국응급구조학회지
• /
• 제13권1호
• /
• pp.19-33
• /
• 2009

Purpose : To check the legal relation between rescue team and patient as well as legal responsibility for patient's damage intentionally or erroneously caused by rescue member, a public official, in the performance of relevant job ; to prevent legal dispute over rescue team and to present program for fair settlement of dispute and equitable and feasible burden of damage. Method : First, the legal principle of Civil Law, Criminal Law and Administrative Law related to the theme of this research will be investigated around research by literature. Second, the case of dispute related to rescue team will be introduced. Result: 1. If 119 rescue members as a public official intentionally or erroneously cause damage to patient in the performance of job, they shall bear civil, criminal and administrative responsibility. They shall bear civil responsibility for indemnity for damage due to default or tort. The typical criminal responsibility includes accidental homicide arising out of duty, preparing falsified official document, dereliction of duty, etc. In the administrative side, the state is responsible for indemnity for peculiar status of the rescue member, public official. 2. Though raising civil petition or legal dispute over unsatisfactory rescue service may be reasonable to guarantee the right of nation, such action may cause stress to rescue member as well as may lead to mental shrinking and defensive attitude only to take the basic first aid treatment which has low possibility of mistake instead of active first aid treatment so as to avoid legal responsibility. 3. The program that may prevent legal dispute over 119 rescue team includes expansion of manpower specialized in first aid treatment, enhancement of education on legal environment, development and application of standard job guideline, formation of mutual trust with patient, detailed explanation, preparing and keeping minute record, improvement of the rescue members' ability of first aid treatment and development of medical instruction mode. Conclusion : The best policy is to prevent legal dispute. If it is impossible to basically exclude the possibility of dispute, however, we need to make effort to minimize the occurrence, settle fairly and divide damage equitably and feasibly. To improve the preventible death rate of our first aid system to the level of advanced country, 119 rescue team which is in charge of the stage before hospital needs to positively enforce special first aid by improving the qualitative level of rescue service and to strive to prevent legal dispute that may occur in the process.

• 비파괴검사학회지
• /
• 제20권4호
• /
• pp.276-284
• /
• 2000

콘크리트 구조물의 노화도 평가를 위한 기초 연구로써 철근 및 무근 콘크리트 빔의 4점 굽힘 시험시 발생하는 음향방출 신호의 발생 거동을 관찰하였다. 본 연구는 미세 균열의 전개, 국부 균열의 진전, 부식, 철근의 박리 등 균열 발생 및 손상기구에 대한 AE 특성 고찰에 주안점을 두었다. 이들 각각의 손상 메카니즘을 모사하기 위해 무근 콘크리트, 노치를 가공한 무근 콘크리트, 정상적인 철근 콘크리트 그리고 부식된 철근 콘크리트 빔을 제작하였다. 손상 정도 및 펠리시티 효과(Felicity effect)를 관찰하기 위해 4점 굽힘 시험시 단계별 하중 증가 방식을 택하였다. AE 파형은 물론 AE event에 대한 발생 특성을 분석하였으며, 노화도 평가에 주요한 영향을 미치는 주요 변수들에 대해 조사하였다. AE event 발생의 누계치 및 Felicity ratio값 등은 손상의 정도에 따라 민감하게 변하는 것을 관찰하였으며, 노화도와도 상관관계가 있음을 확인하였다. 결과적으로 본 연구에서 얻은 AE 분석 기술은 철근 콘크리트 구조물의 균열이나 부식 손상과 같은 노화도 평가를 위해 적용할 수 있는 가능성을 제시하였다.

• 대한한의학방제학회지
• /
• 제22권1호
• /
• pp.177-192
• /
• 2014

Objective : In order to investigate the effect of Curcumae Longae Rhizoma(CLR) extract on the hepatocellular carcinogenesis and acute liver damage induced by diethylnitrosamine(DENA) and $CCl_4$ in rats. Methods : Experimental groups were subdivided into four; normal group (Nor), acute liver damage and hepatocellular cancer inducing control group (Con), and CLR extract 200mg/kg/day (CAA) or 400mg/kg/day (CAB) administered groups to Con. Thereafter the changes of the body weight, the liver weight and the weight of liver/100g body weight, total cholesterol, HDL cholesterol, triglyceride, the activities of AST, ALT, ALP, LDH, AFP, SOD, catalase were measured. And we observed by optical and electron microscopy. Result : 1. The body weight was decreased in Con compared with Nor for 5 weeks, but increased in Con compared with Nor from 6 week to 9 week. During experimental period of total 9 weeks, CAA and CAB were increased compared with Con. 2. The liver weight was increased significantly (p<0.05) in Con compared with Nor. The weight of liver/100g body weight was increased significantly (p<0.05) in Con compared with Nor and decreased significantly (p<0.05) in CAB compared with Con. 3. The level of total cholesterol was increased in Con and CAA compared with Nor, but there was not statistically significant. The level of triglyceride was decreased in Con compared with Nor. But increased in CAA and CAB compared with Con. The level of HDL-cholesterol was significantly increased (p<0.05) in CAA and CAB compared with Con. 4. The activities of AST, ALT were increased in Con compared with Nor, but decreased in CAA compared with Con, significantly decreased (p<0.05) in CAB compared with Con. 5. The activities of ALP, LDH were increased in Con compared with Nor, but decreased in CAA and CAB compared with Con. 6. The activities of AFP was increased significantly (p<0.05) in Con compared with Nor, but decreased significantly (p<0.05) in CAA and CAB compared with Con. 7. The activities of SOD were increased in Con, CAA and CAB compared with Nor, but decreased in CAA and CAB compared with Con. The activities of Catalase was more increased in CAA and CAB compared than Con. 8. The results of light microscopical observation, a number of hepatocytes were damaged in Con compared with Nor and CAB. 9. According to the electron microscopical observation, irregular nuclear membrane, condensed nucleoplasm was observed in Con, the experimental group was observed in the nucleus of the well-preserved and evenly developed nucleoplasm. Conclusions : These results suggest that administration of CLR extract suppress or retard on the hepatocellular carcinogenesis and acute liver damage induced by DENA and $CCl_4$ in rats.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권10호
• /
• pp.5941-5948
• /
• 2013

Tumor response to antineoplastic drugs is not always predictable. This is also true for bladder carcinoma, a highly recurrent neoplasia. Currently, the combination of cisplatin and gemcitabine is well accepted as a standard protocol for treating bladder carcinoma. However, in some cases, this treatment protocol causes harmful side effects. Therefore, we investigated the roles of the genes TP53, RASSF1A (a tumor suppressor gene) and hMLH1 (a gene involved in the mismatch repair pathway) in cell susceptibility to cisplatin/gemcitabine treatment. Two bladder transitional carcinoma cell (TCC) lines, RT4 (wild-type TP53) and 5637 (mutated TP53), were used in this study. First, we evaluated whether the genotoxic potential of cisplatin/gemcitabine was dependent on TP53 status. Then, we evaluated whether the two antineoplastic drugs modulated RASSF1A and hMLH1 expression in the two cell lines. Increased DNA damage was observed in both cell lines after treatment with cisplatin or gemcitabine and with the two drugs simultaneously, as depicted by the comet assay. A lack of RASSF1A expression and hypermethylation of its promoter were observed before and after treatment in both cell lines. On the other hand, hMLH1 downregulation, unrelated to methylation status, was observed in RT4 cells after treatment with cisplatin or with cisplatin and gemcitabine simultaneously (wild-type TP53); in 5637 cells, hMLH1 was upregulated only after treatment with gemcitabine. In conclusion, the three treatment protocols were genotoxic, independent of TP53 status. However, cisplatin was the most effective, causing the highest level of DNA damage in both wild-type and mutated TP53 cells. Gemcitabine was the least genotoxic agent in both cell lines. Furthermore, no relationship was observed between the amount of DNA damage and the level of hMLH1 and RASSF1A expression. Therefore, other alternative pathways might be involved in cisplatin and gemcitabine genotoxicity in these two bladder cancer cell lines.

• 한국식품영양과학회지
• /
• 제38권2호
• /
• pp.154-159
• /
• 2009

알코올에 의해 유도된 간 손상에 대한 지구자 추출물의 보호효과를 연구하였다. HepG2/2E1 세포에서 알코올로 유도된 ROS 생성과 산화적 손상에 대한 지구자 추출물 보호효과를 확인하였다. C57BL/6마우스를 대조군(NC), 알코올군(ET), 알코올과 지구자 추출물 1 g/kg body weight 투여군(ET-HD)으로 나누었다. 5 g/kg body weight의 알코올을 1주일간 ET와 ET-HD군에 투여하였다. 알코올 투여는 혈청 alanine amintransferase(ALT), aspartate aminotransferase(AST) 및 alkaline phosphatase(ALP)를 증가시키고, 지구자 추출물은 이러한 간 기능 지표효소의 증가를 억제시켰다. 간조직의 항산화 효소 활성은 알코올 투여에 의해 감소되었고, ET-HD군에서 SOD 및 GST 활성은 ET군과 비교하여 통계적으로 유의하게 높아졌다. GSH 함량은 ET군에서 NC군에 비하여 유의적으로 낮아졌고, ET-HD군에서 ET군과 비교하여 통계적으로 유의하게 높아졌으며, NC군과 유사한 함량을 나타내어 간 보호 효과를 확인할 수 있었다. 지질과산화물 함량은 ET-HD군과 NC군이 유사한 함량을 나타냄으로써 알코올에 의해 유도된 지질과산화물 증가에 의한 간손상으로부터 지구자 추출물의 보호 효과를 보여 주었다. 이상의 결과로부터, 지구자 추출물은 세포 및 동물 모델에서 알코올로 유도된 간 손상으로부터 항산화 방어 대사의 증가와 지질과산화율의 감소에 의해 간세포 보호 활성을 나타냄을 확인하였다. 이에 지구자 추출물은 알코올성 간 손상으로부터 보호 효과를 갖는 소재로 활용될 수 있을 것으로 사료된다.

• 한방재활의학과학회지
• /
• 제20권2호
• /
• pp.1-15
• /
• 2010

Objectives : This study was performed to evaluate the effects of root of Cibotii rhizoma(CR) ethanol extract on the tissue and neuronal damage of the spinal cord injury(SCI). Methods : SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rats. CR was orally given once a day for 7 days after SCI. Tissue damage and nerve fiber degeneration were examined with cresyl violet and luxol fast blue(LFS) histochemistry. HSP72(as neuronal damage marker), MAP2(as nerve fiber degeneration marker), c-Fos(immediate early gene), and Bax(pro-apoptotic molecule) expressions were examined using immuno-histochemistry. Individual immuno-positive cells expressing HSP72, MAP2, c-Fos and Bax were observed on the damaged level and the upper thoracic and lower lumbar spinal segments. Results : 1. CR reduced degeneration of nerve fibers and motor neuron shrinkage in the ventral horn of the lower lumbar spinal segment, but generally it did not seem to ameliorate the tissue injury following SCI. 2. CR reduced demyelination in the ventral and lateral funiculus of the lower lumbar spinal segment. 3. CR reduced HSP72 expression on the neurons in the peri-central canal gray matter adjacent to the damaged region. 4. CR strengthened MAP2 expression on the motor neurons in the ventral horn and on nerve fibers in the lateral funiculus of the lower lumbar spinal segment. 5. CR reduced c-Fos positive cells in the peri-lesion and the dorsal horn of the damaged level and in the ventral horn of the lower lumbar spinal segment. 6. CR reduced Bax positive cells in the peri-lesion and the dorsal horn of the damaged level and in the ventral horn of the lower lumbar spinal segment. Conclusions : These results suggest that CR plays an inhibitory role against secondary neuronal damage and nerve fiber degeneration. following SCI.

• Strategy21
• /
• 통권44호
• /
• pp.213-253
• /
• 2018

The Russo-Japanese War(1904-1905) in the early 20th century greatly influenced the international politics in Northeast Asia and the destiny of both countries. There are many studies on the cause of the outbreak and its effect on the Korean peninsula. The victory and defeat of the battle of Tsushima also the subject of research by renowned scholars and navy officers. Many previous studies have analyzed the process of engagement. However, There was a lack of research that analyzed at the tactical level of naval commanders. Therefore, this study tries to review the battle of Tsushima in terms of tactical level, that is formation, maneuvering, damage control. Naval operations at sea with many variables are not always done as planned. The intuitive judgement and readiness have had a decisive impact on victory and defeat. The analysis of the naval warfare on the basis of formation, maneuvering, and damage control makes the cause of the win more clearly. The conclusion of the this study can be summarized in five ways. First, victory would be achieved through the suppression of the beginning. The destiny of the Tsushima battle was determined by an 1 hour after first firing. The Japanese fleet caught fire by paralyzing the command and control capabilities of the Russian fleet. Second, the Japanese fleet's power was superior to the Russian fleet. In general, Japan and Russia had similar powers, and Admiral Togo's "T crossing tactics" decisively contributed the victory. However, when compared to the weapon system level, formation and maneuvering, Japan was much more dominant. Third, people realized that one side to be annihilated in the battle between similar powers after the Tsushima battle. The common perception before the Battle of Tsushima was that the battle ship would not sunken, and that the result of wiping out was difficult. However, there is s time for one sided victory and defeat depending on the early suppression nad the destruction of the command and control ability. Fourth, it is the importance of damage control ability. The main cause of the Russian fleet's loss of command and control ability was thick smoke from fire, and maneuverability was greatly deteriorated due to coal overload. In this way, importance is still valid after more than 100 tears. Fifth, the area of uncertainty. In the navy battles, one or two shots of clear firing in the beginning and small misconception and minor mistakes decide win or loss. Ultimately, this area of fortune can be linked to mindset of the commander. I hope this research will be help to naval researchers and naval commanders at the sea.

• 실내환경 및 냄새 학회지
• /
• 제17권4호
• /
• pp.355-361
• /
• 2018

Mold grows more easily when humidity is higher in indoor spaces, and as such is found more often on wetted areas in housing such as walls, toilets, kitchens, and poorly managed spaces. However, there have been few studies that have specifically assessed the level of mold in the indoor spaces of water-damaged housing in the Republic of Korea. We investigated the levels of airborne mold according to the characteristics of water damage types and explored the correlation between the distribution of mold genera and the characteristics of households. Samplings were performed from January 2016 to June 2018 in 97 housing units with water leakage or condensation, or a history of flooding, and in 61 general housing units in the metropolitan and Busan area, respectively. Airborne mold was collected on MEA (Malt extract agar) at flow rate of 100 L/min for 1 min. After collection, the samples were incubated at $25^{\circ}C$ for 120 hours. The cultured samples were counted and corrected using a positive hole conversion table. The samples were then analyzed by single colony culture, DNA extraction, gene amplification, and sequencing. By type of housing, concentrations of airborne mold were highest in flooded housing, followed by water-leaked or highly condensed housings, and then general housing. In more than 50% of water-damaged housing, the level of airborne mold exceeded the guideline of Korea's Ministry of Environment ($500CFU/m^3$). Of particular concern was the fact that the I/O ratio of water-damaged housing was greater than 1, which could indicate that mold damage may occur indoors. The distribution patterns of the fungal species were as follows: Penicillium spp., Cladosporium spp. (14%), Aspergillus spp. (13%) and Alternaria spp. (3%), but significant differences of their levels in indoor spaces were not found. Our findings indicate that high levels of mold damage were found in housing with water damage, and Aspergillus flavus and Penicillium brevicompactum were more dominant in housing with high water activity. Comprehensive management of flooded or water-damaged housing is necessary to reduce fungal exposure.

• 대한약침학회지
• /
• 제1권1호
• /
• pp.1-21
• /
• 1997

In order to investigate experimentally that effect of Moschus, Bovis Calculus, Ursi Fel aqua-acupuncture on acutely damaged liver of rats induced by radix aconiti, the author gave Moschus, Bovis Calculus, Ursi Fel aqua-acupuncture according to method of manufacture stimulation to corresponding points, Kan-su(B18) and Ki-mun(Liv14), and carried out hematological, serological observation. Experimental groups were divided into 2 group : the one group was injected with extracted solution prepared by distillation method (A aqua-acupuncture treatment group), the other group was injected with extracted solution prepared by alchol extraction method (B aqua-acupuncture treatment group). The following results were obtained : 1. WBC level was decreased significantly in the experimental groups at 12, 24 and 48 hours as compared with the control group. RBC and hemoglobin levels were not changed significantly in the experimental groups. 2. Total cholesterol level was decreased significantly in the experimental groups at 12, 24 and 48 hours as compared with the control group. ALP level was decreased significantly in the experimental groups at 6 and 24 hours as compared with the control group. ${\gamma}-GTP$ level was decreased significantly in the experimental groups at 6, 12, 24 and 48 hours as compared with the control group. 3. GOT level was decreased significantly in the experimental groups at 6 and 12 hours as compared with the control group. GPT level was decreased siginificantly in the experimental groups at 12, 24 and 96 hours as compared with the control group. According to the above findings, it is considered that Moschus, Bovis Calculus, Ursi Fel aqua-acupuncture has effects of recovery of acutely damaged liver.

• 한국항해항만학회지
• /
• 제37권4호
• /
• pp.409-418
• /
• 2013

기후변화로 인한 해수면 상승이 우리나라 연안에 장기적으로 큰 영향을 줄 것으로 예측되어 다양한 방법을 사용하여 연안에 대한 해수면 상승의 취약성 평가가 이루어지고 있다. 본 연구에서는 사면이 바다와 접해 해수에 의한 침수가 빈번하여 향후 해수면 상승에 의한 피해가 클 것으로 예상되는 부산의 영도 해안을 대상으로 해수면 상승이 해안에 미치는 영향을 알아보고 그 대책을 마련하였다. 먼저 잠재적 해수면 상승률을 바탕으로 CAD를 이용한 해수면 상승 시뮬레이션을 실시하였으며 다음으로 시뮬레이션결과를 바탕으로 침수범위와 재해위험 지역을 종합적으로 고려하여 피해 예상지역을 추출하였고 최종적으로 침수특성에 따라 지구별로 세분하여 해당 지구에 적합한 대응전략을 수립하였다.