• 환경영향평가
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• 제4권2호
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• pp.123-130
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• 1995

The equipment composed of many complicated electronic stuffs undergoes diverse stresses caused by mechanical vibrations during its service. Thus, to ensure its proper operation in the field a simulated vibration test has to be carried out in the laboratory with the Vibration Qualification Level, the test specification, which can include the real environment. In this paper we intent to deal with method and procedure for determining the Vibration Qualification Level so as to estimate the vibration-endurance for the equipment precisely.

• Journal of Nutrition and Health
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• 제35권2호
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• pp.213-222
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• 2002

The alkaline comet assay has been used with increasing popularity to investigate the level of DNA damage in biomonitoring studies within the last decade in Western countries. The purpose of this study was to evaluate the usefulness of the alkaline comet assay as a biomarker of oxidative DNA damage for monitoring in the Korean population, and also to evaluate the effect of nutritional status and lifestyle factors on H2O2 induced oxidative DNA damage measured by the alkaline comet assay in human lymphocytes. The study population consisted of 61 healthy Korean male volunteers, aged 20-28. Epidemiological background data including dietary habits, smoking habits and anthropometrical measurements were collected through personal interviews. After blood collection, the comet assay in peripheral lymphocytes and plasma lipids analysis was carried out and the results analyzed. Tail moment (TM) and tail length (TL) of the comet assay were use\ulcorner to measure DNA damage in the lymphocytes of the subjects. Statistically significant (p < 0.05) positive correlations were observed between DNA damage (TM or TL) and smoking habits expressed as cigarettes smoked per day and pack years (r = 0.311 and 0.382 for TM, r = 0.294 and 0.350 for TL, respectively). There were also significant positive correlations between DNA damage parameter and waist-hip ratio. Higher plasma triglyceride levels were associated with increased damage to DNA. There were no correlations between the consumption frequencies of vegetables and DNA damage to the subjects. However, consumption frequencies of fruit and fruit juice intake were inversely associated with the TM and TL. The results indicate that die comet assay is a simple, rapid and sensitive method for detecting lymphocyte DNA damage induced by cigarette smoking. Consumption of fruit or fruit juices could potentiall modify the damaged DNA in the human peripheral lymphocytes of young Korean men.

• Journal of Chest Surgery
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• 제31권10호
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• pp.945-951
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• 1998

개심술시 총순환정지는 매우 유용한 방법이나 뇌손상등 부작용으로 그 사용이 제한되고 있다. 이러한 뇌손상의 분석에 유용한 지표로서 뇌 허혈성 손상의 특이한 효소인 크레아티닌 카이네이즈 BB(CK-BB)의 유용성을 재고하고 뇌손상에 영향을 미치는 인자들의 분석을 시도하였다. 총순환정지를 이용하여 개심술을 시행한 18명의 환자를 대상으로 하였다. 이들은 다시 비청색증형 심기 형군과 청색증형 심기형군으로 나누어 각각 6명과 12명으로 하였다. 각 환자에서 총순환정지전 및 후 15, 30, 60, 120, 240, 480, 720분에 동맥혈을 채취하여 CK-BB분획을 측정하였고 이와 동시에 혈색소농도, 이 온화 칼슘농도, 혈당량 등을 측정하였다. 총순환정지시간과 CK-BB와 통계적으로 유의한 관계를 보이는 채혈시간은 찾을 수 없었다. 또 총순환 정지전의 문제로 인한 영향을 줄이기 위하여 각각의 측정치에서 총순환정지전의 측정치를 뺀 값을 구하 여 각기 CKBBD15, CKBBD30....등으로 표시하고 상관관계를 구하였으나 역시 유의한 상관관계를 보이 지 않았다. CKBB30과 CKBBD30값은 비청색증형 군과 청색증형 군 사이에 유의한 차이를 보이지 않았 다. CK-BB농도와 혈색소 농도는 유의한 상관관계를 보였다. 단일 채혈에 의한 CK-BB농도의 지표는 순환정지시간과 유의한 관계가 없음이 확인되었다. 또한 청색 증형 심질환군이 총순환정지에 의한 뇌손상에 비청색증형 심질환군에 비해 더 취약하지는 않은 것으로 생각된다.

• 대한한의학회지
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• 제22권1호
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• pp.10-21
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• 2001

Objective : This study was performed to investigate the protective effect of Stephania tetrandra(ST) against ischemic brain damage after a middle cerebral artery(MCA) occlusion. The effect was evaluated using histological tests, neurobehavioral tests, and biochemical tests. Methods : Rats(Sprague-Dawley) were divided into four groups : sham operated group, MCA occluded group, post MCA occlusion Stephania tetrandra administrated (7.6mg/l00g) group, and normal group. The MCA was occluded by intraluminal method. Stephania tetrandra was administrated orally twice at 1 and 4 hours after MCA occlusion. The neurobehavioral test was performed at 3, 6, 9 and 24 hours after MCA occlusion by posture reflex test and swimming behavioral test. All groups were sacrificed then. The brain tissues were stained with 2% triphenyl tetrazolium chloride(TTC) or 1 % cresyl violet solution, to examine infarct size, volume and cell number. Tumor necrosis $factor-{\alpha}$ level was measured from sera using Enzyme-Linked Immunoabsorbent Assay(ELISA). The mRNA expression level of inflammatory cytokines and related receptor type I and II, $IL-1{\beta}$, IL-6, and IL-10 6hours after MCA occlusion were also studied by reverse transcriptase polymerase chain reaction(RTPCR). Results : The results showed that : Stephania tetrandra (1) reduced infarct size and total infarct volume by 52.2% compared to the control group; (2) attenuated significantly in neuronal death, which was shown by a decrease in cell number(P<0.01) and size(P<0.01) in the boundary area of the infarction; (3) significantly reduced serum $TNF-{\alpha}$ level, and increased the mRNA level of IL-10 in the cortex region(P<0.01). However, there was no significant effect on motor deficit in swimming behavioral test. Conclusions : In conclusion, Stephania tetrandra has protective effects against ischemic brain damage at the early stage of ischemia.

• 한국식품영양과학회지
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• 제16권1호
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• pp.22-28
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• 1987

These studies were conducted to investigate the effects of Leonurus sibiricus extract (L.S.E.) on experimentally $CCl_4-induced$ liver damage and alloxan-induced diabetes in rabbits; Leonurus sibiricus juice (L.S.J.) showed the most rapid recuperation of liver function among samples compared to the control group in $CCl_4-intoxicated$ rabbits. SGPT activity stowed an apparant decreasing effect in 4 days, and the blood level of total cholesterol and total bilirubin in 6 days, and not in alkaline phosphatase level. L.S.J. exhibited more excellent hypoglycemic effect in alloxan-induced diabetes of rabbits, that is, significant to the control group after 2 days and adjacent to the normal level on 8th day. And SGPT activity and total cholesterol level were gradually decreased and showed markedly decreasing effect after 4 days.

• 대한기계학회논문집
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• 제12권4호
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• pp.790-805
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• 1988

본 연구에서는 유리섬유 강화 에폭시 복합재료의 파괴 강도와 피로 수명을 정 규분포, 로그 정규 분포와 2모수 및 3모수 Weibull 분포 함수의 기대값으로 살펴 보았 다. 2연속 응력 피로 실험 [작은 응력에서 큰 응력으로의 실험(low-high test), 큰 응력에서 작은 응력으로의 실험(high-low test)]의 결과도 분포 함수들을 사용하여 분 석하였다. 비통계학적 누적 손상 법칙들(non-statistical cumulative damage rules) 을 2연속 응력 피로 수명 분산 예측에 이용하기 위해서 동등 순위 가정(equal rank assumption)을 확장하여 수정하였다. 수정한 누적 손상 모형은 Miner의 법칙, Brou- tman과 Sahu의 손상모형 및 Hashin과 Rotem의 모형 등이다.

• 한국지진공학회논문집
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• 제23권1호
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• pp.9-18
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• 2019

In 2017 Pohang Earthquake, a number of residential buildings with pilotis at their first level were severely damaged. In this study, the results of an analytical investigation on the seismic performance and structural damage of two bearing wall buildings with pilotis are presented. The vibration mode and lateral force-resisting mechanism of the buildings with vertical and plan irregularity were investigated through elastic analysis. Then, based on the investigations, methods of nonlinear modeling for walls and columns at the piloti level were proposed. By performing nonlinear static and dynamic analyses, structural damages of the walls and columns at the piloti level under 2017 Pohang Earthquake were predicted. The results show that the area and arrangement of walls in the piloti level significantly affected the seismic safety of the buildings. Initially, the lateral resistance of the piloti story was dominated mainly by the walls resisting in-plane shear. After shear cracking and yielding of the walls, the columns showing double-curvature flexural behavior contributed significantly to the residual strength and ductility.

• 한국농림기상학회지
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• 제13권3호
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• pp.140-147
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• 2011

고온과 고광으로 인해 항산화요구도가 높은 8월 시기에 포플러클론들의 산화피해와 항산화반응에 대하여 양돈폐수의 영향에 대하여 알아보았다. 잎의 이온유출량과 항산화효소 APX와 GR의 활성, 그리고 카로테노이드 함량을 조사였다. 포플러클론의 양돈폐수 처리에 따른 산화피해와 항산화반응은 다양하게 나타났다. 산화스트레스로 인한 세포막 피해 수준을 알 수 있는 이온유출량 기준으로, 크게 세 그룹으로 분류하였다. 첫번째 그룹은 세포막 피해수준이 대조구보다 높게 나타난 클론들로서 Eco 28, 62-10, Bonghwa1, Dorskamp가 포함되었다. 이들 그룹은 양돈폐수 처리로 인한 고농도 질소함량이 스트레스로 작용하여 여름철 항산화요구도가 더욱 가중된 것으로 보인다. 그래서 결과적으로 활성산소에 대한 항상성을 유지하지 못하였다. 두번째 그룹은 세포막 피해수준이 대조구와 유사한 Suwon, 72-30, 72-31 이었다. 세 번째 그룹은 세포막 피해수준이 대조구보다 낮게 나타난 97-18 이었다. 97-18 클론의 경우 양돈폐수 처리로 인해 공급된 질소가 여름철 산화스트레스에 대한 피해를 경감시켜, 양돈폐수 처리로 인한 여름철 산화피해가 가장 적은 클론으로 나타났다. 이러한 결과들은 양돈폐수로 인한 고농도 질소가 클론마다 서로 다르게 작용할 수 있음을 의미한다. 생장시기인 여름철에 가중되는 산화피해는 전체 생중량에 영향을 주어 양돈폐수 정화능력에도 영향을 미칠 수 있을 것으로 생각된다. 그러나 이러한 부분에 대해 추후 연구가 더 필요하다.

• 한국지진공학회논문집
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• 제24권6호
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• pp.293-303
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• 2020

Seismic fragility was assessed for non-seismic reinforced concrete shear walls in Korean high-rise apartment buildings in order to implement an earthquake damage prediction system. Seismic hazard was defined with an earthquake scenario, in which ground motion intensity was varied with respect to prescribed seismic center distances given an earthquake magnitude. Ground motion response spectra were computed using Korean ground motion attenuation equations to match accelerograms. Seismic fragility functions were developed using nonlinear static and dynamic analysis for comparison. Differences in seismic fragility between damage state criteria including inter-story drifts and the performance of individual structural members were investigated. The analyzed building had an exceptionally long period for the fundamental mode in the longitudinal direction and corresponding contribution of higher modes because of a prominently insufficient wall quantity in such direction. The results showed that nonlinear static analyses based on a single mode tend to underestimate structural damage. Moreover, detailed assessments of structural members are recommended for seismic fragility assessment of a relatively low performance level such as collapse prevention. On the other hand, inter-story drift is a more appropriate criterion for a relatively high performance level such as immediate occupancy.

• Journal of Welding and Joining
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• 제9권1호
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• pp.40-47
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• 1991

The most fatigue tests carried out under the either stress or strain control, but machines and structures had taken variable stress. This variable stress was treated as statistics based on p-type distributions. In this paper, the cumulative fatigue damage of SM45C round bar specimens having a center hole resulting from block loading with p-distributions in rotating bending conditions, is presented. The value of p was changed in the range from 0.25 to 1; 0.25, 0.5, 0.75, 1. The following conclusions were obtained through the constant stress amplitude experiments and the block loading experiments. (1) In constant loading test, fatigue life was affected by cyclic rate. From experimental data, N$_{f}$ (100cpm)/N$_{f}$(3000cpm)equal to 0.56. (2) In case of the cyclic rate 100cpm and 3000cpm, at the high stress amplitude level the crack propagation life N$_{*}$f is longer than the low stress amplitude level. (3) Miner's hypothesis may be valid for p=0.75 and prediction of fatigue life by Haibach's method agree with experimental data well for the case p=0.5, while the modified Miner's method agree with experimental data well for the case p=0.25.5.