• Earthquakes and Structures
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• v.22 no.1
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• pp.83-94
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• 2022

In recent years, some studies have identified and quantified factors that can increase or decrease the seismic vulnerability of buildings. These modifier factors, related to the building characteristics and condition, are taken into account in the vulnerability assessment, by means of a numerical estimation resulting from the quantification of these modifiers through vulnerability indexes. However, views have differed on the definition and the quantification of modifiers. In this study, modifier parameters and scores of the Risk-UE Level 1 method are adjusted based on the Algerian seismic code recommendations and the reviews proposed in the literature. The adjusted modifiers and scores are applied to reinforced concrete (RC) buildings in Boumerdes city, in order to assess probable seismic damage. Comparison between estimated damage and observed damage caused by the 2003 Boumerdes earthquake is done, with the objective to (i) validate the model involving influence of the modifier parameters on the seismic vulnerability, and (ii) to define the relationship between modifiers and damage. This research may help planners in improving seismic regulations and reducing vulnerability of existing buildings.

• Journal of the Korea Concrete Institute
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• v.18 no.1 s.91
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• pp.37-46
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• 2006

The principal objective of this study is to assess the hierarchical effects of defects on the elastic stiffness properties at different levels of observation. In particular, quantitative damage measures which characterize the fundamental mode of degradation in the form of elastic damage provide quite insightful meanings at the level of constitutive relations and at the level of structures. For illustration, a total of three model problems of increasing complexity, a 1-D bar structure, a 2-D stress concentration problem, and a heterogeneous composite material made of a matrix with particle inclusions. Considering a damage scenario for the particle inclusions the material system degrades from a composite with very stiff inclusions to a porous material with an intact matrix skeleton. In other damage scenario for the matrix, the material system degrades from a composite made of a very stiff skeleton to a disconnected assembly of particles because of progressive matrix erosion. The trace-back and forth of tight bounds in terms of the reduction of the lowest eigenvalues are extensively discussed at different levels of observation.

• The Korean Journal of Physiology and Pharmacology
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• v.8 no.2
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• pp.95-100
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• 2004

Ischemic preconditioning (IPC) has been accepted as a heart protection phenomenon against ischemia and reperfusion (I/R) injury. The activation of ATP-sensitive potassium $(K_{ATP})$ channels and the release of myocardial nitric oxide (NO) induced by IPC were demonstrated as the triggers or mediators of IPC. A common action mechanism of NO is a direct or indirect increase in tissue cGMP content. Furthermore, cGMP has also been shown to contribute cardiac protective effect to reduce heart I/R-induced infarction. The present investigation tested the hypothesis that $K_{ATP}$ channels attenuate DNA strand breaks and oxidative damage in an in vitro model of I/R utilizing rat ventricular myocytes. We estimated DNA strand breaks and oxidative damage by mean of single cell gel electrophoresis with endonuclease III cutting sites (comet assay). In the I/R model, the level of DNA damage increased massively. Preconditioning with a single 5-min anoxia, diazoxide $(100\;{\mu}M)$, SNAP $(300\;{\mu}M)$ and 8-(4-Chlorophenylthio)-guanosine-3',5'-cyclic monophosphate (8-pCPT-cGMP) $(100\;{\mu}M)$ followed by 15 min reoxygenation reduced DNA damage level against subsequent 30 min anoxia and 60 min reoxygenation. These protective effects were blocked by the concomitant presence of glibenclamide $(50\;{\mu}M)$, 5-hydroxydecanoate (5-HD) $(100\;{\mu}M)$ and 8-(4-Chlorophenylthio)-guanosine-3',5'-cyclic monophosphate, Rp-isomer (Rp-8-pCPT-cGMP) $(100\;{\mu}M)$. These results suggest that NO-cGMP-protein kinase G (PKG) pathway contributes to cardioprotective effect of $K_{ATP}$ channels in rat ventricular myocytes.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.2
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• pp.52-62
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• 2013

A stochastic Markov process (MP) model has been developed for evaluating the probability of failure of the armor unit of rubble-mound breakwaters as a function of time. The mathematical MP model could have been formulated by combining the counting process or renewal process (CP/RP) on the load occurrences with the damage process (DP) on the cumulative damage events, and applied to the armor units of rubble-mound breakwaters. Transition probabilities have been estimated by Monte-Carlo simulation (MCS) technique with the definition of damage level of armor units, and very well satisfies some conditions constrained in the probabilistic and physical views. The probabilities of failure have been also compared and investigated in process of time which have been calculated according to the variations of return period and safety factor being the important variables related to design of armor units of rubble-mound breakwater. In particular, it can be quantitatively found how the prior damage levels can effect on the sequent probabilities of failure. Finally, two types of methodology have been in this study proposed to evaluate straightforwardly the repair times which are indispensable to the maintenance of armor units of rubble-mound breakwaters and shown several simulation results including the cost analyses.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.2
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• pp.126-132
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• 2010

An approach to calculating expected damage of breakwater assisted by artificial neural network was developed. Wave height in front of a breakwater was predicted by a trained artificial neural network with inputs of wave height in deep ocean and tidal level. Prediction results by the neural network can be comparable to that by professional numerical model for wave transformation. Using the wave prediction neural network, it was very easy and fast to obtain a number of significant waves at breakwater and finally analysis time for expected damage can be shortened. In addition, the effect of considering tidal level in the calculation of expected damage was revealed by comparing the expected damages with and without tidal variation. Therefore, it was pointed out that tidal variation should be considered to improve prediction accuracy.

• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.544-549
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• 2012

To examine the neuroprotective effects of ginsenoside R0, we investigated the effects of ginsenoside R0 in PC12 cells under an anoxic or oxidative environment with Edaravone as a control. PC12 neuroendocrine cells were used as a model target. Anoxic damage or oxidative damage in PC12 cells were induced by adding sodium dithionite or hydrogen peroxide respectively in cultured medium. Survival ratios of different groups were detected by an AlamarBlue assay. At the same time, the apoptosis of PC12 cells were determined with flow cytometry. The putative neuroprotective effects of ginsenoside R0 is thought to be exerted through enhancing the activity of antioxidant enzymes Superoxide dismutases (SOD). The activity of SOD and the level of malondialdehyde (MDA) and intracellular reactive oxygen species (ROS), were measured to evaluate the protective and therapeutic effects of ginsenoside R0. Ginsenoside R0 treated cells had a higher SOD activity, lower MDA level and lower ROS, and their survival ratio was higher with a lower apoptosis rate. It is suggested that ginsenoside R0 has a protective effect in the cultured PC12 cells, and the protection efficiency is higher than Edaravone. The protective mechanisms of these two are different. The prevent ability of ginsenoside R0 is higher than its repair ability in neuroprotection in vitro.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.1
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• pp.107-114
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• 2018

In this study, the damage detection method is proposed for the rotational stiffness of connections in steel moment frames by using artificial neural network(ANN). The flexural moment of columns, natural frequencies, modeshapes are used for the input layer in ANN while the damage index, that signify the damage level, is used for the output layer in ANN. The 5-story steel moment frame as an example structure is used to generate the train and test data. Total number of damage scenarios considered is 829. From the results of application, it is shown that the proposed method can accurately estimate the location and level of damages.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.5 no.1
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• pp.1-10
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• 1995

Congruent $LiNbO_3$ single crystals and $LiNbO_3$ : Mg single crystals, having high resistance to optical damage, doped with MgO to the levels of 2.0, 5.0 and 7.0 mol% were grown successfully by CZ method and optical damage of each crystal was measured by compen. sation method. With doping level reaching about 5 mol%, there was an abrupt change in the features of optical absorption edge and $OH^-$ absorption band. From these data, we confirmed indirectly the threshold in MgO doping level. When the MgO doping amount reaches about 5 mol% in the melt, $Mg^{2+}$ occupies Nb site and becomes $Mg_{Nb}^{2+}$, resulting in the sharp increase of optical damage resistance. The optical damage resistance of $LiNbO_3$ : Mg was improved more than three times when MgO amount in the melt reaches 5 mol%.

• Journal of the Earthquake Engineering Society of Korea
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• v.20 no.6
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• pp.391-400
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• 2016

For earthquake loss estimation of building structures in Gangnam-Gu district in Seoul, three scenario earthquakes were selected by comparison of the response spectra of these scenario earthquakes with the design spectrum in Korean Building Code (KBC 2009), and then direct losses of the building structures in the Gangnam-Gu district under each scenario earthquake are estimated. The following conclusions are drawn from the results of damage and loss in the second scenario earthquake, which has a magnitude = 6.5 and epicentral distance =15 km: (1) The ratio of building stocks undergoing the extensive and complete damage level is 40.0% of the total. (2) The amount of direct economic losses appears approximately 19 trillion won, which is 1.2% of the national GDP of Korea. (3) About 25% of high-rise (over 10-story) RC building wall structures, were inflicted with the damage exceeding moderate level, when compared to 60% of low-rise building structures. (4) From the economical view point, the main loss, approximately 50%, was caused by the damage in the high-rise RC wall building structures.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.573-584
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• 2021

The purpose of this study is to investigate the factors that affect the discrimination of low-income children among children in the community children's centers. The subjects of the survey were 6th grade elementary school students who were the third respondents of the second Child Panel Survey of the community children's center, among them, 355 children whose family economy level corresponds to basic living allowance, next level, and blind spot. SPSS Statistics 25.0 was used to analyze exploratory factors, reliability analysis, frequency analysis, descriptive statistics, correlation analysis, and multiple regression analysis. The results of this study showed that single parent family, parent social capital, parental abuse, and happiness had a significant effect on the discrimination damage of low-income children in community children's centers. The more one parent's family, the less the parent's role as a counterpart to the discussion, and the more the parental abuse, the higher the child's discrimination damage. In general, parents-related factors were affecting the discrimination damage of low-income children. Community children's centers and related institutions should focus on developing and implementing programs that can improve the quality of family relations of children.