• Environmental Analysis Health and Toxicology
• /
• v.31
• /
• pp.19.1-19.7
• /
• 2016

A large portion of the Korean population has been exposed to toxic humidifier disinfectants (HDs), and considering that the majority of the victims are infants, the magnitude of the damage is expected to be considerably larger than what has currently been revealed. The current victims are voicing problems caused by various diseases, including but not limited to lung, upper respiratory tract, cardiovascular, kidney, musculoskeletal, eye, and skin diseases, etc. However, there has been difficulty in gaining validation for these health problems and identifying causal relationships due to lack of evidence proving that toxic HD is the specific causes of extrapulmonary diseases such as allergic rhinitis. Furthermore, the victims and bereaved families of the HD case have not received any support for psychological distress such as post-traumatic stress disorder, depression, feelings of injustice, and anger caused by the trauma. In addition, because the underlying mechanisms of the toxic materials within the HDs such as polyhexamethylene guanidine phosphate, poly(oxyalkylene guanidine) hydrochloride, chloromethylisothiazolinone /methylisothiazolinone have yet to be determined, the demand for information regarding the HD issue is growing. The victims of the HD cases require support that goes beyond financial aid for medical costs and living expenses. There is a desperate need for government-led integrated support centers that provide individualized support through health screenings; in other words, we need an integrated facility that provides the appropriate social support to allow the victims to recover their physical and mental health, so as to well prepare them to return to a normal life. The implementation of such a plan requires not only the close cooperation between those departments already directly involved such as the Ministry of Environment and the Ministry of Health and Welfare, but also active support on a national scale from pan-governmental consultative bodies.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.16 no.6
• /
• pp.103-108
• /
• 2016

The size of urban areas is currently growing and the functions of cities are becoming increasingly complicated. Furthermore, more people are living in cities. The life of urban is getting closer and linked with neighboring people in many parts. In particular, people are making artificial noise, even though it might not consciously be noticed, in their daily live. Seoul is the most crowded place in Korea and the noise levels are 73dB or higher. People living in cities are exposed to noise pollution. In particular, loudspeakers used during demonstrations or to generate publicity, cause considerable noise, which in turn can be related to stress. Moreover, the noise restrictions defined by law are not adhered to. If enhanced noise regulations, no matter how residents are not forced to be a great stress field close to the noise and reduces the loudness -5dB do not feel well if the difference. Limiting the duration of noise rather than reducing the volume thus is a much more plausible way of reducing the damage caused by noise pollution. If the stress caused by the noise, you will see people or vehicles holding a megaphone at the roadside is not good for health if it may be a wise way to live that is getting rid of the noise pollution so quickly out of the area.

• Environmental Mutagens and Carcinogens
• /
• v.22 no.3
• /
• pp.142-148
• /
• 2002

Although ionizing radiation (IR) has been used to treat the various human cancers, IR is cytotoxic not only to cancer cells but to the adjacent normal tissue. Since normal tissue complications are the limiting factor of cancer radiotherapy, one of the major concerns of IR therapy is to maximize the cancer cell killing and to minimize the toxic side effects on the adjacent normal tissue. As an attempt to develop a method to monitor the degree of radiation exposure to normal tissues during radiotherapy, we investigated the transcriptional responses of human peripheral blood lymphocytes (PBL) following IR using cDNA microarray chip containing 1,221 (1.2 K) known genes. Since conventional radiotherapy is delivered at about 24 h intervals at 180 to 300 cGy/day, we analyzed the transcriptional responses ex-vivo irradiated human PBL at 200 cGy for 24 h-period. We observed and report on 1) a group of genes transiently induced early after IR at 2 h, 2) of genes induced after IR at 6 h, 3) of genes induced after IR at 24 h and on 4) a group of genes whose expression patters were not changed after IR. Since Biological consequences of IR involve generation of various reactive oxygen species (ROS) and thus oxidative stress induced by the ROS is known to damage normal tissues during radiotherapy, we further tested the temporal expression profiles of genes involved in ROS modulation by RT-PCR. Specific changes of 6 antioxidant genes were identified in irradiated PBL among 9 genes tested. Our results suggest the potential of monitoring post-radiotherapy changes in temporal expression profiles of a specific set of genes as a measure of radiation effects on normal tissues. This type of approach should yield more useful information when validated in in vivo irradiated PBL from the cancer patients.

• Journal of the Korea Convergence Society
• /
• v.4 no.2
• /
• pp.29-33
• /
• 2013

From one elementary school of last 2005 Pusan was started "the school police" system is being applied the effect in the elementary school of the human nature receiving entire country. But "with school police system " have a limit about manpower that is insufficient. So we try to make "Baumter-Gikimy " that is extended scollo police in seoul. Despite being like that at 2010 and 2011 cannot forget the elementary student suicide events which are shocking or sexual assault events occur from the campus.From elementary school 4 grade the students between junior high school 1 grade crime occurrence ratio are highest. These people the group leaving out mainly, suicide, with group violence and sexual assault problem gets up same problems. In order to solve like this problems stands the countermeasure of the dimension which is national certainly is necessary. But so far only the damage student and the parents have an interest in about like this problems and they hurt. We the smart phone of Android bases it will be able to solve like this problem points [ayp] from under planning and development boil the elementary student safe helper it will can use. When it uses the elementary student safe helper system which we propose before the accident occurs, it will grasp the state information of the student and it will be able to prevent an accident in advance. We will try to more efficient safe guard to elementary school student by real-time monitoring skill soon.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.24 no.5
• /
• pp.816-828
• /
• 1995

During the industrial preparation and the storage of foods, the side chain of some protein-bound amino acids can react chemically each other or with other molecules present in the food. The following reactions have been described : destruction of amino acids, racemization, protein-protein interactions, reactions of proteins with reducing sugars, oxidizing agents, or polyphenols. Apart from total destruction, the main reacitons are the forming of Maillard reactions products(e.g. fructoselysine) and the crosslinking with other amino acids in the same or in another protein molecule(e.g. lysinoalanine). The most often involved amino acid is lysine because of its free functional ${\varepsilon}-amino$ acid group. Generally derivatives of amino acids or crosslinks in polypeptides influence the bioavailability and the overall digestibility of the protein. This work reviews the technological, analytical, nutritional, and physiological problems related to the formation of fructoselysine and lysinolalnine in human foods, and evaluates the possible health risk for humans. A summary of the available information is of help in considering whether or not the presence of fructoselysine/lysinoalanine in foods represents a danger to man. The reduction in protein quality through these reactions is not a problem for the general population, but it is extremely important in infant foods, since infants are often nourished with a limited number of food product(e.g. formular foods) which are sensitive to the Mailard reaction.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.34 no.1
• /
• pp.135-143
• /
• 2014

This study classified abnormal sea surface temperature changes of the central pacific region according to three evolution patterns. Focusing on typhoons that affect the Korean Peninsula, the research analyzed typhoon's occurrence spot and track, change in the central pressure characteristics, and the characteristics of change in typhoon precipitation and the number of occurrences of heavy rainfall in the Nakdong River Basin. As a result of analysis, in case of prolonged-decaying years and symmetric-decaying years, typhoon-related summer rainfall and heavy rainy days appeared to be higher than long-term average. But in case of abrupt-decaying years, the pattern of general decrease appeared. This is because typhoon's occurrence spot is located comparatively near the Korean peninsula, typhoon's central pressure is high, and typhoon's route generally moves to Japan. As the outcome, this study is expected to reduce flood damage through analyzing the characteristics of typhoon's activity according to CP El Ni$\tilde{n}$o evolution patterns and the characteristics of local typhoon rainfall. In addition, it is expected to provide useful information for establishing adaptation and mitigation to climate change.

• The Journal of Engineering Geology
• /
• v.26 no.1
• /
• pp.129-142
• /
• 2016

National parks, which are located mainly in mountainous areas, are always at risk of damage by landslides. The goal of this study is to establish a method for systematically maintaining hazardous steep slopes along trails in national parks. We produced a checklist suitable for each of the 19 national parks nationwide and investigated 183 slopes. The aim of these investigations is to recommend appropriate slope-stability countermeasures, including field investigations and stability analysis. We made preliminary investigations at specific sites, evaluating the slope hazard using specialized equipment such as terrestrial LiDAR. An investment priority formula was developed, and ranking and hazardous grades were calculated as part of a long-term maintenance plan. Finally, to systematically manage dangerous slopes and to house all the field data within one system, we developed the "Slope Maintenance System in National Parks" based on web server that can show various information for slopes.

• Journal of Internet Computing and Services
• /
• v.11 no.6
• /
• pp.135-144
• /
• 2010

Apple recently announced a new policy about software development kit that banned the use of tools that convert apps built on other platforms into iPhone apps. Therefore, Adobe cannot develop their software to AppStore that inquire to the Department of Justice and the Federal Trade Commission about antitrust actions. Someone argue that Apple try to exclusive smartphone market such as the Microsoft antitrust lawsuit in 1998, but this case is essentially different. First, it need to define Apple's software development kit for iPhone and iPad is whether antitrust or not. Because of the characteristics of two-sided market in Smartphone Apple's iPhone cannot monopoly in cellphone or smartphone market, but it can be an antitrust in application store market. However, Apple re-announced new software development kit policy that shows positive results. Instead of hastily intervened regulatory agencies, the DOJ or the FTC, it is quite desirable that watching the interaction between companies that whether market failures or not and if it's harmful for consumer's benefit. Adobe attack Apple to advocate consumers and developers freedom of choice, but the most important thing is conclusion based on a comprehensive analysis need to objective point of view that Apple do whether antitrust act or not and damage to developers and consumers who are both side of platform.

• Archives of Plastic Surgery
• /
• v.41 no.6
• /
• pp.654-660
• /
• 2014

Background Reactive oxygen species (ROS) damages cell molecules, and modifies cell signaling. The nuclear factor E2-related factor (Nrf2) is a critical transcription regulator, which protects cells against oxidative damage. Nrf2 expression is increased in a large number of cancers. However, little information has been reported regarding the expression of Nrf2 in skin cancers. Hence, we explored the expression of Nrf2 protein in skin cancers. Methods The Nrf2 protein expression in 24 specimens, including 6 malignant melanomas (MM), 6 squamous cell carcinomas (SCC), 6 basal cell carcinomas (BCC), and 6 normal skin tissues, was evaluated by western blotting. Immunohistochemical staining was performed. The expression of Kelch-like ECH-associated protein 1 (Keap1), the key regulator of Nrf2, was also analyzed by western blotting. Results Small interfering RNA transfection to the melanoma cell line G361 confirmed that an approximately 66 kDa band was the true Nrf2 band. The western blot revealed that the Nrf2 protein was definitely expressed in normal skin tissues, but the Nrf2 expression was decreased in MM, SCC, and BCC. Immunohistochemical examination showed that expression of Nrf2 was decreased in all skin cancer tissues compared to the normal skin tissues. Keap1 was not expressed in all malignant skin tumors and normal skin tissues by western blot. Conclusions ROS was increased in various types of cancers which proteins were highly expressed or underexpressed. This study demonstrated that the expression of Nrf2 protein was down-regulated in human malignant skin tumors. We suggest that decreased expression of Nrf2 is related to skin cancers.

• Journal of Korea Water Resources Association
• /
• v.44 no.11
• /
• pp.875-887
• /
• 2011

The objective of this study is to develop and evaluate a Korean threshold runoff computation method. The selected study area is the Han-River basin and the stream channels in the study area are divided into 3 parts; natural channel and artificial manmade channel for small mountainous catchments, and main channel for master stream. The threshold runoff criteria for small streams is decided to 0.5 m water level increase from the channel bottom, which is the level that mountain climbers and campers successfully escape from natural flood damage. Threshold runoff values in natural channel of small mountainous area are computed by the results from the regional regression analysis between parameters of basin and stream channel, while those in artificial channel of small mountainous area are obtained from the data of basin and channel characteristics parameter. On the other hand, the threshold runoff values for master channel are used the warning flood level that is useful information for escaping guideline for riverside users. For verification of the threshold runoff computation method proposed in this study, three flash flood cases are selected and compared with observed values, which is obtained from SCS effective rainfall computation. The 1, 3, 6-hour effective rainfall values are greater than the corresponding threshold runoff values represents that the proposed computation results are reasonable.