• Journal of the Korean Society for Precision Engineering
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• v.23 no.6 s.183
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• pp.44-51
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• 2006

This paper deals with the aspects of die design for the multistage fine tooth hub gear in the cold forging process. In order to manufacture the cold forged product for the precision hub gear used as the ARD 370 system of bicycle, it examines the influences of different designs on the metal flow through experiments and FE-simulation. To find the combination of design parameters which minimize the damage value, the low gear length, upper gear length and inner diameter as design parameters are considered. An orthogonal fraction factorial experiment is employed to study the influence of each parameter on the objective function or characteristics. The optimal punch shape of fine tooth hub gear is designed using the results of FE-simulation and the artificial neural network. To verify the optimal punch shape, the experiments of the cold forging of the hub gear are executed.

• Korean Journal of Clinical Laboratory Science
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• v.39 no.3
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• pp.190-195
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• 2007

In the present study, the author investigated to the cytotoxocity in cultured rat hepatocytes of Viscum album lectin. The cytotoxcity effect in Viscum album lectin on the activity of LDH was also investigated. Viscum album lectin significantly increased LDH leakage into medium of hepatocytes treated or untreated with $CCl_4$ (p<0.001). However, Viscum album lectin significantly increased LDH leakage from $CCl_4$-induced hepatocyte (p<0.001). There was a significant increase in LDH levels relative to the control group. Histological observation basically supported the result obtained from LDH assay. The livers of rats challenged with $CCl_4$ produced a marked increased cytoplasmic vacuoles and inflammatory cells in number, while the number of necrotic cells and swollen hepatocytes did not change significnatly. Rats administered DMSO alone did not alter the normal hepatic architecture. Histological observation of liver section in rat treated 72 hrs with either Viscum album lectin $CCl_4$-induced liver damage showed number of cytoplasmic vaculoe and necrotic cell. The number of inflammatory cell increased markedly. This results suggest to the conclusion that Viscum album lectin has a effect of hepatotoxicity activator.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.4739-4743
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• 2014

Nanotechnology is an emerging field with many promising applications in drug delivery systems. Because of outstanding developments in this field, rapidly increasing research is directed to the development of nanocarriers that may enhance the availability of drugs to the target sites. Substantial fraction of information has been added into the existing scientific literature focusing on the fact that nanoparticles usually generate reactive oxygen species to a greater extent than micro-sized particles. It is worth mentioning that oxidative stress regulates an array of cell signaling cascades that resulted in cancer cell damage. Accumulating experimental evidence over the years has shown that wide-ranging biological mechanisms are triggered by these NPs in cultured cells due to the unique properties of engineered nanoparticles. In this review, we have attempted to provide an overview of the signaling cascades that are activated by oxidative stress in cancer cells in response to different kinds of nanomaterials, including quantum dots, metallic and polymeric nanoparticles.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.186-191
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• 2001

Tensile residual stress happen by difference of coefficients of thermal expansion between fiber and matrix is one of the serious problems in metal matrix composite(MMC). In this study, TiNi alloy fiber was used to solve the problem of the tensile residual stress as the reinforced material. TiNi alloy fiber improves the tensile strength of composite by occurring compressive residual stress in matrix using shape memory effect of it. Pre-strain was added to generate compressive residual stress inside TiNi/A16061 shape memory alloy(SMA) composite. It was also evaluated the effect of compressive residual stress corresponding to pre-strains variation and volume fraction of TiNi alloy. AE technique was used to clarify the microscopic damage behavior at high temperature and the effect of pre-strain difference of TiNi/A16061 SMA composite. In addition, two dimensional AE source location technique was applied to inspect the crack initiation and propagation in composite.

• Korean Journal of Pharmacognosy
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• v.33 no.3 s.130
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• pp.252-256
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• 2002

In the previous study, we demonstrated that ginsenoside $Rb_1$ isolated from the butanol fraction of the head of Panax ginseng had significant gastroprotective activity on gastritis and gastric ulcer models in rats. It has been well established that drugs to have capacity of scavenging or inhibiting the generation of reactive oxygen radicals prevent the gastric mucosal injury. Ginsenoside $Rb_1$ was tested on HCl ethanol-induced gastritis in rats, DPPH-induced free radical scavenging effect, MDA assay, GSH activity, and SOD activity in gastric tissue. It showed significant inhibition in HCl ethanol-induced gastritis, and al~o significantly increase of GSH activated SOD. We speculate that the protective effect of ginsenoside $Rb_1$ against HCl ethanol-induced gastric mucosal damage is originated from the increase of GSH and the activation of SOD.

• Earthquakes and Structures
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• v.17 no.6
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• pp.567-575
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• 2019

In order to investigate the dynamic impact resistance of steel fiber reinforced full light-weight concretes, we implemented drop weight impact test on a total of 6 reinforced beams with 0, 1 and 2%, steel fiber volume fraction. The purpose of this test was to determine the failure modes of beams under different impact energies. Then, we compared and analyzed the time-history curves of impact force, midspan displacement and reinforcement strain. The obtained results indicated that the deformations of samples and their steel fibers were proportional to impact energy, impact force, and impact time. Within reasonable ranges of parameter values, the effects of impact size and impact time were similar for all volumetric contents of steel fibers, but they significantly affected the crack propagation mechanism and damage characteristics of samples. Increase of the volumetric contents of steel fibers not only effectively reduced the midspan displacement and reinforcement strain of concrete samples, but also inhibited crack initiation and propagation such that cracks were concentrated in the midspan areas of beams and the frequency of cracks at supports was reduced. As a result, the tensile strength and impact resistance of full light-weight concrete beams were significantly improved.

• Steel and Composite Structures
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• v.28 no.3
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• pp.349-362
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• 2018

This paper presents a semi-analytical solution for the creep analysis and life assessment of 304L austenitic stainless steel thick truncated conical shells using multilayered method based on the first order shear deformation theory (FSDT). The cone is subjected to the non-uniform internal pressure and temperature gradient. Damages are obtained in thick truncated conical shell using Robinson's linear life fraction damage rule, and time to rupture and remaining life assessment is determined by Larson-Miller Parameter (LMP). The creep response of the material is described by Norton's law. In the multilayer method, the truncated cone is divided into n homogeneous disks, and n sets of differential equations with constant coefficients. This set of equations is solved analytically by applying boundary and continuity conditions between the layers. The results obtained analytically have been compared with the numerical results of the finite element method. The results show that the multilayered method based on FSDT has an acceptable amount of accuracy when one wants to obtain radial displacement, radial, circumferential and shear stresses. It is shown that non-uniform pressure has significant influences on the creep damages and remaining life of the truncated cone.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2017.05a
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• pp.254-255
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• 2017

The aim of this study is to investigate the impact resistant performance of steel short fiber-reinforced cement based composites (SFRCCs) containing 1.0, 1.5, 2.0 and 3.0% volume fraction of steel short fibers subjected to high velocity impact of steel projectile (the diameter of 19.05mm and the mass of 28.13g). The gunpowder impact facility was used for impact tests, and the impact velocity was from about 350 to 700m/s. The specimens were damaged in various failure modes, which are penetration, scabbing, and perforation. Comparing with Plain specimen, SFRCCs have superior capacity on the scabbing limit, and slightly bulged in the back side under the impact velocity of 700m/s. In addition, the impact resistant performance of SFRCCs improved with increase of steel short fiber volume ratio. The fibers play an important role in controlling the local damage of SFRCCs.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2002.10a
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• pp.155-155
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• 2002

Ambient urban particulate matters contain various transition metals. When the particulate matters are inhaled into the lung, not all but some part of metals from the particles might be mobilized to participate in a reaction that can damage various biomolecules, such as DNA and proteins. The dust particle size as well as organic acids may influence the metal mobilization. Thus, the mobilization of the metal from SRM1648 (NIST, USA) and urban particulate matters (PM2.5 and PM10) was measured in the presence of artificial or biological chelator with or without reductant. The degree of the mobilization was higher with the artificial or biological chelator than the control with saline. In some cases, a reductant increased the mobilization as much as about 5 times the control without the reductant. Especially, the mobilization of Fe was greatly influenced by the presence of reductants. In general, the degree of the mobilization of the transition metal was higher with PM2.5 than with PM10. Therefore, it is expected that, considering the previously known toxicities of the transition metals, the PM2.5 is more damaging to various biomolecules than PM10. The results also suggest that not the total amount but the mobilizable fraction of the metal in the dust particles should be considered with regard to the toxicity of the urban particulate matters.

• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.192-198
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• 2007

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a major constituent of rhubarb. Although it has been claimed to have a wild spectrum of therapeutic value, its side effects, especially in human kidney cells have not been well characterized. In this study, we have carried out in vitro genetic toxicity test of emodin and microarray analysis of differentially expressed genes in response to emodin. The result of Ames test showed mutations with emodin treatment in base substitution strain TA1535 both with and without exogenous metabolic activation. Likewise, emodin showed mutations in frame shift TA98 both with and without exogenous metabolic activation. The result of COMET assay in L5178Y cells with emodin treatment showed DNA damage both with and without exogenous metabolic activation. Emodin did not increase micronuclei in CHO cells both with and without exogenous metabolic activation. 150 Genes were selected as differentially expressed genes in response to emodin by microarray analysis and these genes would be candidate biomarkers of genetic toxic action of emodin.