• Molecules and Cells
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• 제43권2호
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• pp.121-125
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• 2020

The identification of adult stem cells is challenging because of the heterogeneity and plasticity of stem cells in different organs. Within the same tissue, stem cells may be highly proliferative, or maintained in a quiescent state and only to be activated after tissue damage. Although various stem cell markers have been successfully identified, there is no universal stem cell marker, which is exclusively expressed in all stem cells. Here, we discuss the roles of master developmental regulator RUNX1 in stem cells and the development of a 270 base pair fragment of the Runx1 enhancer (eR1) for use as stem cell marker. Using eR1 to identify stem cells offers a distinct advantage over gene promoters, which might not be expressed exclusively in stem cells. Moreover, RUNX1 has been strongly implicated in various cancer types, such as leukemia, breast, esophageal, prostate, oral, skin, and ovarian cancers-it has been suggested that RUNX1 dysfunction promotes stem cell dysfunction and proliferation. As tissue stem cells are potential candidates for cancer cells-of-origin and cancer stem cells, we will also discuss the use of eR1 to target oncogenic gene manipulations in stem cells and to track subsequent neoplastic changes.

• The Journal of Korean Medical History
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• 제26권1호
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• pp.27-39
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• 2013

The Theory of Meridian can be classified into early form of pre- and present form of after-. The representative early form of meridian is Eleven Meridians in Mawangdui scrolls(馬王堆帛書) which use Six Qi Diagnosis(六氣辨證). because it did not adopt Visceral Pattern Identification(臟腑辨證). The present form of meridian is Twelve Meridians of . It has developed to investigate relations between Visceral and disease with Five Phase Theory. Analyzing the name of the Six Meridians in the Shanghanlun(傷寒論)On Cold Damage, there are no hands, feet and visceral signs. and it is almost identical to Eleven Meridians in Mawangdui scrolls. According to , Eleven Meridians use only Six Foot Meridians(足六經) to classify diseases. This fact was applied identically to the Six Meridians in the Shanghanlun. Therefore many doctors, especially Hanzhihe(韓祗和) and Zhangzhicong(張志聰) mentioned that "I have never seen a book on Shanghanlun discuss about Hand Meridians(手經)."

• Animal cells and systems
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• 제5권2호
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• pp.139-143
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• 2001

Alzheimer's disease is the most common form of dementia and no cure is known so far. Extensive genetic works and in vitro experiments combined with clinical observations link amyloid $\beta$--protein (A$\beta$-) to the pathogenesis of Alzheimer's disease (AD). It was hypothesized that $A\beta$- becomes toxic when it adopts a fibrillar conformation. Recently, non-fibrillar form of $A\beta$- was observed and the potential role in the pathogenesis of AD became an interesting subject. In this study, the cytotoxicity of non-fibrillar $A\beta$- and fibrillar $A\beta$- was compared on oxidative stress, membrane damage, or nucleosome break down. Non-fibrillar $A\beta$- was not toxic in peripheral nervous system-derived cells but significantly toxic in central nervous system-derived cells while fibrillar $A\beta$- was non-selectively toxic in both cell culture. The neurotoxicity of non-fibrillar $A\beta$- was reproduced in semi-in vivo culture of mouse brain slice. In conclusion, non-fibrillar $A\beta$- could be more relevant to the selective neurodegeneration in Alzheimer's brains than fibrillar $A\beta$- and further research needs to be done for identification of the cause of AD.

• International Journal of Computer Science & Network Security
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• 제21권8호
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• pp.1-12
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• 2021

An operation of an organization is currently using a digital environment which opens to potential cyber-attacks. These phenomena become worst as the cyberattack landscape is changing rapidly. The impact of cyber-attacks varies depending on the scope of the organization and the value of assets that need to be protected. It is difficult to assess the damage to an organization from cyberattacks due to a lack of understanding of tools, metrics, and knowledge on the type of attacks and their impacts. Hence, this paper aims to identify domains and sub-domains of cyber-attack taxonomy to facilitate the understanding of cyber-attacks. Four phases are carried in this research: identify existing cyber-attack taxonomy, determine and classify domains and sub-domains of cyber-attack, and construct the enhanced cyber-attack taxonomy. The existing cyber-attack taxonomies are analyzed, domains and sub-domains are selected based on the focus and objectives of the research, and the proposed taxonomy named AVOIDITALS Cyber-attack Taxonomy is constructed. AVOIDITALS consists of 8 domains, 105 sub-domains, 142 sub-sub-domains, and 90 other sub-sub-domains that act as a guideline to assist administrators in determining cyber-attacks through cyber-attacks pattern identification that commonly occurred on digital infrastructure and provide the best prevention method to minimize impact. This research can be further developed in line with the emergence of new types and categories of current cyberattacks and the future.

• Nuclear Engineering and Technology
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• 제53권2호
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• pp.498-508
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• 2021

Micro reactors are increasingly being considered for utilization as distributed power sources. Hence, the probabilistic safety assessment (PSA) of a direct supercritical-CO₂-cooled fast reactor, called micro modular reactor (MMR), was performed in this study; this reactor was developed using innovative design concepts. It adopted a modular design and passive safety systems to minimize site constraints. As the MMR is in its conceptual design phase, design weaknesses and valuable safety insights could be identified during PSA. Level 1 internal event PSA was carried out involving literature survey, system characterization, identification of initiating events, transient analyses, development of event trees and fault trees, and quantification. The initiating events and scenarios significantly contributing to core damage frequency (CDF) were determined to identify design weaknesses in MMR. The most significant initiating event category contributing to CDF was the transients with the power conversion system initially available category, owing to its relatively high occurrence frequency. Further, an importance analysis revealed that the safety of MMR can be significantly improved by improving the reliability of reactor trip and passive decay heat removal system operation. The findings presented in this paper are expected to contribute toward future applications of PSA for assessing unconventional nuclear reactors in their conceptual design phases.

• Journal of the Earthquake Engineering Society of Korea
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• 제25권3호
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• pp.93-102
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• 2021

The dynamic characterization of a three-story auxiliary building in a nuclear power plant (NPP) constructed with a monolithic reinforced concrete shear wall is investigated in this study. The shear wall is subjected to a joint-research, round-robin analysis organized by the Korea Atomic Energy Research Institute, South Korea, to predict seismic responses of that auxiliary building in NPP through a shake table test. Five different intensity measures of the base excitation are applied to the shaking table test to get the acceleration responses from the different building locations for one horizontal direction (front-back). Simultaneously to understand the global damage scenario of the structure, a frequency search test is conducted after each excitation. The primary motivation of this study is to develop a nonlinear numerical model considering the multi-layered shell element and compare it with the test result to validate through the modal parameter identification and floor responses. In addition, the acceleration amplification factor is evaluated to judge the dynamic behavior of the shear wall with the existing standard, thus providing theoretical support for engineering practice.

• The Plant Pathology Journal
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• 제35권1호
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• pp.19-31
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• 2019

Bud rot (BR) is the most devastating disease affecting oil palm (Elaeis guineensis) crops in Colombia. Its causal agent, Phytophthora palmivora, initiates the infection in immature oil palm leaflets producing necrotic lesions, followed by colonization of opportunistic necrotrophs, which increases disease damage. To improve the characterization of the disease, we transformed P. palmivora using Agrobacterium tumefaciens-mediated transformation (ATMT) to include the fluorescent proteins CFP-SKL (peroxisomal localization), eGFP and mRFP1 (cytoplasmic localization). The stability of some transformants was confirmed by Southern blot analysis and single zoospore cultures; additionally, virulence and in vitro growth were compared to the wild-type isolate to select transformants with the greatest resemblance to the WT isolate. GFP-tagged P. palmivora was useful to identify all of the infective structures that are commonly formed by hemibiotrophic oomycetes, including apoplastic colonization and haustorium formation. Finally, we detected cell death responses associated with immature oil palm tissues that showed reduced susceptibility to P. palmivora infection, indicating that these tissues could exhibit age-related resistance. The aim of this research is to improve the characterization of the initial disease stages and generate cell biology tools that may be useful for developing methodologies for early identification of oil palm materials resistant or susceptible to BR.

• Journal of Information Processing Systems
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• 제15권4호
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• pp.797-819
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• 2019

Internet of Things (IoT) is the paradigm of network of Internet-connected things as objects that constantly sense the physical world and share the data for further processing. At the core of IoT lies the early technology of radio frequency identification (RFID), which provides accurate location tracking of real-world objects. With its small size and convenience, RFID tags can be attached to everyday items such as books, clothes, furniture and the like as well as to animals, plants, and even humans. This phenomenon is the beginning of new applications and services for the industry and consumer market. IoT is regarded as a fourth industrial revolution because of its massive coverage of services around the world from smart homes to artificial intelligence-enabled smart driving cars, Internet-enabled medical equipment, etc. It is estimated that there will be several dozens of billions of IoT devices ready and operating until 2020 around the world. Despite the growing statistics, however, IoT has security vulnerabilities that must be addressed appropriately to avoid causing damage in the future. As such, we mention some fields of study as a future topic at the end of the survey. Consequently, in this comprehensive survey of IoT, we will cover the architecture of IoT with various layered models, security characteristics, potential applications, and related supporting technologies of IoT such as 5G, MEC, cloud, WSN, etc., including the economic perspective of IoT and its future directions.

• Korean Journal of Veterinary Service
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• 제42권2호
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• pp.117-120
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• 2019

Bovine viral diarrhea Virus (BVDV) infections cause respiratory, gastrointestinal, and reproductive problems, such as infertility, abortion, stillbirth, and sickly offspring. Many countries have reduced the economic damage through the application of different control programmes, and some have successfully eradicated BVD. Detection and elimination of cattle persistently infected (PI) with BVDV is important for BVD eradication because PI cattle are a main source of BVD transmission. In this study, the prevalence of Korean native cattle persistently infected (PI) with BVDV was investigated and determined in 49 farms with 3,050 cattle. The all samples were collected by ear notch sampling. Korean native cattle with initial positives on antigen-ELISA (Ag-ELISA) were sampled again after 3~4 weeks and cattle with second positives in both Ag-ELISA and immunohistochemistry (IHC) were identified as PI cattle. Among the 49 farms, 14 (28.6%) farms had at least more than one PI cow and 21 (0.69%) of 3,050 cattle were determined as PI cattle. As a result of this work, it is suggested that national BVD eradication program is required to reduce economic losses by BVDV infection in Korean cattle industries.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제45권2호
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• pp.68-75
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• 2019

Chronic recurrent multifocal osteomyelitis (CRMO) is one of the most severe form of chronic non-bacterial osteomyelitis (CNO), which could result in bone and related tissue damage. This autoinflammatory bone disorder (ABD) is very difficult for its clinical diagnosis because of no diagnostic criteria or biomarkers. CRMO in the jaw must be suspected in the differential diagnosis of chronic and recurrent bone pain in the jaw, and a bone biopsy should be considered in chronic and relapsing bone pain with swelling that is unresponsive to treatment. The early diagnosis of CRMO in the jaw will prevent unnecessary and prolonged antibiotic usage or unnecessary surgical intervention. The updated researches for the identification of genetic and molecular alterations in CNO/CRMO should be studied more for its correct pathophysiological causes and proper treatment guidelines. Although our trial consisted of reporting items from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), there are very few articles of randomized controlled trials. This article was summarized based on the author's diverse clinical experiences. This paper reviews the clinical presentation of CNO/CRMO with its own pathogenesis, epidemiology, recent research studies, and general medications. Treatment and monitoring of the jaw are essential for the clear diagnosis and management of CNO/CRMO patients in the field of dentistry and maxillofacial surgery.