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Establishment of automated manufacturing system for high-purity [18F]Sodium fluoride: 3-year production experience

  • Jung, Soonjae;Kim, Jung Young;Han, Sang Jin;Seo, Youngbeom;Lee, Kyo Chul;Ryu, Young Hoon;Choi, Jae Yong
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.5 no.1
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    • pp.48-53
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    • 2019
  • A bone metastasis is an important factor for prognosis and treatment of breast or prostate cancer patients. [$^{18}F$]Sodium fluoride ([$^{18}F$]NaF) is a PET radiopharmaceutical that can detect bone metastasis. Conventional [$^{18}F$]NaF production process included radioactive metal impurities because the product was prepared by adding saline after beam irradiation to $[^{18}O]H_2O$. In this study, we apply the method of removing radionuclidic impurities. To meet the criteria prescribed by GMP in quality control, we designed the custom-made [$^{18}F$]NaF automatic module. The mean radiochemical yield was $82.1{\pm}4.4%$ (n = 32) productions for 3 years) and the total preparation time was 4 min. The final produced [$^{18}F$]NaF solution meets the USP criteria for quality control. Thus, this fully automated system is validated for clinical use.

A Study on the Direction of Evaluation Indicators for Personalized Beauty Self-care

  • Lee, Yoo-jeong;Choi, Ji-woo;Shin, Sae-young
    • Journal of Fashion Business
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    • v.24 no.6
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    • pp.120-134
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    • 2020
  • Recently, the beauty industry has implemented personalized services based on skin big data. To increase competitiveness in the beauty industry, systematic data measurement and evaluation indicators are necessary to select data and obtain necessary knowledge. In response, this study sought to stably enhance the accuracy of skin diagnosis based on satisfaction and reliability. To this end, the research was conducted through focus group interviews (FGI), a case study of brands, and analysis of prior research results. In particular, as a result of analyzing keywords that classify skin types by brand, common survey items for skin types were oiliness and using moisturizer, cosmetic use and vascular of skin, external stimulus and blemish & freckles, facial wrinkle, outside activities, self-consciousness, and smoke. In additioin to the common questions of the preceding study and the brand survey items, the questions concerning complex skin types, seasonal change, facial color, wrinkles and elasticity were added, and the questions were presented in a total of 40 items. In particular, it suggested that skin measurement could be conducted by focusing on elasticity and pigmentation items by reflecting the results of prior research and the opinions of FGI, and based on this, a customized service with high satisfaction and high accuracy of beauty care based on this could be proposed. We hope that this study will facilitate active self-care by providing more satisfying skin stones and personalized cosmetics proposals, thus laying the foundation for the further development of the cosmetics industry.

Experimental investigation of earth pressure on retaining wall and ground settlement subjected to tunneling in confined space

  • Jinyuan Wang;Wenjun Li;Rui Rui;Yuxin Zhai;Qing He
    • Geomechanics and Engineering
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    • v.32 no.2
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    • pp.179-191
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    • 2023
  • To study the influences of tunneling on the earth pressure and ground settlement when the tunnel passes through the adjacent underground retaining structure, 30 two-dimensional model tests were carried out taking into account the ratios of tunnel excavation depth (H) to lateral width (w), excavation width (B), and excavation distance using a custom-made test device and an analogical soil. Tunnel crossing adjacent existing retaining structure (TCE) and tunnel crossing adjacent newly-built retaining structure (TCN) were simulated and the earth pressure variations and ground settlement distribution during excavation were analyzed. For TCE condition, the earth pressure increments, maximum ground settlement and the curvature of the ground settlement curve are negatively related to H/B, but positively related to H/s and H/w. For TCN condition, most trends are consistent with TCE except that the earth pressure increments and the curvature of ground settlement curve are negatively related to H/w. The maximum ground settlement is larger than that observed in tunnel crossing the existing underground structure. This study provides an assessment basis for the design and construction under confined space conditions.

Impact of gamma radiation on 8051 microcontroller performance

  • Charu Sharma;Puspalata Rajesh;R.P. Behera;S. Amirthapandian
    • Nuclear Engineering and Technology
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    • v.54 no.12
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    • pp.4422-4430
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    • 2022
  • Studying the effects of gamma radiation on the instrumentation and control (I&C) system of a nuclear power plant is critical to the successful and reliable operation of the plant. In the accidental scenario, the adverse environment of ionizing radiation affects the performance of the I&C system and it leads to inaccurate and incomprehensible results. This paper reports the effects of gamma radiation on the AT89C51RD2, a commercial-off-the-shelf 8-bit high-performance flash microcontroller. The microcontroller, selected for the device under test for this study is used in the remote terminal unit for a nuclear power plant. The custom circuits were made to test the microcontroller under different gamma doses using a 60Co gamma source in both ex-situ and in-situ modes. The device was exposed to a maximum dose of 1.5 kGy. Under this hostile environment, the performance of the microcontroller was studied in terms of device current and voltage changes. It was observed that the microcontroller device can operate up to a total absorbed dose of approximately 0.6 kGy without any failure or degradation in its performance.

Channel Gap Measurements of Irradiated Plate Fuel and Comparison with Post-Irradiation Plate Thickness

  • James A. Smith;Casey J. Jesse;William A. Hanson;Clark L. Scott;David L. Cottle
    • Nuclear Engineering and Technology
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    • v.55 no.6
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    • pp.2195-2205
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    • 2023
  • One of the salient nuclear fuel performance parameters for new fuel types under development is changes in fuel thickness. To test the new commercially fabricated U-10Mo monolithic plate-type fuel, an irradiation experiment was designed that consisted of multiple mini-plate capsules distributed within the Advanced Test Reactor (ATR) core, the mini-plate 1 (MP-1) experiment. Each capsule contains eight mini-plates that were either fueled or "dummy" plates. Fuel thickness changes within a fuel assembly can be characterized by measuring the gaps between the plates ultrasonically. The channel gap probe (CGP) system is designed to measure the gaps between the plates and will provide information that supports qualification of U-10Mo monolithic fuel. This study will discuss the design and the results from the use of a custom-designed CGP system for characterizing the gaps between mini-plates within the MP-1 capsules. To ensure accurate and repeatable data, acceptance and calibration procedures have been developed. Unfortunately, there is no "gold" standard measurement to compare to CGP measurements. An effort was made to use plate thickness obtained from post-irradiation measurements to derive channel gap estimates for comparison with the CGP characterization.

Experimental Study on Magnetic Compaction for Reducing Bughole of Free-Form Concrete Panels (비정형 콘크리트 패널 표면 공극저감을 위한 자력 다짐 실험연구)

  • Youn, Jong-Young;Kim, Ji-Hye;Kim, Hye-Kwon;Lee, Donghoon
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2023.05a
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    • pp.25-26
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    • 2023
  • Free-form buildings serve as landmarks, and interest and demand are increasing. However, in the case of free-form concrete members, different curved surfaces are required depending on the location where they are used, and the formwork is custom-made and used. Concrete is poured into the manufactured formwork to produce FCP (Free-form Concrete Panel). However, since it is an atypical building that requires precise curvature, compaction cannot be performed after concrete is poured. This leads to the occurrence of bughole, which reduce the strength and aesthetics of concrete. Therefore, in this study, we intend to conduct basic experiments to develop a magnetic compaction device that can be used for FCP. As a result of the experiment, it was confirmed that the bug hole was improved when the magnetic compaction device was applied, and there was no significant difference in compressive strength and flexural strength. This technology can be used in the field of Free-form concrete where it is difficult to perform compaction work, and it is expected to be used as a basic research related to technology for new automatic compaction.

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Development of Personalized Respiratory Training Device with Real-time Feedback for Respiratory Muscle Strengthening

  • Merve Nur Uygun;Yeong-geol Bae;Yejin Choi;Dae-Sung Park
    • Physical Therapy Rehabilitation Science
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    • v.12 no.3
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    • pp.251-258
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    • 2023
  • Objective: The practice of breathing exercises involves altering the depth and frequency of respiration. Strengthening respiratory muscles plays a crucial role in maintaining overall health and well-being. The efficiency of the respiratory system affects not only physical activity but also various physiological processes including cardiovascular health, lung function, and cognitive abilities. The study evaluated the reliability of the developed device for inspiratory/expiratory training using pressure sensors and Bluetooth connectivity with a smartphone application. Design: Design & development research Methods: The research methodology involved connecting a custom-made respiratory sensor to an IMT-PEP BIC Breath device. Various pressure conditions were measured, and statistical analyses were performed to assess reliability and consistency. Results showed high Intraclass Coefficient Correlation (ICC) values for both inspiratory and expiratory pressures, indicating strong test-retest reliability. The device was designed for ease of use and wireless monitoring through a smartphone app. Results: This study conducted at expiratory pressure confirmed the proper operation of the IMT/PEP breathing trainer at the specified pressure setting in the product. The pressure sensor demonstrated high test-retest reliability with an ICC value of 0.999 for both expiratory and inspiratory pressure measurements. Conclusions: The developed respiratory training device measured and monitored inspiratory and expiratory pressures, demonstrating its reliability for respiratory training. The system could be utilized to record training frequency and intensity, providing potential benefits for patients requiring respiratory interventions. Further research is needed to assess the full potential of the device in diverse populations and applications.

Pattern Development of Waist / Abdominal Area of Obese Womem Using 3D Geometrical Model (3D모델을 이용한 비만체형 여성의 허리-배 부위 패턴 특성 연구)

  • Kim, So-Young;Hong, Kyung-Hi
    • Journal of the Korean Society of Clothing and Textiles
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    • v.29 no.7 s.144
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    • pp.1018-1026
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    • 2005
  • Recent development of 3D scanner and software is regarded as a promising method of acquiring replicas from human body indirectly. It would be very helpful if we could predict the characteristics of 2D pattern from the simple parameters related to 3D shape for ordinary user. Therefore, in this study, investigation of 2D pattern of waist/abdominal area from the 3D geometrical model was conducted for the pattern development of waist nipper. To create body models and develop the surface of them, one ortho commonly used CAD/CAM program, IDEAS(UGS-plm solutions, USA) was used. As for the size of the models, the width, thickness, and circumference ranges of adult women's torso reported in National Anthropometric Survey of Korea (1997) were used as a standard model. Seven size variations were made by changing the width of the waist only, from 19 cm to 40 cm. Therefore, simulated body models include not only the normal body but also obese body who has wider waist and abdomen width than hip width. As results, it was found that the curvature of the unfolded 2D pattern around the abdominal area decreases as the waist width increases. As the width of the waist increases more and more, so that the comparative ratios around the torso becomes in abnormal ranges, there appears inflection points and the direction of curvature was changed. 2D Patterns obtained in this research were quantified by curvature, length of the curve and angle of deflection in the reference frame box for the convenience of the actual pattern making process. It was also possible to find that the shape of patterns of abnormal body resulted in a quite interesting change in the curves of 2D pattern, which could be applied to the custom made waist nipper for obese women.

ACCURACY OF IMPROVED STONE CASTS FROM ELASTOMERIC IMPRESSION MATERIALS (탄성고무인상재에 따른 초경석고 모형의 정밀도에 관한 연구)

  • Kim, Kee-Hong;Chang, Ik-Tae;Yim, Soon-Ho
    • The Journal of Korean Academy of Prosthodontics
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    • v.37 no.3
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    • pp.301-312
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    • 1999
  • The purpose of this study was to compare the accuracy of currently used elastomeric impression materials for complete arch impression taking. Five elastomers (Impregum, Permlastic, Express, Extrude, Examix) and one Irreversible hydrocolloid (Aroma-fine) were tested. For each material, 5 impressions were made of stainless steel model to which five tapered posts were attached. Custom trays were used for polyether and polysulfide impression materials, and putty/wash two step technique was used for addition polyvinylsiloxane impression materials. Improved stone mod els were poured to all impressions. Accuracy of the materials was assessed by measuring ten distances on stone dies poured from impressions of the master model. All measurements for master and improved stone models were made with three dimensional measuring machine. The results were as follows 1. The dimensional accuracy of polyether, extrude, and examix were significantly superior to poly-sulfide, exress, and alginate in reproducing full arch mode (p<0.05) 2. There were no statistical differences in dimensional accuracy for full arch impression between polyether extrude and examix (p>0.05). 3. there were no statistical differences in dimensional accuracy between polysulfide, express, and alginate(p>0.05). 4. There were no statistical differences between addition polyvinyl siloxane materials (p>0.05) 5. There were no statistical differences between anterior-posterior and lateral dimensional changes of all impression materials (p>0.05).

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Camera for Quasars in Early Universe

  • Park, Won-Kee;Pak, Soojong;Im, Myungshin;Choi, Changsu;Jeon, Yiseul;Chang, Seunghyuk;Jeong, Hyeonju;Lim, Juhee;Kim, Eunbin;Choi, Nahyun;Lee, Hye-In;Kim, Sanghyuk;Jeong, Byeongjoon;Ji, Taegeun
    • The Bulletin of The Korean Astronomical Society
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    • v.38 no.2
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    • pp.68.2-68.2
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    • 2013
  • Camera for QUasars in EArly uNiverse (CQUEAN) is an optical CCD camera system made by Center for Exploration of the Origin of the Universe (CEOU). CQUEAN is developed for follow-up observation of red sources such as high-redshift quasar candidates ($z{\geq}5$), gamma-ray bursts (GRB), brown dwarfs and young stellar objects. The CQUEAN is composed of a science camera with deep-depletion CCD chip which is sensitive at around $1{\mu}m$, a set of custom-made wide-band filters for detection of quasar candidates at z~5, and a guide camera. A focal reducer was developed to secure $4.8^{\prime}{\times}4.8^{\prime}$ field of view, and an in-house user software for efficient data acquisition. CQUEAN was attached to 2.1m Otto Struve Telescope in McDonald Observatory, USA, in August 2010. About 1000 quasar candidates including 3 confirmed with follow-up spectroscopy, have been observed so far, and many high-z galaxy cluster candidates, GRBs and supernovae were also observed. And monitoring of HBC 722, a young stellar object, is under way since 2011. Further enhancement of CQUEAN including the introduction of narrow-band filters is planned.

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