• Korean Journal of Radiology
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• 제22권3호
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• pp.464-475
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• 2021

Objective: This study aimed to evaluate the tumor doubling time of invasive lung adenocarcinoma according to the International Association of the Study for Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) histologic classification. Materials and Methods: Among the 2905 patients with surgically resected lung adenocarcinoma, we retrospectively included 172 patients (mean age, 65.6 ± 9.0 years) who had paired thin-section non-contrast chest computed tomography (CT) scans at least 84 days apart with the same CT parameters, along with 10 patients with squamous cell carcinoma (mean age, 70.9 ± 7.4 years) for comparison. Three-dimensional semiautomatic segmentation of nodules was performed to calculate the volume doubling time (VDT), mass doubling time (MDT), and specific growth rate (SGR) of volume and mass. Multivariate linear regression, one-way analysis of variance, and receiver operating characteristic curve analyses were performed. Results: The median VDT and MDT of lung cancers were as follows: acinar, 603.2 and 639.5 days; lepidic, 1140.6 and 970.1 days; solid/micropapillary, 232.7 and 221.8 days; papillary, 599.0 and 624.3 days; invasive mucinous, 440.7 and 438.2 days; and squamous cell carcinoma, 149.1 and 146.1 days, respectively. The adjusted SGR of volume and mass of the solid-/micropapillary-predominant subtypes were significantly shorter than those of the acinar-, lepidic-, and papillary-predominant subtypes. The histologic subtype was independently associated with tumor doubling time. A VDT of 465.2 days and an MDT of 437.5 days yielded areas under the curve of 0.791 and 0.795, respectively, for distinguishing solid-/micropapillary-predominant subtypes from other subtypes of lung adenocarcinoma. Conclusion: The tumor doubling time of invasive lung adenocarcinoma differed according to the IASCL/ATS/ERS histologic classification.

• 한국멀티미디어학회논문지
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• 제14권7호
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• pp.858-865
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• 2011

압축 상태에서 비디오 구조화 및 분류를 하기 위해서는 먼저 압축된 비디오에서 장면전환을 검출해서 비디오를 샷(shot)으로 분리하고 샷내 움직임 정보에 따라 샷을 특징화해야 한다. 장면전환을 검출하는 방법에는 DC 영상의 분산값 이나 복원영상의 에지 픽셀의 분포를 이용한 방법, P-픽쳐의 인트라 블록의 개수를 이용한 방법 등이 있으며 움직임에 따른 샷의 특징 분류는 움직임 벡터의 각 성분들의 평균값을 이용하는 것이 일반적인 방법이다. 그러나 움직임 벡터를 이용한 샷 움직임 분류 방법은 움직임 벡터 자체가 블록의 국부적(local) 움직임을 나타내는 것이므로 글로벌(global)한 카메라 동작을 예측하기 위해서는 많은 제약이 있다. 따라서 본 논문에서는 이러한 것을 보완하기 위해서 MPEG으로 압축된 비디오에서 인트라 프레임을 부분적으로 복호화 하고 빠른 1차원적인 연산을 통해 수평 및 수직 방향으로 평균 밝기 값의 변화 방향을 추정하여 좀더 정확히 샷내 카메라의 움직임을 분류하고자 한다.

• 한국정보통신학회논문지
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• 제22권5호
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• pp.747-753
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• 2018

자동차 블랙박스 영상용 자동차 번호판 인식 시스템에서는 수시로 변하는 도로 주변의 외부 환경에 의해 자동차 번호판에 그림자가 존재하는 경우가 많이 발생한다. 이러한 그림자는 번호판의 문자와 숫자의 개별 문자 분할 과정에서 예상하지 않은 오류를 발생시키게 되고, 그 결과 전체적인 자동차 번호판 인식률을 저하시킨다. 본 논문에서는 이러한 환경에서 번호판 인식률을 높이고자, 번호판의 그림자를 효과적으로 제거하는 번호판 영상 이진화 알고리즘을 제안한다. 제안한 방법에서는 그림자의 경계를 기준으로 그림자가 드리운 영역과 드리우지 않은 영역으로 분할하는데, 그림자의 경계를 찾기 위해 최소 자승법을 사용하여 그림자 경계선에 대한 곡선을 추정한다. 그림자가 존재하는 자동차 번호판의 영상에 대해 시뮬레이션을 수행하였으며, 그 결과 기존 알고리즘 보다 훨씬 높은 인식률을 보임을 확인하였다.

• 대한의용생체공학회:의공학회지
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• 제33권4호
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• pp.169-176
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• 2012

Tumor cell morphology is closely related to its migratory behaviors. An active tumor cell has a highly irregular shape, whereas a spherical cell is inactive. Thus, quantitative analysis of cell features is crucial to determine tumor malignancy or to test the efficacy of anticancer treatment. We use 3D time-lapse phase-contrast microscopy to analyze single cell morphology because it enables to observe long-term activity of living cells without photobleaching and phototoxicity, which is common in other fluorescence-labeled microscopy. Despite this advantage, there are image-level drawbacks to phase-contrast microscopy, such as local light effect and contrast interference ring. Therefore, we first corrected for non-uniform illumination artifacts and then we use intensity distribution information to detect cell boundary. In phase contrast microscopy image, cell is normally appeared as dark region surrounded by bright halo ring. Due to halo artifact is minimal around the cell body and has non-symmetric diffusion pattern, we calculate cross sectional plane which intersects center of each cell and orthogonal to first principal axis. Then, we extract dark cell region by analyzing intensity profile curve considering local bright peak as halo area. Finally, we calculated the Fourier descriptor that morphological characteristics of cell to classify tumor cells into active and inactive groups. We validated classification accuracy by comparing our findings with manually obtained results.

• 한국정밀공학회지
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• 제18권3호
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• pp.68-74
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• 2001

A lane detection based on a road model or feature all needs correct acquirement of information on the lane in an image. It is inefficient to implement a lane detection algorithm through the full range of an image when it is applied to a real road in real time because of the calculating time. This paper defines two (other proper terms including"modes") for detecting lanes on a road. First is searching mode that is searching the lane without any prior information of a road. Second is recognition mode, which is able to reduce the size and change the position of a searching range by predicting the position of a lane through the acquired information in a previous frame. It allows to extract accurately and efficiently the edge candidate points of a lane without any unnecessary searching. By means of inverse perspective transform which removes the perspective effect on the edge candidate points, we transform the edge candidate information in the Image Coordinate System(ICS) into the plan-view image in the World Coordinate System(WCS). We define a linear approximation filter and remove faulty edge candidate points by using it. This paper aims at approximating more correctly the lane of an actual road by applying the least-mean square method with the fault-removed edge information for curve fitting.e fitting.

• 한국수자원학회논문집
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• 제53권7호
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• pp.545-555
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• 2020

본 연구에서는 해외 수력댐 건설 프로젝트의 사전조사 기초자료 제공을 위하여 댐 위치 결정을 위한 사전적지분석 알고리즘을 개발하고, 위성영상 수치표고자료인 ASTER Global Digital Elevation Model (ASTGTM)과 토지피복자료인 Terra/Aqua combined Moderate Resolution Imaging Spectroradiometer (MODIS) MCD12Q1를 사용하였다. 사전적지분석 알고리즘은 DEM의 전처리, 하천망생성, 유역분할과 지형정보를 고려한 적지분석과 댐 건설 시 수몰면적에 따른 보상면적 산정 알고리즘을 포함하고 있으며 Python기반의 오픈소스 GIS로 구현되었다. 적지분석은 사용자가 하천 위의 지점을 선택하면, DEM으로부터 낙차, 도달시간, 내용적곡선과 같은 지형정보와 토지피복자료를 통한 보상면적을 기반으로 지점의 적지여부를 평가한다. 분석알고리즘은 국내 부항, 보현산, 성덕, 영주댐을 대상으로 시범적용 됐으며 해당 지점의 가능 최대낙차는 각각 37, 67, 73, 42 m로 나타났으며 최대저수면적은 1.81, 2.4, 2.8, 8.8 ㎢ 최대저수량은 35.9, 68, 91.3, 168.3×10⁶ ㎥으로 나타났다. 보현산과 성주 댐에서는 타당성을 보였으나, 부항과 영주 댐의 경우 ASTGTM 에러로 인한 잘못된 하천망과 유역경계로 인해 낙차가 제한됨을 보였다, 본 연구의 결과는 향후 해외 수력댐 사업 진출시 사전분석에서 적지의 지형학적 평가에 도움이 될 것으로 기대된다.

• Korean Journal of Radiology
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• 제24권2호
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• pp.133-144
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• 2023

Objective: Cyclin-dependent kinase inhibitor (CDKN)2A/B homozygous deletion is a key molecular marker of isocitrate dehydrogenase (IDH)-mutant astrocytomas in the 2021 World Health Organization. We aimed to investigate whether qualitative and quantitative MRI parameters can predict CDKN2A/B homozygous deletion status in IDH-mutant astrocytomas. Materials and Methods: Preoperative MRI data of 88 patients (mean age ± standard deviation, 42.0 ± 11.9 years; 40 females and 48 males) with IDH-mutant astrocytomas (76 without and 12 with CDKN2A/B homozygous deletion) from two institutions were included. A qualitative imaging assessment was performed. Mean apparent diffusion coefficient (ADC), 5th percentile of ADC, mean normalized cerebral blood volume (nCBV), and 95th percentile of nCBV were assessed via automatic tumor segmentation. Logistic regression was performed to determine the factors associated with CDKN2A/B homozygous deletion in all 88 patients and a subgroup of 47 patients with histological grades 3 and 4. The discrimination performance of the logistic regression models was evaluated using the area under the receiver operating characteristic curve (AUC). Results: In multivariable analysis of all patients, infiltrative pattern (odds ratio [OR] = 4.25, p = 0.034), maximal diameter (OR = 1.07, p = 0.013), and 95th percentile of nCBV (OR = 1.34, p = 0.049) were independent predictors of CDKN2A/B homozygous deletion. The AUC, accuracy, sensitivity, and specificity of the corresponding model were 0.83 (95% confidence interval [CI], 0.72-0.91), 90.4%, 83.3%, and 75.0%, respectively. On multivariable analysis of the subgroup with histological grades 3 and 4, infiltrative pattern (OR = 10.39, p = 0.012) and 95th percentile of nCBV (OR = 1.24, p = 0.047) were independent predictors of CDKN2A/B homozygous deletion, with an AUC accuracy, sensitivity, and specificity of the corresponding model of 0.76 (95% CI, 0.60-0.88), 87.8%, 80.0%, and 58.1%, respectively. Conclusion: The presence of an infiltrative pattern, larger maximal diameter, and higher 95th percentile of the nCBV may be useful MRI biomarkers for CDKN2A/B homozygous deletion in IDH-mutant astrocytomas.