• Journal of Korean Medical classics
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• v.18 no.3 s.30
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• pp.116-125
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• 2005

1) Objective ${\lceil}Wai-Tai-Mi-Yao{\rfloor}$ had been made by Wang-Dao(王燾) in Tang Dynasty(唐朝). It included fumigation therapy and aroma therapy. Therefore we would like to bring out use sphere and detailed method of Fumigation therapy and Aroma therapy in Tang Dynasty and before period. 2) Conclusions (1) Fumigation therapies of ${\lceil}Wai-Tai-Mi-Yao{\rfloor}$ have contained boil and burn. The effects of fumigation therapy are made by cooperation effect of medicine and heat. (2) Aroma therapies of ${\lceil}Wai-Tai-Mi-Yao{\rfloor}$ have been used to cure infectious, internal, psychologic, dental, pediatric, dermatologic and surgical diseases. Especially these therapies have a good effect on cough. (4) Aroma therapies of ${\lceil}Wai-Tai-Mi-Yao{\rfloor}$ have been used to cure infectious, internal, psychologic, dental, ophthalmic, otolaryngologic, obstetrics, gynecologic, dermatologic and surgical diseases. Expecially this therapy has an good effect on nightmare.

• Proceedings of the Microbiological Society of Korea Conference
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• 2002.10a
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• pp.109-115
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• 2002

Gene therapy is to treat and cure diseases by an introduction of therapeutic genes in defective cells or tissues of human body. Gene delivery system, gene expression system, and therapeutic gene are three core elements for gene therapy. The efficient delivery of therapeutic genes and appropriate gene expression are the crucial issues for therapeutic outcome of gene delivery. Because it can be used in common for the treatment and cure of various diseases, gene delivery system is the most important core element for a successful gene therapy. Viruses are naturally evolved to transfer their genomes into host cells efficiently. This ability has made vectorologists exploit viruses as attractive vehicles for the delivery of therapeutic genes. Viral vectors based on adenovirus (Ad) and adeno-associated virus (AAV) have been often used for gene delivery in laboratory. Ad and AAV vectors derived from human DNA viruses differ greatly in their life cycle, expression level and duration of transgenes, immunogenicity, and vector preparation. Both vectors can be used as effective tools for gene therapy and more recently in functional genomics. Here, the characteristics of Ad and AAV vectors are discussed.

• Parasites, Hosts and Diseases
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• v.42 no.1
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• pp.19-26
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• 2004

We investigated the induction of resistance to Clonorchis sinensis infection by prior infection in rat and hamster models. Animals were challenged with C. sinensis metacercariae, then treated with praziquantel and reinfected. Worm recovery rate in reinfected animals was used to estimate resistance to reinfection. The determined resistance rates to reinfection in rats and hamsters were 97.7% and 10.3%, respectively. In rats, cure from the primary infection of C. sinensis increased resistant to reinfection, and the greatert the worm burden and the longer the duration of primary infection, the higher was the resistance rate. For primary infection doses of 10, 40 and 100 metacercariae per rat, the resistance rates were 87.4%, 93.8% and 98.4%, respectively. The resistance rates in rats after 2 or 8-week primary infection were 78.7% and 95.3%, respectively. All worms recovered from reinfected rats were immature. When cured rats were administered with methylprednisolone, resistance to reinfection became impaired. These findings indicate that rats develop a high degree of resistance to reinfection by C. sinensis after cure. The growths and maturations of reinfected worms were also impaired.

• Clinical and Experimental Pediatrics
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• v.45 no.11
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• pp.1317-1324
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• 2002

• Preventive Nutrition and Food Science
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• v.10 no.2
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• pp.198-205
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• 2005

Korean medicated diet (KMD) is not a simple combination of food and Chinese drugs, but a special carefully constructed diet made from Sasang constitutional medicines, food and condiments under the theoretical guidance of diet preparation based on differentiation of symptoms and signs of traditional Sasang medicine (TSM). It combines the functional efficacy of medicine with the delicacy of food, and can be used to prevent and cure diseases, build up one's health and prolong one's life. Korean traditional medicated diet has a long history of development. Although influenced by Chinese medicine, Korean traditional medicine has been developed into a unique system of traditional medicine that has surpassed the continental medical practice, sublimating itself into a native medical practice suitable to Korean lifestyles and physical constitutions. In the 19th century, Lee Jema's Sasang medicine (medicine of four types of energy determining the physical constitution) was introduced. It is an integration of mind and body according to the individual's physical constitution that is categorized allowing a customized method of treatment ideal for each category-making the content of Korean traditional medicated diet even richer. The characteristics of Korean medicated diet are as follows: (1) Laying stress on the wole, selecting medicated diet on the basis of differential diagnosis. (2) Suitable for prevention and treatment, outstanding in effect. (3) Good in taste, convenient for taking. KMD refers to drink and food according to certain prescriptions, by processing and cooking that can be used either for prevention and cure of diseases, or for health care and recovery. The purpose of this review is to introduce TSM and KMD based on Sasang constitutional medicines.

• Journal of Pharmacopuncture
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• v.5 no.1 s.8
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• pp.159-169
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• 2002

Objective: It will be examined in this research whether Lacquer poison can be used as an distinguished treatment to cure incurable diseases by considering literature existing and various papers. Method: I studies origin, alias, species, toxicity, effect, treatment, component, medical action and contraindication of Rhus vemiciflua stokes through various kinds literatures. Results: Sap of Rhus vemiciflua stokes that is used for medical purposes, has an effect on anti-tumor, anti-oxidation, hangover cure, and gastritis suppression. Even though urushiol and fIavonoids, the main ingredient of lacquer, has medical cure effects. but urushiol results in a dermatropic allergy. Sincc xylem of a Rhus vemiciflua stokes, however. does not induce the allergy but has medical efficacy, research on this topic is needed.

• Biomedical Science Letters
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• v.24 no.3
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• pp.157-167
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• 2018

The concept of gene therapy is to treat a disease by transferring therapeutic nucleic acids to a patient's cells. It took several decades from the basic theoretical proposal of gene therapy to the current promising treatment option for some important human diseases. The encountered adverse effects in the early clinical studies boosted the development of sophisticated vectors and elaborate clinical designs. The gene therapy is now considered to have the potential to cure many diseases that are incurable with conventional medications. By the end of 2017, about 2,600 clinical trials of gene therapy have been performed or are ongoing for a variety of diseases such as cancers, monogenic diseases, cardiovascular diseases and neurological diseases etc. Here, we present a brief introduction of technical achievement in relation to gene therapy development, and a review of the current status of global gene therapy clinical development.

• IMMUNE NETWORK
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• v.8 no.4
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• pp.107-123
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• 2008

It has now been well documented in a variety of models that T regulatory T cells (Treg cells) play a pivotal role in the maintenance of self-tolerance, T cell homeostasis, tumor, allergy, autoimmunity, allograft transplantation and control of microbial infection. Recently, Treg cell are isolated and can be expanded in vitro and in vivo, and their role is the subject of intensive investigation, particularly on the possible Treg cell therapy for various immune-mediated diseases. A growing body of evidence has demonstrated that Treg cells can prevent or even cure a wide range of diseases, including tumor, allergic and autoimmune diseases, transplant rejection, graft-versus-host disease. Currently, a large body of data in the literature has been emerging and provided evidence that clear understanding of Treg cell work will present definite opportunities for successful Treg cell immunotherapy for the treatment of a broad spectrum of diseases. In this Review, I briefly discuss the biology of Treg cells, and summarize efforts to exploit Treg cell therapy for autoimmune diseases. This article also explores recent observations on pharmaceutical agents that abrogate or enhance the function of Treg cells for manipulation of Treg cells for therapeutic purpose.

• Korean Journal of Oriental Medicine
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• v.11 no.1
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• pp.43-60
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• 2005

Objective : ${\ulcorner}$Wai-Tai-Mi-Yao${\lrcorner}$ had been made by Wang-Dao(王燾) in Tang Dynasty(唐朝). It included not only in those days medical knowledge, but also before medical knowledge. So it is regarded as important classic in the oriental medicine. And there are various bathing therapy methods. Therefore we would like to bring out use sphere and detailed method of bathing therapy in Tang Dynasty and before period. Methodologies :We have researched bathing therapy of ${\ulcorner}$Wai-Tai-Mi-Yao${\lrcorner}$ according to below the procedure. (1) Making a related words list: We have used existing external treatments technical books to make a list. The list is consist of 23 words and includes not only technical terms, but also general terms. (2) Searching sentence: We have searched sentence that contain terms that related with bathing therapies. (3) Analysis of related sentence: We have searched and classified sentence by disease. Conclusions :(1) ${\ulcorner}$Wai-Tai-Mi-Yao${\lrcorner}$ has described 15,180 records. Bathing therapies of ${\ulcorner}$Wai-Tai-Mi-Yao${\lrcorner}$ had been used to cure 726 records from the whole volume. The contents account for 4.8% of the whole volume. (2) ${\ulcorner}$Wai-Tai-Mi-Yao${\lrcorner}$ has described 1,104 diseases. Bathing therapies of ${\ulcorner}$Wai-Tai-Mi-Yao${\lrcorner}$ had been used to cure 293 diseases from the whole diseases. The contents account for 26.5% of the whole volume. (3) These diseases belong to dermatologic, internal, ophthalmic, otolaryngologic, obstetrics, gynecologic, pediatric, surgical and veterinary diseases.

• Tuberculosis and Respiratory Diseases
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• v.39 no.3
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• pp.209-218
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• 1992

Despite the availability of drugs effective in producing a bacteriological cure, tuberculosis presents continuing problems in its control, especially in the developing world. An effective immunotherapy to be used with chemotherapy is urgently required. Intradermal injection of a suspenison of killed Mycobacterium vaccae switches off the tissue-necrotizing component of the Koch phenomenon, and promotes cell-mediated responses to the common, putative protective, mycobacterial antigens. These properties led to the empolyment of the suspension in immunotherapy as an adjunct to chemotherapy in the treatment of both tuberculosis and leprosy. The evidence leading to these conclusions is reviewed.