• Composites Research
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• 제12권6호
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• pp.1-7
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• 1999

본 논문은 탄소/에폭시 적층판의 온도변화에 대한 열팽창계수 변화를 예측하고 실험적으로 검증한 것으로 재료의 주축 방향에 대한 기계적 탄성 특성과 열팽창계수를 상온에서 경화온도 범위까지 측정하였으며 온도 함수로 특성화 하였다. 온도 함수로 특성화된 물성을 고전 적층판 이론에 적용함으로써 온도 변화에 대해 일반 적층각 적층판 복합재료의 열팽창계수를 예측할 수 있는 해석적 모델을 제시하였다. 이를 증명하기 위해서 일반 적층각 적층판의 열팽창계수를 측정하였으며 이를 해석적 모델로 계산된 예측치와 비교하였다. 실험적 검증 결과 온도 변화에 대한 일반 적층판의 열팽창계수의 변화가 제시된 해석적인 계산 방법을 사용함으로써 적절하게 예측될수 있음을 볼수 있다.

• Parasites, Hosts and Diseases
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• 제46권4호
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• pp.261-263
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• 2008

Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.

• Journal of Chest Surgery
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• 제53권6호
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• pp.381-386
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• 2020

Background: Behçet disease is a chronic inflammatory disorder with a varying etiology. Herein, we report the involvement of peripheral veins in Behçet disease and discuss the treatment thereof. Methods: Thirty-four patients with venous involvement in vasculo-Behçet disease were retrospectively analyzed over 15 years. We reviewed the clinical manifestations, treatment choices, and complications of these patients. Results: Deep vein thrombosis (DVT) was observed in 24 patients (70.59%) and varicose veins in 19 (52.94%). Immunosuppressive treatment was administered to all patients due to the pathological feature of vein wall inflammation. In patients with DVT, anticoagulation therapy was also used, but post-thrombotic syndrome was observed in all patients along with chronic luminal changes. Eleven patients with isolated varicose veins underwent surgery; although symptoms and lesions recurred in half of these patients, no cases of secondary DVT occurred. Conclusion: When DVT was diagnosed in patients with Behçet disease, there was no cure for the lesions. Ultrasonographic abnormalities were observed in all patients, and post-thrombotic syndrome remained to varying degrees. In cases of isolated varicose veins in patients with Behçet disease, DVT did not occur after surgical treatment. If the activity of Behçet disease is controlled, surgical correction of varicose veins is preferable.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제3권10호
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• pp.421-428
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• 2014

파킨슨병은 뇌의 흑질 영역에서 도파민계 신경이 파괴되는 질병으로 알츠하이머병과 함께 대표적인 퇴행성 뇌 질환이다. 현재까지 병을 완치시킬 수 있는 치료법은 없지만 병의 진행을 완화시킬 수 있는 치료법이 존재하기 때문에 병의 진단이 굉장히 중요하다. 파킨슨병을 진단하기 위한 과거의 연구는 대부분 단일 바이오마커를 이용한 것으로 이러한 방법은 파킨슨병 환자를 높은 정확도로 진단할 수 있지만 정상인에 대한 진단은 상대적으로 낮은 성능의 한계성이 존재한다. 따라서 본 연구에서는 생화학적 바이오마커인 뇌척수액 내의 ${\alpha}$-synuclein 단백질 수치와 영상학적 바이오마커인 확산 텐서 영상의 여러 모수들을 결합하여 특징으로 사용하는 파킨슨병 진단 모델을 개발하고 성능을 평가하였다. 진단을 위해 개발된 모든 모델은 10-fold cross validation 성능평가에서 정확도가 최고 91.3%의 높은 성능을 보였으며, test 성능평가에서는 확산 텐서 영상의 모수들 중 FA와 ${\alpha}$-synuclein 단백질 수치가 결합된 모델, MO와 ${\alpha}$-synuclein 단백질 수치가 결합된 두 모델에서 최고 72%의 정확도 성능을 보여 파킨슨병의 진단에 유용하게 사용될 수 있는 가능성을 제시하였다. 파킨슨병의 진단을 위해 개발된 모델의 영상학적 특징 벡터를 통하여 파킨슨병 환자와 정상인의 신경섬유 경로의 특징을 분석하였다.

• BMB Reports
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• 제51권11호
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• pp.584-589
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• 2018

Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in oropharyngeal squamous cell carcinoma (OPSCC). Whole-exome (WES) and whole-genome (WGS) sequencing were performed on peripheral blood and adjacent non-tumor and tumor specimens obtained from eight Korean HNSCC patients from 2013 to 2015. Next-generation sequencing yielded an average coverage of $94.3{\times}$ for WES and $35.3{\times}$ for WGS. In comparative genomic analysis of non-tumor and tumor tissue pairs, we were unable to identify common cancer-associated early mutations and copy number alterations (CNA) except in one pair. Interestingly, in this case, we observed that non-tumor tonsillar crypts adjacent to HPV-positive OPSCC appeared normal under a microscope; however, this tissue also showed weak p16 expression. WGS revealed the infection and integration of high-risk type HPV16 in this tissue as well as in the matched tumor. Furthermore, WES identified shared and tumor-specific genomic alterations for this pair. Clonal analysis enabled us to infer the process by which this transitional crypt epithelium (TrCE) evolved into a tumor; this evolution was accompanied by the subsequent accumulation of genomic alterations, including an ERBB3 mutation and large-scale CNAs, such as 3q27-qter amplification and 9p deletion. We suggest that HPV16-driven OPSCC carcinogenesis is a stepwise evolutionary process that is consistent with a multistep carcinogenesis model. Our results highlight the carcinogenic changes driven by HPV16 infection and provide a basis for the secondary prevention of OPSCC.

• 접착 및 계면
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• 제10권4호
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• pp.191-198
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• 2009

지방족 에폭시 수지인 glycerol diglycidyl ether (GDE)에 단관능성 아크릴 수지인 2-carboxyethyl acrylate (2-CEA) 또는 2-hydroxyethyl acrylate (2-HEA)를 반응시켜 지방족 에폭시 아크릴레이트를 제조하였다. FT-IR, $^1H$-NMR, 그리고 $^{13}C$-NMR를 사용하여 생성물을 확인하였고, 수율은 prep-LC를 사용하여 얻었다. 생성물의 자외선 경화거동은 photo-DSC를 사용하였고, 열경화 반응성은 DSC를 사용하여 얻었다. 2-CEA의 반응성이 2-HEA보다 월등히 높음을 알 수 있었고, 2-CEA로부터 제조한 지방족 에폭시 아크릴레이트(GEA-C)의 수율은 약 83%이었다. 촉매를 제거한 GEA-C 생성물의 자외선 경화반응($T_{max}$)은 약 10 s로 빠르게 진행되었다. GEA-C는 투명하고, 내열성이 우수하며 저점도를 갖고 있음을 확인할 수 있었다. ${\Delta}E^*$는 2.51, 점도는 192 cps, 5% 중량감소 때의 온도는 $299^{\circ}C$이었다. Kissinger와 Ozawa-Flynn-Wall 식으로 얻은 GEA-C의 열경화 반응의 활성화에너지($E_a$)는 91~92 kJ/mol이었다.

• Molecules and Cells
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• 제41권6호
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• pp.515-522
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• 2018

Patients with head and neck cancer are treated with therapeutic irradiation, which can result in irreversible salivary gland dysfunction. Because there is no complete cure for such patients, stem cell therapy is an emerging alternative for functional restoration of salivary glands. In this study, we investigated in vitro characteristics of primarily isolated epithelial cells from human salivary gland (Epi-SGs) and in vivo formation of acini-like structures by Epi-SGs. Primarily isolated Epi-SGs showed typical epithelial cell-like morphology and expressed E-cadherin but not N-cadherin. Epi-SGs expressed epithelial stem cell (EpiSC) and embryonic stem cell (ESC) markers. During long-term culture, the expression of EpiSC and ESC markers was highly detected and maintained within the core population with small size and low cytoplasmic complexity. The core population expressed cytokeratin 7 and cytokeratin 14, known as duct markers indicating that Epi-SGs might be originated from the duct. When Epi-SGs were transplanted in vivo with Matrigel, acini-like structures were readily formed at 4 days after transplantation and they were maintained at 7 days after transplantation. Taken together, our data suggested that Epi-SGs might contain stem cells which were positive for EpiSC and ESC markers, and Epi-SGs might contribute to the regeneration of acini-like structures in vivo. We expect that Epi-SGs will be useful source for the functional restoration of damaged salivary gland.