• Journal of the Korean Society of Safety
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• v.15 no.1
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• pp.153-160
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• 2000

Occupational cumulative traumas (CTDs) are becoming one of leading ailments in industrialized worl $d^{(1.2)}$. The degree of muscle fatigue is important parameter to understand cause of occupational cumulative trauma disorders. To quantify degree of muscle fatigue, muscle EMG activity was measured during isometric and dynamic contractions(repetitive concentric/eccentric muscle contraction) and its analyzed data, such as RMS, median frequency, and median power were compared when the muscle was fresh and exhausted. When muscle become fatigue, it was observed that median frequency decreased and median power and RMS increased However, based on overall prolonged observation, median frequency increased and median power and RMS decreased. Therefore it was concluded that shifting patterns of RMS, median frequency, and median power values can be used as parameter to evaluate degree of muscle fatigue even in dynamic muscle contraction.

• Journal of Biomedical Engineering Research
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• v.9 no.1
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• pp.73-78
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• 1988

The polymer electrolyte complex hydrogels consisting of poly (methacrylic acid) and poly (4-vinylpyrridine) were formed and 5-flurouracil and pilocarpine drugs were loaded on their hydrogels. Cumulative 5-FU released from PEC hydrogel was affected by the degree of loading and release rate of 5-FU was followed by the monolithic type. Cumulative pilocarpine released from PEC hydrogel increased by ionic interaction between cationic pilocarpine and anionic PMA. Release rate showed the zero order after burst effect.

• Journal of Welding and Joining
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• v.32 no.1
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• pp.71-78
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• 2014

Although the fatigue design curve of ASME Code has enough margin with respect to alternating stress and cycles, the welding residual stress(WRS) should be included in fatigue analysis. In this paper, WRS distribution in a nozzle with dissimilar metal weldment was obtained by finite element analysis and was added in fatigue analysis. The fatigue analysis was performed by following the ASME Code including thermal and stress analysis applying with postulated 30 transient conditions. The calculated results of a cumulative fatigue usage factors(CUF) were compared for the case of the models with or without WRS effects. The results showed that the CUF at weldment and heat affected zone was affected by the WRS.

• Journal of Nutrition and Health
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• v.29 no.1
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• pp.97-103
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• 1996

This study was performed to investigate the effects of lipid on cellular senescence, lipid peroxide production, and morphological changes. For this study we used primary skin fibroblasts from neonate rats grown in media various lipid contents. Fibroblasts were cultured until they lost their proliferation potential either in control medium (Dulbecco's modified Eagle's medium supplement with 10% fetal bovine serum) or in media supplemented with various concentrations of lipid-cholesterol rice component from bovine serum. Cumulative population doublings(CPD, as an index of cellular life span), and cellular thiobarbituric acid reactive substances (TBARS, as an index of lipid peroxide) concentrations were measured and morphological changes were observed. CPD were shortened with increasing lipid concentration in media ; 28.12 for cells grown in control medium and 13.42, 11.42, and 6.19 for those grown in 0.1%, 1% and 5% lipid rich components containing media, respectively. Cellular proliferation ratios were those grown in 5% lipid rich components containing media were delayed and they were degenerated soon. TBARS concentrations were increased with increasing concentration of lipid in media. Morphological changes were observed in cells grown in control medium by cellular senescence. Especially lipid droplets were observed in cells grown in 5% lipid rich components containing media. Therefore it seems that lipid contents in media had an effect on cellular proliferation and cellular life span, possibly via lipid peroxide production.

• Journal of Korean Society of Steel Construction
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• v.15 no.4 s.65
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• pp.369-378
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• 2003

This study proposed a damage index for steel members and examined a process where steel square tubular columns under cycle loading failed to meet the damage index. A nonlinear analysis was carried out and a damage process analyzed using a finite element program. Material properties and strain characteristics were obtained from material testing. The effect on the damage of members was analyzed according to varying kinds of steels and conditions of loading based on material testing results. According to strain characteristics and cumulative plastic strain of each variable, the effect of conditions of loading and kinds of steels on the damage could be estimated quantitatively.

• Korean Journal of Soil Science and Fertilizer
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• v.44 no.1
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• pp.48-52
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• 2011

The effect of soil water content on the transformation potential of N compounds derived from hydrolysis of urea applied in a reclaimed tidal soils which was saline-sodic was observed to evaluate nitrification rates of urea. Soil samples were collected from Moonpo series at the newly reclaimed area in Saemanguem. For the transformation potential of N compounds from urea (46% N), newly reclaimed tidal soils (RS) were amended with urea at the rates of 0, 10, and 20 kg $10a^{-1}$. With leachate obtained from the incubated RS in a leaching tube at $25^{\circ}C$, urea hydrolysis and nitrification were measured for a total of 30days. The cumulative amounts of $NO_3{^-}$-N in each of the four soils treated with urea was linear with time of incubation. Results showed that increase in pH occurred with increasing application rate of urea and volumetric water content due to hydrolysis of urea. The total N in the RS was decreased with incubation time, indicating that rates of urea hydrolysis was influenced by soil moisture conditions. Also, the cumulative amount of nitrate in RS gradually increased with increase in time of incubation.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.5
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• pp.116-121
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• 2004

Simulation of proton irradiation in space is undertaken with a cyclotron accelerator. The cyclotron is capable of accelerating protons up to 200MeV with nominal fluxes near $10^6-10^8\;protons/cm^2/s$. Accelerated protons are irradiated onto a MPC860 for space application. Both the transient and cumulative responses of the device are found due to the proton irradiation. The primary transient response of the device is modification of the stored data in the circuit, whereas intermittent functional interrupts are also found. The cumulative response of the device is the increase of current consumption by the device.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.2
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• pp.594-599
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• 2011

In this paper, the effect of the boundary conditions on the reliability and the cumulative distribution characteristics of the fatigue failure life is analyzed in a magnesium alloy AZ31. The boundary conditions are specimen thickness, stress ratio, and maximum fatigue load. The statistical data of the fatigue failure life are obtained by fatigue crack propagation tests under the detail conditions for each boundary condition. The 3-parameter Weibull distribution is used to analyze a statistical characteristics of the fatigue failure life in magnesium alloy AZ31. It is found that the statistical fatigue failure life is long in the case of a thicker specimen, a larger stress ratio, and a smaller maximum fatigue load. Under the opposite cases, the reliability on the fatigue failure life is rapidly dropped.

• East Asian Economic Review
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• v.25 no.2
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• pp.205-230
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• 2021

This study examines the impact of the number of coronavirus cases on regime-switching in stock return volatility. This study documents the empirical evidence that the COVID-19 cases had an asymmetric effect on the regime of stock return volatility. When the stock return is in the low volatility regime, the probability of switching to the high volatility regime in the next trading day increases as the number of cumulative cases increases. In contrast, in the high volatility regime, the effect of cumulative cases on the transition probability is not statistically significant. This study also documents the evidence that the government measures against the pandemic contribute to promoting the high volatility regime of the KOSPI during the pandemic. Besides, this study projects future stock prices through the Monte Carlo simulation based on the estimated parameters and the predicted number of the COVID-19 new cases. Under a scenario where the number of new cases rapidly increases, stock price indices in Korea are expected to be in a downward trend over the next three months. On the other hand, under the moderate scenario and the best scenario, the stock indices are likely to continue to rise.

• Journal of Pharmaceutical Investigation
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• v.38 no.6
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• pp.373-380
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• 2008

In order to develop optimal formulation and iontophoresis condition for the transdermal delivery of levodopa, we have evaluated the effect of two permeation enhancers, ethanol and oleic acid in microemulsion, on transdermal delivery of levodopa. In vitro flux studies were performed at $33^{\circ}C$, using side-by-side diffusion cell and full thickness hairless mouse skin. Current density applied was $0.4\;mA/cm^2$ and current was off after 6 hours application. Levodopa was analysed by HPLC at 280 nm. The o/w microemulsions of oleic acid in buffer solution (pH 2.5 & 4.5) were prepared using oleic acid, Tween 80 and ethanol. The existence of microemulsion regions were investigated in pseudo-ternary phase diagrams. Contrary to our expectation, cumulative amount of levodopa transported from microemulsion (pH 2.5) for 10 hours was similar to that from aqueous solution in all delivery methods (passive, anodal and cathodal). When pH of the micro-emulsion was pH 4.5, cumulative amount of levodopa transported for 10 hours increased about 40% (anodal) to 50% (cathodal), when compared to that from aqueous solution. Flux from pH 4.5 microemulsion showed higher value than that from pH 2.5 in all delivery methods. These results seem to indicate that electroosmosis plays more dominant role than electrorepulsion in the flux of levodopa at pH 2.5. The effect of ethanol on iontophoretic flux was studied using pH 2.5 phosphate buffer solution containing 3% or 5% (v/v) ethanol. Flux enhancement was observed in passive and anodal delivery as the concentration of the ethanol increased. Without ethanol, cathodal delivery showed higher flux than anodal delivery. Anodal delivery increased the cumulative amount of levodopa transported 1.6 fold by 5% ethanol after 10 hours. However, in cathodal delivery, no flux enhancement of levodopa was observed during current application and only marginal increase in cumulative amount transported after 10 hours was observed by 5% ethanol. These results seem to be related to the decrease in dielectric constant of the medium and the lipid extraction of the ethanol, which decrease the electroosmotic flow, and thus decrease the flux. Overall, the results provide important insights into the role of electroosmosis and electrorepulsion in the transport of levodopa through skin, and provide some useful informations for optimal formulation for levodopa.