• Title/Summary/Keyword: cumulative effect

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DIFFERENTIAL EXPRESSION OF RADIATION RESPONSE GENES IN SPLEEN, LUNG, AND LIVER OF RATS FOLLOWING ACUTE OR CHRONIC RADIATION EXPOSURE

  • Jin, Hee;Jin, Yeung Bae;Lee, Ju-Woon;Kim, Jae-Kyung;Lee, Yun-Sil
    • Journal of Radiation Protection and Research
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    • v.40 no.1
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    • pp.25-35
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    • 2015
  • We analyzed the differential effects of histopathology, apoptosis and expression of radiation response genes after chronic low dose rate (LDR) and acute high dose rate (HDR) radiation exposure in spleen, lung and liver of rats. Female 6-week-old Sprague-Dawley rats were used. For chronic low-dose whole body irradiation, rats were maintained for 14 days in a $^{60}Co$ gamma ray irradiated room and received a cumulative dose of 2 Gy or 5 Gy. Rats in the acute whole body exposure group were exposed to an equal dose of radiation delivered as a single pulse ($^{137}Cs$-gamma). At 24 hours after exposure, spleen, lung and liver tissues were extracted for histopathologic examination, western blotting and RT-PCR analysis. 1. The spleen showed the most dramatic differential response to acute and chronic exposure, with the induction of substantial tissue damage by HDR but not by LDR radiation. Effects of LDR radiation on the lung were only apparent at the higher dose (5 Gy), but not at lower dose (2 Gy). In the liver, HDR and LDR exposure induced a similar damage response at both doses. RT-PCR analysis identified cyclin G1 as a LDR-responsive gene in the spleen of rats exposed to 2 Gy and 5 Gy gamma radiation and in the lung of animals irradiated with 5 Gy. 2. The effects of LDR radiation differed among lung, liver, and spleen tissues. The spleen showed the greatest differential effect between HDR and LDR. The response to LDR radiation may involve expression of cyclin G1.

Performance Analysis of Initial Cell Search in WCDMA System over Rayleigh Fading Channels (레일리 페이딩 채널에서 W-CDMA 시스템의 초기 셀 탐색 성능 해석)

  • Song, Moon-Kyou
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.38 no.4
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    • pp.1-10
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    • 2001
  • The 3-step cell search has been considered for fast acquisition of the scrambling code unique to a cell in the W -CDMA system. In this paper, the performance of the cell search scheme is analyzed in Rayleigh fading channels. And the system parameters for cell search scheme and the design parameters for the receivers are examined. The probabilities of detection, miss and false alarm for each step are derived in closed forms based on the statistics of CDMA noncoherent demodulator output. Through the analysis, the effect of threshold setting and post detection integration for each step is investigated, and the optimal values of the power allocation for the synchronization channels are also considered. The number of post-detection integrations for each step is a design parameter for the receiver, and the optimum values may depend on not only the power allocation for each channel related to the cell search, but the false alarm penalty time. It is shown that optimal values could be determined through the analysis. Also, the cumulative probability distribution of the average cell search time is obtained.

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Performance of Indoor Positioning using Visible Light Communication System (가시광 통신을 이용한 실내 사용자 단말 탐지 시스템)

  • Park, Young-Sik;Hwang, Yu-Min;Song, Yu-Chan;Kim, Jin-Young
    • Journal of Digital Contents Society
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    • v.15 no.1
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    • pp.129-136
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    • 2014
  • Wi-Fi fingerprinting system is a very popular positioning method used in indoor spaces. The system depends on Wi-Fi Received Signal Strength (RSS) from Access Points (APs). However, the Wi-Fi RSS is changeable by multipath fading effect and interference due to walls, obstacles and people. Therefore, the Wi-Fi fingerprinting system produces low position accuracy. Also, Wi-Fi signals pass through walls. For this reason, the existing system cannot distinguish users' floor. To solve these problems, this paper proposes a LED fingerprinting system for accurate indoor positioning. The proposed system uses a received optical power from LEDs and LED-Identification (LED-ID) instead of the Wi-Fi RSS. In training phase, we record LED fingerprints in database at each place. In serving phase, we adopt a K-Nearest Neighbor (K-NN) algorithm for comparing existing data and new received data of users. We show that our technique performs in terms of CDF by computer simulation results. From simulation results, the proposed system shows that a positioning accuracy is improved by 8.6 % on average.

Preliminary Analysis of Climate Change Damage in Korea Using the PAGE Model (PAGE 모델을 이용한 한국 기후변화의 피해비용 분석)

  • Chae, Yeo-Ra
    • Journal of Environmental Policy
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    • v.9 no.1
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    • pp.31-55
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    • 2010
  • This study aims to estimate potential climate change damage in Korea using the PAGE model. This study reviewed previous a reasearch to compare relative sensitivity to climate change in Korea and other regions to generate climate change damage function. It was found that sensitivity to climate change in Korea is similar to other Organization for Economic Cooperation and Development (OECD) countries. This study estimated climate change impact for three scenarios. If no action is taken, climate change damage cost in Korea could reach US$ 12,928 ~ 57,900 M. Cumulative Net Present Value (NPV)of climate change impact from 1990 to 2100 would be between US$ 143,226 ~ 921,701 Mdepending on emission scenarios. However, this result should be interpreted with caution as it draws its damage function based on only a few available references. Results also showed that an adaptation policy could decrease the degree of climate change impact significantly. If an adaptation policy is implemented, climate change impact will be decreased by US$ 11,355 million dollars in Korea in 2100.

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Complementary and Alternative Medicine for Oral Health : a Literature Review of Randomized Controlled Clinical Trials (구강건강에 이용되는 보완대체의학 치료: 무작위대조임상연구를 통한 문헌적 고찰)

  • Kim, Da-Hee;Choi, Gwang-Ho;Hwang, Eui-Hyoung;Heo, Kwang-Ho;Kim, Yong-Deok;Shin, Byung-Cheul
    • Journal of Society of Preventive Korean Medicine
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    • v.18 no.3
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    • pp.23-39
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    • 2014
  • Objective : This review aims at analyzing Complementary and Alternative Medicine (CAM) therapies, using for oral health to know current use of CAM in dental area by analyzing randomized controlled clinical trials (RCTs). Method : We searched the following 6 electronic databases until 1 July 2014. : Pubmed, Medline, Embase, Allied and Complementary Medicine Database(AMED), Cumulative Index to Nursing and Allied Health Literature(CINAHL), the Cochrane Library. We included parallel RCTs and cross-over RCTs that assessed the efficacy of CAM regardless of blinding and language. Results : A total of 154 RCT articles were included. There were 2-arm parallel study design(69.5%), 3-arm parallel study design(20.8%), 4-arm parallel study design(4.5%) and Cross-over design(5.2%). Complementary and alternative medicine RCTs in oral health tend to increase in the early-2000s and in the mid-2010s. In addition, 154 citations were classified according to diseases and interventions that categorized Natural Products studies(68.2%), Mind and Body Practices studies(31.8%). We classified in detail that vitamin and mineral therapies(29.9%), dietary supplements(24.7%), acupuncture(23.3%), Herbal medicine(13.6%), homeopathy (2.6%), energy therapies(2.6%), Massage(1.9%), biofeedback(0.6%), traditional medicine(0.6%). Conclusion : Increasing publications and diverse interventions regarding CAM for oral health is observed by analyzing RCTs from the literature review. Further studies are needed to be performed as systematic reviews to verify their effectiveness and the research to inquire into side effect.

A Study on the Monitoring Technique for Musculoskeletal Safety Management and Implementation of the System (근골격계 안전관리를 위한 모니터링 기법에 관한 연구 및 시스템 구현)

  • Shin, Yeong-Ju;Joo, Ha-Young;Yang, Jin-Hong
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.13 no.3
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    • pp.267-276
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    • 2020
  • Manufacturing workers are easily exposed to the risk of musculoskeletal disorders caused by repetitive tasks in their working environment. This is due to problems with occupational characteristics that repeatedly use the body. However, the current lack of monitoring systems for monitoring and prevention has led to an increase in workers' exposure to risks each year. This paper presents how to solve these problems in real working environment by producing wearable devices using IMU sensors. After wearing a wearable type device, the user's movement is judged through data analysis by receiving the rotation value according to musculoskeletal movement. At this time, the risk is determined by measuring the number of rotations of the user by eliminating bias and eliminating cumulative error, acquiring sophisticated data, and analyzing it in the form of dynamic threshold values. Using the wearable device proposed in this paper, the effect of this method could be checked through a web page measuring the number of rotations for elbow musculoskeletal disorders.

An Analysis of the International Transportation Route at the Sight of Wind Power Equipment Manufacturing Company (풍력발전부품 제조업체의 관점에서 본 국제 운송경로 분석)

  • Yun, Seok-Hwan;Park, Jin-Hee
    • Journal of Navigation and Port Research
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    • v.39 no.4
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    • pp.361-370
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    • 2015
  • Wind energy began to receive attention as a new alternative fuel since 20 years ago and is growing as a booming global business model. Global wind power generation in the world has been continuously increasing for the past 10 years, accounting for over 30% of cumulative rate compared to total power generation. Global demand for wind power generation is gradually expanding due to restriction on carbon emission and environmental problems caused by increased greenhouse effect. Accordingly in this study, current transportation routes are classified into three types including access-priority route, economics-priority route, and convenience- priority route depending on distribution characteristics of wind power equipment in order to suggest transportation methods other than ships. The three types of transportation route that this study declared can make the Wind power equipment manufacturing companies can judge not only the duration of transportation but also effectiveness and economic feasibility. It means that the manufacturers can analyze and compare the effectiveness and economic feasibility, which are proceed by the shipping company and freight forwarder until now days.

Biogas Production Effect by addition of Red Pepper Powder through Single Stage Anaerobic Co-Biogasification of Mechanically Pre-treated Food Waste and Primary Sewage Sludge Mixture (하수슬러지와 음식폐기물의 단상 혐기성 통합 소화 처리 시 고춧가루 함량 변화가 바이오 가스 생산에 미치는 영향)

  • Lee, Byung Sun
    • Resources Recycling
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    • v.26 no.1
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    • pp.59-68
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    • 2017
  • This study has been conducted to evaluate the effects of a single stage anaerobic co-biogasification of food waste and primary sewage sludge mixture (1 : 5 V/V%) according to mixing ratio (0% : CAP0, 0.5% : CAP0.5, 1%: CAP1.0) in red pepper powder, which was reported as the material anti-bacterial and anti-fungi, under mesophilic condition ($35^{\circ}C$). during 31 days. It showed that red pepper powder effected anaerobic bacteria, Especially, Hydrolytic bacteria and methanogenic bacteria was inhibited much more than Acetogenic bacteria with red pepper powder. at CAP0, Experimental cumulative methane yield (ECMY) and Experimental bio-energy production (EBEP) were 0.17 L $CH_4/g$ $VS_{fed}$ and 1,465 cal/g $VS_{fed}$ individually as the highest value during 31 days.

Clinical Effect of Left Ventricular Dysfunction in Patients with Mitral Stenosis after Mitral Valve Replacement

  • Park, Kwon Jae;Woo, Jong Soo;Park, Jong Yoon;Jung, Jae Hwa
    • Journal of Chest Surgery
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    • v.49 no.5
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    • pp.350-355
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    • 2016
  • Background: Mitral stenosis (MS) remains one of the important heart diseases. There are many factors that influence the clinical outcomes, and little is known about how left ventricular (LV) dysfunction clinically affects the prognosis of the patient with MS after mitral valve replacement (MVR). We reviewed our clinical experiences of MVR in patients with MS who had LV dysfunction. Methods: Between January 1991 and January 2013, 110 patients with MS who underwent MVR were analyzed and divided into two groups according to ejection fraction (EF). Group 1 ($EF{\leq}45%$) included 13 patients and group 2 (EF>45%) included 97 patients. Results: Thromboembolism occurred in 8 patients after MVR (group 1: n=3, 23.1%; group 2: n=5, 5.2%) and its incidence was significantly higher in group 1 than in group 2 (p=0.014). There were 3 deaths each in groups 1 and 2 during follow-up. The overall rate of cardiac-related death in group 1 was significantly higher than in group 2 (group 1: n=3, 23.1%; group 2: n=3, 3.1%; p=0.007). The cumulative survival rate at 1 and 15 years was 83.9% and 69.9% in group 1 and 97.9% and 96.3% in group 2 (p=0.004). The Cox regression analysis revealed that survival was significantly associated with postoperative stroke (p=0.011, odds ratio=10.304). Conclusion: This study identified postoperative stroke as an adverse prognostic factor in patients with MS after MVR, and a s more prevalent in patients with LV dysfunction. Postoperative stroke should be reduced to improve clinical outcomes for patients. Preventive care should be made in multiple ways, such as management of LV dysfunction, atrial fibrillation, and anticoagulation.

Impacts of Managing Water in a Closed Basin: A Study of the Walker River Basin, Nevada, USA

  • Tracy, John C.
    • Proceedings of the Korea Water Resources Association Conference
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    • 2012.05a
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    • pp.1-10
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    • 2012
  • Throughout much of the world, many ecological problems have arisen in watersheds where a significant portion of stream flows are diverted to support agriculture production. Within endorheic watersheds (watersheds whose terminus is a terminal lake) these problems are magnified due to the cumulative effect that reduced stream flows have on the condition of the lake at the stream's terminus. Within an endorheic watershed, any diversion of stream flows will cause an imbalance in the terminal lake's water balance, causing the lake to transition to a new equilibrium level that has a smaller volume and surface area. However, the total mass of Total Dissolved Solids within the lake will continue to grow; resulting in a significant increase in the lake's TDS concentration over time. The ecological consequences of increased TDS concentrations can be as limited as the intermittent disruption of productive fisheries, or as drastic as a complete collapse of a lake's ecosystem. A watershed where increasing TDS concentrations have reached critical levels is the Walker Lake watershed, located on the eastern slope of the central Sierra Nevada range in Nevada, USA. The watershed has an area of 10,400 sq. km, with average annual headwater flows and stream flow diversions of 376 million $m^3/yr$ and 370 million $m^3/yr$, respectively. These diversions have resulted in the volume of Walker Lake decreasing from 11.1 billion m3 in 1882 to less than 2.0 billion $m^3$ at the present time. The resulting rise in TDS concentration has been from 2,560 mg/l in 1882 to nearly 15,000 mg/l at the current time. Changes in water management practices over the last century, as well as climate change, have contributed to this problem in varying degrees. These changes include the construction of reservoirs in the 1920s, the pumpage of shallow groundwater for irrigation in the 1960s and the implementation of high efficiency agricultural practices in the 1980s. This paper will examine the impacts that each of these actions, along with changes in the region's climate, has had on stream flow in the Walker River, and ultimately the TDS concentration in Walker Lake.

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