• Parasites, Hosts and Diseases
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• v.55 no.2
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• pp.175-183
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• 2017

Codon usage bias (CUB) is a unique property of genomes and has contributed to the better understanding of the molecular features and the evolution processes of particular gene. In this study, genetic indices associated with CUB, including relative synonymous codon usage and effective numbers of codons, as well as the nucleotide composition, were investigated in the Clonorchis sinensis tyrosinase genes and their platyhelminth orthologs, which play an important role in the eggshell formation. The relative synonymous codon usage patterns substantially differed among tyrosinase genes examined. In a neutrality analysis, the correlation between $GC_{12}$ and $GC_3$ was statistically significant, and the regression line had a relatively gradual slope (0.218). NC-plot, i.e., $GC_3$ vs effective number of codons (ENC), showed that most of the tyrosinase genes were below the expected curve. The codon adaptation index (CAI) values of the platyhelminth tyrosinases had a narrow distribution between 0.685/0.714 and 0.797/0.837, and were negatively correlated with their ENC. Taken together, these results suggested that CUB in the tyrosinase genes seemed to be basically governed by selection pressures rather than mutational bias, although the latter factor provided an additional force in shaping CUB of the C. sinensis and Opisthorchis viverrini genes. It was also apparent that the equilibrium point between selection pressure and mutational bias is much more inclined to selection pressure in highly expressed C. sinensis genes, than in poorly expressed genes.

• Journal of Veterinary Clinics
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• v.25 no.4
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• pp.310-313
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• 2008

C. perfringens is the most important enteric clostridial pathogen of animals. C. perfringens type A has been associated with hemorrhagic enteritis in a wide lange of domestic and wild mammals. But all types of C. perfringens can be normal inhabitants of the intestine of most mammals. We have a special case that showed C. perfringens type A infection in a hippopotamus (Hippopotamus amphibius) cub at Seoul Grand Park Zoo. Male, hippopotamus cub died in 3 days after birth. Clinical features of the hippopotamus cub have showed lethargy and anorexia before death. Gross post-mortem findings of the hippopotamus were hemorrhagic enteritis of intestine. Histopathologically, ruminant stomach and intestine showed hemorrhagic lesions and the lumen of the small intestine was filled with mucoid and hemorrhagic fluid. Also, intestine and stomach of hippopotamus were distended with gas and hemorrhagic fluid. C. perfringens was isolated in culture of small intestine and the presence of C. perfringens type A was confirmed by PCR. This case indicated that C. perfringens type A could be considered as a virulence factor responsible for causing death of a newborn hippopotamus.

• Journal of Embryo Transfer
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• v.26 no.3
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• pp.215-217
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• 2011

This is about the successful use of eCG and hCG for producing a Siberian tiger pup born from 10-year-old, primiparous, albino Siberian tiger. From February 2010 to July 2010, natural breeding had been tried three times with no conception. During this period of five months, estrus behaviors appeared to be typically normal and a lot of matings were observed. After consecutive failures, 1000 IU eCG (equine chorionic gonadotropin) were intramuscularly injected on the day showing estrus behavior, followed with an injection of 750 IU hCG (human chorionic gonadotropin) 80 hours later. The tiger stopped recurrence of estrus, and a cub, weighed 780 gram, was born alive 104 days after hCG injection. This study is the first report showing the unique, successful use of exogenous hormones as one of artificial breeding programs in the long history of captive breeding of carnivorous zoo animals in Korea.

• Korean Journal of Veterinary Research
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• v.55 no.2
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• pp.141-143
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• 2015

Dermatophytosis was found on the right front leg of a 4-month-old female African lion cub (Panthera leo) kept at a zoo with locally marginal alopecia. For diagnosis, culturing on sabouraud dextrose agar was performed and skin scrapings from the lesion were analyzed. The ones from the culture and skin scrapings were identified as Trichophyton mentagrophytes. A zookeeper that had been in contacted with the lion for artificial rearing developed skin lesions with well-defined erythematous plaques on the right arm about 1 month after the lesion in the lion was observed. The ringworm was probably transmitted from the lion through continuous contact.

• Journal of Korea Multimedia Society
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• v.8 no.4
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• pp.492-501
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• 2005

In this paper, we proposed the new segmentation method of optic nerve head and optic cub to consider the depth of optic nerve head on stereo fundus image. We analyzed the error factor of stereo matching on stereo fundus image, and compensated them. For robust extraction of optic nerve head and optic cub, we proposed the modified active contour model to consider the 3D depth of optic nerve head. As experiment result to various stereo fundus images, we confirmed that proposed method can segment optic nerve head and optic cup effectively.

• Journal of Digital Contents Society
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• v.18 no.4
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• pp.739-745
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• 2017

This paper presents and discusses an implementation of the GPU shifted sorting method to find approximate k nearest neighbors which executes within "warp", the minimum execution unit in GPU parallel architecture. Also, this paper presents the comparison results with other two common nearest neighbor searching methods, GPU-based kd-tree and ANN (Approximate Nearest Neighbor) library. The proposed implementation focuses on the cases when k is small, i.e. 2, 4, 8, and 16, which are handled efficiently within warp to consider it is very common for applications to handle small k's. Also, this paper discusses optimization ways to implementation by improving memory management in a loop for the CUB open library and adopting CUDA commands which are supported by GPU hardware. The proposed implementation shows more than 16-fold speed-up against GPU-based other methods in the tests, implying that the improvement would become higher for more larger input data.

• Korean journal of dermatology
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• v.56 no.10
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• pp.609-613
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• 2018

Background: Psoriasis is a chronic inflammatory skin disease with an incidence of 0.5~3% of the worldwide population. The pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune reactions. Notably, genetic factors are considered important etiological contributors. Globally, several researchers have recently performed genome-wide association studies (GWAS) to identify the genes related with psoriasis. Objective: We aimed to investigate the expression pattern of 2 candidate genes that were identified by GWAS. These include interleukin 28 receptor alpha (IL28RA) and CUB and Sushi multiple domains 1 (CSMD1). Methods: We applied imiquimod cream to develop a psoriasis-like mouse model and obtained skin tissue. We performed immunohistochemistry to detect the expression of IL-28A and CSMD1. Results: IL28RA expression increased at an early time point such as 1 day after the topical application of 5% imiquimod cream. However, its expression returned to baseline levels 2 weeks after the topical application of imiquimod cream. CSMD1 expression also increased after the topical application of imiquimod, with increased expression particularly observed in the upper epidermal layer. Notably, CSMD1 expression decreased 7 days after imiquimod cream application. Conclusion: These results suggest that IL28RA and CSMD1 may play key roles in the pathogenesis of psoriasis.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.2
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• pp.204-211
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• 2020

In this paper, we propose an optimal deep learning network architecture for main object location detection through weak supervised learning. The proposed network adds convolution blocks for improving the localization accuracy of the main object through weakly-supervised learning. The additional deep learning network consists of five additional blocks that add a composite product layer based on VGG-16. And the proposed network was trained by the method of weakly-supervised learning that does not require real location information for objects. In addition, Grad-CAM to compensate for the weakness of GAP in CAM, which is one of weak supervised learning methods, was used. The proposed network was tested through the CUB-200-2011 data set, we could obtain 50.13% in top-1 localization error. Also, the proposed network shows higher accuracy in detecting the main object than the existing method.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.05a
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• pp.293-296
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• 2018

생성적 적대 네트워크를 활용하여 텍스트, 스케치 등 다양한 자원으로부터 이미지를 생성하기 위한 연구는 활발하게 진행되고 있으며 많은 실용적인 연구가 존재한다. 하지만 기존 연구들은 텍스트나 스케치 등 각 하나의 자원을 통해 이미지를 생성하기 때문에 설명이 부족한 텍스트, 실제 이미지와 상이한 스케치와 같이 자원의 정보가 불완전한 경우에는 제대로 된 이미지를 생성하지 못한다는 한계가 있다. 본 논문에서는 기존 연구의 한계점올 극복하기 위해 텍스트와 스케치 두 개의 자원을 동시에 활용하여 이미지를 생성하는 새로운 생성 기법 TS-GAN 을 제안한다. TS-GAN 은 두 단계로 이루어져 있으며 각 단계를 통해 더욱 사실적인 이미지를 생성한다. 본 논문에서 제안한 기법은 컴퓨터 비전 분야에서 많이 활용되는 CUB 데이터세트를 사용하여 이미지 생성 결과의 우수성을 보인다.

• Advances in aircraft and spacecraft science
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• v.6 no.5
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• pp.371-389
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• 2019

The implementation of a robust $H_{\infty}$ Control, which is numerically efficient for uncertain nonlinear dynamics, on longitudinal and lateral autopilots is realised for a quarter scale Piper J3-Cub model accepted as an unmanned aerial vehicle (UAV) under the condition of sensor noise and disturbance effects. The stability and control coefficients of the UAV are evaluated through XFLR5 software, which utilises a vortex lattice method at a predefined flight condition. After that, the longitudinal trim point is computed, and the linearization process is performed at this trim point. The "${\mu}$-Synthesis"-based robust $H_{\infty}$ control algorithm for roll, pitch and yaw displacement autopilots are developed for both longitudinal and lateral linearised nonlinear dynamics. Controller performances, closed-loop frequency responses, nominal and perturbed system responses are obtained under the conditions of disturbance and sensor noise. The simulation results indicate that the proposed control scheme achieves robust performance and guarantees stability under exogenous disturbance and measurement noise effects and model uncertainty.