• Title/Summary/Keyword: crossover rate

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Success rate of nitrous oxide-oxygen procedural sedation in dental patients: systematic review and meta-analysis

  • Rossit, Marco;Gil-Manich, Victor;Ribera-Uribe, Jose Manuel
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.21 no.6
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    • pp.527-545
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    • 2021
  • The aim of this systematic review was to determine the success rate of nitrous oxide-oxygen procedural sedation (NOIS) in dentistry. A systematic digital search was conducted for publications or reports of randomized controlled trials evaluating the clinical performance of NOIS. Abstracts of research papers were screened for suitability, and full-text articles were obtained for those who met the inclusion and exclusion criteria accordingly. The quality of the studies was assessed using the revised Cochrane risk-of-bias tool (RoB 2). A total of 19 articles (eight randomized clinical trials with parallel intervention groups and 11 crossover trials), published between May 1988 and August 2019, were finally selected for this review. The studies followed 1293 patients reporting NOIS success rates, with a cumulative mean value of 94.9% (95% CI: 88.8-98.9%). Thirteen trials were conducted on pediatric populations (1098 patients), and the remaining six were conducted on adults (195 patients), with cumulative efficacy rates of 91.9% (95% CI: 82.5-98.1%) and 99.9% (95% CI: 97.7-100.0%), respectively. The difference was statistically significant (P = 0.002). Completion of treatment and Section IV of the Houpt scale were the most used efficacy criteria. Within the limitations of this systematic review, the present study provides important information on the efficacy rate of NOIS. However, further well-designed and well-documented clinical trials are required and there is a need to develop guidelines for standardization of criteria and definition of success in procedural sedation. Currently, completion of treatment is the most used parameter in clinical practice, though many others also do exist at the same time. To maximize NOIS efficacy, clinicians should strictly consider appropriate indications for the procedure.

Dental plaque removal efficiency of a smart toothbrush based on augmented reality in children (증강현실 기반 스마트 칫솔의 치면세균막 제거효과 평가)

  • Min-Ji Park;Suk-Bin Jang;Jae-Young Lee
    • Journal of Korean society of Dental Hygiene
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    • v.23 no.1
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    • pp.33-42
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    • 2023
  • Objectives: Based on the strengths of augmented reality (AR), this study aimed to determine the dental plaque removal efficiency of a guided brushing program in children. Methods: This randomized, controlled, double-blind crossover clinical trial evaluated the plaque removal rate after regular brushing versus AR-based guided toothbrushing in 20 children aged 5-12 years. Results: Overall, the dental plaque removal efficiency of AR-based brushing was superior to that of regular brushing (p<0.05). When classified in detail, no significant difference was noted in the plaque removal rate between the two brushing methods in the anterior region (p=0.056), whereas a significant difference in the plaque removal rate was observed in the posterior region (p<0.05). Conclusions: Based on these results, the efficacy of dental plaque removal for brushing using an AR-based smartphone application was confirmed; thus, this can be used for oral health education incorporating ICT technology in the future.

Quality of life, patient preferences, and implant survival and success of tapered implant-retained mandibular overdentures as a function of the attachment system

  • Ilze Indriksone;Pauls Vitols;Viktors Avkstols;Linards Grieznis;Kaspars Stamers;Susy Linder;Michel Dard
    • Journal of Periodontal and Implant Science
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    • v.53 no.3
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    • pp.194-206
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    • 2023
  • Purpose: A novel attachment system for implant-retained overdentures (IRODs) with novel material combinations for improved mechanical resilience and prosthodontic success (Novaloc) has been recently introduced as an alternative to an existing system (Locator). This study investigated whether differences between the Novaloc and Locator attachment systems translate into differences in implant survival, implant success, and patient-centered outcomes when applied in a real-world in-practice comparative setting in patients restored with mandibular IRODs supported by 2 interforaminal implants (2-IRODs). Methods: This prospective, intra-subject crossover comparison compared 20 patients who received 2 intra-foraminal bone level tapered implants restored with full acrylic overdentures using either the Locator or Novaloc attachment system. After 6 months of function, the attachment in the corresponding dentures was switched, and the definitive attachment system type was delivered based on the patient's preference after 12 months. For the definitive attachment system, implant survival was evaluated after 24 months. The primary outcomes of this study were oral health-related quality of life and patient preferences related to prosthetic and implant survival. Secondary outcomes included implant survival rate and success, prosthetic survival, perceived general health, and patient satisfaction. Results: Patient-centered outcomes and patient preferences between attachment systems were comparable, with relatively high overall patient satisfaction levels for both attachment systems. No difference in the prosthetic survival rate between study groups was detected. The implant survival rate over the follow-up period after 24 months in both groups was 100%. Conclusions: The results of this in-practice comparison indicate that both attachment systems represent comparable candidates for the prosthodontic retention of 2-IRODs. Both systems showed high rates of patient satisfaction and implant survival. The influence of material combinations of the retentive system on treatment outcomes between the tested systems remains inconclusive and requires further investigations.

Evaluating Reverse Logistics Networks with Centralized Centers : Hybrid Genetic Algorithm Approach (집중형센터를 가진 역물류네트워크 평가 : 혼합형 유전알고리즘 접근법)

  • Yun, YoungSu
    • Journal of Intelligence and Information Systems
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    • v.19 no.4
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    • pp.55-79
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    • 2013
  • In this paper, we propose a hybrid genetic algorithm (HGA) approach to effectively solve the reverse logistics network with centralized centers (RLNCC). For the proposed HGA approach, genetic algorithm (GA) is used as a main algorithm. For implementing GA, a new bit-string representation scheme using 0 and 1 values is suggested, which can easily make initial population of GA. As genetic operators, the elitist strategy in enlarged sampling space developed by Gen and Chang (1997), a new two-point crossover operator, and a new random mutation operator are used for selection, crossover and mutation, respectively. For hybrid concept of GA, an iterative hill climbing method (IHCM) developed by Michalewicz (1994) is inserted into HGA search loop. The IHCM is one of local search techniques and precisely explores the space converged by GA search. The RLNCC is composed of collection centers, remanufacturing centers, redistribution centers, and secondary markets in reverse logistics networks. Of the centers and secondary markets, only one collection center, remanufacturing center, redistribution center, and secondary market should be opened in reverse logistics networks. Some assumptions are considered for effectively implementing the RLNCC The RLNCC is represented by a mixed integer programming (MIP) model using indexes, parameters and decision variables. The objective function of the MIP model is to minimize the total cost which is consisted of transportation cost, fixed cost, and handling cost. The transportation cost is obtained by transporting the returned products between each centers and secondary markets. The fixed cost is calculated by opening or closing decision at each center and secondary markets. That is, if there are three collection centers (the opening costs of collection center 1 2, and 3 are 10.5, 12.1, 8.9, respectively), and the collection center 1 is opened and the remainders are all closed, then the fixed cost is 10.5. The handling cost means the cost of treating the products returned from customers at each center and secondary markets which are opened at each RLNCC stage. The RLNCC is solved by the proposed HGA approach. In numerical experiment, the proposed HGA and a conventional competing approach is compared with each other using various measures of performance. For the conventional competing approach, the GA approach by Yun (2013) is used. The GA approach has not any local search technique such as the IHCM proposed the HGA approach. As measures of performance, CPU time, optimal solution, and optimal setting are used. Two types of the RLNCC with different numbers of customers, collection centers, remanufacturing centers, redistribution centers and secondary markets are presented for comparing the performances of the HGA and GA approaches. The MIP models using the two types of the RLNCC are programmed by Visual Basic Version 6.0, and the computer implementing environment is the IBM compatible PC with 3.06Ghz CPU speed and 1GB RAM on Windows XP. The parameters used in the HGA and GA approaches are that the total number of generations is 10,000, population size 20, crossover rate 0.5, mutation rate 0.1, and the search range for the IHCM is 2.0. Total 20 iterations are made for eliminating the randomness of the searches of the HGA and GA approaches. With performance comparisons, network representations by opening/closing decision, and convergence processes using two types of the RLNCCs, the experimental result shows that the HGA has significantly better performance in terms of the optimal solution than the GA, though the GA is slightly quicker than the HGA in terms of the CPU time. Finally, it has been proved that the proposed HGA approach is more efficient than conventional GA approach in two types of the RLNCC since the former has a GA search process as well as a local search process for additional search scheme, while the latter has a GA search process alone. For a future study, much more large-sized RLNCCs will be tested for robustness of our approach.

Degradation Accelerated Stress Test of Electrode and Membrane in PEMFC (PEMFC에서 전극과 전해질 막의 열화 가속 시험)

  • Song, Jin-Hoon;Kim, Sae-Hoon;Ahn, Byung-Ki;Ko, Jai-Joon;Park, Kwon-Pil
    • Korean Chemical Engineering Research
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    • v.50 no.5
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    • pp.778-782
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    • 2012
  • Until a recent day, degradation of PEMFC MEA (membrane and electrode assembly) has been studied, separated with membrane degradation and electrode degradation, respectively. But membrane and electrode were degraded coincidentally at real PEMFC operation condition. Therefore in this work, AST (Accelerated Stress Test) of MEA degradation was done at the condition that membrane and electrode were degraded simultaneously. There was interaction between membrane degradation and electrode degradation. Membrane degradation reduced the decrease range of catalyst active area by electrode degradation. Electrode degradation reduces increase range of the hydrogen crossover current and FER (Fluoride Emission Rate) by membrane degradation.

Rheological Behaviors of White and Brown Rice Flours During In-vitro Simulation of Starch Digestion (In-vitro 전분 소화 모델에서 백미와 현미 가루의 물성학적 특성 분석)

  • Kim, Hyeon Ji;Lee, Jeom-Sig;Ko, Sanghoon;Lee, Suyong
    • Korean Journal of Food Science and Technology
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    • v.47 no.6
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    • pp.793-796
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    • 2015
  • The in-vitro starch digestibility of white and brown rice flours was continuously characterized from a rheological point of view. Specifically, the in-vitro viscosities of the rice digesta samples were monitored under simulated oral, gastric, and intestinal conditions. A trend of decreasing viscosities in all the digesta samples was observed during the in-vitro digestion. After cooking, the brown rice sample exhibited lower viscosity than that of the white rice flour due to the presence of more non-starch components. A similar tendency was observed during the simulated oral and gastric digestions. However, the viscosity crossover between the white and brown rice samples was observed during intestinal digestion. In addition, the amount of glucose released from the brown rice flour was significantly lower than that from the white rice flour. Thus, the slower rate of starch hydrolysis in the brown rice flour could be related to its in-vitro rheological behaviors.

Hydrogen Transport through Palladium Foil Placed in Nafion Electrolyte of H2/O2 Fuel Cellsorption

  • Song, Seong-Min;Koo, Il-Gyo;Lee, Woong-Moo
    • Journal of Hydrogen and New Energy
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    • v.12 no.4
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    • pp.257-265
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    • 2001
  • Placing a hydrogen conducting, methanol impermeable metallic barrier like palladium (Pd) is a well-known method for preventing methanol crossover through solid polymer electrolyte for direct methanol fuel cells (DMFC). Applying a bias potential between the anode and the barrier can further develop this concept so that the hydrogen transfer rate is enhanced. Since hydrogen diffuses in Pd as atomic form while it moves through nafion electrolyte as ion, it has to be reduced or oxidized whenever it passes the interface formed by Pd and the electrolyte. We performed experiments to measure the hydrogen transport through the Pd membrane placed in Nafion electrolyte of hydrogen/oxygen fuel cell (PEMFC). Applying a bias potential between the hydrogen electrode of the cell and the Pd membrane facilitated the hydrogen passage through the Pd membrane. The results show that the cell current measured with the Pd membrane placed reached almost 40 % the value measured with the cell without Pd membrane. It was found that the current flown through the bias path is only a few percent of the cell current.

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An Adaptive Genetic Algorithm for a Dynamic Lot-sizing and Dispatching Problem with Multiple Vehicle Types and Delivery Time Windows (다종의 차량과 납품시간창을 고려한 동적 로트크기 결정 및 디스패칭 문제를 위한 자율유전알고리즘)

  • Kim, Byung-Soo;Lee, Woon-Seek
    • Journal of Korean Institute of Industrial Engineers
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    • v.37 no.4
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    • pp.331-341
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    • 2011
  • This paper considers an inbound lot-sizing and outbound dispatching problem for a single product in a thirdparty logistics (3PL) distribution center. Demands are dynamic and finite over the discrete time horizon, and moreover, each demand has a delivery time window which is the time interval with the dates between the earliest and the latest delivery dates All the product amounts must be delivered to the customer in the time window. Ordered products are shipped by multiple vehicle types and the freight cost is proportional to the vehicle-types and the number of vehicles used. First, we formulate a mixed integer programming model. Since it is difficult to solve the model as the size of real problem being very large, we design a conventional genetic algorithm with a local search heuristic (HGA) and an improved genetic algorithm called adaptive genetic algorithm (AGA). AGA spontaneously adjusts crossover and mutation rate depending upon the status of current population. Finally, we conduct some computational experiments to evaluate the performance of AGA with HGA.

Effect of Progressive Muscle Relaxation using Biofeedback on Perceived Stress, Stress Response, Immune Response and Climacteric Symptoms of Middle-Aged Women (바이오피드백을 이용한 점진적 근육이완이 중년여성의 지각된 스트레스, 스트레스반응, 면역반응 및 갱년기 증상에 미치는 효과)

  • 정인숙
    • Journal of Korean Academy of Nursing
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    • v.34 no.2
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    • pp.213-224
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    • 2004
  • Purpose: This study was aimed to evaluate the effect of progressive muscle relaxation training using biofeedback on perceived stress, stress response, immune response and climacteric symptoms, Method: This was a crossover, pre-post test design, The study subjects are 36 middle-aged women who were selected at 2 public health centers, The independent variable was Biofeedback training for 4 weeks, twice a week and home training for 4 weeks, Dependent variables were perceived stress, stress response, immune response, and climacteric symptoms measured with Hildtch's scale (1996), Result: Progressive muscle relaxation training using biofeedback was not effective in reducing perceived stress, but it was shown to be effective in reducing physiological stress responses such as pulse rate and EMG, Though blood pressure and skin conductance were repeatedly down, and skin temperature slowly increased, there were no statistically significant differences. Progressive muscle relaxation training using biofeedback was not effective in reducing serum cortisol, enhancing immune responses, or decreasing climacteric symptoms. Conclusion: The findings point to a pressing need for further, well-controlled and designed research with consideration in selection of subjects and instruments, frequency of measurements, the sampling method, and intervention modalities.

Influence of Smokers's Jogging Exercises on Cardiopulmonary Function of Normal Adults in Their Twenties (20대 성인 흡연자의 조깅운동이 심장호흡기능에 미치는 영향)

  • Lee, Sam-Cheol
    • Journal of Korean Physical Therapy Science
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    • v.23 no.1
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    • pp.9-17
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    • 2016
  • Background and Purpose : Effects of smokers's jogging exercises on oxygen uptake, ventilation, heart rate, and vital-capacity of normal adults have not been studied in details on. In this study, people that had completed the established jogging exercises was selected for the study. We could examine the effects of imposed jogging in smokers who might be considered by an experienced physical therapist to be well practiced and proficient in this exercises. Subjects and Methods : A total number of 24 young healthy subjects participated in a randomized crossover controlled study and completed the study. The subjects of this study were divided into jogging and controlled groups which were composed 14 people respectively. The members of exercise group had jogging exercises 50 minutes a day, five times a week, for 5 weeks in same conditions, otherwise controlled group did not. Results : The results of this study were as follows. The jogging group demonstrated significant increases in cardiopulmonary function, vital-capacity and exercise capacity, compared with control group, which demonstrated no change in baseline measurements of 5 weeks. Conclusion : Jogging exercises can increase cardiopulmonary function in people after they have undergone successful PA. These results suggested that it was improved on cardiopulmonary function and lung capacity, since jogging exercise had. The results of this study could be applied for valuable criterion cardiopulmonary function. It is necessary to selects in various groups of the purpose of enhancing confidence in of this research.

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