• Asian-Australasian Journal of Animal Sciences
• /
• v.33 no.2
• /
• pp.187-196
• /
• 2020

Objective: Porcine respiratory disease is one of the most important health problems causing significant economic losses. To understand the genetic basis for susceptibility to swine enzootic pneumonia (EP) in pigs, we detected 102,809 single nucleotide polymorphisms in a total of 249 individuals based on genome-wide sequencing data. Methods: Genome comparison of susceptibility to swine EP in three pig breeds (Jinhua, Erhualian, and Meishan) with two western lines that are considered more resistant (Duroc and Landrace) using cross-population extended haplotype homozygosity and F-statistic (F_ST) statistical approaches identified 691 positively selected genes. Based on quantitative trait loci, gene ontology terms and literature search, we selected 14 candidate genes that have convincible biological functions associated with swine EP or human asthma. Results: Most of these genes were tested by several methods including transcription analysis and candidate genes association study. Among these genes: cytochrome P450 1A1 and catenin beta 1 (CTNNB1) are involved in fertility; transforming growth factor beta receptor 3 plays a role in meat quality traits; Wnt family member 2, CTNNB1 and transcription factor 7 take part in adipogenesis and fat deposition simultaneously; plasminogen activator, urokinase receptor (completely linked to AXL receptor tyrosine kinase, r² = 1) plays an essential role in the successful ovulation of matured oocytes in pigs; colipase like 2 (strongly linked to SAM pointed domain containing ETS transcription factor, r² = 0.848) is involved in male fertility. Conclusion: These adverse genes susceptible to swine EP may be selected while selecting for economic traits (especially reproduction traits) due to pleiotropic and hitchhiking effect of linked genes. Our study provided a completely new point of view to understand the genetic basis for susceptibility or resistance to swine EP in pigs thereby, provides insight for designing sustainable breed selection programs. Finally, the candidate genes are crucial due to their potential roles in respiratory diseases in a large number of species, including human.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.38 no.4
• /
• pp.231-239
• /
• 2012

Objectives: This study sought to provide guidelines in order to decrease the incidence of nerve injury during mandibular ramus bone harvesting, and to improve understanding of the anatomical structure of the inferior alveolar canal (IAC) to include its distance from the exterior buccal cortex. Materials and Methods: In January and February 2009, 20 patients who visited the Wonkwang University Department of Oral and Maxillofacial Surgery reporting various conditions underwent cone beam computed tomography and were included in this study. Patients with missing left or right mandibular first molars or incisors, or who had jaw fracture or bone pathologies, were excluded. The reference point (R point) was defined as the point where the occlusal plane reached the anterior ramus of the mandible. The position of the IAC in relation to the R point, the buccal bone width (BW), the alveolar crest distance (ACD), the distance from the alveolar crest to the occlusal plane (COD), and the distance from the IAC to the sagittal plane (CS) were determined using proprietary image analysis software which produced cross-sectional coronal and axial images. Results: The distance medially from the R point to the IAC along the axial plane was $6.19{\pm}1.21mm$. The HD from the R point, posteriorly to IAC, in the lateral view was $13.07{\pm}2.45mm$, the VD from the R point was $14.24{\pm}2.41mm$, and the ND from the R point was $10.12{\pm}1.76mm$. The pathway of the IAC was positioned almost in a straight line along a sagittal plane within $0.56{\pm}0.70mm$. The distance from the buccal bone surface to the IAC increased anteriorly from the R point. Conclusion: Marking osteotomy lines in the retromolar area in procedures involving bone harvesting should be discouraged due to the risk of damage to IAC structures. Our measurements indicated that the area from the R point in the ramus of the mandible to 10 mm anterior can be safely harvested for bone grafting purposes.

• Journal of Environmental Health Sciences
• /
• v.11 no.2
• /
• pp.41-54
• /
• 1985

This study was conducted for the improvement of milk quality and milk hygiene in public health point of view. Investigation of mastiris infection rate, isolation and identification of causative microorganisms in CMT positive milk, investigation of milk contamination level by measuring the bacteria and soma tic cell counts and investigation of dairy management in farms were performed on 1.605 quarters milk of 434 cows of 20 dairy farms in Gyunggi-area from September 1983 to March 1984. The results were summarized as follows 1. Sixteen (3.7%) of 434 cows were found to be infected with clinical mastiris. 234 (53.9%) of 434 cows and 608(37.9%) of 1, 605 quarters were found to be infected with subclinical mastiris. 2. The causative microorganisms isolated were Staphylococcus aureus (38.3%), Staphylococcus epidermidis(21.0%), Micrococci(13.6%), Streptococcus spp. (12.3%), E. coli (7.4%), Fungus & Yeast (1.6%) and others (5.8%). 3. Total numbers of bacteria were $9.2{\times}10^6$ to $1.21{\times}10^7/ml$(av. $1.805{\times} 10^7/ml$), numbers of coliform bacteria were $4.1{\times} 10^5$ to $9.4{\times} 10^5$/ml(av. $7.05{\times} 10^5$/ml) and somatic cell counts were $4.8{\times} 10^5$ to $1.52{\times} 10^6$ cells/ml (av. $9.5{\times} 10^5$cells/ml) in bulk milk. 4. As comparing with CMT score of +, ++ and +++, somatic cell counts were $3.4{\times} 10^5$ to $1.64{\times} 10^6$ cells/ml (av. $6.41{\times} 10^5$cells/ml), $5.4{\times} 10^5$ to $2.75{\times} 10^6$ cells/ml(av. $1.762{\times} 10^6$cells/ml) and $1.97{\times} 10^6$ to $9.75{\times} 10^6$ cells/ml(av. $7.781{\times} 10^6$cells/ml), respectively. 5. In investigation on dairy management, performance of dry cow therapy, teat dipping after milking, disinfection of milking machine at every milking, replacement of milk liner within 6months and opportunity of acquirement for the mastiris control techniques by dairy education were 65%, 40%, 45%, 55% and 50% in 20 dairy farms, respectively.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.40 no.4
• /
• pp.51-61
• /
• 2012

Kyong-Eui Railway used to be one of the major cross-country railways connecting Busan and Shineuiju. Being the central axis of logistics and transportation in Korea, it also signifies a symbolic meaning of the people's desire for the unification of divided Korean peninsula. A steam locomotive that had stopped in Jangdan Station was bombed out during the Korean War. The locomotive has been neglected and covered with rust in DMZ over a half century, and now is becoming a historic reminder of divided Korea. The initial design approach was based on the three main perspectives of the relocation plan of the steam locomotive in Jangdan Station which is designated as the registered cultural asset no. 78: historical significance, role of a monumental space, and influence on and from the local culture and tourism. Three design subjects were especially highlighted which would represent the identity of the cultural asset, the stream locomotive. First, a vertical watching deck was installed to provide various view points toward the locomotive while ensuring the security of visitors as well as the cultural asset. Second, the Dokgae bride area has good design potentials being on the railway. However, the site is too narrow. Thus, a new ramp and a stairway were placed responding to the existing topography so that the pedestrian environment could be secured last, to respect the local context where the locomotive was originally located, mulberry trees in the locomotive were transplanted as well. Flowering plants were planted around the display area for better ventilation to minimize the negative impact on the locomotive.

• Journal of the Institute of Electronics Engineers of Korea CI
• /
• v.46 no.4
• /
• pp.61-68
• /
• 2009

In this paper, we propose a Cluster-based Cooperative Routing using ARQ (CCRA) for supporting both reliability and transmitting efficient service in mobile ad-hoc wireless sensor networks with Rayleigh fading environments. The main contributions and features of this paper are as follows. First, the clustering method which uses the position information of nodes as underlying structure for supporting reliable transmission services is used. Second, the cooperative data transmission method based on the underlying clustering informations is used to improve both reliability and data transmission efficiency. Third, the ARQ-based transmission is used to improve transmission reliability. Fourth, we consider a realistic approach, in the points of view of mobile ad-hoc wireless sensor networks, based on mobile sensor nodes as well as fixed sensor nodes in the sensor fields while the conventional research for sensor networks focus on mainly fixed sensor networks. The performance evaluation of proposed routing protocol implemented via simulation using Optimized Network Engineering Tool (OPNET) and theoretical analysis.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.28 no.1
• /
• pp.180-184
• /
• 2001

Cleidocranial Dysplasia(CCD) is an autosomal dominant human bone disease characterized by abnormal clavicles, patent sutures and fontanelles, and dental anomalies. Among dental anomalies, it is characterized that permanent dentition is severly disturbed due to multiple supernumerary teeth and abnormalities of tooth morphology. A eight-year-old female patient diagnosed as cleidocranial dysplasia visited in our hospital. Upon clinical oral exam, retained deciduous teeth, constriction of dental arch, anterior cross bite, and multiple dental caries were observed. In the dental panoramic radiograph, retained deciduous teeth and multiple supernumerary teeth in the maxilla and the mandible were found. In the cephalometric radiograph, open sutures and wormian bones were seen. In the chest P-A view absence of clavicles was observed. The cleidocranial dysplasia patients have eruption problems in permanent dentition both in regions with and without supernumerary teeth. The severely delayed or arrested eruption of permanent teeth has been ascribed to various factors : 1) The presence of multiple supernumerary teeth, 2) malformed roots with lack of cellular cementum, 3) the jaw bone being too dense, and 4) abnormal resorption of bone and primary teeth. Formation and maturation of primary teeth in cleidocranial dysplasia are normal, whereas the permanent dentition has various anomalies. Therefore, dentists should understand the development of dentition in cleidocranial dysplasia, and treat them in proper time.

• Korean Journal of Social Welfare
• /
• v.68 no.4
• /
• pp.143-167
• /
• 2016

While there have been numerous studies on various issues of aging of the individuals and the population, little is known about the process and consequences of aging of the disabled. Aging is irreversible for the disabled as well as for the not-disabled. With the advances of age, the disabled confront double jeopardy from disability and old age. This study aims to explore the meaning of aging and death for 40s and 50s living with disability for more than 20 years. It utilizes the data set collected through focus groups discussions of the disabled The cases in our analysis are composed of the disabled capable of articulating their feelings and thoughts. Thus, they are selected from the less privileged ones. The analysis shows that aging of the disabled, often involving secondary disability, overwhelms their current disability. Nonetheless, it does not necessary mean that they become an ordinary elderly person. Rather they still feel exclusion from the elderly for their disability. As getting older they turn to face social barrier for both disability and old age. Also, they are trying to live their present lives in full while accepting the presence of death Our findings are hoped to help to understand how the disabled get old and view their death in their own way.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.17
• /
• pp.7781-7784
• /
• 2015

Background: The commonly held view of the tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of p 53. Therefore, this study aimed to determine the correlation between the patterns of Mdm2 SNIP 309 and the inflammation grading of Helicobacter pylori associated gastritis in a Thai population. Materials and Methods: A cross-sectional study was carried out from November 2014 through June 2015. Biopsy specimens were obtained from infected patients and infection was proved by positive histology. The gastric mucosa specimens were sent to the Molecular Genetic Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 using the real-time PCR hybridization probe method. The results were analyzed and compared with the Updated Sydney classification. Results: A total of 100 infected patients were interviewed and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous correlated with mild to moderate inflammation (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with severe inflammation (P<0.01). Conclusions: Our study found the frequency of Mdm2 SNP309 G/G in our Thai population to be very low, and suggests that this can explain to some extent the low incidence of severe inflammation and gastric cancer changes in the Thai population. Mild to moderate inflammation are the most common pathologic gradings due to the unique genetic polymorphism of Mdm2 SNIP 309 in the Thai population.

• Journal of architectural history
• /
• v.20 no.3
• /
• pp.7-22
• /
• 2011

With the accumulations of outcomes from archaeological excavations of mountain fortress of three kingdoms period, there have been studies about time-periodic territory range of mountain fortress, difference in the way(method) of construction, defence system and so on from various points of view. This is an empirical study on the construction method of the valley part of stone fortress. First of all, it is required to secure large quantity of fresh water for those who lived at mountain fortress. Especially when builders of fortress construct a fortification at the valley part of stone fortress, in advance they must sufficiently consider several options including the establishment of sustainable water resources. First, when it comes to build a fortification on a ridge[or a slope] of a mountain, you have only to consider a vertical stress. However, when it comes to build a fortification at the valley part of a mountain, You must have more sufficient preparations for the constructing process. Because there are not only a vertical stress but also a horizontal pressure simultaneously. Second, a fortification of mountain fortress built by using unit building stone is a structure of masonry construction like brick construction, and the valley part of it is where the construction of the fortification begins. Third, when it comes to build a fortification at the valley part of a mountain, it seems that they use a temporary method such as coffer dam in oder to prevent the collapse of the fortification due to heavy rain. Furthermore, in response to a horizontal pressure a fortification is built by the way of its plane make an arch, or by piling up the soil with the plate method(類似版築) and earthen wall harder method(敷葉) they increase cross-sectional area of the fortification and its cutoff capacity. In front direction they put the reservoir facility for the fear that the hydraulic pressure and earth pressure are directly transmitted to the fortification. The process of constructing the fortification at the valley part of a mountain is done in the same oder as follows; leveling of ground(整地) ${\Rightarrow}$ construction of coffer dam ${\Rightarrow}$ construction of the fortification between the both banks of the valley ${\Rightarrow}$ construction of the fortification at bottom part of spill way(餘水路) between the both banks of the valley ${\Rightarrow}$ construction of spill way(餘水路) & reservoir facility ${\Rightarrow}$ construction of the fortification at upper part of spill way between the both banks of the valley. Coffer dam facility seems to be not only the protection device on occasion of flood but also an important criterion to measure the proper height of spill way or tailrace(放水路). This study has a meaningful significance in that it empirically examines the method of reduction of the horizontal pressure which the fortification at the valley part of a mountain takes, the date the construction was done, and wether the changes in climate such as heavy rainfall influence the process of construction.

• Korean journal of applied entomology
• /
• v.19 no.4 s.45
• /
• pp.203-211
• /
• 1980

The pattern of blast disease incidence of Tonsil-line rice varieties derived from the cross between Indica and Japonica type was quite different from that of Japonica-type rice varieties. The former showed discontinuity between the incidence of leaf blast and panicle blast; the incidence .of leaf blast was slight, while that of panicle blast was very severe. Different level of nitrogen fertilizer applied influenced significantly the incidence of leaf blast but influenced slightly the incidence of panicle blast of Tongil-line rice varieties. The infection percentage of panicle blast of Tongil-line rice varieties was about $90\%$ and most of them were infected in leaf sheaths during booting stage, but infection of panicle blast of Japonica-type rice varieties in leaf sheaths during booting stage was very low, only about $3\%$. Infection route of panicle blast in leaf sheaths during booting stage, microflora in leaf sheaths, and specific susceptibility of young panicle to blast disease were investigated in the epidemiological point of view.