• Title/Summary/Keyword: cross protection.

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Study of the Standard Testing Specifications for a Non-loading Performance Evaluation of Coating Material-sprayed Circular Steel Structures (뿜칠 피복 원형 철골구조의 비재하 내화성능 평가용 시험체 제안을 위한 연구)

  • Ok, Chi-Yeol;Kim, Jae-Jun
    • Fire Science and Engineering
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    • v.30 no.3
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    • pp.7-15
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    • 2016
  • The cross-sectional shape factor is used worldwide to evaluate the scientific performance of fire-resistant structures. In South Korea, however, a system for applying a cross-sectional shape factor has not been arranged and circular or rectangular steel pipes are commonly used for large-scale steel frame buildings. On the other hand, coating material-spray steel beams and pillars that have received the certification of a fire-resistant structure from recognized organizations are mostly limited to a H-beam. A H-beam is granted a wide range of certifications without size limitations from a non-loading performance test with test standards based on the relevant provisions. Other types of steel pipe are to be certified for fireresistance according to shape. In this study, a cross-sectional shape factor was used to propose standard testing specifications for the application of coating material-sprayed circular and rectangular steel pipes, eventually to set the scope of certification for reasonable fire-resistant structures.

Cross-reaction of 6B and 19F Specific Antibodies to Serotypes 6A, 6C, and 19A after Immunization with 7-valent Pneumococcal Conjugate Vaccine in Korean Children Aged 12-23 Months (한국 12-23개월 소아에서 7가 폐구균 단백결합 백신 추가접종으로 유도된 6B와 19F 혈청형 특이 방어항체의 교차혈청형 6A, 6C, 19A에 대한 교차 반응)

  • Kim, Kyung-Hyo;Yang, Joo Yun;Park, In Ho;Lim, Soo Young
    • Pediatric Infection and Vaccine
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    • v.20 no.2
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    • pp.53-62
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    • 2013
  • Purpose: The cross-protection of 7-valent pneumococcal conjugate vaccine (PCV7) against vaccine-related serotypes has been controversial. We investigated the serological properties of cross-protective antibodies against vaccine-related serotypes 6A, 6C, and 19A induced in young children aged 12-23 months after booster immunization of PCV7. Methods: IgG and IgM antibody concentrations and opsonic index (OI) against vaccine serotypes 6B and 19F and vaccine-related serotypes 6A, 6C, and 19A were measured by ELISA and opsonophagocytic killing assay (OPA) in 4 selected immunesera. The serological properties and antigenic specificity of protective antibodies were determined by IgM depletion of immunesera, OPA, and competitive OPA against serogroup 6 and 19 pneumococci. Results: Compared to pre-IgM depleted immunesera, OI of IgM-depleted immunesera against 6B and 19F decreased and OI against 6A, 6C, and 19A decreased, too. In competition OPA, free 6B and 19F polysaccharide completely inhibited the immune protection against vaccine-related serotypes 6A, 6C, and 19A as well as vaccine types 6B and 19F. Conclusions: The booster immunization of PCV7 certainly induced cross-protective antibodies against vaccine-related serotypes 6A, 6C, and 19A with both IgG and IgM isotypes. Furthermore, IgM antibodies are more highly contributed to opsonophagocytic activity against vaccine-related serotypes as well as most of vaccine types than do IgG antibodies. Further studies are needed for the more immunized sera in the children as well as adults.

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A Clinical Study on the Effects of Myocardial Protection of St. Thomas Hospital Cardioplegic Solution During Open Heart Surgery (개심술에서 St. Thomas Hospital 심정지액의 심근보호효과에 관한 임상적 연구)

  • Kim, Yeong-Hak;Kim, Geun-Ho
    • Journal of Chest Surgery
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    • v.22 no.2
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    • pp.225-233
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    • 1989
  • Cardioplegia and myocardial protection were performed under cardiopulmonary bypass during open heart surgery with the use of St. Thomas Hospital cardioplegic solution [4 [C] for the coronary artery perfusion and normal saline solution [4[ c] for the topical cardiac cooling. To maintain the state of myocardial protection, coronary artery reperfusion was carried out using St. Thomas Hospital cardioplegic solution at the interval of 30 minutes. A total number of patients studied were 57 cases, including 37 cases of correction for congenital anomalies and 20 cases for acquired heart diseases. Cardiopulmonary bypass time during the surgery was observed to be average of 87.89*47.55 hours, aortic cross-clamping time [ACCT] to be average of 76.68*44.27 hours raging from 30 to 191 minutes. In order to evaluate the effects of myocardial protection in the surgery, serum enzyme levels were determined. To observe the relationship between ACCT and myocardial protection effects, patients studied were divided into the following 3 groups. I group: ACCT 60 minutes, II group: ACCT 90 minutes, III group: ACCT over 91 minutes [1] SGOT; The positive value [increased over 200 units] for ischemic myocardial injury during operation was observed in 11 cases [19.3% of the total] of the total patients studied, of which 4 cases [13.3%] in I group, 1 case [10.0%] in II group, and 6 cases [35.3%] in III group. [2] LDH; The positive value [increased over 900 units] for ischemic myocardial injury during operation was observed in 9 cases [15.7% of the total] of the total patients studied, of which 2 cases [6.6%] in I group, 1 case [10.0%] in II group and 6 cases [35.3%] in III group. [3] CPK; The positive value [increased over 800 units] for ischemic myocardial injury during operation was observed in 10 cases [17.5% of the total] of the total patients studied, including 4 cases [13.3%] in I group, 1 case [10.0%] in II group, and 5 cases [29.4%] in III group [4] The myocardial protection method used in the present study was demonstrated to be effective for the myocardial protection in the surgery with ACCT of up to 90 minutes. A few ischemic myocardial injury were observed in the surgery with ACCT over 91 minutes, but no significant cardiac dysfunction was noted. The surgery with ACCT of up to 191 minutes did not appear to give rise any significant interference with postoperative recovery.

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Embryo-Fetal Developmental Toxicity Study of Methoxycinnamidopropyl Polysilsesquioxane (Methoxycinnamidopropyl Polysilsesquioxane의 랫드를 이용한 배.태자 발생독성 연구)

  • Hong, Jeong-Sup;Lim, Jeong-Hyeon;Kim, Kang-Hyun;Park, Myeong-Kyu;Jo, Ki-Yeon;Park, Gil-Jong;Jung, Taek-Kyu;Kim, Ja-Young;Yoon, Kyung-Sup
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.37 no.3
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    • pp.247-256
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    • 2011
  • Existing organic UV protection materials seem to be problematic due to their penetration and irritation to skin. Inorganic UV protection materials are also at issue for safety of their nano-type transformation. Therefore, the recent studies of UV protection materials have been focused not only on the effectiveness but also on their safety. One of the UV protection materials in study which have higher safety is the organic-inorganic conjugation type UV protection material. Previously, we have reported the manufacturing process, physical property and UV protection efficiency of methoxychinnamidoprophy poloysilsesquixan as a new cross-linked polymer type UV protection material. In this study, we have evaluated the effect of the methoxychinnamidoprophy poloysilsesquixan on embryo-fetal development in SD rats. This study is expected to show some definite information related to the effect on pregnancy or embryo-fetal abnormality in case of the clinical exposure of the methoxychinnamidoprophy poloysilsesquixan.

Functional Immunity to Cross-Reactive Serotype 6A Induced by Serotype 6B in Pneumococcal Polysaccharide Vaccine (폐구균 다당질 백신 내 혈청형 6B에 의해 유도되는 교차 반응 혈청형 6A에 대한 기능적 면역)

  • Kim, Kyung Hyo
    • Clinical and Experimental Pediatrics
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    • v.48 no.5
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    • pp.506-511
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    • 2005
  • Purpose : Streptococcus pneumoniae serotype 6B and 6A are important pathogens in pneumococcal infections. It is commonly assumed that the 6B vaccines elicit antibodies cross-reacting with the 6A serotype and the cross-reactive antibodies protect against infections of 6A. To examine this assumption, we measured the opsonophagocytic capacity to serotype 6A and 6B in adults. Methods : Twenty-four adults were immunized with pneumococcal PS vaccine that contains 6B PS. Their preimmune and postimmune sera were studied for the capacity to opsonize 6B and 6A serotypes with opsonophagocytic killing assay. Results : Opsonization titers to 6B were significantly higher than those to 6A in preimmune and postimmune sera. Because significant increasesof opsonization titers were observed in adults with polysaccharide vaccines for 6A(cross-reactive) serotype as well as for 6B(vaccine) serotype, 6B PS in vaccine elicited cross-protective antibodies to 6A, but not in all cases. One adult did not have detectable levels of opsonization titers to 6A after immunization. Conclusion : Although 6B PS in pneumococcal PS vaccine elicits antibodies cross-reacting with 6A serotype in some adults, it may not occur always. This study should be extended to other age groups such as children and elderly people. The presence of the cross-protection should be directly determined in clinical trials of the pneumococcal vaccines as well as during the postlicensure monitoring surveys by serotyping the clinical isolates of pneumococci.

Clarification of the Thermal Properties of Intumescent Paint and Suggestion of the Required Fire Protection Thickness for Steel and Composite columns (철골 및 합성기둥 내화성능 확보를 위한 내화페인트 열적 물성치 규명과 소요두께 제안)

  • Kim, Sun-Hee;Ok, Chi Yeol;Choi, Sung-Mo
    • Journal of the Korean Society for Advanced Composite Structures
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    • v.6 no.1
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    • pp.21-29
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    • 2015
  • Other countries(USA, Europe) have performed the fire resistance design of buildings by the alternative performance design methods, which are based on fire engineering theories. However, in Korea, the process on the alternative fire resistance performance design has only suggested without any applications for real steel structures. Therefore, In the case of steel structures stagnant research on refractory measures face difficulties in introducing fire resistance design. In this study, first of all, Intumescent paint was analyze the thermal properties(thermal conductivity, specific heat and density). In Sequence, using the section factor by H-standard section propose of section concrete filled steel tube and hollow. finally presents a reasonable thickness Intumescent paint takes time to target performance of the proposed cross-section steel tube.

Calculation of Neutron and Gamma-Ray Flux-to-Dose-Rate Conversion Factors (중성자(中性子) 및 감마선(線)에 대한 선량율(線量率) 환산인자(換算因子) 계산(計算))

  • Kwon, Seog-Guen;Lee, Soo-Yong;Yook, Chong-Chul
    • Journal of Radiation Protection and Research
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    • v.6 no.1
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    • pp.8-24
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    • 1981
  • This paper presents flux-to-dose-rate conversion factors for neutrons and gamma rays based on the American National Standard Institute(ANSI) N666. These data are used to calculated the dose rate distribution of neutron and gamma ray in radiation fields. Neutron flux-to-dose-rate conversion factors for energies from $2.5{\times}10^{-8}$ to 20 MeV are presented; the corresponding energy range for gamma rays is 0.01 to 15 MeV. Flux-to-dose-rate conversion factors were calculated, under the assumption that radiation energy distribution has nonlinearity in the phantom, have different meaning from those values obtained by monoetiergetic radiation. Especially, these values were determined with the cross section library. The flux-to-dose-rate conversion factors obtained in this work were in a good agreement to the values presented by ANSI. Those data will be a useful for the radiation shielding analysis and the radiation dosimetry in the case of continuous energy distributions.

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Evaluation in ELISA for the Residue Analysis of Metalaxyl in Crops (작물체중 Metalaxyl 의 잔류분석을 위한 ELISA의 응용)

  • Lee, Kang-Bong;Im, Geon-Jae;Jung, Young-Ho;Suh, Yong-Tack
    • Korean Journal of Environmental Agriculture
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    • v.14 no.1
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    • pp.23-27
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    • 1995
  • The cross-reactivities of antibody derived from rabbit immunized with metalaxyl-HSA conjugate were identified to 44% and 28% for metalaxyl acid and metolachlor respectively. The detection range of metalaxyl in competitive ELISA was 5 ppb to 5 ppm. The recoveries of metalaxyl in ELISA for 6 crops; potato, sesame, pepper, cabbage, cucumber and onion was ranged 77.5-103.6%. In this test, CV% were calculated below 10% except for sesame sample as shown 21.5%.

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What Turkish Nurses Know and Do about Skin Cancer and Sun Protective Behavior

  • Andsoy, Isil Isik;Gul, Asiye;Sahin, Aysegul Oksay;Karabacak, Hanife
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7663-7668
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    • 2013
  • Background: Skin cancer is a global health problem that can be prevented by protective behavior promoted by nurses. In Turkey, only few studies have examined current knowledge of nurses related to skin cancer and to reveal their attitudes towards sun exposure and current protective behavior. Materials and Methods: This descriptive cross-sectional study was performed from March 11 to May 30, 2013 with a study sample of 310 nurses working in two state hospitals located in Karab$\ddot{u}$k and Safranbolu. Results: Mean age of the nurses was $30.3{\pm}6.89$ years and 96.1% of them had graduated with a Bachelor degree. The participants were predominantly female (n=284). Knowledge level about skin cancer was significantly higher for females compared to males. Conclusions: Nurses do not have sufficient knowledge about skin cancer and are not adequately protecting themselves from ultraviolet light, the primary risk factor for skin cancer. While they demonstrated a responsible attitude towards avoiding sunburn and the need for adequate sun protection, they do not fully appreciate the extent to which the sun can cause skin cancer and that they lack full understanding about the need to protect the skin from burning and to avoid long term sun exposure in Turkey.

ANALYSIS BY SYNTHESIS FOR ESTIMATION OF DOSE CALCULATION WITH gMOCREN AND GEANT4 IN MEDICAL IMAGE

  • Lee, Jeong-Ok;Kang, Jeong-Ku;Kim, Jhin-Kee;Kim, Bu-Gil;Jeong, Dong-Hyeok
    • Journal of Radiation Protection and Research
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    • v.37 no.3
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    • pp.146-148
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    • 2012
  • The use of GEANT4 simulation toolkit has increased in the radiation medical field for the design of treatment system and the calibration or validation of treatment plans. Moreover, it is used especially on calculating dose simulation using medical data for radiation therapy. However, using internal visualization tool of GEANT4 detector constructions on expressing dose result has deficiencies because it cannot display isodose line. No one has attempted to use this code to a real patient's data. Therefore, to complement this problem, using the result of gMocren that is a three-dimensional volume-visualizing tool, we tried to display a simulated dose distribution and isodose line on medical image. In addition, we have compared cross-validation on the result of gMocren and GEANT4 simulation with commercial radiation treatment planning system. We have extracted the analyzed data of dose distribution, using real patient's medical image data with a program based on Monte Carlo simulation and visualization tool for radiation isodose mapping.