• Korean Journal of Health Education and Promotion
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• v.29 no.1
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• pp.1-11
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• 2012

Objectives: The nurse visiting health service named Customized Visiting Health Care Program(CVHCP) requires the service innovations incorporating community support into a local service network. The purpose of this study was to assess the community network in CVHCP and inform improvement in this network. Methods: We used Social Network Analysis(SNA) in one CVHCP at H city. Network links were generated by self-administered questionnaires by the 14 community resource centers who quantified their links to all other 25 agents on the list. Links were analyzed by a dichotomous scale for any experience of collaboration and a scored scale of 0 to 3 for level of collaboration using UCINET v6. Results: A list of 14 agents was generated, and local network was dominated by the Public Health Center and a local welfare center named Unlimited Care Center(UCC). According to centrality score, UCC was the most prominent agent, and Public Health Center was the most influential agent, being a link in the pathway flow between other agents for 9.5% of contribution. CVHCP scored lower rank of prominent with 30.8% of other agents reported referring to it. Conclusions: Social network analysis provides a useful network description for informing and evaluation service network improvement in maximizing its service for the CVHCP.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.32B no.5
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• pp.720-729
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• 1995

We proposed a XMESH(crossed-mesh) topology as a suitable interconnection for the massively parallel computer architectures, and presented performance analysis of the proposed interconnection topology. Horizontally, the XMESH has the same links as those of the toroidal mesh(TMESH) or toroid, but vertically, it has diagonal cross links instead of the vertical links. It reveals desirable interconnection characteristics for the massively parallel computers as the number of nodes increases, while retaining the same structural advantages of the TMESH such as the symmetric structure, periodic placement of subsystems, and constant degree, which are highly recommended features for VLSI/WSI implementations. Furthermore, n*k XMESH can be easily expanded without increasing the diameter as long as n.leq.k.leq.n+4. Analytical performance evaluations show that the XMESH has a shorter diameter, a shorter mean internode distance, and a higher message completion rate than the TMESH or the diagonal mesh(DMESH). To confirm these results, an optimal self-routing algorithm for the proposed topology is developed and is used to simulate the average delay, the maximum delay, and the throughput in the presence of contention. In all cases, the XMESH is shown to outperform the TMESH and the DMESH regardless of the communication load conditions or the number of nodes of the networks, and can provide an attractive alternative to those networks in implementing massively parallel computers.

• Journal of Photoscience
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• v.9 no.2
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• pp.382-384
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• 2002

When illuminated with strong visible light, the reaction center Dl protein of photo system II is photodamage and degraded. Reactive oxygen species and endogenous cationic radicals generated by photochemical reactions are the cause of the damage to the Dl protein. Recently we found that the photodamaged Dl protein cross-links with the surrounding polypeptides such as D2 and CP43 in photosystem II. As the cross-linking reaction is dependent on the presence of oxygen, reactive oxygen species are suggested to be involved. Among the reactive oxygen species examined, ？ OH was most effective in the formation of the cross-linked products. These results indicate that the cross-linking is mostly due to ？ OH generated at photosystem II. The cross-linking site of the Dl protein is not known. As several tyrosine residues exist at the D­E loop of the Dl protein, there is a possibility that di-Tyr is formed between the D­E loop of the Dl protein and surrounding polypeptides during the strong illumination. Therefore, we examined the formation of di-Tyr using the monoclonal antibody against di-Tyr under excess illumination of the photosystem II membranes. The results obtained here suggest that no di-Tyr is formed during the excess illumination of photosystem II.

• Journal of the Korean Society for Precision Engineering
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• v.10 no.4
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• pp.81-93
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• 1993

The three dimensional(3D) shape reconstruction from two dimensional(2D) cross-sections can be completed through three main phases : the input compilation, the triangular grid formation, and the smooth surface construction. In the input compilation phase, the cross-sections are analyzed to exctract the input data required for the shape reconstruction. This data includes the number of polygonized contours per cross-section and the vertices defining each polygonized contour. In the triangular grid formation phase, a triangular grid, leading to a polyhedral approximations, is constructed by extracting all the information concerning contour links between two adjacent cross- sections and then performing the appropriate triangulation procedure for each contour link. In the smooth surface construction phase, a smooth composite surface interpolating all vertices on the triangular grid is constructed. Both the smooth surface and the polyhedral approximation can be used as reconstructed models of the object. This paper proposes a new method for reconstructing the geometric model of a 3D objdect from a sequence of planar contours representing 2D cross-sections of the objdect. The method includes the triangular grid formation algorithms for contour closing, one-to-one branching, and one-to-many braanching, and many-to-many branching. The shape reconstruction method has been implemented on a SUN workstation in C.

• Archives of Plastic Surgery
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• v.51 no.1
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• pp.20-26
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• 2024

The etiology and pathophysiology of delayed inflammatory reactions caused by hyaluronic acid fillers have not yet been elucidated. Previous studies have suggested that the etiology can be attributed to the hyaluronic acid filler itself, patient's immunological status, infection, and injection technique. Hyaluronic acid fillers are composed of high-molecular weight hyaluronic acids that are chemically cross-linked using substances such as 1,4-butanediol diglycidyl ether (BDDE). The mechanism by which BDDE cross-links the two hyaluronic acid disaccharides is still unclear and it may exist as a fully reacted cross-linker, pendant cross-linker, deactivated cross-linker, and residual cross-linker. The hyaluronic acid filler also contains impurities such as silicone oil and aluminum during the manufacturing process. Impurities can induce a foreign body reaction when the hyaluronic acid filler is injected into the body. Aseptic hyaluronic acid filler injections should be performed while considering the possibility of biofilm formation or delayed inflammatory reaction. Delayed inflammatory reactions tend to occur when patients experience flu-like illnesses; thus, the patient's immunological status plays an important role in delayed inflammatory reactions. Large-bolus hyaluronic acid filler injections can induce foreign body reactions and carry a relatively high risk of granuloma formation.

• Archives of Pharmacal Research
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• v.24 no.5
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• pp.455-465
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• 2001

The highly potent cytotoxic DNA-DNA cross-linker consists of two cyclopropa[c]pyrrolo[3,4-3]indol-4(5H)-ones insoles [(+)-CPI-I] joined by a bisamido pyrrole (abbreviated to "Pyrrole"). The Pyrrole is a synthetic analog of Bizelesin, which is currently in phase II clinical trials due to its excellent in vivo antitumor activity. The Pyrrole has 10 times more potent cytotoxicity than Bizelesin and mostly form DNA-DNA interstrand cross-links through the N3 of adenines spaced 7 bp apart. The Pyrrole requires a centrally positioned GC base pair for high cross-linking reactivity (i.e., $5^1$-T$AT_2$A*-$3^1$), while Bizelesin prefers purely AT-rich sequences (i.e., $5^1$-T$AT_4$A*-$3^1$, where /(equation omitted) represents the cross-strand adenine alkylation and A* represents an adenine alkylation) (Park et al., 1996). In this study, the high-field $^1$H-NMR and rMD studies are conducted on the 1 1-mer DNA duplex adduct of the Pyrrole where the 5′(equation omitted)TAGTTA*-3′sequence is cross-linked by the drug. A severe structural perturbation is observed in the intervening sequences of cross-linking site, while a normal B-DNA structure is maintained in the region next to the drug-modified adenines. Based upon these observations, we propose that the interplay between the bisamido pyrrole unit of the drug and central C/C base pair (hydrogen-bonding interactions) is involved in the process of cross-linking reaction, and sequence specificity is the outcome of those interactions. This study suggests a mechanism for the sequence specific cross-linking reaction of the Pyrrole, and provides a further insight to develop new DNA sequence selective and distortive cross-linking agents.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.8 no.1
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• pp.53-62
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• 2008

Cross-lingual text retrieval(CLTR) is the information retrieval in which a user tries to search a set of documents written in one language for a query another language. This thesis proposes a CLTR system based on fuzzy multilingual thesaurus to handle a partial matching between terms of two different languages. The proposed CLTR system uses a fuzzy term matrix defined in our thesis to perform the information retrieval effectively. In the defined fuzzy term matrix, all relation degrees between terms are inferred from using the transitive closure algorithm to reflect all implicit links between terms into processing of the information retrieval. With this framework, the CLTR system proposed in our thesis enhances the retrieval effectiveness because it is able to emulate a human expert's decision making well in CLTR.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.65-66
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• 2003

The cause of Huntington's disease (HD) is a pathological expansion of the polyglutamine domain within the N-terminal region of huntingtin. Neuronal aggregates composed of mutant huntingtin within certain neuronal populations are a characteristic hallmark of HD. Because tissue transglutaminase (tTG) cross-links proteins into aggregates and polypeptide-bound glutamines are primary determining factors for tTG-catalyzed reactions, it has been hypothesized that tTG may contribute to the formation of aggregates. (omitted)

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.29-32
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• 1998

Segmented block copolyetheresters defined as copolymers having sequences of alternating polyester hard blocks and polyether soft blocks create labile physical cross-links upon crystallization of hard polyester blocks Since the nature of the physical interlocking is a crystallite formed exclusively from the crystallizable hard segment, the basic understanding of interrelationship between crystallization condition and phase morphology is very important for the property control of the segmented block copolyetheresters. (omitted)

• Proceedings of the Korean Fiber Society Conference
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• 1998.10a
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• pp.33-36
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• 1998

Segmented block copolyetheresters defined as copolymers having sequences of alternating polyester hard blocks and polyether soft blocks create labile physical cross-links upon crystallization of hard polyester blocks Since the nature of the physical interlocking is a crystallite formed exclusively from the crystallizable hard segment, the hard segment content (HSC) and hard segment length (HSL) will play an important role in determining the properties such as mechanical property and dynamic mechanical property. (omitted)