• International Journal of Stem Cells
• /
• 제15권1호
• /
• pp.26-40
• /
• 2022

Region specific brain organoids are brain organoids derived by patterning protocols using extrinsic signals as opposed to cerebral organoids obtained by self-patterning. The main focus of this review is to discuss various region-specific brain organoids developed so far and their application in modeling neurodevelopmental disease. We first discuss the principles of neural axis formation by series of growth factors, such as SHH, WNT, BMP signalings, that are critical to generate various region-specific brain organoids. Then we discuss various neurodevelopmental disorders modeled so far with these region-specific brain organoids, and findings made on mechanism and treatment options for neurodevelopmental disorders (NDD).

• 설비공학논문집
• /
• 제13권8호
• /
• pp.674-681
• /
• 2001

An experiment is conducted to investigate the effect of the inclination angle on convective boiling heat transfer of a uniformly heated tube. The test section used is a stainless steel tube with10.7mm in inner diameter. The hating length is 3m and is heated directly by an AC current. The test fluid is R-113. Experiment are carried out with mass flow rates of 300, 500 and $700\;kg/m^{2}s$, and heat fluxes varying from 5 to 65 kW/$m^2$. The inclination angles of the tube are $0^{\circ},\;5^{\circ},\;11^{\circ}\;and\;25^{\circ}$. the circumferential temperature variation at low quality region and the location of dryout at high quality region are mainly observed. Circumferential anisothermality occurring at low mass flow rate and low quality conditions is gradually reduced with the increase in the inclination angle and finally disappears at the inclination angle of $25^{\circ}$. Critical quality where dryout is initiated is seriously influenced by the inclination angle. Wall temperature after critical quality is also affected by the inclination angle.

• Journal of Advanced Marine Engineering and Technology
• /
• 제23권4호
• /
• pp.533-542
• /
• 1999

In this study the flow characteristics of developing turbulent pulsating flows in a square-sec-tional 180。 curved duct are investigated experimentally. The experimental study of air flow in a square-sectional curved duct is carried out to measure axial velocity distribution secondary flow velocity profiles and wall shear stress distributions by using a Laser Doppler Velocimetry system with the data acquisition and processing system of Rotating Machinery Resolver (RMR) and PHASE software at the entrance region of the duct which is divided into 7 sections from the inlet(${{\o}}=0_{\circ}$) to the outlet (${{\o}}=180_{\circ}$) in $30_{\circ}$ intervals. The results obtained from the study are summarized as follows: (1) The time-averaged critical Dean number of turbulent pulsating flow(De ta, cr) is greater than $75{\omega}+$ It is understood that the critical Dean number and the critical Reynolds number are related to the dimensionless angular frequency in a curved duct. (2) Axial velocity profiles of turbulent pulsating flows are of an annular type similar to those of turbulent stead flows. (3) Secondary flows of trubulent pulsating flows are strong and complex at the entrance region. As velocity amplitudes(A1) become larger secondary flows become stronger. (4) Wall shear stress distributions of turbulent pulsating flows in a square-sectional $180_{\circ}$ curved duct are exposed variously in the outer wall and are stabilized in the inner wall without regard to the phase angle.

• 치과방사선
• /
• 제25권2호
• /
• pp.437-445
• /
• 1995

The purpose of this study was to evaluate the equivalent and effective dose, and estimate radiation risk to the critical organs of head and neck region from the use of adult and child mode in panoramic radiography. The results were as follows. 1. The salivary glands showed the highest equivalent and effective dose in adult and child mode. the equivalent and effective dose in adult mode were 837μSv and 20.93μSv, those in child mode were 462μSv and 11.54μSv, respectively. 2. Total effective doses to the critical head and neck organs were estimated 34.21μSv in adult mode, 20.14μSv in child mode. From these datas, the probabilities of stochastic effect from adult and child mode were 2.50x10/sup -6/ and 1.47x10/sup -6/. 3. The other remainder showed the greatest risk of fatal cancer. The risk estimate were 4.5 and 2.7 fatal malignancies in adult and child mode from million panoramic examinations. The bone marrow and thyroid gland showed about 0.1 fatal cancer in adult and child mode from these examinations.

• 산업경영시스템학회지
• /
• 제38권3호
• /
• pp.21-28
• /
• 2015

As film products are increasingly used in a wide range of areas, from producing traditional flexible packaging to high-tech electronic products, a higher level of quality is demanded. Most film products are made in the form of rolled finished goods, therefore, various quality issues related to their shape characteristics must be addressed. The thickness of the film products is one of the most common and important critical-to-quality attributes (CTQs). Particularly, the degree of thickness uniformity is more important than other thickness parameters, because it will be potential causes of many secondary thickness-related quality problems, such as wrinkles or faulty windings. To control the degree of thickness uniformity, the fixed bending region is oneof the most important CTQs to manage. Fixed bending regions are special points in the transverse direction of a rolled product with consistent minute variations of the thickness gap. This paper describes the measurement and analysis of thickness uniformity data, which were performed in a real manufacturing field of biaxial oriented polypropylene (BOPP) film. In previous researches, quality function deployment (QFD) or fault tree analysis were used to find the most critical process attributes out to controlthe CTQ of thickness uniformity. Whereas, this paper uses traditional control charts to find the most critical process attributes out in this problem. In addition, the selection of one of the major critical process attributes (CTPs) that is expected to affect the CTQ of thickness uniformity is also described. The selected critical-to-process attributes are the controlled temperatures along the transverse direction. A dramatic improvement in thickness uniformity was observed when the selected CTPs were controlled.

• 한국지진공학회:학술대회논문집
• /
• 한국지진공학회 2002년도 춘계 학술발표회 논문집
• /
• pp.195-202
• /
• 2002

Lap splices of longitudinal reinforcement steels were practically located in the potential plastic hinge region of most bridge columns that were constructed before the 1992 seismic design provision of Roadway Bridge Design Specification in Korea. The objective of this research is to evaluate the seismic performance of shear-critical reinforced concrete(RC) bridge piers with poor detailing of the starter bars in the plastic hinge region, and to develop the enhancement scheme of their seismic capacity by retrofitting with fiber composites. Seven test specimens in the aspect ratio of 2.5 were made with three confinement ratios and two types of lap splices. Quasi-static test was conducted in a displacement-controlled test mode. A significant reduction of displacement ductility ratios were observed for test columns with lap splices of longitudinal steels.

• Journal of Welding and Joining
• /
• 제20권2호
• /
• pp.116-124
• /
• 2002

The fatigue life is predicted on tensile-shear spot weldment made from Al-Mg alloy sheet with thickness of 0.8mm using Mitchell's method and uniform material law by $B{\ddot{a}}umel$ and Seeger based on local strain approach. The fatigue properties of critical HAZ region are estimated from the tensile property using simple hardness method. To predict the fatigue life of spot weldment, the local stresses and strains at the potential critical region are estimated by Neuber's rule. The predicted fatigue life based on uniform material law using HAZ's material properties provides good results within a factor of 3, conservatively.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2008년도 제39회 하계학술대회
• /
• pp.1817-1818
• /
• 2008

Even though efficiency of coal-fired power plant is proportional to operating temperature, increasement of operating temperature is limited by a technological level of each power plant components. It is an alternative plan to increase operating pressure up to ultra super critical point for efficiency enhancement. It is difficult to control in that pressure within safety guideline that many unexpected phenomena are happen because that region is highly nonlinear region. In this paper, Advanced process control algorithm, ARX and Fuzzifier, is introduced. Then power plant control logics applied Unit Step Optimizer, which is combination of ARX and Fuzzifier are proposed. Its performance is tested and analyzed with design guide line.

• 한국멀티미디어학회논문지
• /
• 제18권7호
• /
• pp.843-852
• /
• 2015

Binarization of document images is a critical pre-processing step required for character recognition. Even though various research efforts have been devoted, the quality of binarization results largely depends on the noise amount and condition of images. We propose a new binarization method that combines Maximally Stable External Region(MSER) with down-sampling. Particularly, we propose to apply different threshold values for character regions, which turns out to be effective in reducing noise. Through a set of experiments on test images, we confirmed that the proposed method was superior to existing methods in reducing noise, while the increase of execution time is limited.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2003년도 추계학술대회논문집
• /
• pp.277-283
• /
• 2003

It is well known that the natural frequencies of the pipe come to be lower as internal fluid velocity and pressure increase, and the pipe will be unstable if the fluid velocity is higher than critical velocity. But even if the velocity of the fluid below the critical velocity, resonance will be caused by pulsation of the fluid. So it should be also taken into consideration that the effect of pulsating fluid in pipe design. The research of the piping system vibration due to a fluid pulsation has been studied by many people. But almost is dealt with determining the boundary between stable and unstable region without analyzing forced response in the stable region. In this study, not only stability analysis but also forced response analysis, which is caused by harmonically excited fluid especially, is conducted.