• 대한화학회지
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• 제68권4호
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• pp.221-234
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• 2024

이 연구는 초등학교 과학수업에서 논의기반 탐구수업이 초등학생의 비판적 사고에 미치는 영향을 알아보는 것을 목적으로 하였다. 이를 위하여 광역시의 초등학교 5학년 2개 학급 학생 23명을 대상으로 하였고, 이 중 1개 학급(11명)을 실험집단으로 하여 10개 주제의 논의기반 탐구수업을 적용하였다. 논의기반 탐구수업이 비판적 사고에 미치는 영향을 알아보기 위해 수업 전과 후에 비판적 사고 검사 결과와 실험집단 학생들의 논의과정 녹음자료를 분석하였다. 비판적 사고 분석 결과, 연역 항목에서 실험집단의 평균 점수가 비교집단보다 통계적으로 유의미하게 더 높았으며, 논의과정 녹음자료 분석 결과, 학생들은 연역 추론을 귀납 추론보다 자주 사용하였고 주장·증거 단계에서 그 빈도가 크게 증가하였다.

• Biomolecules & Therapeutics
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• 제18권4호
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• pp.363-374
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• 2010

Growing evidence suggests a prominent role for leptin in human cancer progression. The intricate pattern of leptin cross-talk with other associated signaling pathways is a critical area of research that will ultimately contribute to comprehending the role of leptin in cancer progression. This review summarizes a portion of the current understanding of leptin signaling, with a critical focus on its contribution to tumor cell invasion and metastasis. Five topics are addressed in this review: (1) Leptin receptor, (2) Leptin signaling, (3) Leptin and cancer, and (4) Leptin and tumor invasion. Due to the complex cellular effects of leptin, a more precise understanding of leptin signaling pathways must still be elucidated. Leptin is clearly a major factor for stimulating tumor progression through a complex spectrum of interplay and cross-talk among various signaling molecules. An understanding of the role of leptin in invasion and metastasis will provide valuable information for establishing strategies to modulate leptin signaling, which should be a high priority for the development of anti-cancer therapeutics.

• 지식경영연구
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• 제16권3호
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• pp.129-147
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• 2015

Building on previous literature of human resource management and development, this paper investigates the effect of various characteristics of informal education a firm offers on employees' individual creativity. we identify quantity, quality, and variety as three critical components of informal educational and training circumstances. Data from a multi-informant survey conducted to 442 employees in Korean postal service show that a firm's informal educational training has significant effects on its employee creativity. The results indicate that enough high quality of program, various training method have a positive relationship with his/her individual creativity although time and opportunity don't have an critical impact on employee creativity. This study highlights the importance of a firm's informal education in terms of motivation and skills, and helps to explain individual discrepancies in creativity.

• Nuclear Engineering and Technology
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• 제47권2호
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• pp.212-218
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• 2015

We describe a comparative analysis of different tools used to assess safety-critical software used in nuclear power plants. To enhance the credibility of safety assessments and to optimize safety justification costs, $Electricit{\acute{e}}$ de France (EDF) investigates the use of methods and tools for source code semantic analysis, to obtain indisputable evidence and help assessors focus on the most critical issues. EDF has been using the PolySpace tool for more than 10 years. Currently, new industrial tools based on the same formal approach, Abstract Interpretation, are available. Practical experimentation with these new tools shows that the precision obtained on one of our shutdown systems software packages is substantially improved. In the first part of this article, we present the analysis principles of the tools used in our experimentation. In the second part, we present the main characteristics of protection-system software, and why these characteristics are well adapted for the new analysis tools. In the last part, we present an overview of the results and the limitations of the tools.

• Journal of Information Technology Applications and Management
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• 제11권3호
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• pp.147-159
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• 2004

Empirical evidence on the maintainability of object-oriented systems is far from conclusive, partly due to lack of representativeness of the subjects and systems used in the study. The present research empirically examined this issue with the systems that are mission-critical. currently operational and maintained by professionals. It was found that the 00 group appeared to consume less time while maintaining more amount of software artifacts than the NOO counterpart. This economical utilization of time appeared evident regardless of software development life cycle. This was due to the usefulness of UML for impact analysis which contributed to effective comprehension and communication. Insufficient design specifications led to ambiguity and costly defects in transferring design solutions to development. Also. the encapsulation of 00 seemed to reduce mental loads at maintenance tasks and improved code reuse. However, the number of files to manage increased and thus. dependency management is required for the 00 systems.

• 대한전기학회논문지
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• 제39권9호
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• pp.956-963
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• 1990

The general shapes of prebreakdown pulses in a discharge gap were calculated and the current pulses due to avalanche were detected in SF6 by changing the polarity of the protrusion placed on an electrode at pressures up to about 400 Kpa. The mathematical model of prebreakdown pulse development with a negative protrusion shows agreement with the observed pulses. No evidence of intense bursts of field-emitted electrons was observed. Breakdown probably results from a single avalanche developing to a critical size. However the calculated shape of prebreakdown current pulse does not agree with the observed pulses with a positive protrusion. The breakdown is preceded by multiple avalanche development at pressures less than about 200 Kpa. This observation has been interpreted as due to the formation of negative ions following photoionization in the gas which drift into the critical volume near a positive protrusion.

• 대한한의학원전학회지
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• 제34권2호
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• pp.75-84
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• 2021

Objectives : To examine texts dealing with the Wenyilun in South Korea and to re-evaluate its medical theories that have been underrated in previous texts. Methods : The contents and organization of the Gejiaxueshuo were analyzed. In addition, a research paper on the overall contents of the Wenyilun was studied. Results : Common theories of the miscellaneous qi that were mentioned in the two documents such as 'specificity', 'nine-part transition treatment theory', and 'one disease one formula' are either irrelevant or resulting from erroneous interpretation. While both texts evaluated the merits and harms of the Wenyilun, erroneously deducted contents were used as evidence for negative assessments in both. Conclusions : Should the contents of the Wenyilun be evaluated with a focus on the critical points that clinicians with vast experiences with epidemic disease patients raised, we would be judging the text differently.

• BMB Reports
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• 제56권9호
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• pp.469-481
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• 2023

The gut microbiome is widely recognized as a dynamic organ with a profound influence on human physiology and pathology. Extensive epidemiological and longitudinal cohort studies have provided compelling evidence that disruptions in the early-life microbiome can have long-lasting health implications. Various factors before, during, and after birth contribute to shaping the composition and function of the neonatal and infant microbiome. While these alterations can be partially restored over time, metabolic phenotypes may persist, necessitating research to identify the critical period for early intervention to achieve phenotypic recovery beyond microbiome composition. In this review, we provide current understanding of changes in the gut microbiota throughout life and the various factors affecting these changes. Specifically, we highlight the profound impact of early-life gut microbiota disruption on the development of diseases later in life and discuss perspectives on efforts to recover from such disruptions.

• Tuberculosis and Respiratory Diseases
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• 제86권3호
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• pp.151-157
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• 2023

The introduction of inhaled corticosteroids (ICS) for the management of asthma has led to a decrease in acute exacerbation of asthma. However, there are concerns regarding the safety of long-term ICS use, particularly pneumonia. Growing evidence indicates that ICS use is associated with an increased risk of pneumonia in patients with chronic obstructive pulmonary disease, whereas the risk in patients with asthma remains unclear. This review discusses the effect of ICS on pneumonia among patients with asthma to update the existing literature. Asthma is associated with an increased risk of pneumonia. Several hypotheses have been proposed to explain this association, including that asthma impairs the clearance of bacteria owing to chronic inflammation. Therefore, controlling airway inflammation with ICS may prevent the occurrence of pneumonia in asthma. In addition, two meta-analyses investigating randomized control trials showed that ICS use was associated with a protective effect against pneumonia in asthma.

• Tuberculosis and Respiratory Diseases
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• 제79권1호
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• pp.14-21
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• 2016

Cough is one of the most common symptom of many respiratory diseases. The Korean Academy of Tuberculosis and Respiratory Diseases organized cough guideline committee and cough guideline was developed by this committee. The purpose of this guideline is to help clinicians to diagnose correctly and treat efficiently patients with cough. In this article, we have stated recommendation and summary of Korean cough guideline. We also provided algorithm for acute, subacute, and chronic cough. For chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered. If UACS is suspicious, first generation anti-histamine and nasal decongestant can be used empirically. In CVA, inhaled corticosteroid is recommended in order to improve cough. In GERD, proton pump inhibitor is recommended in order to improve cough. Chronic bronchitis, bronchiectasis, bronchiolitis, lung cancer, aspiration, angiotensin converting enzyme inhibitor, habit, psychogenic cough, interstitial lung disease, environmental and occupational factor, tuberculosis, obstructive sleep apnea, peritoneal dialysis, and idiopathic cough can be also considered as cause of chronic cough. Level of evidence for treatment is mostly low. Thus, in this guideline, many recommendations are based on expert opinion. Further study regarding treatment for cough is mandatory.