• Parasites, Hosts and Diseases
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• 제24권2호
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• pp.171-176
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• 1986

In order to obtain the most specific and sensitive antigen from crude antigens of Fasciola hepatica for the immunodiagnosis of bovine fascioliasis by the enzyme linked immunosorbent assay (ELISA), phosphate buffered saline extract of F. hepatica was prepared. The crude extract was fractionated into 7 antigens using sephadex G-100 column chromatography. Seven fractionated antigens were applied to ELISA, precipitation test and intradermal test, respectively. Results obtained are as follows: 1. The specificity (95% confidence interval in negative sera of bovine fascioliasis; Mean+$2{\times}SD$ of absorbence) of the first (MW>150,000) and the second antigens(MW 120,000) were 93.7%, but those of others including crude antigen showed 100%. 2. The sensitivity(positive sera of bovine fascioliasis having higher values with compared to the criterion) of the first, the sixth (MW 16,000) and the seventh antigen (MW<5,000) were 91.6%, 87.5% and 0%, respectively, but those of others showed all 100%. 3. The absorbance by ELISA using the fifth antigen (MW 26,000) was 8. 43-folds higher in the positive sera than that in the negative sera. This could be used as one of the most specific antigens for the immunodiagnosis of bovine fascioliasis. 4. In Ouchterlony test, precipitin lines were not found in the sera naturally infected with F. hepatica, but some were found in the sera of rabbits immunized with the crude antigens. The numbers of precipitin lines in the sera of rabbits were different in the different fractionated antigens. They were 6 in the crude, 2 in the second and the third antigens, 1 in the fourth, the fifth and the sixth antigens and absent in the seventh antigen, respectively. 5. The wheal size for bovine infected with F. hepatica was $2.46{\pm}0.15cm$ in the intradermal test antigen(saline extract of F. hepatica) supplied by the Veterinary Research Institute, Rural Development Administration, Korea. The wheal size of the first, the second and the third antigens were larger than that. of intradermal test antigen, whereas those of the fouth, the fifth, the sixth and the seventh antigens showed smaller than that of the intradermal test antigen. The results suggest that the fifth antigen may be specific antigen for the immunodiagnosis of bovine fascioliasis.

• 한국의학물리학회지:의학물리
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• 제28권1호
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• pp.16-21
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• 2017

This study assessed the feasibility of a dual-channel (DC) compound method for film dosimetry. The red channel (RC) is usually used to ensure dosimetric quality using a conventional fraction dose because the RC is more accurate at low doses within 3 Gy than is the green channel (GC). However, the RC is prone to rapid degradation of sensitivity at high doses, while degradation of the GC is slow. In this study, the DC compound method combining the RC and GC was explored as a means of providing accurate film dosimetry for high doses. The DC compound method was evaluated at various dose distributions using EBT3 film inserted in a solid-water phantom. Measurements with $10{\times}20cm^2$ radiation field and $60^{\circ}$ dynamic-wedge were done. Dose distributions acquired using the RC and GC were analyzed with root-mean-squares-error (RMSE) and gamma analyses. The DC compound method was used based on the RC after correcting the GC for high doses in the gamma analysis. The RC and GC produced comparatively more accurate RMSE values for low and high doses, respectively. Gamma passing rates with an acceptance criterion of 3%/3 mm revealed that the RC provided rapid reduction in the high dose region, while the GC displayed a gradual decrease. In the whole dose range, the DC compound method had the highest agreement (93%) compared with single channel method using either the RC (80%) or GC (85%). The findings indicate that the use of DC compound method is more appropriate in dosimetric quality assurance for radiotherapy using high doses.

• 대한방사선기술학회지:방사선기술과학
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• 제39권4호
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• pp.549-555
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• 2016

본 연구는 다운증후군 위험도의 예측을 위해 통합선별검사를 실시한 산모를 대상으로, 각 표지자의 유의성에 대한 평가를 하였다. 초음파로 측정한 NT 영상, 산모혈청 PAPP-A, AFP, uE3, hCG, 인히빈 A의 상관성을 후향적으로 분석하였다. 그 결과 NT, uE3, hCG, 인히빈 A와 유의한 상관관계를 보였다(p<.001). ROC분석에서 인히빈 A의 AUC가 0.851로 다운증후군의 가장 큰 예측인자로 분석되었으며. cut-off value 1.33 MoM(민감도 87.5%, 특이도 71.5%)으로 결정되었다. 결론적으로 통합선별검사에서 인히빈 A가 다운증후군을 예측하는 가장 유용한 인자로 나타났다. 이에 각 표지자(parameter)들의 cut-off value를 바탕으로 통합선별검사의 단점을 보완한다면 다운증후군 선별의 독립적인 지표로 사용될 수 있을 것으로 사료된다.

• 한방안이비인후피부과학회지
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• 제26권4호
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• pp.60-69
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• 2013

Objective : This case series study was designed to assess the effect of Gamisungmagalguntang for chronic urticaria identified as "Wind-Heat" pattern by retrospective methods. Methods : We treated 19 patients for chronic urticaria with Gamisungmagalguntang(加味升麻葛根湯), who visited to care chronic urticaria at the department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine at Kyunghee University Korean Medical Center from 1st January 2013 to 31st August 2013. We analyzed information and body conditions of 19 patients. And by using Urticaria Activicy Score(UAS), frequency and number of wheals, itch severity and total score on a 4-point(0-3) scale were assessed in 19 patients. The change of each criterion and total scores between baseline and follow up were analyzed using paired t-test and Wilcoxon test(p<0.05). Results : 1. UAS improvement was statistically significant(p<0.001). Effects of symptom improvement were excellent(31.58%) that means symptom remission and good(42.10%) that means symptom improved over 50%. 2. Heat sensitivity as suspected provocation factor could be a marker for the Wind-Heat pattern urticaria. 3. Among the Wind-Heat pattern urticaria patients, normal digestion(52.63%) and no thirst(78.95%) were higher than abnormal conditions. Whereas about sweat item, abnormal conditions(57.89%) were higher than normal. That means abnormal sweat conditions could be a marker for a defense qi(衛氣) dysfunction of the Wind-Heat pattern urticaria. Conclusions : Our findings suggest that Gamisungmagalguntang could be effective on the Wind-Heat pattern urticaria.

• 대한전자공학회논문지SP
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• 제45권1호
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• pp.47-54
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• 2008

본 논문은 PpIX 유도물질인 포르피린 혼합제 methyl 5-aminolaevulinate(MAL)를 환자의 피부 종양부위에 도포하고, 우드램프를 이용하여 획득한 PpIX 형광영상으로부터 기저세포암을 검출하는 알고리즘을 제안한다. 제안된 알고리즘은 형광영상의 밝기값 특징을 분석하여 육안으로 확인이 가한 암이 존재하는 영역, 암이 존재할 수 있는 의심영역 및 암이 없는 정상영역으로 구분한다. 그리고 암이 존재하는 영역을 포함한 의심영역에 대해 국부적 워터쉐드 알고리즘을 적용하여 인접화소와 유사한 값을 가지는 소규모의 영역으로 분할한다. 그리고 국부적 워터쉐드 알고리즘으로 분할된 소규모 영역들의 평균 밝기값 차이를 병합기준 척도로 사용하는 계층적 큐 기반의 고속 영역병합을 수행하여 정확한 기저세포암을 추출한다. 10명의 기저세포암 환자에게 제안 알고리즘을 적용하여 검출한 암영역에 대해 50개의 조직 샘플을 획득하고, 피부과 전문의가 병리학적 검사를 수행했다. 실험결과 제안된 알고리즘은 94.1%의 민감도와 82.6%의 정확도로 신뢰성 있는 추출결과를 제공한다.

• 한국전산구조공학회논문집
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• 제20권6호
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• pp.751-759
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• 2007

저자는 기존의 연구에서 대용량-비선형성을 가지는 유체의 최적화를 수행하기 위해 몇 가지 강력한 방법들을 제시한 바 있다. 즉, 최적화 과정에서 수렴성을 높이기 위해 step by step기법을 사용하였고, 또한 수렴속도를 높이기 위하여 최적화이터레이션 과정에서 얻어지는 민감도정보를 이용하여 시스템 평형방정식의 해석을 위한 좋은 초기치를 제공하는 방법과, 평형방정식을 구속조건으로 사용하는 동시기법(simultaneous technique)에서 착안하여 해석과 최적화 수렴 판정치를 조작하는 방법을 제시한 바 있다. 그러나 그들 기법은 기본적으로 유사뉴턴법에 기본을 두고 있다. 현재까지 최적화에서 SQP기법을 사용할 때는 정확한 헤시안 매트릭스의 유도가 매우 까다롭고 힘들기 때문에 유사뉴턴법을 사용하고 있는 실정이다. 그러나 3차원 문제와 같이 더욱 큰 용량의 문제를 위해서는 진정한 의미에서의 뉴턴법, 트루 뉴턴법(true Newton method)을 사용할 필요가 있다. 본 연구에서는 트루 뉴턴법을 사용하기 위해 헤시안 매트릭스의 정확치를 얻는 과정을 유도하고 이를 기본으로 트루 뉴턴법을 이용한 최적화 루틴을 만들었다. 그리고 이를 3차원 문제에 적용하여 그 효과를 검증하였다.

• 디자인학연구
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• 제18권3호
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• pp.15-24
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• 2005

충분한 디자인 전문인력을 갖추지 못한 중소기업에서 부적절한 제품디자인 개발과정으로 인하여 시간, 비용, 생산적 측면에서 많은 낭비와 시행착오가 발생하고 있다. 특히 디자인 프로세스에서 가장 중시하는 구상단계의 디자인 컨셉 도출이나 전개단계의 스케치 및 렌더링의 진행을 통한 의사결정에 있어서 객관적이고, 과학적인 접근방법은 제고되지 않고 있으며, 이의 개선을 위한 연구도 매우 드물다. 이에 본 연구에서는 이와 같은 체계적이지 못한 의사결정단계의 보완 및 정량화 된 데이터의 산출을 통한 리스크 감소를 위해 디자인 프로세스의 전개단계 및 결정단계에 AHP기법과 쌍대분석법의 개념을 적용하였다. AHP기법의 기본 개념은 쌍대비교에서 출발한다. 일반적으로 인간은 절대적 판단보다는 상대적 판단에 의한 의사결정을 보다 효율적으로 수행할 수 있으며, 쌍대비교는 이와 같은 인간 특성에 바탕을 두고 스케치 대안들을 두개의 대안끼리 짝을 지어 비교하는 상대적 비교개념을 사용하고 있다. 따라서 디자이너들의 디자인 스케치 대안비교에 있어서 보다 효율적인 판단을 유도할 수 있으며 여러 대안들에 대한 평가를 일관성 있게 수행할 수 있도록 도와줌으로서 의사결정의 효율향상과 최종 디자인 선택시의 리스크를 상당부분 감소시킬 수 있는 것이다. 그리고 각 대안들의 정량적인 순위를 도출하고 여러 감성적인 디자인 결과물들에 대하여 100% 정확한 디자인 대안의 선택은 아니지만 여러 디자인 대안들의 필터링과 의사결정을 수 행함에 있어서 기존의 방법보다는 개선되어 정량적이고 일관적인 기준을 제공해주는 것이며, 상당부분에 있어서 개성과 감성의 차를 극복하는 효율적인 방법이 될 것이고 연구 의의도 여기에 있다 하겠다. 끝으로 품질개선을 위한 기법적용의 연구결과에 대해서는 실제 디자인 개발 아이템의 사례연구를 통하여 타당성을 검증하고, 이상의 품질 개선을 위한 기법이 적용된 이상적인 신 프로세스를 제안하고자 한다.

• Journal of Preventive Medicine and Public Health
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• 제35권4호
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• pp.359-374
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• 2002

Objectives : To develop a physical functioning instrument for older adults living in the community. Methods : A representative sample of 979 people aged 65 years or over were interviewed in-person. Of these, 199 people also completed a detailed in-hospital examination. The scale items were selected based on the frequency of endorsement, along with the item-total and inter-item correlations. The associations of the scale with their physical performance and clinical examination were analyzed to evaluate the criterion-related validity. Construct validity was assessed using factor analysis, and internal consistency through Cronbach's alpha and item-total correlations. Test-retest reliability was measured by agreement between the household survey and the repeat survey at the in-hospital examination. Results : Initially, 23 items on the level of difficulty, ranging from no difficulty to an inability to complete a task, with the specific mobility and self-care tasks were included. Those with a high frequency of endorsement and a low inter-item or item-total correlations were excluded, resulting in a 10-item Physical Functioning (PT) scale. Equal weights were given to each item and a summated score was calculated. Significant associations were found between the PF scores and the physical performance, surrey and clinical data. The scale revealed a 2-factor (mobility and self-care) structure. Cronbach's alpha was 0.92 and the item-total correlations were in the 0.63 to 0.78 range. Pearson's correlations for the test-retest ranged between 0.56 and 0.61. Conclusions : The newly developed Physical Functioning (PF) scale showed good psychometric properties in older people. Further work, however, is needed to improve its sensitivity to discriminate higher levels of functioning, in addition to assessing its predictive value in detecting changes in health.

• 임상간호연구
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• 제29권2호
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• pp.198-209
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• 2023

Purpose: The purpose of this study was to develop a Korean Adult Patients Delirium Screening Tool (K-APDS) for those admitted to general wards, and to verify its reliability and validity. Methods: For the development of the tool, 12 items were derived through the results of literature review and focus group interviews with general ward nurses, and the content validity was confirmed by experts. To verify the reliability and validity of the developed tool, 317 adult patients who were admitted to general wards of three tertiary general hospitals from October to November 2022 were evaluated by the attending nurse and data were collected. Results: After factor analysis for construct validity verification, two factors were extracted, which explained 60.1% of the total variance. After the validation of the control group, the difference in the delirium incidence scores calculated using the K-APDS between the delirium group and non-delirium group was very significant (Z=-10.82, p<.001). To verify the criterion validity, K-APDS, Delirium Observation Screening, and Pearson's correlation coefficient were checked and found to be .94 (p<.001). The predictive validity test reported that the sensitivity was 91.1%, specificity was 82.4%, positive predictive value was 52.6%, and negative predictive value was 97.8%. The reliability of K-APDS was found to be high with Cronbach's ⍺=.91. Conclusion: K-APDS can screen for delirium with 2 or more points, excellent validity and reliability have been verified. Therefore, this tool could be applied immediately in the clinical field, and will contribute to the early detection of delirium, enabling rapid interventions.

• 한국산업보건학회지
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• 제34권1호
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• pp.67-76
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• 2024

Objectives: Direct reading instruments (DRIs) are widely used by industrial hygienists and other experts for preliminary survey and identifying source locations in many industrial fields. Photoionization detectors (PIDs), which are a form of hand-held portable DRIs, have been used for a variety of airborne vaporized chemicals, especially evaporated hydrocarbon solvents. The benefits of PIDs are high sensitivity between each chemical, competitive price, and portability. With the goal of increasing the accuracy of logged PID concentrations, previous studies have performed tests for the assessment of single chemical compounds, not mixtures. The purpose of this preliminary study was to measure mixtures with a PID and charcoal tube at the same time and compare the accuracy between them. Methods: A chamber test was implemented with different mixtures of hydrocarbon chemicals (acetone, isopropyl alcohol, toluene, m-xylene) and levels in the range of 14 to 864 ppm. Three PIDs and charcoal tubes were connected to the chamber and measured the chemical mixtures simultaneously. A comparison of accuracy and the PID group of concentrations with manufacture correction factor (M_CF) and field correction factor (F_CF) applied was performed. Results: The accuracy of the PID concentrations data-logged from the PID did not meet the accuracy criteria except for the mixture level B and C logged from PID No. 2, which was 18% of all tests for meeting accuracy criteria. The mean and standard deviation (SD) of concentration (ppm) of the charcoal tube followed by each mixtures' level were 10.37±0.26, 155.33±5.28, 300.80±11.65, and 774.93±22.65, respectively. When applying F_CF into the PID concentrations, the accuracy increased by nearly 82%. However, in the case of M_CF, none met the accuracy criterion. Between the PID there were differences of logged concentrations. Conclusions: In this preliminary study, the concentration of a logged PID with F_CF applied was a better way to increase accuracy compared to applying M_CF. We suggest that additional research is necessary to consider environmental factors such as temperature and humidity.