• 대한수학회보
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• 제57권6호
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• pp.1529-1539
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• 2020

The present work is aimed at presenting some characteristic properties of functions that map open unit disk onto a lune in the right half plane. Furthermore, we introduce subclasses of functions with boundary and radius rotations which are related to crescent regions. Some useful results, which include coefficient inequalities and some subordination properties associated with these subclasses are derived. Consequently, related problems concerning these classes are also studied.

• Molecules and Cells
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• 제37권10호
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• pp.753-758
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• 2014

Sorting nexin 9 (SNX9) is a member of the sorting nexin family of proteins and plays a critical role in clathrinmediated endocytosis. It has a Bin-Amphiphysin-Rvs (BAR) domain which can form a crescent-shaped homodimer structure that induces deformation of the plasma membrane. While other BAR-domain containing proteins such as amphiphysin and endophilin have an amphiphatic helix in front of the BAR domain which plays a critical role in membrane penetration, SNX9 does not. Thus, whether and how SNX9 BAR domain could induce the deformation of the plasma membrane is not clear. The present study identified the internal putative amphiphatic stretch in the $1^{st}$ ${\alpha}$-helix of the SNX9 BAR domain and proved that together with the N-terminal helix ($H_0$) region, this internal putative amphiphatic stretch is critical for inducing membrane tubulation. Therefore, our study shows that SNX9 uses a unique mechanism to induce the tubulation of the plasma membrane which mediates proper membrane deformation during clathrinmediated endocytosis.

• BMB Reports
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• 제42권8호
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• pp.511-515
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• 2009

Downstream of Bid (DOBI) known as Pus10, has been identified as a modulator of TRAIL-induced cell death using RNAi library screening. The crystal structure of DOBI has revealed that it is a crescent-shaped protein containing the pseudouridine synthase catalytic domain and a THUMP-containing domain. Here, we demonstrated that DOBI is expressed in various tissues such as heart and lung, and is also expressed in various tumor cells such as HeLa and A549. Although ectopic expression of DOBI does not promote TRAIL death signaling in HeLa cells, knock-down of DOBI expression using shRNA inhibited TRAIL death signaling. DOBI is cleaved into a 54 kD cleaved DOBI during cell death, and the recombinant DOBI protein can be directly cleaved by caspases-3, or -8 in vitro. Together, these data suggest that the cleaved DOBI may acquire a new function, possibly by cooperating with tBid in the mitochondrial event of cell death caused by TRAIL.

• 한국자기학회지
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• 제14권2호
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• pp.65-70
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• 2004

도메인 확장형 광자기 디스크 시스템(magnetic amplifing magnetooptical system; MAMMOS)의 기록마크 시뮬레이션을 위한 온도분포와 재생신호를 연구하였다. 정지된 디스크에서 레이저 빔에 의한 기록층과 이웃하는 층들의 온도 분포를 계산하였으며, 마크 크기와 길이 및 위치를 계산하였다. 또한 마크 모양에 따른 재생신호의 크기, 기록층에 기록되는 마크의 재생신호 및 판독층에서 확대된 재생신호를 시뮬레이션 하였다. 간소화된 열전달 특성 모델을 계산함으로써, 기록층과 인접한 층에서의 온도분포를 시간의 함수로 계산하였다. 마크 크기는 디스크가 회전할 때 기록 빔 펄스 파형에 의한 온도분포로부터 계산하였으며, 기록빔 펄스 파형으로부터 디스크의 온도분포를 이용하여 마크의 길이와 위치를 계산하였다. 재생신호는 디스크의 반사도 패턴과 가우시안 빔의 컨볼루션 연산을 이용하여 계산하였다. 판독층에서 빔 크기만큼 확대된 도메인의 재생신호가 기록층에서의 초승달 모양 마크에 기한 재생신호보다 2배 이상 증가되는 것을 알 수 있었다.