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Studies on the Serum Total Creatine Phosphokinase (CPK) Activities and CPK Isosenzymes Fractions of Chicken (닭의 혈청 Creatine phosphokinase (CPK) 총 활성 및 CPK isoenzymes분획에 관한 연구)

  • Kim, Bong-Sik;Hurh, In;Kim, Jong-Hyung;Jang, Myong-Whan;Kim, Won-Sun;Kim, Duk-Whan
    • Korean Journal of Veterinary Service
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    • v.16 no.2
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    • pp.120-126
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    • 1993
  • Clinically healthy 66 female Maniker breed chicken(22 of 2-week-old : group A, 23 of 8-week-old: group B and 21 of 27-week-old: group C) and 66 female Manina breed chicken (21 of 2-week-old : group D, 22 of 8-week-old : group E and 23 of 27-week-old : group F) were examined to establish physiological basic data on serum total Creatine phosphokinase (CPK) activities and CPK isoenzymes fractions. The results obtained were summarized as follows; 1. Serum total CPK activities were $1,088{\pm}254.0\;IU\;/{\ell},$ $1,454{\pm}337.2\;IU\;/{\ell}$ and $1,440{\pm}526.3\;IU\;/{\ell}$ in gorup A, group B and group C of Maniker breed, respectively. Group B and group C showed higher values than that of group A (P<0.01) meaning high values nth aging. 2. Serum total CPK activities were $1,676{\pm}420.5\;IU\;/ {\ell},$ $1,007{\pm}283.1\;IU\;/{\ell}$ and $862{\pm}294.5\;IU/{\ell}$ in group D, group E and group F of Manina breed, respectively. Group D showed the highest value among groups (P<0.01) and Manina breed showed the low values of serum total CPK activities with aging. 3. Manina breed at 2-week-old and Maniker breed at 8-week-old and 27-week-old showed significant high values of total serum CPK activities in breed differance (P<0.01) 4. In the pattern of serum CPK isoenzyme fractions, group A and group B were high with decreasing order of $CK_3>CK_2>CK_1$ and group C was high with decreasing order of $CK_2> CK_3>CK_1$ Groihp D, E and F showed the same pattern with decreasing order of $CK_2>CK_3> CK_1.$ 5. Significance of CPK isoenzymes fractions in breed differance was only found at 8-week-old. $CK_1\;and \;CK_3$ in Maniker breed (P<0.05), and $CK_2$ in Manina breed were higher than that of the other breed (P < 0.01).

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Blood chemical research for the diagnosis of cardiac disease in ruminant (반추수 심장질병의 진단을 위한 혈액화학적 연구)

  • Kim, Duck-hwan;Lee, Kyo-young;Chang, Seuk-jin;Song, Kun-ho;Lee, Yoon-kyung;Yoon, Sang-bo
    • Korean Journal of Veterinary Research
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    • v.35 no.2
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    • pp.399-404
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    • 1995
  • In order to clarify the significance of serum CPK for the diagnosis of the cardiac disease in ruminant, the fluctuation of serum total CPK activities and CPK isoenzyme fractions was examined before and after operation in Korean native goats with artificially induced cardiac injury. In the change of serum total CPK activities, those of experimental group were changed with higher values than those of control group and significant increase was found on 2-week after operation(P<0.05). In the fluctuation of serum CPK isoenzyme fractions, significant increase of both CK1 and CK3 fractions was observed on 2-week after operation in experimental group(P<0.05), but significant difference was not found in CK2 fraction between experimental and control groups. From these findings, it is considered that taking note of increase of not only serum total CPK activities but also CK1 and CK3 fractions is important for the diagnosis of traumatic cardiac disease in ruminant.

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Comparison of serum isoenzyme levels of CPK and LDH in patients ungergoing thoracic operations (흉부수술 환자에서의 CPK 와 LDH I soenzyme 의 변화)

  • 이영욱
    • Journal of Chest Surgery
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    • v.15 no.4
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    • pp.460-466
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    • 1982
  • A analysis of CPK & LDH Isoenzyme was done on the consecutive patients undergoing thoracic operations from July 1982 to October 1982 in the Department of Thoracic and Cardiovascular Surgery, Capital Armed Forces General Hospital. Eighteen patients were analysed by three groups, such as open heart surgery [group A], major thoracic operation [group B] , minor thoracic operation group [group C]. In all patients serial determination of total level and Isoenzyme of CPK, LDH wad done on preoperative operative and up to 8th post-operative day, The results obtained are as follows. 1. The average value of serum CPK before the operation was 61 IU/L. The value of serum CPK was increased following the operation mainly MM portion and reached to the maximal level of 536107 IU/L in A group 1200191 IU/L in B group, 306150 IU/L in C group on the first postoperative day. The enzyme activity was gradually decreased thereafter and returned to the normal range on the 3rd or 4th day after the operation. 2. The average value of serum LDH before the operation was found to be 83 IU/L. The value was increased during the operation and reached to the maximal level of 481108 IU/L in group A, 14827 I U/L in group B, 10035 IU/L in group C on the second day after the operation. The enzyme activity was gradually decreased thereafter and returned to the normal range on the seventh day after the operation. The enzyme activity was dependent to the duration of operation, severity of muscle damage, type of thoracotomy, effect of extracorporeal circulation, state of disease.

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Effects of Aerobic Exercise Variables on Production of Creatine Phosphokinase in Stroke Patients

  • Yun, Youngdae
    • Journal of International Academy of Physical Therapy Research
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    • v.12 no.1
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    • pp.2295-2301
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    • 2021
  • Background: Physical therapy applied to stroke patients is recognized as a treatment that promotes function recovery, and it is a widely known fact that constant exercise should be performed. However, there are insufficient studies on exercise intensity and exercise time that can minimize side effects and maximize function recovery for exercise therapy. Objectives: To determine the effect of exercise variables on CPK generation during aerobic exercise in stroke patients and to discover how to use appropriate exercise intensity and time when conducting an exercise for function recovery in stroke patients. Design: Quasi-experimental research. Methods: This study classified subjects into three groups (low-intensity exercise group: LIE, moderate-intensity exercise group: MIE and high-intensity exercise group: HIE) according to exercise intensity, and was further classified into two groups (10-minute exercise group: 10MG and 20-minute exercise group: 20MG) according to exercise time variables within each exercise intensity group. After, the change in CPK according to exercise intensity and time was confirmed through hematological analysis. Results: In LIE and MIE, the CPK blood concentrations before and after exercise were increased in 10MG and 20MG, which was not statistically significant (P>.05). In HIE, the CPK blood concentrations before and after exercise were increased in 10MG, and it was statistically significant (P<.05). In HIE, the CPK blood concentrations before and after exercise were increased in 20MG, and it was statistically significant (P<.01). In 10MG and 20MG, the CPK blood concentrations before and after exercises were increased in all intensity group, and there was a statistically significant difference only in HIE. Conclusion: From the results of this study, considering CPK, it will be helpful to recover and improve function if the exercise intensity setting is applied in the type of moderate intensity exercise during physical therapy interventions in stroke patients.

A study on Process Capabilit Index using Semi-Variance

  • DaeKyung Kim
    • Communications for Statistical Applications and Methods
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    • v.6 no.1
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    • pp.77-88
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    • 1999
  • A new measure of the process capability index(PCI) $\textit{C}_{cpk}$ is proposed that takes into account the proximity to the target value as well as process mean and process variation when we assessing process performance. using the semivariance estimators proposed by Choobineh and Branting (1986) and Josephy and Aczel (1993) the estimator($\textit{C}_{cpk}$) of new index has been solved and the properties of these estimators have been examined through simulations. Also we compare the performance between $\textit{C}_{cpk}$ and $\textit{C}_{jpk}$ which is developed by Johnson kotz and Pearn(1992).

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Phage Typing and Lysotype Distribution of Xanthomonas axonopodis pv, citri, the Causal Agent of Citrus Bacterial Canker in Korea

  • Myung, Inn-Shik;Yongsup Cho;Lee, Young-Hee;Kwon, Hyuk-Mo
    • The Plant Pathology Journal
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    • v.17 no.6
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    • pp.336-341
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    • 2001
  • The distribution of citrusphages and phage types of Xanthomonas axonopodis pv. citri was investigated in Korea. Forty-eight strains of the bacterial pathogen and 28 bacteriophage strains were isolated from citrus leaves showing the citrus canker symptom. Only a single bacteriophage group, named CPK, was identified based on their aggressiveness to the bacterial pathogen. The bacterial strains were differentiated into two Iysotypes based on their sensitivity to CPK. Lysotype I, which was sensitive to CPK, was more predominant (96%), while only 4% belonged to Iysotype II, which was resistant to CPK. Among the 13 xanthomonads including Iysotype A and Iysotype B of X axonopodis pv. citri, CPKs were only aggressive to BC 83 (=Xc 62) strain of X. axonopodis pv, citri reported as Iysotype A. Thus, bacterial pathogens and citrusphages related to citrus plants mainly distributed in Korea were presumed as Iysotype A of X. axonopodis pv, citri, and Iysotype A-infecting CP$_1$ respectively.

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Clinical Observations on Myocardial Protection with Cold Blood Potassium Cardioplegia According to the Duration of Ischemic Arrest (냉혈K+ 심정지약을 사용한 개심술 예에서 심정지시간에 따른 심근보호효과에 관하여)

  • Jeong, J.G.;Lee, D.H.
    • Journal of Chest Surgery
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    • v.24 no.7
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    • pp.647-655
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    • 1991
  • The efficacy of cold blood potassium cardioplegia during periods of ischemic arrest was assessed in 88 patients undergoing open heart surgical procedures at Chonnam National University Medical School from December, 1987 to January, 1989. The purpose of this study was to determine if the aortic cross clamping time[ACCT] over 120 minutes correlated with operative mortality, incidence of postoperative ventricular tachyarrhythmias, needs of postoperative inotropic support and serum enzyme levels. The patients were divided according to aortic cross clamping time[less than 120 minutes and 120 minutes or greater]. The results were as follows: 1. The operative mortality was 3.2% in ACCT<120min group and 7.7% in ACCT>120 min group. 2. The incidence of postoperative ventricular tachyarrhythmia was 1.6% in ACCT <120min group and 11.5% in ACCT>120min group[p<0.05]. 3. The incidence of postoperative inotropic support in congenital heart disease was 13.0Fo in ACCT<120min group and 45.0%o in ACCT>120min group[p<0.05]. The incidence in acquired heart disease was 26.0% in ACCT<120min group and 40.0% in ACCT> 120min group. 4. After cardiopulmonary bypass, serum GOT, LDH, CPK and CPK - MB were elevated prominently. Children showed higher value of the enzymes examined than adults did before and after cardiopulmonary bypass. In congenital heart diseases, postoperative serum GOT, LDH, CPK and CPK - MB levels of ACCT>120min group were significantly higher than those of ACCT<120min group. Postoperative serum GOT, LDH and CPK - MB levels of ACCT>=120min group were significantly higher than those of ACCT<120min group also in acquired heart diseases. The results suggest that the myocardial protective effect with cold blood potassium cardioplegic solutions was not sufficient when the aortic cross clamping time was over 120 minutes.

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Studies on the Blood Chemical Properties in Racehorses: I. Serum Enzyme Activities (경주마(競走馬)의 혈액화학성상(血液化學性狀)에 관한 연구: I. 혈청효소(血淸酵素) 활성치(活性値))

  • Kang, Chung-boo
    • Korean Journal of Veterinary Research
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    • v.28 no.1
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    • pp.199-202
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    • 1988
  • The present study was carried out to investigate the serum enzyme activities of racehorses. The enzymes investigated were aspartate and alanine aminotransferase (GOT, GPT), ${\gamma}$-glutamyl transpeptidase(${\gamma}$-GTP), Lactic dehydrogenase(LDH), creatine phosphokinase(CPK), and alkaline phosphatase(ALP). Animals used were 30 healthy racehorses(♀17, ♂13) average weighing 435kg and were from 2 to 8 years of age. LDH activity was progressively decreased with age and next in the order of GOT and CPK activities. GOT and ${\gamma}$-GPT activities were not changed with age but ALP activity tended to be decreased wish age. Activities of GOT, GPT, ${\gamma}$-GTP and ALP were higher in female than in male. There was no difference in CPK activity by sex, and no difference was found out among breeds.

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Incidence level of abnormality in creatine phosphokinase by statin

  • Kim, Yoo-Ni;Bae, Kyun-Seop;Jung, Sun-Hoi;Lee, Seung-Mi;Yoon, Kyoung-Eun;Kim, Hwa-Young;Chae, Young-Moon;Park, Byung-Joo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.237-237
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    • 2002
  • Creatine phosphokinase (CPK) was a marker in diagnosis of rhabdomyolysis. The CPK abnormality could be induced by intake of HMG CoA reductase inhibitors (statins). The objective of this study was to estimate the incidence rate of CPK abnormality by each statin. (omitted)

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