• Wind and Structures
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• v.7 no.4
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• pp.281-291
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• 2004

The flutter characteristics of long span bridges are discussed from the point of the unsteady pressure distribution on bridge deck surface during heaving/torsional vibration related to the aerodynamic derivatives. In particular, it is explained that the coupling terms, which consist of $A_1^*$ and $H_3^*$, play a substantial role on the coupled flutter, in comparison with the flutter characteristics of various structural sections. Also the effect of the torsional/heaving frequency ratio of bridge structures on the flutter instability is discussed from the point of the coupling effect between heaving and torsional vibrations.

• Bulletin of the Korean Chemical Society
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• v.28 no.12
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• pp.2219-2225
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• 2007

The reaction mechanisms for the cyclizations of N-methyl-2-(2-chloropyridin-3-yloxy)acetamide to 1-methylpyrido[ 3,2-b][1,4]oxazin-2-one and 1-methyl-pyrido[2,3-b][1,4]oxazin-2-one were investigated using ab initio Hartree-Fock, second-order Moller-Plesset perturbation, single point coupled cluster with both single and double substitution, and density functional theory methods. The 5-membered spiro intermediate (2) is optimized from the cyclization of the acyclic reactants through the proton-transfer reaction, and this intermediate proceeds continuously to the 6-membered intermediate through either a stepwise or a concerted reaction. In the stepwise reaction, an N-bridge-type intermediate as a stable structure is optimized, whereas, in the concerted reaction, the O-bridge-type intermediate is not optimized.

• Fibers and Polymers
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• v.2 no.4
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• pp.212-220
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• 2001

A series of polymeric dyes wre synthesized by free radical addition polymerication of monomeric dyes. The 2-amino-5-mrecapto-1,3,4-thiadiazole was diazotized and coupled with various N-arlmaleimides to give monomeric dyes. All the polymeric dyes were characterized by elemental analysis, infrared spectroscopy, visible absorption spectroscopy, viscometry. and thermogravimetric analysis. Color and dyeing properties of the polymeric dyes were discussed by comparing them with those of the corresponding monomeric dyes. The dyeing performance of these dyes was assessed on nylon fiber. These dyes were found to give various color shades with good to very good depth and levelness on the fiber. The dyeing of the monomeric dyes showed moderate fastness to light and good to excellent fastness properties. The dyebath exhaustion and fixation on nylon fiber has been found to be good.

• Journal of the Korean Chemical Society
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• v.16 no.5
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• pp.320-327
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• 1972

The coupling of aromatic diazonium salts with humic or nitrohumic acid, as a supplemental method of determining the structure and utilization of humic acid, were studied. The following results were obtained. 1) Humic acids have many vacan to-and p-positions in their phenol kernels. 2) Humic acids have not so many benzene kernels in their structure units. 3) When coupled with aromatic diazonium salts (such as aniline, aminonaphthalene and aminoanthraquinone derivatives), various azo-dye were obtained.

• Biomolecules & Therapeutics
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• v.21 no.6
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• pp.411-422
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• 2013

G-protein-coupled receptors (GPCR) are the largest superfamily of receptors responsible for signaling between cells and tissues, and because they play important physiological roles in homeostasis, they are major drug targets. New technologies have been developed for the identification of new ligands, new GPCR functions, and for drug discovery purposes. In particular, intercellular lipid mediators, such as, lysophosphatidic acid and sphingosine 1-phosphate have attracted much attention for drug discovery and this has resulted in the development of fingolimod (FTY-720) and AM095. The discovery of new intercellular lipid mediators and their GPCRs are discussed from the perspective of drug development. Lipid GPCRs for lysophospholipids, including lysophosphatidylserine, lysophosphatidylinositol, lysophosphatidylcholine, free fatty acids, fatty acid derivatives, and other lipid mediators are reviewed.

• Archives of Pharmacal Research
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• v.26 no.12
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• pp.997-1001
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• 2003

This paper deals with chiral enzymatic resolution of 4-arylthio-2-butanols by lipase to prepare potential intermediates of $\beta$-lactam antibiotics. Among several lipases employed, lipase P type enzyme gave the highest ee value to prepare (R)-4-arylthio-2-butyl acetate. The enzymatic resolution of phenyl substituted alcohol (6a) using lipase P showed the highest ee value (99.7%) among those of 4-arylthio-2-butanol derivatives. Lipase P mediated hydrolysis of acylester 7a gave also (R)-alcohol 6a selectively. For determination of enantiomeric purity of these enzymatic resolved analytes, liquid chromatographic analysis was performed using two coupled Chiralcel OD and (R,R)-WhelkO chiral column.

• Bulletin of the Korean Chemical Society
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• v.17 no.7
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• pp.599-604
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• 1996

The synthesis is reported of p-nitrophenyl glycosides of D-galactose modified at C-4 with azido- (5), amino- (6) group and fluorine (13). 4-Azido-2,3,6-tri-O-benzoyl-4-deoxy-α-D-galactopyranosyl chloride and 2,3,6-tri-O-benzoyl-4-deoxy-4-fluoro-α-D-galactopyranosyl bromide were coupled with potassium p-nitrophenoxide in the presence of 18-crown-6 giving the corresponding p-nitrophenyl 4-azido-and 4-fluoro-4-deoxy-β-D-galactopyranoside derivatives. p-Nitrophenyl 4-amino-4-deoxy-β-D-galactopyranoside (6) was obtained by selective reduction of p-nitrophenyl 4-azido-4-deoxy-β-D-galactopyranoside (5) using 1,3-propane dithioltriethylamine. These galactoside analogs were slowly hydrolyzed in the increasing rate order of 5, 6 and 13 by β-galactosidase from Escherichia coli.

• Bulletin of the Korean Chemical Society
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• v.16 no.7
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• pp.625-630
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• 1995

α-Linked D-altropyranosidic derivatives were obtained by configurational change at C-3 of α-D-mannopyranosides as the key step in preparation of allyl and methyl α-D-glycopyranosides of 6-deoxy-D-altro-heptose. The manno-altro conversion was effected by sequential reactions of Swern oxidation and stereoselective borohydride reduction. Allyl 4,6-O-benzylidene-2-O-p-methoxybenzyl-α-D-mannopyranoside was transformed to the corresponding altropyranoside via 3-oxo-arabino-hexopyranoside. Allyl 7-O-benzyl-6-deoxy-3,4-O-isopropylidene-α-D-altro-heptopyranoside has been prepared as a glycosyl acceptor to be coupled with β-D-GlcpNAc-(1→3)-α-D-Galp glycosyl donor for the synthesis of an O-antigen repeating unit of Campylobacter jejuni serotypes O:23 and O:36. Stereoselective borohydride reduction also succeeded in yielding methyl 2,4,7-tri-O-benzyl-6-deoxy-α-D-altro-heptopyranoside from the corresponding 3-oxo-α-D-arabino-heptopyranoside. C-6 Homologation was achieved by sequential reactions of cyanide displacement of 6-sulphonates, reduction of the resulting heptopyranosidurononitrile with diisobutylaluminum hydride, hydrolysis of the imine, and further reduction with sodium borohydride.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.173-173
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• 2018

본 연구는 기상-수문 분야에서 고해상도 수문기상요소를 산출하기 위해 WRF-Hydro(Weather Research and Forecasting and Model Hydrological modeling extension package) 모형을 한반도 대상으로 구축하였다. 모형은 미국 대기 연구 국립센터(NOAA)에서 개발된 커뮤니티형 고해상도 예측모델이므로 미국 등에서 활발히 활용되기 시작하였으나 아직 우리나라 적용성에 대한 연구는 많지 않다. 본 연구에서는 WRF-Hydro 모형을 한반도에 적절히 사용하기 위해 표면유출, 보수깊이, 표면거칠기와 같은 파라미터를 보정하였다. WRF-Hydro는 지역 기상모형인 WRF와 연계하여 coupled WRF/WRF-Hydro 모형을 구동하였으며, 고해상도 유출값을 얻기 위해 미국 지질조사국(USGS)에서 제공한 HydroSHEDS(Hydrological data and map based on SHuttle Elevation Derivatives at multiple Scales)를 이용하였다. 본 연구에서는 관측된 유출값을 Markov Chain Monte Carlo(MCMC) 방법을 활용하여 모형값과 비교하여 파라미터 보정을 수행하였으며, 파라미터 보정된 WRF/WRF-Hydro를 활용해 한반도 과거 홍수 및 가뭄 사상을 모의하여 결과를 분석하였다.

• Structural Engineering and Mechanics
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• v.46 no.4
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• pp.549-569
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• 2013

A passive control using flaps will be an alternative solution for flutter stability and buffeting response of a long suspension bridge. This method not only enables a lightweight economic stiffening girder without an additional stiffness for aerodynamic stability but also avoid the problems from the malfunctions of control systems and energy supply system of an active control by winglets and flaps. A time domain approach for predicting the coupled flutter and buffeting response of bridge deck with flaps is investigated. First, the flutter derivatives of bridge deck and flaps are found by experiment. Next, the derivation of time domain model of self-excited forces and control forces of sectional model is reported by using the rational function approximation. Finally, the effectiveness of passive flap control is investigated by the numerical simulation. The results show that the passive control by using flaps can increase the flutter speed and decrease the buffeting response. The experiment results are matched with numerical ones.