• BMB Reports
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• v.52 no.7
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• pp.457-462
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• 2019

[18F]Fluorodeoxyglucose (FDG) PET/CT imaging has been widely used in the diagnosis of malignant tumors. ATPase family AAA domain-containing protein 2 (ATAD2) plays important roles in tumor growth, invasion and metastasis. However, the relationship between [18F]FDG accumulation and ATAD2 expression remains largely unknown. This study aimed to investigate the correlation between ATAD2 expression and [18F]FDG uptake in lung adenocarcinoma (LUAD), and elucidate its underlying molecular mechanisms. The results showed that ATAD2 expression was positively correlated with maximum standardized uptake value ($SUV_{max}$), total lesion glycolysis (TLG), glucose transporter type 1 (GLUT1) expression and hexokinase2 (HK2) expression in LUAD tissues. In addition, ATAD2 knockdown significantly inhibited the proliferation, tumorigenicity, migration, [18F]FDG uptake and lactate production of LUAD cells, while, ATAD2 overexpression exhibited the opposite effects. Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway). In summary, to explore the correlation between ATAD2 expression and glycometabolism is expected to bring good news for anti-energy metabolism therapy of cancers.

• Journal of The Korean Society of Grassland and Forage Science
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• v.12 no.4
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• pp.226-231
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• 1992

This experiment was carried out to estimate the dry matter accumulation using growth analysis in spring growth of perennial ryegrass varieties grown under space planting conditions, based on the data of previous paper9'. The results obtained were as follows: 1. Growth parameters of leaf area ratio(LAR), specific leaf area(SLA) and leaf weight ratio(LWR) were recognized siginificant differences between varieties. But, specific leaf area(SLA), leaf weight ratio (LWR) and relative tiller appearance rate(RTAR) were recognized significant differences between growth stages. Specific leaf area(SLA) was significant difference for the interaction of variety Xgrowth stage. 2. The relative growth rate of biological yields(BYRGR) indicated significantly positive correlations with relative growth rate of shoot(RGR) and root(RWGR), and net assimilation rate(NAR) as affected by the varieties and growth stages. 3. The relative growth rate of biological yields(BYRGR) indicated significantly positive correlation with nct assimilation rate(NAR) in all varieties. Leaf area ratio(LAR) had significantly positive correlation with specific leaf area(SLA) in all varieties, but shows a significant negative correlation with leaf weight ratio(LWR) of Maprima variety. 4. The relative growth rate of biological yields(BYRGR) indicated significantly positive correlations with the absolute growth rates of yield components.

• Nuclear Engineering and Technology
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• v.34 no.4
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• pp.396-405
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• 2002

An experimental study on counter-current flow limitation phenomena in narrow annular passages was carried out The gap sizes tested were 1, 2 and 3 mm. This is very small compared with the outer diameter of the annular passage, 500 mm. It was visually observed that a CCFL might occur in some part of the periphery while the other part is remained in a counter current flow pattern. That is, non-uniform behaviour of fluids due 4o a 2-dimensional effect appear in a large diameter facility. Because of this non-uniformity, a CCFL is defined in the present work as the situation where net water accumulation is sustained. That is, some amount of water should not be allowed to penetrate the gap and accumulate over the gap at CCFL criterion. The measured data are presented in the form of Wallis＇type correlation with characteristic length of gap size. It was found that the present correlation is in good agreement with other empirical correlation based on measurements whose test section diameter is close and the gap size is much larger than that of the present test section.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.39 no.5
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• pp.329-341
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• 2021

This study derives the risk-Influence factors for subway structures, the basis for the transition from the current subway disaster recovery-oriented maintenance system to a preemptive disaster management system, to reduce risk factors for existing subway structures. To apply reasonable risk assessment techniques, risk influence factors for subway underground structures using statistical information(spatial information) and risk influence factors according to frequency of accidents were selected to derive the risk factors. The significant risk factors were verified through ground subsidence (SI: Subsidence Impact)-based correlation analysis. This process confirmed that the subsidence of the ground was a risk influence factor for the subway structure. The main result of this study is that derive the risk factors to improve the risk factors of subway structures due to the rapid increase in disaster risk factors. The derived risk factors that were expected to affect the depression around subway stations and track structures did not show a noticeable correlation, but the cause of this may be that there is no physical connection between them, but on the other hand, the accumulated data may not accurately record the surrounding depression. Accordingly, in order to evaluate the risk of depression around the station and track, more intensive observation and data accumulation around the structure are required.

• Journal of radiological science and technology
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• v.44 no.4
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• pp.315-325
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• 2021

The purpose of this study is to investigate the changes in lipid proton (LP) composition according to the induced obese fatty liver and to use it as basic data for treatment and diagnosis of fatty liver in the future. The phantom study was conducted to identify differences between STEAM and PRESS Pulse sequences in LP concentration. A high-fat diet (60%) was administered to eight Sprague-Dawley rats to induce obesity and fatty liver disease. Baseline magnetic resonance imaging /spectroscopy data were obtained prior to the introduction of high-fat diet, and data acquisition experiments were performed after eight weeks using procedures identical to those used for baseline studies. The six lipid proton metabolites were calculated using LCModel software. The correlation between the fat percentage and each LP, revealed that the methylene protons at 1.3 ppm showed the highest positive correlation. The α-methylene protons to carboxyl and diallylic protons showed negative correlation with fat percentage. The methylene proton showed the highest increase in the LP; however, it constituted only 71.86% of the total LP concentration. The methylene proton plays a leading role in fat accumulation in liver parenchyma.

• Biomedical Science Letters
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• v.27 no.4
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• pp.208-215
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• 2021

The purpose of this study was to explain the pathology of Alzheimer's disease (AD) and to investigate the correlation between AD and microRNA. AD is the most common type of dementia, accounting for about 80% of all types of dementia, causing dysfunction in various daily activities such as memory loss, cognitive impairment, and behavioral impairment. The typical pathology of AD is explained by the accumulation of beta-amyloid peptide plaques and neurofibrillary tangles containing hyperphosphorylated tau protein. On the other hand, microRNA is small non-coding RNA 22~23 nucleotides in length that binds to the 3' untranslated region of messenger RNA to inhibit gene expression. Many reports explain that microRNAs found in circulating biofluids are abundant in the central nervous system, are involved in the pathogenic mechanism of AD, and act as important factors for early diagnosis and therapeutic agents of AD. Therefore, this paper aims to clarify the correlation between AD and microRNA. In this review, the basic mechanism of miRNAs is described, and the regulation of miRNAs in the pathological processes of AD are highlighted. Furthermore, we suggest that miRNA-based system in development of therapeutic and diagnostic agents of AD can be a promising tool.

• Journal of Korean Society of Forest Science
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• v.96 no.5
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• pp.539-542
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• 2007

This study was carried out to investigate the impacts of jasmonic acid (JA) on adventitious root culture of Eleutherococcus senticosus. Adventitious root of E. senticosus were treated with jasmonic acid (JA) and cultured for 30 days. JA inhibited the root growth but increased eleutherosides accumulation, total phenolic contents and antioxidant activity. Among various concentrations of JA, 1.0 mg/L JA increased the total phenolic contents in E. senticosus adventitious root to $39.81{\mu}g/g$, about 2.6 times higher than that of the control. Consequently, high accumulation of total phenolic contents led to increase the antioxidant activity to 82.41%. The antioxidant activity of control was 37.89% at $2500{\mu}g/mL$. A linear correlation ($R^2$ = 0.9937, 0.9648 and 0.9883) was also shown between antioxidant activity (at 1250, 1875, and $2500{\mu}g/mL$) and total phenolic contents of adventitious root of E. senticosus.

• Proceedings of the Korea Concrete Institute Conference
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• 1999.10a
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• pp.389-392
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• 1999

Fatigue is a process of progressive permanent internal structural change in a material subjected to repeitive stresses. These change may be damaging and result in progressive growth of cracks and complete fracture if the stress repetitins are sufficiently large. For structural members subjected to cyclic loads, the continuous and irrecoverable damage processes are taking place. These processes are referred as the cumulative damage processes due to fatigue loading. Moreover, increased use of high strength concrete makes the fatigue problem more important because the cross-section and dead weight are reduced by using high strength concrete. The purpose of this study is to investigate the shear fatigue behavior of reinforced concrete beams according to shear reinforcement ratio and concrete compressive strength under repeated loadings. For this purpose, comprehensive static and fatigue tests of reinforced concrete beams were conducted. The major test variables for the fatigue teats are the concrete strength and the amount of shear reinforcements. The increase of deflections and steel strains according to load repetition has been plotted and analyzed to explore the damage accumulation phenomena of reinforced concrete beams. An analytical model for shear fatigue behavior has been introduced to analyze the damage accumulation under fatigue loads. The failure mode and fatigue lives have been also studied in the present study. The comparisons between analytical results and experimental data show good correlation.

• Molecules and Cells
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• v.22 no.3
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• pp.269-274
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• 2006

In order to characterize saikosaponin biosynthesis in Bupleurum falcatum, the expression of five isoprenoid pathway genes and their relationship to saikosaponin accumulation in the hairy roots were analyzed. The hairy roots exhibited a rapid accumulation of saikosaponins when incubated in a root culture medium (3XRCM). Homology-based RT-PCR was used to isolate core fragments of five genes, HMGR, IPPI, FPS, SS, and OSC, from the hairy roots. The deduced amino acid sequences exhibited amino acid identities of more than 85% to previously reported genes. Using the fragments as probes, the expression of these five genes in the hairy roots during incubation in 3XRCM medium was examined. Expression of all five genes in the hairy roots increased soon after incubation. In particular, the SS and OSC genes were coordinately induced at 8 days of incubation, and their expression persisted throughout the incubation period. A quantitative HPLC analysis showed that the saikosaponin content of the hairy root culture also began to increase at 8 days of culture. The correlation between SS transcript level and saikosaponin content in the hairy roots suggests that transcriptional regulation plays a regulatory role in saikosaponin biosynthesis.

• Asian Journal of Turfgrass Science
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• v.6 no.1
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• pp.29-37
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• 1992

This experiment was carried out in order to study the changes of morphological characters of the growth and thatch accumulation in :3 varieties of Kentucky bluegrass under removing clipping residues as affected by cutting management. The varieties used were Park, Kenhiuc and Newport.The results obtained are as follows; 1. The dry weight of leaf. stem and number of tiller was highest at 22. June and lowest at 21. Aug in alt varieties. And then the dry weight of rhizome, root and thatch increased with growth progressed) Tabte 3). 2. The relationship of the dry weight of biological yield and number of tillers was quadratic ally increased in the growth stage of spring($R^2$= 0.982**), and linearlly increased in the growth stage of autumn(r 0.944*)(Fig. 1). :3. The dry weight of thatch increased as an exponentially equation in alt :3 varieties of Kentucky blue-grass(Fig. 2). Thatch increased rate(TIR) can used to estimate the specifying a quantity of thatch accumulation from the turf. Thatch increase rate equation as follows. where TH$_2$ is the dry weightof thatch at T$_2$ survey time and TH$_1$ is the dry weight of thatch at $TH_1$ is the dry weight of thatch at $T_1$ survey time. $TIR(mg/cm^2/day)=\frac{Ln\;TH_2 - Ln\; TH_1}{T_2 - T_1}$ 4. Correlation coefficients between the dry weight of thatch and leaf weight was -0.633(P>0.05), and number of tiller of tillers was -0.666(P>0.5), respectively. It means that thatch accumu-lation increased with growth depression of leaf and stem.