• Korean Chemical Engineering Research
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• v.43 no.6
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• pp.704-714
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• 2005

Phase separations of Poly(4-vinylphenol)(PVPh)/Ethyl Acetate and PVPh/Butyl Acetate solutions were measured using the thermal optical analysis (TOA) method. The experimental phase separation data were correlated with liquid-liquid equilibria relations based on PC-SAFT equation of state. The phase separations of these system showed the behaviors of LCST (lower critical solution temperature)-type. The measured cloud temperatures were lowered with increasing in molecular weights of polymer(PVPh), and cloud temperatures of PVPh/Ethyl Acetate solutions shifted to lower temperature regions, compared to the PVPh/Butyl Acetate solutions. Extents of cross-association between solvent molecule and polymer in the PVPh/Ethyl Acetate solutions were measured using the FT-IR spectrum analysis method, and cross-association parameters of PC-SAFT model were estimated from experimental extents of cross-association. By using the estimated cross-association parameters between PVPh and solvent molecule, binodal and spinodal curves of liquid-liquid equilibria in PVPh/Ethyl Acetate and PVPh/Butyl Acetate solutions were calculated from PC-SAFT equation of state. The calculated binodal curves of these system were shown to be well agreeable with the experimental cloud temperature curves.

• The Korean Journal of Quaternary Research
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• v.15 no.1
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• pp.37-45
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• 2001

Morphometric parameters such as cone height, cone height/width ratio($H_{co}$/$W_{co}$), cone height/difference between cone width and crater width ratio($H_{co}$/$W_{co-cr}$) and slope angle are measured to investigate the rates of slope development of scoria cones in Cheju Island. The parameters systematically decrease with increasing age of scoria cones, suggesting that comparative morphology of scoria cones is a useful age indicator. Cone age is most highly correlated with $H_{co}$/($W_{co-cr}$ or average slope angle because summit craters are infilled and eventually removed by erosional processes. The average slope angle is estimated as $\theta_{ave}$= $tan^{-1}$/〔2.$H_{co}$/$W_{co-cr}$〕. Cheju Island was formed through four eruptive stages during Pleistocene. The youngest cones of stage 4(0.1~0.025Ma) have a mean average slope angle of 23.6$\pm$1.7$^{\circ}$, whereas stage 3(0.3~0.1Ma) and stage 2(0.6~0.3Ma) cones have mean values of 18.9$\pm$$1.7^{\circ}C$and 12.6$\pm$$1.9^{\circ}C$, respectively.

• Korean Journal of Environmental Biology
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• v.20 no.4
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• pp.339-346
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• 2002

From March 1998 to August 2000, the phonology and morphometrics change of Zostera caespitosa Miki were examined at the Duksan Port in the eastern coast of Korea. Morphometric characteristics (shoot height, leaf length, sheath length, leaf width, and number of leaf per shoot), size and number of reproductive structures (spathe, spadix, and seeds), shoot density, biomass and physiochemical parameters (water temperature and nutrient concentrations) were measured. Significant differences between months (p < 0.05) existed for morphometric characteristics except for sheath length. The sequence of shoot heights clearly showed cyclical annual variation with water temperature. Vegetative shoots of Z. caespitosa were present throughout the year, but reproductive shoots were rarely occurred from mid January to early April in water temperature of $9-12^\circ{C}$. Flowering in the spathe began in mid February, and seed maturing was occurred in early April. Water column nitrate and phosphate concentration showed seasonal variation, but ammonia concentration was variable with season. Relationships between shoot morphometrics and physiochemical parameters were not significantly correlated but water temperature seemed to regulate the re-productive phase and annual life cycle. The mean shoot density and above biomass of the populations were $511.6\pm{25.6}\;shoots\;m^{-2}$ and $413.4\pm{19.8}\;g\;dry\;wt\;m^{-2}$, respectively.

• Korean Journal of Ecology and Environment
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• v.43 no.2
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• pp.232-241
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• 2010

Epilithic diatom communities and water quality were monitored to evaluate the ecological impact of the inflow of Wonju-stream passing through the urban area in the Seom River Watershed. We selected the 14 sampling stations (5 main stream sites and 9 tributary sites), and collected diatom and water samples between October 2007 and September 2008, on the seasonal basis. The results indicate that most water quality parameters showed the site-specific patterns over the study, except for water temperature and dissolved oxygen. The levels of water quality parameters were highest at the site of Wonju stream, whereas the lowest in the upstream sites, and intermediate or gradually decreased in the downstream sites of the Seom river. One species, Achnanthes convergens, showed the highest biomass and frequency over the sites, while three saprophilous species-Navicula goeppertiana, Navicula subminuscula, Nitzschia palea were appeared only in Wonju Stream and other polluted sites. According to trophic diatom index (TDI) values, which were highly correlated with nutrients and EC, the study sites were classified into three classes: upstream and tributary (Class A and B), Wonju Stream (Class D), and mixed zone and downstream (Class C). A cluster analysis supported the result of TDI classification. Therefore, Wonju-stream located in populated urban area exerted the adverse ecological effects on the epilithic diatom community and water quality of the lower Seom River System, although its severity gradually decreased downstream.

• The korean journal of orthodontics
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• v.34 no.5 s.106
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• pp.380-393
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• 2004

The Purpose of this study was to investigate the dentoalveolar compensation according to anteroposterior skeletal discrepancy in normal occlusion and to evaluate cephalometric parameters that quantitatively describe dental compensations. The study consisted of 90 subjects (50 males. 40 females) who were selected among specimens of normal occlusion at Seoul National, University Dental Hospital, Dept. of Orthodontics. Lateral cephalograms in centric occlusion were traced and digitized for each subject. According to the anteroposterior skeletal pattern the sample was divided into three groups. Cephalometric data were analyzed for the three groups using the SPSS program. Independent t-test, correlation analysis and regression analysis were carried out. The results were as fellows: Dentoalveolar compensation was found in upper and lower incisor inclination and occlusal plane inclination. As the mandible located anterior to the maxilla, the maxillary incisors incisors more labially. the mandibular incisors more lingually, and the occlusal plane continued to flatten. The dental parameters most correlated with anteroposterior skeletal discrepancy were L1 to SN and L1 to FH. Among the compensatory dentoalveolar changes, lower incisor inclination was strongly related to the anteroposterior jaw relationship and played au imposrtant role in obtaining a normal incisor relationship U1 to PtGn and L1 to APog were constant irrelevant to anteroposterior skeletal discrepancy.

• Korean Journal of Soil Science and Fertilizer
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• v.46 no.3
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• pp.193-202
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• 2013

The concentrations of heavy metals such as cadmium (Cd), chromium (Cr), copper (Cu), lead (Pb), zinc (Zn), nickel (Ni), and arsenic (As) in sand samples collected from selected children's playground and their correlation with environmental parameters, such as concentration of particulate matter in the atmosphere ($PM_{10}$), apartment age (> 5 years), clay and organic matter contents in sand samples, were analyzed. The average heavy metal concentration in samples was 0.040 mg $kg^{-1}$ for Cd, 0.200 mg $kg^{-1}$ for Cr, 1.75 mg $kg^{-1}$ for Cu, 15.1 mg $kg^{-1}$ for Ni, 3.42 mg $kg^{-1}$ for Pb, 66.7 mg $kg^{-1}$ for Zn and 0.750 mg $kg^{-1}$ for As, all of which were below the environmental regulatory level established by Korea Ministry of Environment. However, in the consideration of direct and oral exposure by children to playground sand, the risk of the concentration range in the samples might be greatly enhanced. Heavy metal concentration in samples collected from high $PM_{10}$ (> $70{\mu}gm^{-3}$) area was slightly greater than in samples from low $PM_{10}$ (< $70{\mu}gm^{-3}$), indicating the contribution of particulate matter in air phase to heavy metal concentration in playground sand samples. The concentrations of both Cd and Pb were the highest in apartments older than 21 years (0.050 mg $kg^{-1}$ and 5.28 mg $kg^{-1}$ for Cd and Pb respectively) and showed positive correlation with apartment age (p<0.01 and p<0.001 for Cd and Pb, respectively). Clay content in playground sands ranged 3.8~11.2% and was positively correlated with heavy metal concentration. Organic matter content was negligible (mostly < 0.1%) and showed poor correlation with heavy metal concentration. In conclusion, concentration of heavy metals in playground sand was found to be predominantly influenced by the apartment age and clay content in sand samples and supplemented by dust deposition of particulate matter ($PM_{10}$) from atmosphere.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.8 no.2
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• pp.70-77
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• 2003

From March 1998 to August 2000, the phenological and morphometric changes of Zostera marina L. were examined at the Duksan Port in the eastern coast of Korea. Morphometric characteristics, phenological stage, shoot density, biomass of Z. marina population and environmental parameters were also measured. Nutrient levels in water column varied over the season. Morphometric characteristics of vegetative shoot changed with season; shoot heights ranged from 54.2 cm (March) to 100.0 cm (October). Reproductive shoots appeared from mid-March to early September of which the height was ranged from 97.8 cm (March) to 213.0 cm (July). The flowering phase started at 12$^{\circ}C$ and the fruit development was resulted up to 21$^{\circ}C$. The seed maturing was developed at 22$^{\circ}C$-$25^{\circ}C$. Shoot density and biomass in permanent quadrate (0.25 m$^2$) were significantly different among seasons ranging from 38 to 136 shoots (mean 80.3$\pm$6.5) for shoot density, and 190 g dry wt m$^{-2}$ in October 1998 to 922 g dry wt m$^{-2}$ in June 1998 for biomass respectively. Relationships between shoot morphometrics and physico-chemical parameters were not significantly correlated. Seasonal changes in water temperature seemed responsible for the replacement of reproductive phases and the annual changes of shoot morphometrics in Z. marina populations.

• Journal of Korean Neurosurgical Society
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• v.60 no.5
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• pp.577-583
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• 2017

Objective : Laminoplasty is an effective surgical method for treating cervical degenerative disease. However, postoperative complications such as kyphosis, restriction of neck motion, and instability are often reported. Despite sufficient preoperative lordosis, this procedure often aggravates the lordotic curve of the cervical spine and straightens cervical alignment. Hence, it is important to examine preoperative risk factors associated with postoperative kyphotic alignment changes. Our study aimed to investigate preoperative radiologic parameters associated with kyphotic deformity post laminoplasty. Methods : We retrospectively reviewed the medical records of 49 patients who underwent open door laminoplasty for cervical spondylotic myelopathy (CSM) or ossification of the posterior longitudinal ligament (OPLL) at Pusan National University Yangsan Hospital between January 2011 and December 2015. Inclusion criteria were as follows : 1) preoperative diagnosis of OPLL or CSM, 2) no previous history of cervical spinal surgery, cervical trauma, tumor, or infection, 3) minimum of one-year follow-up post laminoplasty with proper radiologic examinations performed in outpatient clinics, and 4) cases showing C7 and T1 vertebral body in the preoperative cervical sagittal plane. The radiologic parameters examined included C2-C7 Cobb angles, T1 slope, C2-C7 sagittal vertical axis (SVA), range of motion (ROM) from C2-C7, segmental instability, and T2 signal change observed on magnetic resonance imaging (MRI). Clinical factors examined included preoperative modified Japanese Orthopedic Association scores, disease classification, duration of symptoms, and the range of operation levels. Results : Mean preoperative sagittal alignment was $13.01^{\circ}$ lordotic; $6.94^{\circ}$ lordotic postoperatively. Percentage of postoperative kyphosis was 80%. Patients were subdivided into two groups according to postoperative Cobb angle change; a control group (n=22) and kyphotic group (n=27). The kyphotic group consisted of patients with more than $5^{\circ}$ kyphotic angle change postoperatively. There were no differences in age, sex, C2-C7 Cobb angle, T1 slope, C2-C7 SVA, ROM from C2-C7, segmental instability, or T2 signal change. Multiple regression analysis revealed T1 slope had a strong relationship with postoperative cervical kyphosis. Likewise, correlation analysis revealed there was a statistical significance between T1 slope and postoperative Cobb angle change (p=0.035), and that there was a statistically significant relationship between T1 slope and C2-C7 SVA (p=0.001). Patients with higher preoperative T1 slope demonstrated loss of lordotic curvature postoperatively. Conclusion : Laminoplasty has a high probability of aggravating sagittal balance of the cervical spine. T1 slope is a good predictor of postoperative kyphotic changes of the cervical spine. Similarly, T1 slope is strongly correlated with C2-C7 SVA.

• Korean Journal of Remote Sensing
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• v.24 no.4
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• pp.359-367
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• 2008

TRMM TMI data were used to investigate a relationship between physical parameters from microwave sensor and typhoon intensities from June to September, 2004. Several data such as 85GHz brightness temperature (TB), polarization corrected temperature (PCT), precipitable water, ice content, rain rate, and latent heat release retrieved from the TMI observation were correlated to the maximum wind speeds in the best-track database by RSMC-Tokyo. Correlation coefficient between TB and typhoon intensity was -0.2 - -0.4 with a maximum value in the 2.5 degree radius circle from the center of tropical cyclone. The value of correlation between in precipitable water, rain, latent heat, and typhoon intensity is in the range of 0.2-0.4. Correlation analysis with respect to storm intensity showed that maximum correlation is observed at 1.0-1.5 degree radius circle from the center of tropical cyclone in the initial stage of tropical cyclone, while maximum correlation is shown in 0.5 degree radius in typhoon stage. Correlation coefficient was used to produce regressed intensities and adopted for typhoon Rusa (2002) and Maemi (2003). Multiple regression with 85GHz TB and precipitable water was found to provide an improved typhoon intensity when taking into account the storm size. The results indicate that it may be possible to use TB and precipitable water from satellite observation as a predictor to estimate the intensity of a tropical cyclone.

• Journal of Breast Cancer
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• v.21 no.4
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• pp.406-414
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• 2018

Purpose: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is an emerging immune response molecule related to T-cell anergy. There has been tremendous interest in breast cancer targeting immune checkpoint molecules, especially in the triple-negative breast cancer (TNBC). This study was designed to investigate TIM-3 expression on tumor infiltrating lymphocytes (TILs), its relationships with clinicopathological parameters and expression of programmed death receptor 1 (PD-1)/programmed death receptor ligand 1 (PD-L1), and its prognostic role. Methods: Immunohistochemistry on tissue microarray blocks produced from 109 samples of invasive ductal carcinoma type TNBC was performed with antibodies toward TIM-3, PD-1, PD-L1 and breast cancer-related molecular markers. Associations between their expression and clinicopathological parameters as well as survival analyses were performed. Results: TIM-3 was expressed in TILs from all 109 TNBCs, consisting of 17 cases (<5%), 31 cases (6%-25%), 48 cases (26%-50%), and 13 cases (>51%). High TIM-3 was significantly correlated with younger patients (p=0.0101), high TILs (p=0.0029), high tumor stage (p=0.0018), high PD-1 (p=0.0001) and high PD-L1 (p=0.0019), and tended to be associated with higher histologic grade, absence of extensive in situ components and microcalcification. High TIM-3 expression was significantly associated with a combinational immunophenotype group of high PD-L1 and high PD-1 (p<0.0001). High TIM-3 demonstrated a significantly better disease-free survival (DFS) (p<0.0001) and longer overall survival (OS) (p=0.0001), together with high TILs and high PD-1. In univariate survival analysis, high TIM-3 showed reduced relapse risk (p<0.0001) and longer OS (p=0.0003), together with high PD-1 expression. In multivariate analysis, high TIM-3 was statistically significant in predicting prognosis, showing better DFS (hazard ratio [HR], 0.0994; 95% confidence interval [CI], 0.0296-0.3337; p=0.0002) and longer OS (HR, 0.1109; 95% CI, 0.0314-0.3912; p=0.0006). Conclusion: In this study, we demonstrate that TIM-3 expression is an independent positive prognostic factor in TNBC, despite its association with poor clinical and pathologic features.